LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 20

Search options

  1. Article ; Online: Millets as an alternative diet for gluten-sensitive individuals: A critical review on nutritional components, sensitivities and popularity of wheat and millets among consumers

    Asrani, Purva / Ali, Ansheef / Tiwari, Keshav

    Food Reviews International. 2023 Aug. 18, v. 39, no. 6 p.3370-3399

    2023  

    Abstract: Wheat is a widely consumed crop across the world. Its flavour, aroma, and taste has been successful in attracting people to include this cereal as a part of their staple diet. However, wheat gluten protein primarily consisting of gliadin and glutenin ... ...

    Abstract Wheat is a widely consumed crop across the world. Its flavour, aroma, and taste has been successful in attracting people to include this cereal as a part of their staple diet. However, wheat gluten protein primarily consisting of gliadin and glutenin limits their consumption in certain susceptible population. Various gluten disorders that has been associated with their consumption suggests the introduction of gluten-free breads and other baked products in the diet. However, the structural, functional, and rheological properties offered by gluten to the dough could not be replaced, and hence, this study suggests the use of millets as an alternative diet. Millets not only protect from gluten sensitivities but also provide all other essential micro- and macronutrients required for the growth and metabolism of the body. They also hold potential in eradicating the malnutrition owning to their high nutritional, phenolic, and other antioxidant elements, indicating their probability to help in achieving a major sustainable goal related to good health and well-being. Despite offering a wide variety of health benefits, the consumer acceptability of millets is quite low at the moment. This paper is a wake-up call for the researchers and farmers to gear up in popularizing millets and their associated products and in improving the limitations associated with the shelf life of certain millets. Different physical processing technologies in the production of traditional and modern millet-based food products are also discussed in this paper, providing an overview of how various major millets can be used in promoting the health security with lesser dependency on environmental conditions for their growth and production.
    Keywords antioxidants ; at-risk population ; consumer acceptance ; diet ; dough ; flavor ; gliadin ; glutenins ; malnutrition ; metabolism ; odors ; people ; probability ; shelf life ; taste ; wheat ; wheat gluten ; gliadins and glutenins ; gluten senstivity ; millet based diet ; sustainable goal
    Language English
    Dates of publication 2023-0818
    Size p. 3370-3399.
    Publishing place Taylor & Francis
    Document type Article ; Online
    ZDB-ID 53834-6
    ISSN 1525-6103 ; 8755-9129
    ISSN (online) 1525-6103
    ISSN 8755-9129
    DOI 10.1080/87559129.2021.2012790
    Database NAL-Catalogue (AGRICOLA)

    More links

    Kategorien

  2. Article ; Online: Potassium viroporins as model systems for understanding eukaryotic ion channel behaviour.

    Asrani, Purva / Seebohm, Guiscard / Stoll, Raphael

    Virus research

    2022  Volume 320, Page(s) 198903

    Abstract: Ion channels are membrane proteins essential for a plethora of cellular functions including maintaining cell shape, ion homeostasis, cardiac rhythm and action potential in neurons. The complexity and often extensive structure of eukaryotic membrane ... ...

    Abstract Ion channels are membrane proteins essential for a plethora of cellular functions including maintaining cell shape, ion homeostasis, cardiac rhythm and action potential in neurons. The complexity and often extensive structure of eukaryotic membrane proteins makes it difficult to understand their basic biological regulation. Therefore, this article suggests, viroporins - the miniature versions of eukaryotic protein homologs from viruses - might serve as model systems to provide insights into behaviour of eukaryotic ion channels in general. The structural requirements for correct assembly of the channel along with the basic functional properties of a K
    MeSH term(s) Animals ; Chlorella/metabolism ; Eukaryota ; Ion Channels/metabolism ; Mammals/metabolism ; Phycodnaviridae/genetics ; Phycodnaviridae/metabolism ; Potassium/metabolism ; Potassium Channels/chemistry ; Potassium Channels/genetics ; Potassium Channels/metabolism ; Viroporin Proteins ; Viruses/metabolism
    Chemical Substances Ion Channels ; Potassium Channels ; Viroporin Proteins ; Potassium (RWP5GA015D)
    Language English
    Publishing date 2022-08-28
    Publishing country Netherlands
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 605780-9
    ISSN 1872-7492 ; 0168-1702
    ISSN (online) 1872-7492
    ISSN 0168-1702
    DOI 10.1016/j.virusres.2022.198903
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  3. Article: Potassium viroporins as model systems for understanding eukaryotic ion channel behaviour

    Asrani, Purva / Seebohm, Guiscard / Stoll, Raphael

    Virus research. 2022 Aug. 25,

    2022  

    Abstract: Ion channels are membrane proteins essential for a plethora of cellular functions including maintaining cell shape, ion homeostasis, cardiac rhythm and action potential in neurons. The complexity and often extensive structure of eukaryotic membrane ... ...

