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  1. Article ; Online: Reply to M.A.N. Şendur et al and J. Michels.

    Penson, David F / Armstrong, Andrew J / Concepcion, Raoul / Agarwal, Neeraj / Olsson, Carl / Karsh, Lawrence / Dunshee, Curtis / Wang, Fong / Wu, Kenneth / Krivoshik, Andrew / Phung, De / Higano, Celestia S

    Journal of clinical oncology : official journal of the American Society of Clinical Oncology

    2016  Volume 35, Issue 1, Page(s) 123

    MeSH term(s) Death ; Humans ; Male ; Phenylthiohydantoin/analogs & derivatives ; Prostatic Neoplasms, Castration-Resistant
    Chemical Substances Phenylthiohydantoin (2010-15-3) ; enzalutamide (93T0T9GKNU)
    Language English
    Publishing date 2016-10-31
    Publishing country United States
    Document type Letter ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 604914-x
    ISSN 1527-7755 ; 0732-183X
    ISSN (online) 1527-7755
    ISSN 0732-183X
    DOI 10.1200/JCO.2016.69.9371
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1847: Show issues Location:
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    Zs.MO 650: Show issues

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  2. Article ; Online: What's Important: Operating Room Waste: Why We Should Care.

    Blough, Christian L / Karsh, Kaylee J

    The Journal of bone and joint surgery. American volume

    2021  Volume 103, Issue 9, Page(s) 837–839

    MeSH term(s) Forecasting ; Greenhouse Effect ; Hazardous Waste/classification ; Hazardous Waste/prevention & control ; Humans ; Incineration ; Medical Waste/classification ; Medical Waste/legislation & jurisprudence ; Medical Waste/prevention & control ; Medical Waste/statistics & numerical data ; Medical Waste Disposal/legislation & jurisprudence ; Medical Waste Disposal/methods ; Operating Rooms/statistics & numerical data ; Orthopedic Procedures/statistics & numerical data ; Waste Management/methods
    Chemical Substances Hazardous Waste ; Medical Waste ; Medical Waste Disposal
    Language English
    Publishing date 2021-01-07
    Publishing country United States
    Document type Journal Article
    ZDB-ID 220625-0
    ISSN 1535-1386 ; 0021-9355
    ISSN (online) 1535-1386
    ISSN 0021-9355
    DOI 10.2106/JBJS.20.01816
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.MO 464: Show issues

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  3. Article ; Online: Next-generation imaging in localized high-risk prostate cancer.

    Patel, Devin N / Karsh, Lawrence I / Daskivich, Timothy J

    Prostate cancer and prostatic diseases

    2021  Volume 24, Issue 3, Page(s) 585–586

    MeSH term(s) Gallium Isotopes/metabolism ; Gallium Radioisotopes/metabolism ; Humans ; Male ; Positron Emission Tomography Computed Tomography/methods ; Prognosis ; Prostatic Neoplasms/diagnostic imaging ; Prostatic Neoplasms/metabolism ; Prostatic Neoplasms/pathology ; Radiopharmaceuticals/metabolism
    Chemical Substances Gallium Isotopes ; Gallium Radioisotopes ; Radiopharmaceuticals ; gallium 68 PSMA-11
    Language English
    Publishing date 2021-03-31
    Publishing country England
    Document type Editorial
    ZDB-ID 1419277-9
    ISSN 1476-5608 ; 1365-7852
    ISSN (online) 1476-5608
    ISSN 1365-7852
    DOI 10.1038/s41391-021-00356-x
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    Zs.A 5277: Show issues Location:
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  4. Article: Management of rheumatoid arthritis 2012: a Canadian state of the art.

