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Article ; Online: Neutrophil count in sputum is associated with increased sputum glucose and sputum L-lactate in cystic fibrosis.

Nielsen, Bibi Uhre / Kolpen, Mette / Jensen, Peter Østrup / Katzenstein, Terese / Pressler, Tacjana / Ritz, Christian / Mathiesen, Inger Hee Mabuza / Faurholt-Jepsen, Daniel

PloS one

2020 Volume 15, Issue 9, Page(s) e0238524

Abstract: ... the potential of improving the timing of antibiotic treatment in cystic fibrosis (CF). L-Lactate might be ... lungs. We aimed to investigate changes in and associations between PMNs, glucose and L-lactate in sputum ... treatment. Sputum PMNs were positively associated with both glucose (log coefficient = 0.20, p = 0.01) and L ...

Abstract	Background: Markers of lung inflammation measured directly in expectorated sputum have the potential of improving the timing of antibiotic treatment in cystic fibrosis (CF). L-Lactate might be a marker of inflammation, as it is produced from glucose by polymorphonuclear neutrophils (PMNs) in CF lungs. We aimed to investigate changes in and associations between PMNs, glucose and L-lactate in sputum during antibiotic treatment. In addition, the effect of hemoglobin A1c and plasma glucose on these biomarkers were investigated. Methods: We sampled non-induced sputum at day 0, 7, 14 and 42 in 27 chronically infected CF patients electively treated with 14 days of intravenous antibiotic. To analyze sputum samples, we used flowcytometry to count PMNs and colorimetric assays to estimate lactate and glucose. Results: No changes in levels of PMNs, glucose and lactate were detected in sputum during the antibiotic treatment. Sputum PMNs were positively associated with both glucose (log coefficient = 0.20, p = 0.01) and L-lactate (log coefficient = 0.34, p<0.001). In multivariate analyses, hemoglobin A1c was negatively associated with sputum PMNs (log coefficient = -1.68, p<0.001) and plasma glucose was negatively associated with sputum glucose (log coefficient = -0.09, p = 0.02). Conclusions: In CF sputum PMNs, glucose and lactate were unchanged during elective antibiotic treatment. However, sputum PMNs were associated with both sputum glucose and sputum lactate. Surprisingly, hyperglycemia seemed to be associated with less PMNs infiltration and less glucose in CF sputum.
MeSH term(s)	Adult ; Aged ; Anti-Bacterial Agents/administration & dosage ; Anti-Bacterial Agents/therapeutic use ; Biomarkers/metabolism ; Blood Glucose/metabolism ; Cystic Fibrosis/blood ; Cystic Fibrosis/physiopathology ; Female ; Glucose/metabolism ; Glycated Hemoglobin A/metabolism ; Humans ; Injections, Intravenous ; Lactic Acid/metabolism ; Leukocyte Count ; Male ; Multivariate Analysis ; Neutrophils/metabolism ; Respiratory Function Tests ; Sputum/metabolism ; Young Adult
Chemical Substances	Anti-Bacterial Agents ; Biomarkers ; Blood Glucose ; Glycated Hemoglobin A ; Lactic Acid (33X04XA5AT) ; Glucose (IY9XDZ35W2)
Language	English
Publishing date	2020-09-11
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1932-6203
ISSN (online)	1932-6203
DOI	10.1371/journal.pone.0238524
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Neutrophil count in sputum is associated with increased sputum glucose and sputum L-lactate in cystic fibrosis.

Bibi Uhre Nielsen / Mette Kolpen / Peter Østrup Jensen / Terese Katzenstein / Tacjana Pressler / Christian Ritz / Inger Hee Mabuza Mathiesen / Daniel Faurholt-Jepsen

PLoS ONE, Vol 15, Iss 9, p e

2020 Volume 0238524

Abstract: ... of improving the timing of antibiotic treatment in cystic fibrosis (CF). L-Lactate might be a marker ... to investigate changes in and associations between PMNs, glucose and L-lactate in sputum during antibiotic ... were positively associated with both glucose (log coefficient = 0.20, p = 0.01) and L-lactate (log ...

