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Article ; Online: Expression of Neighbor of Punc E11 (NOPE) in early stage esophageal adenocarcinoma is associated with reduced survival.

Kütting, Fabian / Gebauer, Florian / Zweerink, Susanne / Krämer, Laurenz / Schramm, Christoph / Quaas, Alexander / Bruns, Christiane / Goeser, Tobias / Nierhoff, Dirk

Scientific reports

2022 Volume 12, Issue 1, Page(s) 3584

Abstract: Current recommendations suggest neoadjuvant treatment in node-positive esophageal cancer or tumors staged T3 and upwards but some T2 N0 patients might benefit from neoadjuvant therapy. It is of clinical relevance to identify this subgroup. Loss of ... ...

Abstract	Current recommendations suggest neoadjuvant treatment in node-positive esophageal cancer or tumors staged T3 and upwards but some T2 N0 patients might benefit from neoadjuvant therapy. It is of clinical relevance to identify this subgroup. Loss of epithelial apicobasal polarity is a key factor in the development of invasive capabilities of carcinoma. The oncofetal stem/progenitor cell marker NOPE is expressed in adult depolarized murine hepatocytes and in murine/human hepatocellular carcinoma. We analyzed NOPE expression in 363 patients with esophageal adenocarcinoma using an RNA Scope Assay on a tissue microarray and correlated results with clinical data. Median follow-up was 57.7 months with a 5-year survival rate of 26.6%. NOPE was detectable in 32 patients (8.8%). In pT1/2 stages, NOPE expression was associated with a significantly reduced median OS of 6.3 months (95% CI 1.2-19.4 months), the median OS is not reached in the NOPE-negative group (calculated mean OS 117.1 months) (P = 0.012). In advanced tumor stages, a NOPE dependent survival difference was not detected. This is the first report of NOPE expression demonstrating a prognostic value in esophageal cancer. Early stage, NOPE positive patients are at a high risk of tumor progression and may benefit from neoadjuvant treatment analogous to advanced stage cancer.
MeSH term(s)	Adenocarcinoma/pathology ; Adult ; Animals ; Carcinoma, Hepatocellular/pathology ; Esophageal Neoplasms/pathology ; Humans ; Immunoglobulins/metabolism ; Liver Neoplasms/pathology ; Mice ; Neoadjuvant Therapy ; Neoplasm Staging ; Nerve Tissue Proteins/metabolism ; Prognosis ; Retrospective Studies ; Survival Rate
Chemical Substances	Immunoglobulins ; Nerve Tissue Proteins ; Nope protein, mouse
Language	English
Publishing date	2022-03-04
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-022-07580-y
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Article: Epitranscriptomic Reader YTHDF2 Regulates SEK1(

Malovic, Emir / Ealy, Alyssa / Hsu, Phillip J / Sarkar, Souvarish / Miller, Cameron / Rokad, Dharmin / Goeser, Cody / Hartman, Aleah Kristen / Zhu, Allen / Palanisamy, Bharathi / Zenitsky, Gary / Jin, Huajun / Anantharam, Vellareddy / Kanthasamy, Arthi / He, Chuan / Kanthasamy, Anumantha G

bioRxiv : the preprint server for biology

2024

Abstract: As the most abundant glial cells in the CNS, astrocytes dynamically respond to neurotoxic stress, however, the key molecular regulators controlling the inflammatory status of these sentinels during neurotoxic stress have remained elusive. Herein, we ... ...