    Karsh, Jacob

    The Journal of rheumatology

    2012  Volume 39, Issue 8, Page(s) 1497–1499

    MeSH term(s) Antirheumatic Agents/therapeutic use ; Arthritis, Rheumatoid/drug therapy ; Canada ; Humans ; Practice Guidelines as Topic
    Chemical Substances Antirheumatic Agents
    Language English
    Publishing date 2012-08
    Publishing country Canada
    Document type Editorial
    ZDB-ID 194928-7
    ISSN 1499-2752 ; 0315-162X
    ISSN (online) 1499-2752
    ISSN 0315-162X
    DOI 10.3899/jrheum.120407
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1168: Show issues Location:
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    Zs.MO 135: Show issues

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  5. Article: Pinpoint: trajectory planning for multi-probe electrophysiology and injections in an interactive web-based 3D environment.

    Birman, Daniel / Yang, Kenneth J / West, Steven J / Karsh, Bill / Browning, Yoni / Siegle, Joshua H / Steinmetz, Nicholas A

    bioRxiv : the preprint server for biology

    2023  

    Abstract: Targeting deep brain structures during electrophysiology and injections requires intensive training and expertise. Even with experience, researchers often can't be certain that a probe is placed precisely in a target location and this complexity scales ... ...

    Abstract Targeting deep brain structures during electrophysiology and injections requires intensive training and expertise. Even with experience, researchers often can't be certain that a probe is placed precisely in a target location and this complexity scales with the number of simultaneous probes used in an experiment. Here, we present
    Language English
    Publishing date 2023-07-15
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2023.07.14.548952
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Prediction of Response to Treatment Using Doppler Signal Positivity Measured by Ultrasound in Rheumatoid Arthritis: A Proof-of-Concept Study.

    Gazel, Ummugulsum / Ayan, Gizem / Solmaz, Dilek / Maltez, Nancy / Ramsay, Tim / Karsh, Jacob / Cabral, Antonio R / Akar, Servet / Aydin, Sibel Zehra

    European journal of rheumatology

    2023  Volume 10, Issue 3, Page(s) 118–119

    Language English
    Publishing date 2023-08-18
    Publishing country Turkey
    Document type Journal Article
    ZDB-ID 2873727-1
    ISSN 2148-4279 ; 2147-9720
    ISSN (online) 2148-4279
    ISSN 2147-9720
    DOI 10.5152/eurjrheum.2023.23005
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Comparison of Female Sexual Function Index in patients with psoriatic and rheumatoid arthritis and healthy controls.

    Boone, Denise / Ronson, Ashley / Karsh, Jacob

    Musculoskeletal care

    2019  Volume 17, Issue 3, Page(s) 226–230

    Abstract: Objective: The aim of the recent study was to identify and compare the Female Sexual Function Index (FSFI) of three female populations: those with rheumatoid arthritis (RA), psoriatic arthritis (PsA), and healthy individuals.: Methods: In this ... ...

    Abstract Objective: The aim of the recent study was to identify and compare the Female Sexual Function Index (FSFI) of three female populations: those with rheumatoid arthritis (RA), psoriatic arthritis (PsA), and healthy individuals.
    Methods: In this descriptive correlational study, convenience sampling was used to recruit 50 female RA patients, 36 female PsA patients and 50 healthy women between June and September 2018.
    Results: The mean ages of the RA patients, PsA patients and healthy controls were, respectively, 53.1 ± 11.8 years, 51.6 ± 13.7 years and 37.4 ± 10.4 years. Controls were significantly younger than RA (p < 0.001) and PsA (p = 0.002) patients. Data including all participants: Based on the total sexual functioning cut-off score of 26.55, 68% of RA patients (34/50), 67% of PsA patients (22/33) and 44% of healthy controls (11/25) met the criteria for sexual dysfunction. Data excluding participants who reported not having had sex in the previous month: Controls had significantly higher FSFI scores than the RA patients across all six domains (p ≤ 0.001) and the overall score (p < 0.001). Controls had significantly higher FSFI scores than the PsA patients across four of the six domains (p ≤ 0.026) and the overall score (p = 0.008). There were no statistically significant differences between the RA and PsA groups. Patient pain, patient global status and Health Assessment Questionnaire scores were not significantly correlated with the total FSFI score in either PsA or RA.
    Conclusions: These findings demonstrate that decreased sexual functioning is more common in women with RA and PsA when compared with controls. All female patients with RA and PsA should be screened for sexual dysfunction.
    MeSH term(s) Adult ; Aged ; Arthritis, Psoriatic/complications ; Arthritis, Psoriatic/physiopathology ; Arthritis, Psoriatic/psychology ; Arthritis, Rheumatoid/complications ; Arthritis, Rheumatoid/physiopathology ; Arthritis, Rheumatoid/psychology ; Case-Control Studies ; Cross-Sectional Studies ; Female ; Humans ; Middle Aged ; Sexual Behavior/physiology ; Sexual Behavior/psychology ; Sexual Behavior/statistics & numerical data ; Sexual Dysfunction, Physiological/etiology
    Language English
    Publishing date 2019-06-20
    Publishing country England
    Document type Comparative Study ; Journal Article
    ZDB-ID 2171452-6
    ISSN 1557-0681 ; 1478-2189
    ISSN (online) 1557-0681
    ISSN 1478-2189
    DOI 10.1002/msc.1405
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6046: Show issues Location:
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  8. Article ; Online: Metabolomics as a tool for in situ study of chronic metal exposure in estuarine invertebrates.