Abstract	Background Markers of lung inflammation measured directly in expectorated sputum have the potential of improving the timing of antibiotic treatment in cystic fibrosis (CF). L-Lactate might be a marker of inflammation, as it is produced from glucose by polymorphonuclear neutrophils (PMNs) in CF lungs. We aimed to investigate changes in and associations between PMNs, glucose and L-lactate in sputum during antibiotic treatment. In addition, the effect of hemoglobin A1c and plasma glucose on these biomarkers were investigated. Methods We sampled non-induced sputum at day 0, 7, 14 and 42 in 27 chronically infected CF patients electively treated with 14 days of intravenous antibiotic. To analyze sputum samples, we used flowcytometry to count PMNs and colorimetric assays to estimate lactate and glucose. Results No changes in levels of PMNs, glucose and lactate were detected in sputum during the antibiotic treatment. Sputum PMNs were positively associated with both glucose (log coefficient = 0.20, p = 0.01) and L-lactate (log coefficient = 0.34, p<0.001). In multivariate analyses, hemoglobin A1c was negatively associated with sputum PMNs (log coefficient = -1.68, p<0.001) and plasma glucose was negatively associated with sputum glucose (log coefficient = -0.09, p = 0.02). Conclusions In CF sputum PMNs, glucose and lactate were unchanged during elective antibiotic treatment. However, sputum PMNs were associated with both sputum glucose and sputum lactate. Surprisingly, hyperglycemia seemed to be associated with less PMNs infiltration and less glucose in CF sputum.
Keywords	Medicine ; R ; Science ; Q
Subject code	670
Language	English
Publishing date	2020-01-01T00:00:00Z
Publisher	Public Library of Science (PLoS)
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Neutrophil count in sputum is associated with increased sputum glucose and sputum L-lactate in cystic fibrosis

Bibi Uhre Nielsen / Mette Kolpen / Peter Østrup Jensen / Terese Katzenstein / Tacjana Pressler / Christian Ritz / Inger Hee Mabuza Mathiesen / Daniel Faurholt-Jepsen / Monica Cartelle Gestal

PLoS ONE, Vol 15, Iss

2020 Volume 9

Abstract	Background Markers of lung inflammation measured directly in expectorated sputum have the potential of improving the timing of antibiotic treatment in cystic fibrosis (CF). L-Lactate might be a marker of inflammation, as it is produced from glucose by polymorphonuclear neutrophils (PMNs) in CF lungs. We aimed to investigate changes in and associations between PMNs, glucose and L-lactate in sputum during antibiotic treatment. In addition, the effect of hemoglobin A1c and plasma glucose on these biomarkers were investigated. Methods We sampled non-induced sputum at day 0, 7, 14 and 42 in 27 chronically infected CF patients electively treated with 14 days of intravenous antibiotic. To analyze sputum samples, we used flowcytometry to count PMNs and colorimetric assays to estimate lactate and glucose. Results No changes in levels of PMNs, glucose and lactate were detected in sputum during the antibiotic treatment. Sputum PMNs were positively associated with both glucose (log coefficient = 0.20, p = 0.01) and L-lactate (log coefficient = 0.34, p<0.001). In multivariate analyses, hemoglobin A1c was negatively associated with sputum PMNs (log coefficient = -1.68, p<0.001) and plasma glucose was negatively associated with sputum glucose (log coefficient = -0.09, p = 0.02). Conclusions In CF sputum PMNs, glucose and lactate were unchanged during elective antibiotic treatment. However, sputum PMNs were associated with both sputum glucose and sputum lactate. Surprisingly, hyperglycemia seemed to be associated with less PMNs infiltration and less glucose in CF sputum.
Keywords	Medicine ; R ; Science ; Q
Subject code	670
Language	English
Publishing date	2020-01-01T00:00:00Z
Publisher	Public Library of Science (PLoS)
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Book: Practical solutions to common problems in pulmonary pathology

Myers, Jeffrey L. / Katzenstein, Anna-Luise A.

USCAP long course 2011 [March 2, 2011, San Antonio, TX]

(Modern pathology ; 25, Suppl. 1)

2012

Title variant	Long course articles
Institution	United States and Canadian Academy of Pathology
Author's details	course directors: Jeffrey L. Myers and Anna-Luise A. Katzenstein
Series title	Modern pathology ; 25, Suppl. 1
Collection
Language	English
Size	S78 S. : zahlr. Ill., graph. Darst.
Publisher	Nature Publ. Group
Publishing place	New York, NY
Publishing country	United States
Document type	Book
HBZ-ID	HT017192421
Database	Catalogue ZB MED Medicine, Health

In stock of ZB MED Cologne/Königswinter

Shelf mark	Loan status	Location
Zs A 2450 -25,Suppl.1-	not available for loan	Zeitschriften-Lesesaal

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Book ; Thesis: Molecular biological assessment methods and understanding the course of the HIV infection

Katzenstein, Terese L.