Abstract	As the most abundant glial cells in the CNS, astrocytes dynamically respond to neurotoxic stress, however, the key molecular regulators controlling the inflammatory status of these sentinels during neurotoxic stress have remained elusive. Herein, we demonstrate that the m6A epitranscriptomic mRNA modification tightly regulates the pro-inflammatory functions of astrocytes. Specifically, the astrocytic neurotoxic stresser, manganese (Mn), downregulated the m6A reader YTHDF2 in human and mouse astrocyte cultures and in the mouse brain. Functionally, YTHDF2 knockdown augmented, while its overexpression dampened, neurotoxic stress induced proinflammatory response, suggesting YTHDF2 serves as a key upstream regulator of inflammatory responses in astrocytes. Mechnistically, YTHDF2 RIP-sequencing identified
Language	English
Publishing date	2024-01-26
Publishing country	United States
Document type	Preprint
DOI	10.1101/2024.01.26.577106
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Article ; Online: Comparison of Pre-Endoscopic C-WATCH Score with Established Risk Assessment Tools in Patients with Upper Gastrointestinal Bleeding.

Allo, Gabriel / Bürger, Martin / Gillessen, Johannes / Kasper, Philipp / Franklin, Jeremy / Mück, Vera / Nierhoff, Dirk / Steffen, Hans-Michael / Goeser, Tobias / Schramm, Christoph

Digestive diseases (Basel, Switzerland)

2022 Volume 40, Issue 6, Page(s) 826–834

Abstract: ... bleeding (UGIB) is recommended by various guidelines. We compared Cologne-WATCH (C-WATCH) score ... 594-0.735), and 0.694 (95% CI: 0.612-0.775) for C-WATCH score, 0.724 (95% CI: 0.653-0.796) and 0.751 ... for patients with estimated low risk for all three endpoints (C-WATCH score ≤1, RS ≤2, p-RS <1, and GBS ≤1 ...

Abstract	Introduction: Use of risk scores for early assessment of patients with upper gastrointestinal bleeding (UGIB) is recommended by various guidelines. We compared Cologne-WATCH (C-WATCH) score with Glasgow-Blatchford score (GBS), Rockall score (RS), and pre-endoscopic RS (p-RS). Methods: Patients with UGIB between January and December 2017 were retrospectively analyzed for 30-day mortality and composite endpoints risk of complications and need for intervention using areas under the receiver-operating characteristics curve (AUROC). Subgroup analysis was conducted for patients with UGIB on admission and in-hospital UGIB. Results: A total of 252 patients were identified (67.5% men, mean age 63.8 ± 14.9 years). In-hospital UGIB occurred in 49.6%. AUROCs for 30-day mortality, risk of complications, and need for intervention (not applicable to RS) were 0.684 (95% confidence interval [CI]: 0.606-0.763), 0.665 (95% CI: 0.594-0.735), and 0.694 (95% CI: 0.612-0.775) for C-WATCH score, 0.724 (95% CI: 0.653-0.796) and 0.751 (95% CI: 0.687-0.815) for RS, 0.652 (95% CI: 0.57-0.735), 0.653 (95% CI: 0.579-0.727), and 0.673 (95% CI: 0.602-0.745) for p-RS and 0.652 (95% CI: 0.572-0.732), 0.663 (95% CI: 0.592-0.734), and 0.752 (95% CI: 0.683-0.821) for GBS. RS outperformed pre-endoscopic scores in predicting risk of complications, while there were no significant differences between pre-endoscopic scores except GBS outperforming p-RS in predicting need for intervention. The subgroup analysis obtained similar results. Positive predictive values for patients with estimated low risk for all three endpoints (C-WATCH score ≤1, RS ≤2, p-RS <1, and GBS ≤1) were 89%, 69%, 78%, and 92%. Conclusion: C-WATCH score performed similar to the established pre-endoscopic risk scores in patients with UGIB regarding relevant patient-related endpoints with no significant differences between both the subgroups.
MeSH term(s)	Male ; Humans ; Middle Aged ; Aged ; Female ; Retrospective Studies ; Severity of Illness Index ; Gastrointestinal Hemorrhage/diagnosis ; Gastrointestinal Hemorrhage/etiology ; Area Under Curve ; Risk Assessment/methods ; ROC Curve ; Prognosis
Language	English
Publishing date	2022-01-24
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	632798-9
ISSN	1421-9875 ; 0257-2753
ISSN (online)	1421-9875
ISSN	0257-2753
DOI	10.1159/000522121
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Zs.A 1853: Show issues

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Article ; Online: Fecal microbiota transfer for refractory intestinal graft-versus-host disease - Experience from two German tertiary centers.