    Hillyer, Katie E / Raes, Eric / Karsh, Kristen / Holmes, Bronwyn / Bissett, Andrew / Beale, David J

    Environmental pollution (Barking, Essex : 1987)

    2021  Volume 292, Issue Pt B, Page(s) 118408

    Abstract: Estuaries are subject to intense human use globally, with impacts from multiple stressors, such as metal contaminants. A key challenge is extending beyond traditional monitoring approaches to understand effects to biota and system function. To explore ... ...

    Abstract Estuaries are subject to intense human use globally, with impacts from multiple stressors, such as metal contaminants. A key challenge is extending beyond traditional monitoring approaches to understand effects to biota and system function. To explore the metabolic effects of complex metal contaminants to sediment dwelling (benthic) fauna, we apply a multiple-lines-of-evidence approach, coupling environmental monitoring, benthic sampling, total metals analysis and targeted metabolomics. We characterise metabolic signatures of metal exposure in three benthic invertebrate taxa, which differed in distribution across sites and severity of metal exposure: sipunculid (very high), amphipod (high), maldanid polychaete (moderate). We observed sediment and tissue metal loads far exceeding sediment guidelines where toxicity-related adverse effects may be expected, for metals including, As, Cd, Pb, Zn and Hg. Change in site- and taxa-specific metabolite profiles was highly correlated with natural environmental drivers (sediment total organic carbon and water temperature). At the most metal influenced sites, metabolite variation was also correlated with sediment metal loads. Using supervised multivariate regression, taxa-specific metabolic signatures of increased exposure and possibility of toxic effects were characterised against multiple reference sites. Metabolic signatures varied according to each taxon and degree of metal exposure, but primarily indicated altered cysteine and methionine metabolism, metal-binding and elimination (lysosomal) activity, coupled to change in complex biosynthesis pathways, responses to oxidative stress, and cellular damage. This novel multiple-lines-of-evidence approach combining metabolomics with traditional environmental monitoring, enabled detection and characterisation of chronic metal exposure effects in situ in multiple invertebrate taxa. With capacity for application to rapid and effective monitoring of non-model species in complex environments, these approaches are critical for improved assessment and management of systems that are increasingly subject to anthropogenic drivers of change.
    MeSH term(s) Animals ; Environmental Monitoring ; Geologic Sediments ; Humans ; Invertebrates ; Metabolomics ; Metals/analysis ; Metals/toxicity ; Water Pollutants, Chemical/analysis ; Water Pollutants, Chemical/toxicity
    Chemical Substances Metals ; Water Pollutants, Chemical
    Language English
    Publishing date 2021-10-27
    Publishing country England
    Document type Journal Article
    ZDB-ID 280652-6
    ISSN 1873-6424 ; 0013-9327 ; 0269-7491
    ISSN (online) 1873-6424
    ISSN 0013-9327 ; 0269-7491
    DOI 10.1016/j.envpol.2021.118408
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    Zs.A 2599: Show issues Location:
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  9. Article: How I Do It: Hydrogel spacer placement in men scheduled to undergo prostate radiotherapy.