(Acta pathologica, microbiologica et immunologica Scandinavica : Supplementum ; 114)

2003

Author's details	by Terese L. Katzenstein
Series title	Acta pathologica, microbiologica et immunologica Scandinavica : Supplementum ; 114 Acta pathologica, microbiologica et immunologica Scandinavica Acta pathologica, microbiologica et immunologica Scandinavica ; Supplementum
Collection	Acta pathologica, microbiologica et immunologica Scandinavica Acta pathologica, microbiologica et immunologica Scandinavica ; Supplementum
Language	English
Size	40 S. : graph. Darst.
Publisher	Blackwell Munksgaard
Publishing place	Copenhagen
Publishing country	Denmark
Document type	Book ; Thesis
Thesis / German Habilitation thesis	København, Univ., Diss
HBZ-ID	HT013840214
ISBN	1-4051-2136-X ; 978-1-4051-2136-1
Database	Catalogue ZB MED Medicine, Health

In stock of ZB MED Cologne/Königswinter

Shelf mark	Loan status	Location
2003 E 3302	order for loan	Magazin
Ud II Zs 73 -Suppl.114-	verfügbar in Königswinter	Königswinter

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Article: Unsuccessful treatment of chronic norovirus infection with enteral immunoglobulin in patients with common variable immunodeficiency, case report.

Christensen, A C W / Drabe, C H / Loft, A / Lebech, A M / Katzenstein, T L

IDCases

2023 Volume 32, Page(s) e01737

Abstract: Background: Norovirus gastroenteritis is commonly an acute infection that lasts 2-3 days, but in immunocompromised patients norovirus can cause a chronic gastroenteritis lasting for years. Norovirus replicates in the gastrointestinal tract, but the ... ...

Abstract	Background: Norovirus gastroenteritis is commonly an acute infection that lasts 2-3 days, but in immunocompromised patients norovirus can cause a chronic gastroenteritis lasting for years. Norovirus replicates in the gastrointestinal tract, but the pathway of viral clearance is not yet known. Promising results of enterally administered immunoglobulin in the treatment of chronic norovirus gastroenteritis in immunocompromised patients have previously been published. Case presentation: We report two individuals with common variable immunodeficiency and chronic debilitating norovirus gastroenteritis. Both patients were treated with enterally administered immunoglobulin via a duodenal feeding tube as other treatment modalities have been unsuccessful. The patients did not experience any immediate or long-term benefit of enterally administered immunoglobulin. Conclusion: Despite previous case reports of successful treatment of chronic norovirus infection among immunocompromised patients with enterally administered immunoglobulin, these two patients experienced no benefit of the treatment. This demonstrates the need for further research in treatment of chronic norovirus infection in immunocompromised patients.
Language	English
Publishing date	2023-03-06
Publishing country	Netherlands
Document type	Case Reports
ZDB-ID	2745454-X
ISSN	2214-2509
ISSN	2214-2509
DOI	10.1016/j.idcr.2023.e01737
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Behavior Intervention Response Team: Piloting an Effective Means to Manage Patient- and Family-Disruptive Behaviors.

Katzenstein, Jennifer M / Boatman, Sondra L / Newman, Kevin / Maier, Kristin

Journal of healthcare management / American College of Healthcare Executives

2023 Volume 68, Issue 6, Page(s) 420–426

Abstract: Goal: This article describes the development and implementation of a behavior intervention response team (BIRT). Pilot data indicate the successful implementation of BIRT interventions with patients and families and the positive staff response to these ... ...