Goeser, Felix / Sifft, Barbara / Stein-Thoeringer, Christoph / Farowski, Fedja / Strassburg, Christian P / Brossart, Peter / Higgins, Paul G / Scheid, Christoph / Wolf, Dominik / Holderried, Tobias A W / Vehreschild, Maria J G T / Cruz Aguilar, Marta Rebeca

European journal of haematology

2021 Volume 107, Issue 2, Page(s) 229–245

Abstract: Rationale: Steroid refractory graft-vs-host disease (sr-GvHD) represents a challenging complication after allogeneic hematopoietic cell transplantation (allo-HCT). Intestinal microbiota (IM) diversity and dysbiosis were identified as influencing factors ...

Abstract	Rationale: Steroid refractory graft-vs-host disease (sr-GvHD) represents a challenging complication after allogeneic hematopoietic cell transplantation (allo-HCT). Intestinal microbiota (IM) diversity and dysbiosis were identified as influencing factors for the development of acute GvHD. Fecal microbiota transfer (FMT) is hypothesized to restore IM dysbiosis, but there is limited knowledge about the significance of FMT in the treatment of sr-GvHD. Objectives: We studied the effects of FMT on sr-GvHD in allo-HCT patients from two German tertiary clinical centers (n = 11 patients; period: March 2017 until July 2019). To assess safety and clinical efficacy, we analyzed clinical data pre- and post-FMT (day -14 to +30 relative to FMT). Moreover, IM were analyzed in donor samples and in a subset of patients pre- and post-FMT by 16S rRNA sequencing. Results: Post-FMT, we observed no intervention-associated, systemic inflammatory responses and only minor side effects (5/11 patients: abdominal pain and transformation of peristalsis-each 3/11 and vomiting-1/11). Stool frequencies and volumes were significantly reduced [pre- vs post-FMT (d14): P < .05, respectively] as well as clear attenuation regarding both grading and staging of sr-GvHD was present upon FMT. Moreover, IM analyses revealed an increase of alpha diversity as well as a compositional shifts toward the donor post-FMT. Conclusions: In our study, we observed positive effects on sr-GVHD after FMT without the occurrence of major adverse events. Although these findings are in line with published data on beneficial effects of FMT in sr-GvHD, further randomized clinical studies are urgently needed to better define the clinical validity including mode of action.
MeSH term(s)	Adult ; Aged ; Biodiversity ; Disease Management ; Fecal Microbiota Transplantation/methods ; Female ; Gastrointestinal Diseases/diagnosis ; Gastrointestinal Diseases/etiology ; Gastrointestinal Diseases/therapy ; Gastrointestinal Microbiome ; Germany ; Graft vs Host Disease/diagnosis ; Graft vs Host Disease/etiology ; Graft vs Host Disease/therapy ; Hematopoietic Stem Cell Transplantation/adverse effects ; Hematopoietic Stem Cell Transplantation/methods ; Humans ; Male ; Middle Aged ; Tertiary Care Centers ; Transplantation, Homologous ; Treatment Outcome
Language	English
Publishing date	2021-06-09
Publishing country	England
Document type	Journal Article
ZDB-ID	392482-8
ISSN	1600-0609 ; 0902-4441
ISSN (online)	1600-0609
ISSN	0902-4441
DOI	10.1111/ejh.13642
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Zs.A 323: Show issues

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Article ; Online: Study protocol of an open-label, single arm phase II trial investigating the efficacy, safety and quality of life of neoadjuvant chemotherapy with liposomal irinotecan combined with Oxaliplatin and 5-fluorouracil/Folinic acid followed by curative surgical resection in patients with hepatic Oligometastatic adenocarcinoma of the pancreas (HOLIPANC).