    Abstract Ion channels are membrane proteins essential for a plethora of cellular functions including maintaining cell shape, ion homeostasis, cardiac rhythm and action potential in neurons. The complexity and often extensive structure of eukaryotic membrane proteins makes it difficult to understand their basic biological regulation. Therefore, this article suggests, viroporins – the miniature versions of eukaryotic protein homologs from viruses – might serve as model systems to provide insights into behaviour of eukaryotic ion channels in general. The structural requirements for correct assembly of the channel along with the basic functional properties of a K⁺ channel exist in the minimal design of the viral K⁺ channels from two viruses, Chlorella virus (Kcv) and Ectocarpus siliculosus virus (Kesv). These small viral proteins readily assemble into tetramers and they sort in cells to distinct target membranes. When these viruses-encoded channels are expressed into the mammalian cells, they utilise their protein machinery and hence can serve as excellent tools to study the cells protein sorting machinery. This combination of small size and robust function makes viral K⁺ channels a valuable model system for detection of basic structure-function correlations. It is believed that molecular and physiochemical analyses of these viroporins may serve as basis for the development of inhibitors or modulators to ion channel activity for targeting ion channel diseases - so called channelopathies. Therefore, it may provide a potential different scope for molecular pharmacology studies aiming at novel and innovative therapeutics associated with channel related diseases. This article reviews the structural and functional properties of Kcv and Kesv upon expression in mammalian cells and Xenopus oocytes. The mechanisms behind differential protein sorting in Kcv and Kesv are also thoroughly discussed.
    Keywords Chlorella ; Ectocarpus ; Xenopus ; action potentials ; homeostasis ; ion channels ; mammals ; oocytes ; pharmacology ; potassium ; research ; therapeutics ; viruses
    Language English
    Dates of publication 2022-0825
    Publishing place Elsevier B.V.
    Document type Article
    Note Pre-press version
    ZDB-ID 605780-9
    ISSN 1872-7492 ; 0168-1702
    ISSN (online) 1872-7492
    ISSN 0168-1702
    DOI 10.1016/j.virusres.2022.198903
    Database NAL-Catalogue (AGRICOLA)

    More links

    Kategorien

  4. Article ; Online: SARS-CoV-2 mediated lung inflammatory responses in host: targeting the cytokine storm for therapeutic interventions.

    Asrani, Purva / Hassan, Md Imtaiyaz

    Molecular and cellular biochemistry

    2020  Volume 476, Issue 2, Page(s) 675–687

    Abstract: The recent exposure of novel coronavirus strain, severe acute respiratory syndrome (SARS-CoV-2) has spread to different countries at an alarming rate. Faster transmission rate and genetic modifications have provoked scientists to search for an immediate ... ...

    Abstract The recent exposure of novel coronavirus strain, severe acute respiratory syndrome (SARS-CoV-2) has spread to different countries at an alarming rate. Faster transmission rate and genetic modifications have provoked scientists to search for an immediate solution. With an increasing death rate, it becomes important to throw some light on the life cycle of the virus and its associated pathogenesis in the form of lung inflammation through cytokine storm (CS) production. This paper highlights the different stages of viral-mediated inflammatory responses in the host respiratory system. Previously, known anti-inflammatory drugs and therapeutic strategies that might show potential in controlling the CS of Coronavirus disease-2019 (COVID-19) is also mentioned in this study. Our critical analysis provides insights into the inflammation cycle induced in the lungs by early virus replication, downregulation and shedding of angiotensin-converting enzyme 2 (ACE2), and in the CS production. Identification of suitable targets within the inflammatory pathways for devising the therapeutic strategies useful in controlling the prognosis of COVID-19 finds a special mention in this article. However, antibody-dependent enhancement is the key aspect to consider before testing any drug/compound for therapeutic purposes. Our in-depth analysis would provide similarities and differences between the inflammatory responses induced by SARS-CoV and SARS-CoV-2, providing an excellent avenue to further look at how earlier outbreaks of coronaviruses were controlled and where new steps are required?
    MeSH term(s) Antibodies/immunology ; Antibodies/therapeutic use ; Antibody-Dependent Enhancement/immunology ; COVID-19/epidemiology ; COVID-19/immunology ; COVID-19/virology ; Cytokine Release Syndrome/drug therapy ; Cytokine Release Syndrome/immunology ; Cytokine Release Syndrome/pathology ; Cytokine Release Syndrome/virology ; Humans ; Inflammation/drug therapy ; Inflammation/pathology ; Inflammation/virology ; Lung/metabolism ; Lung/pathology ; Lung/virology ; SARS-CoV-2/drug effects ; SARS-CoV-2/pathogenicity ; Virus Replication/drug effects ; COVID-19 Drug Treatment
    Chemical Substances Antibodies
    Keywords covid19
    Language English
    Publishing date 2020-10-16
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 184833-1
    ISSN 1573-4919 ; 0300-8177
    ISSN (online) 1573-4919
    ISSN 0300-8177
    DOI 10.1007/s11010-020-03935-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  5. Article ; Online: Implications of the second wave of COVID-19 in India.