Abstract	Goal: This article describes the development and implementation of a behavior intervention response team (BIRT). Pilot data indicate the successful implementation of BIRT interventions with patients and families and the positive staff response to these interventions. Methods: Patient- and family-disruptive behaviors are increasing in hospitals. Those behaviors arise from stress, financial burdens, and the mental weight of the patient's medical condition on the family. These distressed patients and their families tax an already overwhelmed staff, exacerbating the caregivers' exhaustion, depersonalization, and frustration. We recognized the need to proactively address these disruptions at our children's hospital with an interdisciplinary response. Disciplines engaged in the BIRT development included risk management, behavioral health, child life, service excellence, patient and family services, social work, and chaplaincy. Following multiple brainstorming sessions, we created a comprehensive, clear intervention strategy to engage with a disruptive patient or family. The BIRT was developed to work with both the family and their medical team to intervene at the first signs of potential disruption. Principal findings: With the BIRT, we were able to reduce disruptive behaviors and limit the subsequent removal of problematic individuals from the facility. Of the families who worked with the BIRT, 75.8% required no postintervention follow-up. Practical applications: The development of a BIRT can help head off disruptive behaviors and improve family-medical team relationships to support the highest quality and safest healthcare.
MeSH term(s)	Child ; Humans ; Problem Behavior ; Child, Hospitalized ; Patient Care Team ; Family
Language	English
Publishing date	2023-11-08
Publishing country	United States
Document type	Journal Article
ZDB-ID	1418083-2
ISSN	1944-7396 ; 1096-9012
ISSN (online)	1944-7396
ISSN	1096-9012
DOI	10.1097/JHM-D-23-00103
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Zs.A 977: Show issues

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Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

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Article ; Online: Acute loss of smell and taste among patients with symptoms compatible with COVID-19.

Bodnia, Nadia Calvo / Katzenstein, Terese L

Danish medical journal

2020 Volume 67, Issue 9

Abstract: Introduction: The aim of this study was to describe the clinical symptoms, including affection of sense of smell and taste, among participants in a party held in Copenhagen after which many participants reported symptoms compatible with coronavirus ... ...

Abstract	Introduction: The aim of this study was to describe the clinical symptoms, including affection of sense of smell and taste, among participants in a party held in Copenhagen after which many participants reported symptoms compatible with coronavirus disease 2019 (COVID-19). Methods: A 37-item questionnaire was sent electronically to all 95 participants seven weeks after the party. The questionnaire included questions about the type, timing and duration of COVID-19 symptoms. Results: In total, 65 of 95 (68%) participants responded, among whom 51/65 (78%) had symptoms compatible with COVID-19; 53% (27/51) had affection of their sense of smell and taste; 70% (19/27) reported a total loss of taste. These symptoms continued for 1-3 weeks for 78% and 3-6 weeks for 22% (6/27). Interestingly, 11/27 (41%) reported that they had not fully regained their sense of taste and 3/27(11%) were still very affected by this symptom. Moreover, 44% of the respondents who had lost their sense of taste perceived this symptom as moderate to severe. Eighty-one percent (22/27) reported a total loss of smell. This symptom continued for 1-3 and > 3 weeks in 74% and 26%, respectively. At the time of the investigation, 48% had not fully regained their sense of smell and 7% were still very affected. More than half of the respondents who lost their sense of smell perceived this symptom as moderate to severe. Conclusions: Many patients with clinically diagnosed COVID-19 report an affected sense of smell and taste. The duration of these symptoms currently remains unknown. Funding: none. Trial registration: not relevant.
MeSH term(s)	Betacoronavirus ; COVID-19 ; Coronavirus Infections/complications ; Coronavirus Infections/epidemiology ; Denmark/epidemiology ; Female ; Humans ; Incidence ; Male ; Olfaction Disorders/diagnosis ; Olfaction Disorders/epidemiology ; Olfaction Disorders/etiology ; Pandemics ; Pneumonia, Viral/complications ; Pneumonia, Viral/epidemiology ; SARS-CoV-2 ; Smell/physiology ; Surveys and Questionnaires ; Taste/physiology
Keywords	covid19
Language	English
Publishing date	2020-08-06
Publishing country	Denmark
Document type	Journal Article
ZDB-ID	2648771-8
ISSN	2245-1919 ; 2245-1919
ISSN (online)	2245-1919
ISSN	2245-1919
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: [No title information]

Christensen, Ann-Camilla Worsøe / Drabe, Camilla Heldbjerg / Lebech, Anne-Mette / Katzenstein, Terese L

Ugeskrift for laeger

2023 Volume 185, Issue 12

Abstract: Norovirus is generally an acute infection causing symptoms such as diarrhea, nausea, and vomiting lasting for 24-48 hours. However, for immunocompromised patients, norovirus gastroenteritis can last for several years and result in villous atrophy and ... ...