Gebauer, Florian / Damanakis, Alexander Ioannis / Popp, Felix / Quaas, Alexander / Kütting, Fabian / Lutz, Katrin / Held, Swantje / Deuß, Burkhard / Göser, Tobias / Waldschmidt, Dirk / Bruns, Christiane

BMC cancer

2021 Volume 21, Issue 1, Page(s) 1239

Abstract: Background: According to current guidelines, treatment of patients with hepatic oligometastasis in pancreatic cancer is not reflected and systemic chemotherapy is recommended in those patients. Retrospective data suggest beneficial outcomes in patients ... ...

Abstract	Background: According to current guidelines, treatment of patients with hepatic oligometastasis in pancreatic cancer is not reflected and systemic chemotherapy is recommended in those patients. Retrospective data suggest beneficial outcomes in patients with hepatic oligometastasis, though prospective data from clinical trials addressing this particular patient group is not available. Methods: In this single arm, phase-2 trial, survival data from patients receiving neoadjuvant chemotherapy followed by R0/R1 resection will be compared to historic data from patients with oligometastatic adenocarcinoma of the pancreas. The clinical trial will focus on a well-defined patient collective with metastatic load limited to the liver as target organ with a maximum of five metastases. The combination of liposomal irinotecan (nal-IRI), oxaliplatin (OX) and 5-fluouracil (5-FU)/folinic acid (FA) (nal-IRI + OX+ 5-FU/FA, NAPOX) was chosen as neoadjuvant chemotherapy; the choice was based on an ongoing clinical study in which NAPOX appeared manageable, with promising anti-tumor activity in first-line treatment of patients with metastatic pancreatic adenocarcinoma. In total 150 patients will be enrolled for this trial with an aim of 55 patients receiving a complete macroscopic synchronous tumor and metastatic resection. Discussion: This is the first clinical study to prospectively evaluate the value of multimodality therapy concepts in oligometastatic pancreatic cancer. Trial registration numbers: EudraCT 2019-002734-37 NCT04617457 .
MeSH term(s)	Adult ; Female ; Humans ; Male ; Adenocarcinoma/drug therapy ; Adenocarcinoma/mortality ; Adenocarcinoma/secondary ; Adenocarcinoma/surgery ; Antineoplastic Combined Chemotherapy Protocols/adverse effects ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Chemotherapy, Adjuvant/adverse effects ; Chemotherapy, Adjuvant/methods ; Fluorouracil/administration & dosage ; Germany ; Irinotecan/administration & dosage ; Leucovorin/administration & dosage ; Liposomes ; Liver Neoplasms/mortality ; Liver Neoplasms/secondary ; Liver Neoplasms/surgery ; Neoadjuvant Therapy/adverse effects ; Neoadjuvant Therapy/methods ; Oxaliplatin/administration & dosage ; Pancreatic Neoplasms/drug therapy ; Pancreatic Neoplasms/mortality ; Pancreatic Neoplasms/pathology ; Pancreatic Neoplasms/surgery ; Progression-Free Survival ; Quality of Life ; Clinical Trials, Phase II as Topic ; Multicenter Studies as Topic
Chemical Substances	Fluorouracil (U3P01618RT) ; Irinotecan (7673326042) ; Leucovorin (Q573I9DVLP) ; Liposomes ; Oxaliplatin (04ZR38536J)
Language	English
Publishing date	2021-11-18
Publishing country	England
Document type	Clinical Trial Protocol ; Journal Article
ZDB-ID	2041352-X
ISSN	1471-2407 ; 1471-2407
ISSN (online)	1471-2407
ISSN	1471-2407
DOI	10.1186/s12885-021-08966-3
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Article ; Online: Serrated polyposis syndrome may go undiagnosed even in structured colorectal cancer screening programmes performed by endoscopists with otherwise good quality indices.