    Asrani, Purva / Eapen, Mathew Suji / Hassan, Md Imtaiyaz / Sohal, Sukhwinder Singh

    The Lancet. Respiratory medicine

    2021  Volume 9, Issue 9, Page(s) e93–e94

    MeSH term(s) Aspergillosis/epidemiology ; Aspergillosis/immunology ; Aspergillosis/microbiology ; Aspergillus/immunology ; COVID-19/complications ; COVID-19/epidemiology ; COVID-19/immunology ; COVID-19/virology ; Humans ; India/epidemiology ; Mucorales/immunology ; Mucormycosis/epidemiology ; Mucormycosis/immunology ; Mucormycosis/microbiology ; Pandemics/prevention & control ; Pandemics/statistics & numerical data ; Risk Factors ; SARS-CoV-2/genetics ; SARS-CoV-2/immunology ; SARS-CoV-2/pathogenicity
    Language English
    Publishing date 2021-06-30
    Publishing country England
    Document type Letter
    ZDB-ID 2686754-0
    ISSN 2213-2619 ; 2213-2600
    ISSN (online) 2213-2619
    ISSN 2213-2600
    DOI 10.1016/S2213-2600(21)00312-X
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  6. Article ; Online: Containment strategies for COVID-19 in India: lessons from the second wave.

    Asrani, Purva / Tiwari, Keshav / Eapen, Mathew Suji / Hassan, M D Imtaiyaz / Sohal, Sukhwinder Singh

    Expert review of anti-infective therapy

    2022  Volume 20, Issue 6, Page(s) 829–835

    Abstract: Introduction: The COVID-19 pandemic in India has resulted in mass destruction in the form of second wave.Indian citizens and government were badly affected and were left constrained with basic medical facilities in treating the heavy load of patients. ... ...

    Abstract Introduction: The COVID-19 pandemic in India has resulted in mass destruction in the form of second wave.Indian citizens and government were badly affected and were left constrained with basic medical facilities in treating the heavy load of patients. The possibility of reemergence of virulent strains of SARS-CoV-2 still exists.
    Area covered: In this article, we tend to discuss why India is at high risk to be to be affected by the other waves and what strategies could be implemented to contain the viral spread. It provides these insights with reference to the gaps and the lessons learnt from the second wave along with the possible solutions to tackle these problems that were not effectively handled during the previous episodes of viral spread. We propose strategies for implementing effective vaccination programs, focus on speeding up different ways of diagnosis, management of essential hospital aids, prevention from vaccine escape mutant strains  and implementation of COVID-appropriate behavior in rural areas of India.
    Expert opinion: This article has significance to the researchers and government officials in understanding the gaps that led to COVID-19 second wave in India and provides an opportunity to improve on certain areas for handling the future waves with more vigilance.
    MeSH term(s) COVID-19/prevention & control ; Humans ; India/epidemiology ; Pandemics/prevention & control ; SARS-CoV-2
    Language English
    Publishing date 2022-02-07
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2181279-2
    ISSN 1744-8336 ; 1478-7210
    ISSN (online) 1744-8336
    ISSN 1478-7210
    DOI 10.1080/14787210.2022.2036605
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  7. Article: SARS-CoV-2 mediated lung inflammatory responses in host: targeting the cytokine storm for therapeutic interventions

    Asrani, Purva / Hassan, Md Imtaiyaz

    Mol. cell. biochem

    Abstract: The recent exposure of novel coronavirus strain, severe acute respiratory syndrome (SARS-CoV-2) has spread to different countries at an alarming rate. Faster transmission rate and genetic modifications have provoked scientists to search for an immediate ... ...