Title translation	Treatment options for chronic norovirus infection in immunocompromised patients.
Abstract	Norovirus is generally an acute infection causing symptoms such as diarrhea, nausea, and vomiting lasting for 24-48 hours. However, for immunocompromised patients, norovirus gastroenteritis can last for several years and result in villous atrophy and lead to severe malnutrition, dehydration, electrolyte imbalance and continuous viral shedding. Several treatment strategies have been suggested in case reports: nitazoxanide, ribavirin and enterally administered immunoglobulin with varying results. Favipiravir is also suggested but not tested on humans, highlighting the need for further research.
MeSH term(s)	Humans ; Gastroenteritis/therapy ; Norovirus ; Diarrhea ; Caliciviridae Infections/diagnosis ; Caliciviridae Infections/therapy ; Immunocompromised Host
Language	Danish
Publishing date	2023-03-31
Publishing country	Denmark
Document type	English Abstract ; Journal Article
ZDB-ID	124102-3
ISSN	1603-6824 ; 0041-5782
ISSN (online)	1603-6824
ISSN	0041-5782
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Zs.B 302: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Ua VI Zs.6/30: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)

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Article ; Online: Perception and Emotional Experiences of Infant Feeding Among Women Living With HIV in a High-Income Setting: A Longitudinal Mixed Methods Study.

Moseholm, Ellen / Fetters, Michael D / Aho, Inka / Mellgren, Åsa / Johansen, Isik S / Katzenstein, Terese L / Pedersen, Gitte / Storgaard, Merete / Weis, Nina

Journal of acquired immune deficiency syndromes (1999)

2023 Volume 95, Issue 1, Page(s) 52–64

Abstract: Background: The recommendation of breastfeeding avoidance for women living with HIV in high-income settings may be influenced by cultural beliefs and come at an emotional cost. This multicenter, longitudinal, convergent mixed methods study aimed to ... ...

Abstract	Background: The recommendation of breastfeeding avoidance for women living with HIV in high-income settings may be influenced by cultural beliefs and come at an emotional cost. This multicenter, longitudinal, convergent mixed methods study aimed to compare differences in attitudes, concerns, and experiences surrounding breastfeeding in women living with HIV of Nordic and non-Nordic origin. Setting: High-income setting. Methods: Pregnant women living with HIV in the Nordic countries Denmark, Finland, and Sweden were recruited in 2019-2020. Quantitative data on attitudes surrounding infant feeding were assessed using the Positive Attitudes Concerning Infant Feeding questionnaire completed in the third trimester (T1), and 3 (T2) and 6 (T3) months postpartum. Women who completed the survey were also invited to participate in semistructured interviews at T1 and T3. The findings from the quantitative survey and qualitative interviews were brought together through merging to assess for concordance, complementarity, expansion, or discordance between the data sets and to draw metainferences. Results: In total, 44 women completed the survey, of whom 31 also participated in qualitative interviews. The merged analyses identified three overarching domains representing commonalities across the quantitative and qualitative data: emotional impact, justifying not breastfeeding, and coping strategies. Not being able to breastfeed was emotionally challenging. Cultural expectations influenced the women's experiences and the strategies they used to justify their infant feeding choice. Conclusions: For women living with HIV in Nordic countries not breastfeeding was a complex, multilayered process substantially influenced by social and cultural expectations.
MeSH term(s)	Infant ; Female ; Pregnancy ; Humans ; HIV Infections/psychology ; Pregnant Women ; Breast Feeding/psychology ; Postpartum Period ; Perception ; Mothers/psychology
Language	English
Publishing date	2023-10-05
Publishing country	United States
Document type	Multicenter Study ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	645053-2
ISSN	1944-7884 ; 1077-9450 ; 0897-5965 ; 0894-9255 ; 1525-4135
ISSN (online)	1944-7884 ; 1077-9450
ISSN	0897-5965 ; 0894-9255 ; 1525-4135
DOI	10.1097/QAI.0000000000003314
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Zs.A 2442: Show issues

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