Schramm, Christoph / Janhsen, Katharina / Demir, Münevver / Nierhoff, Dirk / Goeser, Tobias / Steffen, Hans Michael

Gut

2017 Volume 67, Issue 9, Page(s) 1746–1747

MeSH term(s)	Adenoma ; Colonic Polyps ; Colonoscopy ; Colorectal Neoplasms ; Early Detection of Cancer ; Humans ; Syndrome
Language	English
Publishing date	2017-10-21
Publishing country	England
Document type	Letter ; Comment
ZDB-ID	80128-8
ISSN	1468-3288 ; 0017-5749
ISSN (online)	1468-3288
ISSN	0017-5749
DOI	10.1136/gutjnl-2017-315321
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Article: Predicting ADR from PDR and individual adenoma-to-polyp-detection-rate ratio for screening and surveillance colonoscopies: A new approach to quality assessment.

Schramm, C / Scheller, I / Franklin, J / Demir, M / Kuetting, F / Nierhoff, D / Goeser, T / Toex, U / Steffen, H M

United European gastroenterology journal

2017 Volume 5, Issue 5, Page(s) 742–749

Abstract: Background and aims: Adenoma detection rate (ADR) has been established as a quality indicator for screening colonoscopy. Because ADR is cumbersome to obtain in routine practice, polyp detection rate (PDR), polypectomy rate (PR) and adenoma-to-polyp- ... ...

Abstract	Background and aims: Adenoma detection rate (ADR) has been established as a quality indicator for screening colonoscopy. Because ADR is cumbersome to obtain in routine practice, polyp detection rate (PDR), polypectomy rate (PR) and adenoma-to-polyp-detection-rate-ratio (APDRR) have been proposed to estimate ADR. This study aimed to evaluate APDRR in order to estimate ADR (ADR Methods: Average risk screening and surveillance colonoscopies from a community-based private practice and a tertiary academic hospital setting were retrospectively evaluated. APDRR was calculated as averaged group APDRR for all study procedures (APDRR) and for the first half of study procedures of each gastroenterologist (APDRR Results: A total of 2717 individuals were analyzed. Using APDRR, significant correlations between ADR and ADR Conclusions: ADR for subsequent colonoscopies of an individual endoscopist can be reliably estimated from PDR by using an individually calculated APDRR. Prospective studies are needed to verify this promising approach in different practice settings.
Language	English
Publishing date	2017-08
Publishing country	England
Document type	Journal Article
ISSN	2050-6406
ISSN	2050-6406
DOI	10.1177/2050640616675220
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Article ; Online: A Novel Study Design Using Continuous Intravenous and Intraduodenal Infusions of Midazolam and Voriconazole for Mechanistic Quantitative Assessment of Hepatic and Intestinal CYP3A Inhibition.

Li, Xia / Junge, Lisa / Taubert, Max / von Georg, Anabelle / Dahlinger, Dominik / Starke, Chris / Frechen, Sebastian / Stelzer, Christoph / Kinzig, Martina / Sörgel, Fritz / Jaehde, Ulrich / Töx, Ulrich / Goeser, Tobias / Fuhr, Uwe

Journal of clinical pharmacology

2020 Volume 60, Issue 9, Page(s) 1237–1253

Abstract: The extent of a drug-drug interaction (DDI) mediated by cytochrome P450 (CYP) 3A inhibitors is highly variable during a dosing interval, as it depends on the temporal course of victim and perpetrator drug concentrations at intestinal and hepatic CYP3A ... ...