    Montoya, Juan / Gross, Eric / Karsh, Lawrence

    The Canadian journal of urology

    2018  Volume 25, Issue 2, Page(s) 9288–9293

    Abstract: Hydrogel spacer placement between the prostate and rectum in men scheduled to undergo prostate radiotherapy is an emerging technique well suited for urologists. The hydrogel spacer reduces rectal injury during radiotherapy by displacing the rectum away ... ...

    Abstract Hydrogel spacer placement between the prostate and rectum in men scheduled to undergo prostate radiotherapy is an emerging technique well suited for urologists. The hydrogel spacer reduces rectal injury during radiotherapy by displacing the rectum away from the high dose region. Following radiotherapy the hydrogel spacer then liquifies, is absorbed, and then clears via renal filtration in approximately 6 months. Herein we describe the appropriate patients eligible for this procedure, and the application technique we use in our clinic.
    MeSH term(s) Aged ; Equipment Design ; Humans ; Hydrogels/pharmacology ; Male ; Middle Aged ; Neoplasm Invasiveness/pathology ; Neoplasm Staging ; Patient Positioning ; Prognosis ; Prostatic Neoplasms/pathology ; Prostatic Neoplasms/radiotherapy ; Radiation Injuries/prevention & control ; Radiation Protection/instrumentation ; Radiotherapy Dosage ; Radiotherapy, Intensity-Modulated/adverse effects ; Radiotherapy, Intensity-Modulated/methods ; Rectum/radiation effects ; Treatment Outcome
    Chemical Substances Hydrogels
    Language English
    Publishing date 2018-04-04
    Publishing country Canada
    Document type Journal Article ; Randomized Controlled Trial
    ZDB-ID 2064475-9
    ISSN 1195-9479
    ISSN 1195-9479
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5607: Show issues Location:
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  10. Article ; Online: Anti-inflammatory effect of biologic therapy in patients with psoriatic disease: A prospective cohort FDG PET study.

    Boczar, Kevin E / Beanlands, Rob S / Glassman, Steven J / Wang, Jerry / Zeng, Wanzhen / deKemp, Robert A / Ward, Natalie C / Fehlmann, Christophe A / Wells, George A / Karsh, Jacob / Dwivedi, Girish

    Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology

    2023  Volume 30, Issue 4, Page(s) 1642–1652

    Abstract: Aim: The aim of the study was to evaluate the changes in central vascular inflammation measured by FDG PET and myocardial blood flow reserve (MFR) determined by : Methods and results: Target-to-background ratio (TBR) by FDG PET in the most diseased ... ...

    Abstract Aim: The aim of the study was to evaluate the changes in central vascular inflammation measured by FDG PET and myocardial blood flow reserve (MFR) determined by
    Methods and results: Target-to-background ratio (TBR) by FDG PET in the most diseased segment of the ascending aorta (TBR
    Conclusion: In a cohort of psoriasis patients treated with biologics, FDG uptake in the thoracic aorta decreased over the study period. Patients who demonstrated a significant anti-inflammatory response on FDG PET imaging maintained their MFR compared to non-responders.
    MeSH term(s) Humans ; Arthritis, Psoriatic/diagnostic imaging ; Arthritis, Psoriatic/drug therapy ; Fluorodeoxyglucose F18/therapeutic use ; Prospective Studies ; Positron-Emission Tomography ; Psoriasis/diagnostic imaging ; Psoriasis/drug therapy ; Biological Factors/therapeutic use ; Inflammation/diagnostic imaging ; Anti-Inflammatory Agents/therapeutic use
    Chemical Substances Fluorodeoxyglucose F18 (0Z5B2CJX4D) ; Biological Factors ; Anti-Inflammatory Agents
    Language English
    Publishing date 2023-02-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1212505-2
    ISSN 1532-6551 ; 1071-3581
    ISSN (online) 1532-6551
    ISSN 1071-3581
    DOI 10.1007/s12350-023-03204-8
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