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  1. Article: Therapeutic procedures for submucosal tumors in the gastrointestinal tract.

    Ponsaing, Laura-Graves / Hansen, Mark-Berner

    World journal of gastroenterology

    2007  Volume 13, Issue 24, Page(s) 3316–3322

    Abstract: This review is part three of three and will present an update on the therapeutic options and procedures concerning gastrointestinal (GI) submucosal tumors (SMTs). The aim of this paper is to investigate the treatments of GI SMTs and to present a case of ... ...

    Abstract This review is part three of three and will present an update on the therapeutic options and procedures concerning gastrointestinal (GI) submucosal tumors (SMTs). The aim of this paper is to investigate the treatments of GI SMTs and to present a case of a gastrointestinal stromal tumor (GIST). Literature searches were performed to find information on therapy for GI SMTs. Based on these searches, the optimal therapeutic procedures could be outlined. The choice of treatment of localized tumors is endoscopic resection if possible or, alternatively, laparoscopic resection or surgical resection by an open procedure. However, benign SMTs should only be excised if symptoms are present, and GISTs should be treated with particular precautions. Irresectable or recurrent GISTs may be successfully treated with the tyrosine kinase inhibitor, imatinib.
    MeSH term(s) Benzamides ; Endoscopy, Gastrointestinal ; Female ; Gastric Mucosa/pathology ; Gastrointestinal Neoplasms/therapy ; Gastrointestinal Stromal Tumors/therapy ; Humans ; Imatinib Mesylate ; Intestinal Mucosa/pathology ; Middle Aged ; Piperazines/therapeutic use ; Pyrimidines/therapeutic use
    Chemical Substances Benzamides ; Piperazines ; Pyrimidines ; Imatinib Mesylate (8A1O1M485B)
    Language English
    Publishing date 2007-07-11
    Publishing country United States
    Document type Case Reports ; Journal Article ; Review
    ZDB-ID 2185929-2
    ISSN 2219-2840 ; 1007-9327
    ISSN (online) 2219-2840
    ISSN 1007-9327
    DOI 10.3748/wjg.v13.i24.3316
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Classification of submucosal tumors in the gastrointestinal tract.

    Ponsaing, Laura-Graves / Kiss, Katalin / Hansen, Mark-Berner

    World journal of gastroenterology

    2007  Volume 13, Issue 24, Page(s) 3311–3315

    Abstract: This review is part two of three, which will present an update on the classification of gastrointestinal submucosal tumors. Part one treats of the diagnosis and part three of the therapeutic methods regarding gastrointestinal submucosal tumors. In the ... ...

    Abstract This review is part two of three, which will present an update on the classification of gastrointestinal submucosal tumors. Part one treats of the diagnosis and part three of the therapeutic methods regarding gastrointestinal submucosal tumors. In the past there has been some confusion as to the classification of gastrointestinal submucosal tumors. Changes in classifications have emerged due to recent advances in mainly immunohistochemistry and electron microscopy. The aim of this paper is to update the reader on the current classification. Literature searches were performed to find information related to classification of gastrointestinal submucosal tumors. Based on these searches the twelve most frequent submucosal tumor types were chosen for description of their classification. The factors that indicate whether tumors are benign or malignant are mainly size and number of mitotic counts. Gastrointestinal stromal tumors are defined mainly by their CD117 positivity. In the future, there should be no more confusion between gastrointestinal stromal tumors and other types of submucosal tumors.
    MeSH term(s) Antigens, CD34/analysis ; Gastric Mucosa/pathology ; Gastrointestinal Neoplasms/classification ; Gastrointestinal Neoplasms/pathology ; Gastrointestinal Stromal Tumors/classification ; Gastrointestinal Stromal Tumors/pathology ; Humans ; Intestinal Mucosa/pathology ; Proto-Oncogene Proteins c-kit/analysis
    Chemical Substances Antigens, CD34 ; Proto-Oncogene Proteins c-kit (EC 2.7.10.1)
    Language English
    Publishing date 2007-07-11
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2185929-2
    ISSN 2219-2840 ; 1007-9327
    ISSN (online) 2219-2840
    ISSN 1007-9327
    DOI 10.3748/wjg.v13.i24.3311
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Diagnostic procedures for submucosal tumors in the gastrointestinal tract.

    Ponsaing, Laura-Graves / Kiss, Katalin / Loft, Annika / Jensen, Lise-Ingemann / Hansen, Mark-Berner

    World journal of gastroenterology

    2007  Volume 13, Issue 24, Page(s) 3301–3310

    Abstract: This review is part one of three, which will present an update on diagnostic procedures for gastrointestinal (GI) submucosal tumors (SMTs). Part two identifies the classification and part three the therapeutic methods regarding GI SMTs. Submucosal tumors ...

    Abstract This review is part one of three, which will present an update on diagnostic procedures for gastrointestinal (GI) submucosal tumors (SMTs). Part two identifies the classification and part three the therapeutic methods regarding GI SMTs. Submucosal tumors are typically asymptomatic and therefore encountered incidentally. Advances in diagnostic tools for gastrointestinal submucosal tumors have emerged over the past decade. The aim of this paper is to provide the readers with guidelines for the use of diagnostic procedures, when a submucosal tumor is suspected. Literature searches were performed to find information on diagnostics for gastrointestinal submucosal tumors. Based on the searches, the optimal diagnostic procedures and specific features of the submucosal tumors could be outlined. Standard endoscopy, capsule endoscopy and push-and-pull enteroscopy (PPE) together with barium contrast X-ray do not alone provide sufficient information, when examining submucosal tumors. Endoscopic ultrasound (EUS), computed tomography (CT), magnetic resonance imaging (MRI) and fluorodeoxyglucose-labeled positron emission tomography (FDG-PET) are recommended as supplementary tools.
    MeSH term(s) Biopsy, Needle ; Endoscopy, Gastrointestinal ; Endosonography ; Gastric Mucosa/pathology ; Gastrointestinal Neoplasms/diagnosis ; Gastrointestinal Stromal Tumors/diagnosis ; Humans ; Imaging, Three-Dimensional ; Intestinal Mucosa/pathology ; Magnetic Resonance Imaging ; Positron-Emission Tomography ; Tomography, X-Ray Computed
    Language English
    Publishing date 2007-07-11
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2185929-2
    ISSN 2219-2840 ; 1007-9327
    ISSN (online) 2219-2840
    ISSN 1007-9327
    DOI 10.3748/wjg.v13.i24.3301
    Database MEDical Literature Analysis and Retrieval System OnLINE

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