Abstract	The extent of a drug-drug interaction (DDI) mediated by cytochrome P450 (CYP) 3A inhibitors is highly variable during a dosing interval, as it depends on the temporal course of victim and perpetrator drug concentrations at intestinal and hepatic CYP3A expression sites. Capturing the time course of inhibition is therefore difficult using standard DDI studies assessing changes in area under the curve; thus, a novel design was developed. In a 4-period changeover pilot study, 6 healthy men received intraduodenal or intravenous infusions of the CYP3A substrate midazolam (MDZ) at a rate of 0.26 mg/h for 24 hours. This was combined with intraduodenal or intravenous infusion of the CYP3A inhibitor voriconazole (VRZ), administered at rates of 7.5 mg/h from 8 to 16 hours and of 15 mg/h from 16 to 24 hours, after starting midazolam administration. Plasma and urine concentrations of VRZ, MDZ, and its major metabolites were quantified by liquid chromatography-tandem mass spectrometry and analyzed by semiphysiological population pharmacokinetic nonlinear mixed-effects modeling. A model including mechanism-based inactivation of the metabolizing enzymes (maximum inactivation rate constant k
MeSH term(s)	Adult ; Anti-Anxiety Agents/administration & dosage ; Anti-Anxiety Agents/metabolism ; Anti-Anxiety Agents/pharmacokinetics ; Biotransformation/drug effects ; Computer Simulation ; Cytochrome P-450 CYP3A/drug effects ; Cytochrome P-450 CYP3A/metabolism ; Cytochrome P-450 CYP3A Inhibitors/administration & dosage ; Cytochrome P-450 CYP3A Inhibitors/metabolism ; Cytochrome P-450 CYP3A Inhibitors/pharmacokinetics ; Drug Interactions ; Duodenum ; Healthy Volunteers ; Humans ; Infusions, Intravenous ; Infusions, Parenteral ; Intestines/drug effects ; Intestines/enzymology ; Liver/drug effects ; Liver/enzymology ; Male ; Midazolam/administration & dosage ; Midazolam/metabolism ; Midazolam/pharmacokinetics ; Models, Biological ; Pilot Projects ; Voriconazole/administration & dosage ; Voriconazole/metabolism ; Voriconazole/pharmacokinetics
Chemical Substances	Anti-Anxiety Agents ; Cytochrome P-450 CYP3A Inhibitors ; CYP3A protein, human (EC 1.14.14.1) ; Cytochrome P-450 CYP3A (EC 1.14.14.1) ; Voriconazole (JFU09I87TR) ; Midazolam (R60L0SM5BC)
Language	English
Publishing date	2020-05-19
Publishing country	England
Document type	Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
ZDB-ID	188980-1
ISSN	1552-4604 ; 0091-2700 ; 0021-9754
ISSN (online)	1552-4604
ISSN	0091-2700 ; 0021-9754
DOI	10.1002/jcph.1619
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Article ; Online: Modification of a rumen fluid priming technique for measuring in vitro neutral detergent fiber digestibility.

Goeser, J P / Hoffman, P C / Combs, D K

Journal of dairy science

2009 Volume 92, Issue 8, Page(s) 3842–3848

Abstract: ... to produce 0.12 mL of gas/mL of rumen fluid before sample inoculation [Combs-Goeser (CG) method]; or 3 ...