    Abstract The recent exposure of novel coronavirus strain, severe acute respiratory syndrome (SARS-CoV-2) has spread to different countries at an alarming rate. Faster transmission rate and genetic modifications have provoked scientists to search for an immediate solution. With an increasing death rate, it becomes important to throw some light on the life cycle of the virus and its associated pathogenesis in the form of lung inflammation through cytokine storm (CS) production. This paper highlights the different stages of viral-mediated inflammatory responses in the host respiratory system. Previously, known anti-inflammatory drugs and therapeutic strategies that might show potential in controlling the CS of Coronavirus disease-2019 (COVID-19) is also mentioned in this study. Our critical analysis provides insights into the inflammation cycle induced in the lungs by early virus replication, downregulation and shedding of angiotensin-converting enzyme 2 (ACE2), and in the CS production. Identification of suitable targets within the inflammatory pathways for devising the therapeutic strategies useful in controlling the prognosis of COVID-19 finds a special mention in this article. However, antibody-dependent enhancement is the key aspect to consider before testing any drug/compound for therapeutic purposes. Our in-depth analysis would provide similarities and differences between the inflammatory responses induced by SARS-CoV and SARS-CoV-2, providing an excellent avenue to further look at how earlier outbreaks of coronaviruses were controlled and where new steps are required?
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #871519
    Database COVID19

    Kategorien

  8. Article ; Online: Molecular Basis of Pathogenesis of Coronaviruses: A Comparative Genomics Approach to Planetary Health to Prevent Zoonotic Outbreaks in the 21st Century.

    Asrani, Purva / Hasan, Gulam Mustafa / Sohal, Sukhwinder Singh / Hassan, Md Imtaiyaz

    Omics : a journal of integrative biology

    2020  Volume 24, Issue 11, Page(s) 634–644

    Abstract: In the first quarter of the 21st century, we are already facing the third emergence of a coronavirus outbreak, the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) responsible for the coronavirus disease 2019 (COVID-19) pandemic. Comparative ... ...

    Abstract In the first quarter of the 21st century, we are already facing the third emergence of a coronavirus outbreak, the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) responsible for the coronavirus disease 2019 (COVID-19) pandemic. Comparative genomics can inform a deeper understanding of the pathogenesis of COVID-19. Previous strains of coronavirus, SARS-CoV, and Middle-East respiratory syndrome-coronavirus (MERS-CoV), have been known to cause acute lung injuries in humans. SARS-CoV-2 shares genetic similarity with SARS-CoV with some modification in the S protein leading to their enhanced binding affinity toward the angiotensin-converting enzyme 2 (ACE2) receptors of human lung cells. This expert review examines the features of all three coronaviruses through a conceptual lens of comparative genomics. In particular, the life cycle of SARS-CoV-2 that enables its survival within the host is highlighted. Susceptibility of humans to coronavirus outbreaks in the 21st century calls for comparisons of the transmission history, hosts, reservoirs, and fatality rates of these viruses so that evidence-based and effective planetary health interventions can be devised to prevent future zoonotic outbreaks. Comparative genomics offers new insights on putative and novel viral targets with an eye to both therapeutic innovation and prevention. We conclude the expert review by (1) articulating the lessons learned so far, whereas the research is still being actively sought after in the field, and (2) the challenges and prospects in deciphering the linkages among multiomics biological variability and COVID-19 pathogenesis.
    MeSH term(s) Angiotensin-Converting Enzyme 2 ; Animals ; Betacoronavirus/genetics ; Betacoronavirus/pathogenicity ; COVID-19 ; Chiroptera/virology ; Coronavirus Infections/epidemiology ; Coronavirus Infections/mortality ; Coronavirus Infections/virology ; Eutheria/virology ; Genomics/methods ; Global Health/trends ; Humans ; Middle East Respiratory Syndrome Coronavirus/genetics ; Middle East Respiratory Syndrome Coronavirus/pathogenicity ; Pandemics ; Peptidyl-Dipeptidase A/genetics ; Peptidyl-Dipeptidase A/metabolism ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/mortality ; Pneumonia, Viral/virology ; Protein Binding ; Receptors, Virus/genetics ; Receptors, Virus/metabolism ; SARS Virus/genetics ; SARS Virus/pathogenicity ; SARS-CoV-2 ; Severe Acute Respiratory Syndrome/epidemiology ; Severe Acute Respiratory Syndrome/mortality ; Severe Acute Respiratory Syndrome/virology ; Severity of Illness Index ; Spike Glycoprotein, Coronavirus/genetics ; Spike Glycoprotein, Coronavirus/metabolism ; Survival Analysis
    Chemical Substances Receptors, Virus ; Spike Glycoprotein, Coronavirus ; Peptidyl-Dipeptidase A (EC 3.4.15.1) ; ACE2 protein, human (EC 3.4.17.23) ; Angiotensin-Converting Enzyme 2 (EC 3.4.17.23)
    Keywords covid19
    Language English
    Publishing date 2020-09-16
    Publishing country United States
    Document type Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2030312-9
    ISSN 1557-8100 ; 1536-2310
    ISSN (online) 1557-8100
    ISSN 1536-2310
    DOI 10.1089/omi.2020.0131
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  9. Article ; Online: Identification of intrinsically disorder regions in non-structural proteins of SARS-CoV-2: New insights into drug and vaccine resistance.

    Anjum, Farah / Mohammad, Taj / Asrani, Purva / Shafie, Alaa / Singh, Shailza / Yadav, Dharmendra Kumar / Uversky, Vladimir N / Hassan, Md Imtaiyaz

    Molecular and cellular biochemistry

    2022  Volume 477, Issue 5, Page(s) 1607–1619

    Abstract: The outbreak of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) emerged in December 2019 and caused coronavirus disease 2019 (COVID-19), which causes pneumonia and severe acute respiratory distress syndrome. It is a highly infectious ... ...

    Abstract The outbreak of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) emerged in December 2019 and caused coronavirus disease 2019 (COVID-19), which causes pneumonia and severe acute respiratory distress syndrome. It is a highly infectious pathogen that promptly spread. Like other beta coronaviruses, SARS-CoV-2 encodes some non-structural proteins (NSPs), playing crucial roles in viral transcription and replication. NSPs likely have essential roles in viral pathogenesis by manipulating many cellular processes. We performed a sequence-based analysis of NSPs to get insights into their intrinsic disorders, and their functions in viral replication were annotated and discussed in detail. Here, we provide newer insights into the structurally disordered regions of SARS-CoV-2 NSPs. Our analysis reveals that the SARS-CoV-2 proteome has a chunk of the disordered region that might be responsible for increasing its virulence. In addition, mutations in these regions are presumably responsible for drug and vaccine resistance. These findings suggested that the structurally disordered regions of SARS-CoV-2 NSPs might be invulnerable in COVID-19.
    MeSH term(s) COVID-19 ; Humans ; SARS-CoV-2 ; Vaccines
    Chemical Substances Vaccines
    Language English
    Publishing date 2022-02-24
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 184833-1
    ISSN 1573-4919 ; 0300-8177
    ISSN (online) 1573-4919
    ISSN 0300-8177
    DOI 10.1007/s11010-022-04393-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  10. Article: Guidelines and Safety Considerations in the Laboratory Diagnosis of SARS-CoV-2 Infection: A Prerequisite Study for Health Professionals.

    Asrani, Purva / Hussain, Afzal / Nasreen, Khalida / AlAjmi, Mohamed Fahad / Amir, Samira / Sohal, Sukhwinder Singh / Hassan, Md Imtaiyaz

    Risk management and healthcare policy

    2021  Volume 14, Page(s) 379–389

    Abstract: Coronavirus disease 2019 (COVID-19) is an emerging challenging area for the researchers to buckle up against the spread and control of the virus. Since earlier times, the diagnosis has been an important procedure in estimating the fate of epidemics by ... ...

    Abstract Coronavirus disease 2019 (COVID-19) is an emerging challenging area for the researchers to buckle up against the spread and control of the virus. Since earlier times, the diagnosis has been an important procedure in estimating the fate of epidemics by indicating the extent to which disease has been spread and to the extent, further disease prognosis would occur. The absence of anti-viral therapies and vaccines for COVID-19 at present suggests early diagnosis and isolation of the patients as the only smart approach available as of now. Presently, the increasing death rates, faster rates of transmission, non-availability of vaccines, and treatment have over-pressurized the researchers, health professionals, and government officials to develop effective clinical strategies in diagnosis and to come up with guidelines to be followed during conduction of each diagnostic procedure for maintaining healthcare systems. Since the incubation period of this virus is 2-14 days, a patient can transmit the infection without showing symptoms. Therefore, early diagnosis and isolation of susceptible individuals are the only way to limit the spread of the virus. Significance of diagnosis and triaging, information on specimen collection, safety considerations while handling, transport, and storage of samples have been highlighted in this paper to make people more aware and develop better clinical strategies in the future.
    Language English
    Publishing date 2021-02-03
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2495128-6
    ISSN 1179-1594
    ISSN 1179-1594
    DOI 10.2147/RMHP.S284473
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

To top