Abstract	Recently, we developed an alternate method to measure in vitro neutral detergent fiber (NDF) digestibility (ivNDFD) based on a primed rumen fluid inoculum. Pretreating rumen fluid inoculum with cellulose and holding the inoculum until it generated 0.3 mL of gas/mL of rumen fluid before inoculating forage samples improved ivNDFD assay repeatability but depressed ivNDFD means. Our objective in this study was to determine if pretreating rumen fluid with a mixture of carbohydrates and urea would affect the ivNDFD mean and variance. We also used the modified procedure as a reference assay to calibrate near-infrared reflectance spectroscopy (NIRS) to predict 24-, 30-, and 48-h ivNDFD. Two experiments were completed. In experiment A, 3 ivNDFD assays modified from the method of Goering and Van Soest were evaluated over 24, 28, 48, 54, and 72 h by using dried, ground alfalfa (1 mm) or wheat straw (0.5 g) sealed in Ankom F57 forage fiber bags. Bags were placed individually in 125-mL Erlenmeyer flasks and incubated with Goering and Van Soest media and 10 mL of rumen fluid. Rumen fluid was collected before feeding from 2 cannulated cows fed a high-forage diet and was prepared in 1 of 3 ways: 1) pooled rumen fluid was strained and used immediately to inoculate flasks (modified Goering and Van Soest method); 2) strained, pooled fluid was combined with buffer, reducing solution, and 1.25 mg of primer/mL of rumen fluid and allowed to produce 0.12 mL of gas/mL of rumen fluid before sample inoculation [Combs-Goeser (CG) method]; or 3) the CG method was used without the primer mixture (unprimed method). The assay was repeated 5 times, with 5 time points (24, 28, 48, 54, and 72 h) and 2 subsamples per time point for each method. Neutral detergent fiber was analyzed using an Ankom(200) forage fiber analyzer and ivNDFD was determined as follows: ivNDFD (% of NDF) = 100 x [(NDF(0h) - NDF(residue))/(NDF(0h))]. Results were analyzed using a mixed model procedure, and data were blocked by method to obtain repetition sums of squares, which were compared by an F-test to assess interassay error. Repetition sums of squares were reduced with the CG method compared with the Goering and Van Soest method (19 vs. 228), and mean ivNDFD estimates were similar at 28, 48, and 54 h. In experiment B, 24-, 30-, and 48-h ivNDFD data for 54 feeds were determined in triplicate using the CG method, and corresponding samples were then scanned with an NIRS instrument. Calibrations were computed using partial least squares regression techniques. The NIRS calibration equation R(2) values were 0.93, 0.93, and 0.89 for 24-, 30-, and 48-h ivNDFD. Results suggest that the modified ivNDFD method using rumen fluid primed with a mixture of carbohydrate and urea (CG method) reduced interassay error.
MeSH term(s)	Animal Feed/analysis ; Animals ; Cattle ; Dairying/methods ; Dietary Fiber/metabolism ; Digestion/physiology ; Female ; Gastrointestinal Contents ; Rumen/metabolism
Language	English
Publishing date	2009-08
Publishing country	United States
Document type	Journal Article ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	242499-x
ISSN	1525-3198 ; 0022-0302
ISSN (online)	1525-3198
ISSN	0022-0302
DOI	10.3168/jds.2008-1745
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Article ; Online: [No title information]

Staudacher, Jonas J / Backes, Moritz / Bettinger, Dominik / Blüthner, Elisabeth / Dietz-Fricke, Christopher / Dugic, Ana / Fusco, Stefano / Garbe, Jakob / Goeser, Felix / Guliyeva, Sura / Hamesch, Karim / Hollenbach, Marcus / Huber, Yvonne / Kasper, Philipp / Kocheise, Lorenz / Langsch, Philippa / Leppkes, Moritz / Martens, Nora / Mücke, Marcus M /

Munker, Stefan / Murillo, Katharina / Nagl, Sandra / Sanoubara, Feras / Sturm, Niklas / Stathopoulos, Petros / Storck, Kirsten / Sulzer, Sabrina / Thiel-Bodenstaff, Angela / Tran, Florian / Wiessner, Johannes R / Willuweit, Katharina / Yaqubi, Kaneschka / Zeidler, Christoph / Schlosser, Sophie

Zeitschrift fur Gastroenterologie

2023 Volume 61, Issue 8, Page(s) 997–999

Title translation	Positionspapier „Universitäre Karrierewege“.
MeSH term(s)	Humans ; Universities ; Career Choice
Language	German
Publishing date	2023-08-11
Publishing country	Germany
Document type	Journal Article
ZDB-ID	201387-3
ISSN	1439-7803 ; 0172-8504 ; 0044-2771
ISSN (online)	1439-7803
ISSN	0172-8504 ; 0044-2771
DOI	10.1055/a-2116-6308
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In stock of ZB MED Cologne/Königswinter

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Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito