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Article ; Online: T

Sherwood, J / Rich, M / Lovas, K / Warram, J / Bolding, M S / Bao, Y

2017 Volume 9, Issue 32, Page(s) 11785–11792

Abstract: Iron oxide nanoparticles with extremely low dimensions have recently been explored as positive (T ...

Abstract	Iron oxide nanoparticles with extremely low dimensions have recently been explored as positive (T
MeSH term(s)	Animals ; Breast Neoplasms/drug therapy ; Cell Line, Tumor ; Contrast Media ; Drug Delivery Systems ; Female ; Ferric Compounds/chemistry ; Humans ; Magnetic Resonance Imaging ; Mice, Inbred C57BL ; Mice, Nude ; Nanoparticles/chemistry ; Neoplasms, Experimental/drug therapy ; Polymers
Chemical Substances	Contrast Media ; Ferric Compounds ; Polymers ; ferric oxide (1K09F3G675)
Language	English
Publishing date	2017-08-16
Publishing country	England
Document type	Journal Article
ZDB-ID	2515664-0
ISSN	2040-3372 ; 2040-3364
ISSN (online)	2040-3372
ISSN	2040-3364
DOI	10.1039/c7nr04181k
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Article: Improvements in Glycemic Control Achieved by Altering the t

Russell, Steven J / Balliro, Courtney / Ekelund, Magnus / El-Khatib, Firas / Graungaard, Tina / Greaux, Evelyn / Hillard, Mallory / Jafri, Rabab Z / Rathor, Naveen / Selagamsetty, Raj / Sherwood, Jordan / Damiano, Edward R

Diabetes therapy : research, treatment and education of diabetes and related disorders

2021 Volume 12, Issue 7, Page(s) 2019–2033

Abstract: ... randomized to a default t: Results: Overall, 24 participants were randomized into three cohorts. Two ... of cohort 3 (t: Conclusion: There were no safety concerns with faster aspart in the iLet at non-default t ...

Abstract	Introduction: We investigated the safety of, and glucose control by, the insulin-only configuration of the iLet Methods: We performed a single-center, single-blinded, crossover (two 7-day treatment periods) escalation trial over three sequential cohorts. Participants from each cohort were randomized to a default t Results: Overall, 24 participants were randomized into three cohorts. Two participants discontinued treatment, one due to reported 'low blood glucose' during the first treatment period of cohort 3 (t Conclusion: There were no safety concerns with faster aspart in the iLet at non-default t Trial registration: ClinicalTrials.gov, NCT03816761.
Language	English
Publishing date	2021-06-19
Publishing country	United States
Document type	Journal Article
ZDB-ID	2566702-6
ISSN	1869-6961 ; 1869-6953
ISSN (online)	1869-6961
ISSN	1869-6953
DOI	10.1007/s13300-021-01087-x
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Article ; Online: Identifying immune signatures of common exposures through co-occurrence of T-cell receptors in tens of thousands of donors

May, Damon H. / Woodhouse, Steven / Zahid, H. Jabran / Elyanow, Rebecca / Doroschak, Kathryn / Noakes, Matthew T. / Taniguchi, Ruth / Yang, Zheng / Grino, John R. / Byron, Rachel / Oaks, Jamie / Sherwood, Anna / Greissl, Julia / Chen-Harris, Haiyin / Howie, Bryan / Robins, Harlan S.

bioRxiv

Abstract: Memory T cells are records of clonal expansion from prior immune exposures, such as infections ... vaccines and chronic diseases like cancer. A subset of the receptors of these expanded T cells in a typical ... For the most part, the exposures associated with these public T cells are unknown. To identify public T-cell ...

Abstract	Memory T cells are records of clonal expansion from prior immune exposures, such as infections, vaccines and chronic diseases like cancer. A subset of the receptors of these expanded T cells in a typical immune repertoire are highly public, i.e., present in many individuals exposed to the same exposure. For the most part, the exposures associated with these public T cells are unknown. To identify public T-cell receptor signatures of immune exposures, we mined the immunosequencing repertoires of tens of thousands of donors to define clusters of co-occurring T cells. We first built co-occurrence clusters of T cells responding to antigens presented by the same Human Leukocyte Antigen (HLA) and then combined those clusters across HLAs. Each cross-HLA cluster putatively represents the public T-cell signature of a single prevalent exposure. Using repertoires from donors with known serological status for 7 prevalent exposures (HSV-1, HSV-2, EBV, Parvovirus, Toxoplasma gondii, Cytomegalovirus and SARS CoV-2), we identified a single T-cell cluster strongly associated with each exposure and used it to construct a highly sensitive and specific diagnostic model for the exposure. These T-cell clusters constitute the public immune responses to prevalent exposures, 7 known and many others unknown. By learning the exposure associations for more T cell clusters, this approach could be used to derive a ledger of a person9s past and present immune exposures.
Keywords	covid19
Language	English
Publishing date	2024-03-27
Publisher	Cold Spring Harbor Laboratory
Document type	Article ; Online
DOI	10.1101/2024.03.26.583354
Database	COVID19

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Article ; Online: Reversal of sepsis-induced T cell dysfunction: OX-40 to the rescue?

Sherwood, Edward R / Williams, David L

Journal of leukocyte biology

2020 Volume 109, Issue 4, Page(s) 689–691

Abstract: The study of Unsinger and colleagues provide important insights into OX40 mediated immunotherapy as a potential approach for the treatment of sepsis induced immune suppression. ...

Abstract	The study of Unsinger and colleagues provide important insights into OX40 mediated immunotherapy as a potential approach for the treatment of sepsis induced immune suppression.
MeSH term(s)	Antibodies ; Humans ; Immunotherapy ; Receptors, OX40 ; Sepsis/therapy ; T-Lymphocytes
Chemical Substances	Antibodies ; Receptors, OX40
Keywords	covid19
Language	English
Publishing date	2020-09-29
Publishing country	England
Document type	Editorial ; Research Support, N.I.H., Extramural ; Comment
ZDB-ID	605722-6
ISSN	1938-3673 ; 0741-5400
ISSN (online)	1938-3673
ISSN	0741-5400
DOI	10.1002/JLB.3CE0720-468
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Article: Reversal of sepsis-induced T cell dysfunction: OX-40 to the rescue?

Sherwood, Edward R / Williams, David L

J. leukoc. biol

Abstract: The study of Unsinger and colleagues provide important insights into OX40 mediated immunotherapy as a potential approach for the treatment of sepsis induced immune suppression. ...

Abstract	The study of Unsinger and colleagues provide important insights into OX40 mediated immunotherapy as a potential approach for the treatment of sepsis induced immune suppression.
Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #32991749
Database	COVID19

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Article ; Online: Quantification and correction of distortion in diffusion-weighted MRI at 1.5 and 3 T in a muscle-invasive bladder cancer phantom for radiotherapy planning.

Rogers, Jane / Sherwood, Victoria / Wayte, Sarah C / Duffy, Jonathan A / Manolopoulos, Spyros

The British journal of radiology

2020 Volume 93, Issue 1114, Page(s) 20190710

Abstract: ... related distortion.: Results: Fiducial marker locations on CT and T2W-MRI agreed within 1.2 mm at 3 T ... and 1.8 mm at 1.5 T. The greatest discrepancy between CT and apparent diffusion coefficient (ADC) maps ... was 6.3 mm at 3 T, reducing to 1.8 mm when corrected for distortion. At 1.5 T, these values were 3.9 ...

Abstract	Objective: Limited visibility of post-resection muscle-invasive bladder cancer (MIBC) on CT hinders radiotherapy dose escalation of the residual tumour. Diffusion-weighted MRI (DW-MRI) visualises areas of high tumour burden and is increasingly used within diagnosis and as a biomarker for cancer. DW-MRI could, therefore, facilitate dose escalation, potentially via dose-painting and/or accommodating response. However, the distortion inherent in DW-MRI could limit geometric accuracy. Therefore, this study aims to quantify DW-MRI distortion via imaging of a bladder phantom. Methods: A phantom was designed to mimic MIBC and imaged using CT, DW-MRI and T2W-MRI. Fiducial marker locations were compared across modalities and publicly available software was assessed for correction of magnetic susceptibility-related distortion. Results: Fiducial marker locations on CT and T2W-MRI agreed within 1.2 mm at 3 T and 1.8 mm at 1.5 T. The greatest discrepancy between CT and apparent diffusion coefficient (ADC) maps was 6.3 mm at 3 T, reducing to 1.8 mm when corrected for distortion. At 1.5 T, these values were 3.9 mm and 1.7 mm, respectively. Conclusions: Geometric distortion in DW-MRI of a model bladder was initially >6 mm at 3 T and >3 mm at 1.5 T; however, established correction methods reduced this to <2 mm in both cases. Advances in knowledge: A phantom designed to mimic MIBC has been produced and used to show distortion in DW-MRI can be sufficiently mitigated for incorporation into the radiotherapy pathway. Further investigation is therefore warranted to enable individually adaptive image-guided radiotherapy of MIBC based upon DW-MRI.
MeSH term(s)	Diffusion Magnetic Resonance Imaging/methods ; Fiducial Markers ; Humans ; Image Enhancement/methods ; Neoplasm Invasiveness ; Phantoms, Imaging ; Radiotherapy, Image-Guided ; Tomography, X-Ray Computed ; Urinary Bladder Neoplasms/diagnostic imaging ; Urinary Bladder Neoplasms/pathology ; Urinary Bladder Neoplasms/radiotherapy
Language	English
Publishing date	2020-08-05
Publishing country	England
Document type	Journal Article
ZDB-ID	2982-8
ISSN	1748-880X ; 0007-1285
ISSN (online)	1748-880X
ISSN	0007-1285
DOI	10.1259/bjr.20190710
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Article ; Online: Longitudinal immunosequencing in healthy people reveals persistent T cell receptors rich in highly public receptors.

Chu, Nathaniel D / Bi, Haixin Sarah / Emerson, Ryan O / Sherwood, Anna M / Birnbaum, Michael E / Robins, Harlan S / Alm, Eric J

BMC immunology

2019 Volume 20, Issue 1, Page(s) 19

Abstract: Background: The adaptive immune system maintains a diversity of T cells capable of recognizing ... a broad array of antigens. Each T cell's specificity for antigens is determined by its T cell receptors ... TCRs), which together across all T cells form a repertoire of millions of unique receptors ...

Abstract	Background: The adaptive immune system maintains a diversity of T cells capable of recognizing a broad array of antigens. Each T cell's specificity for antigens is determined by its T cell receptors (TCRs), which together across all T cells form a repertoire of millions of unique receptors in each individual. Although many studies have examined how TCR repertoires change in response to disease or drugs, few have explored the temporal dynamics of the TCR repertoire in healthy individuals. Results: Here we report immunosequencing of TCR β chains (TCRβ) from the blood of three healthy individuals at eight time points over one year. TCRβ repertoires of all peripheral-blood T cells and sorted memory T cells clustered clearly by individual, systematically demonstrating that TCRβ repertoires are specific to individuals across time. This individuality was absent from TCRβs from naive T cells, suggesting that the differences resulted from an individual's antigen exposure history, not genetic background. Many characteristics of the TCRβ repertoire (e.g., diversity, clonality) were stable across time, although we found evidence of T cell expansion dynamics even within healthy individuals. We further identified a subset of "persistent" TCRβs present across all time points. These receptors were rich in clonal and highly public receptors and may play a key role in immune system maintenance. Conclusions: Our results highlight the importance of longitudinal sampling of the immune system, providing a much-needed baseline for TCRβ dynamics in healthy individuals. Such a baseline will improve interpretation of changes in the TCRβ repertoire during disease or treatment.
MeSH term(s)	Adaptive Immunity ; Biodiversity ; Cell Differentiation ; Cells, Cultured ; Clonal Selection, Antigen-Mediated ; Genes, T-Cell Receptor beta/genetics ; Healthy Volunteers ; High-Throughput Nucleotide Sequencing ; Humans ; Immunologic Memory ; Lymphocyte Activation ; Species Specificity ; T-Lymphocyte Subsets/immunology ; T-Lymphocytes/immunology ; Time Factors
Language	English
Publishing date	2019-06-21
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
ISSN	1471-2172
ISSN (online)	1471-2172
DOI	10.1186/s12865-019-0300-5
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Article ; Online: Composite biomarker panel for prediction of severity and diagnosis of acute GVHD with T-cell-depleted allogeneic stem cell transplants-single centre pilot study.

Min, San San / Mehra, Varun / Clay, Jennifer / Cross, Gemma F / Douiri, Abdel / Dew, Tracy / Basu, Tanya N / Potter, Victoria / Ceesay, M Mansour / Pagliuca, Antonio / Sherwood, Roy A / Vincent, Royce P

Journal of clinical pathology

2017 Volume 70, Issue 10, Page(s) 886–890

Abstract: ... and to help predict and differentiate between severity of aGVHD following T-cell-depleted allogeneic ... who underwent T-cell-depleted HSCT and matched them with negative controls without any evidence of aGVHD. Post ... of aGVHD in patients undergoing T-cell-depleted reduced intensity allogeneic HSCT. ...

Abstract	Aims: Acute graft-versus-host disease (aGVHD) is a leading cause of morbidity and mortality following allogeneic haematopoietic stem cell transplantation (HSCT). The aim of this study was to evaluate the clinical utility of a composite biomarker panel to help identify individuals at risk of developing aGVHD, and to help predict and differentiate between severity of aGVHD following T-cell-depleted allogeneic HSCT. Methods: We retrospectively analysed our cohort of biopsy confirmed patients with aGVHD, who underwent T-cell-depleted HSCT and matched them with negative controls without any evidence of aGVHD. Post-transplant serum samples on days 0 and 7 and at onset of aGVHD were analysed for elafin, regenerating islet-derived 3-α, soluble tumour necrosis factor receptor-1, soluble interleukin-2 receptor-α and hepatocyte growth factor. Biomarker data were combined as composite panels A-F (table 2) using logistic regression analysis. Receiver operating characteristic analysis was performed to study sensitivity and specificity of the composite panels. Results: Our composite biomarker panels significantly differentiated between aGVHD and no GVHD patients at time of onset (panel E) and reliably predicted severity of GVHD grades at days 0 and 7 post-transplant (panels B and D). The area under the curve for the composite panel at time of onset was 0.65 with specificity, sensitivity, positive and negative predictive values of 100%, 55.6%, 100% and 78.9%, respectively ( Conclusions: This pilot data support the usefulness of these composite biomarker panels in the prediction of severity and diagnosis of aGVHD in patients undergoing T-cell-depleted reduced intensity allogeneic HSCT.
MeSH term(s)	Adult ; Area Under Curve ; Biomarkers/blood ; Enzyme-Linked Immunosorbent Assay ; Female ; Graft vs Host Disease/blood ; Graft vs Host Disease/diagnosis ; Hematopoietic Stem Cell Transplantation/adverse effects ; Hematopoietic Stem Cell Transplantation/methods ; Humans ; Male ; Middle Aged ; Pilot Projects ; ROC Curve ; Retrospective Studies ; Sensitivity and Specificity ; T-Lymphocytes/immunology ; Transplantation, Homologous
Chemical Substances	Biomarkers
Language	English
Publishing date	2017-10
Publishing country	England
Document type	Journal Article
ZDB-ID	80261-x
ISSN	1472-4146 ; 0021-9746
ISSN (online)	1472-4146
ISSN	0021-9746
DOI	10.1136/jclinpath-2017-204399
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Article ; Online: Shape-dependent cellular behaviors and relaxivity of iron oxide-based T

Sherwood, J / Lovas, K / Rich, M / Yin, Q / Lackey, K / Bolding, M S / Bao, Y

Nanoscale

2016 Volume 8, Issue 40, Page(s) 17506–17515

Abstract: ... based T ...

Abstract	Recent research efforts about iron oxide nanoparticles has focused on the development of iron oxide-based T
Language	English
Publishing date	2016-10-14
Publishing country	England
Document type	Journal Article
ZDB-ID	2515664-0
ISSN	2040-3372 ; 2040-3364
ISSN (online)	2040-3372
ISSN	2040-3364
DOI	10.1039/c6nr06158c
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Article ; Online: T box riboswitches in Actinobacteria: translational regulation via novel tRNA interactions.

Sherwood, Anna V / Grundy, Frank J / Henkin, Tina M

Proceedings of the National Academy of Sciences of the United States of America

2015 Volume 112, Issue 4, Page(s) 1113–1118

Abstract: The T box riboswitch regulates many amino acid-related genes in Gram-positive bacteria. T box ... T box leader sequences found in organisms of the phylum Actinobacteria was investigated. The Stem ... with the tRNA ligand in other T box RNAs. Many of these RNAs were predicted to regulate gene expression ...

Abstract	The T box riboswitch regulates many amino acid-related genes in Gram-positive bacteria. T box riboswitch-mediated gene regulation was shown previously to occur at the level of transcription attenuation via structural rearrangements in the 5' untranslated (leader) region of the mRNA in response to binding of a specific uncharged tRNA. In this study, a novel group of isoleucyl-tRNA synthetase gene (ileS) T box leader sequences found in organisms of the phylum Actinobacteria was investigated. The Stem I domains of these RNAs lack several highly conserved elements that are essential for interaction with the tRNA ligand in other T box RNAs. Many of these RNAs were predicted to regulate gene expression at the level of translation initiation through tRNA-dependent stabilization of a helix that sequesters a sequence complementary to the Shine-Dalgarno (SD) sequence, thus freeing the SD sequence for ribosome binding and translation initiation. We demonstrated specific binding to the cognate tRNA(Ile) and tRNA(Ile)-dependent structural rearrangements consistent with regulation at the level of translation initiation, providing the first biochemical demonstration, to our knowledge, of translational regulation in a T box riboswitch.
MeSH term(s)	Actinobacteria/genetics ; Actinobacteria/metabolism ; Bacterial Proteins/biosynthesis ; Bacterial Proteins/genetics ; Isoleucine-tRNA Ligase/biosynthesis ; Isoleucine-tRNA Ligase/genetics ; Nucleic Acid Conformation ; Peptide Chain Initiation, Translational/physiology ; RNA Stability/physiology ; RNA, Bacterial/genetics ; RNA, Bacterial/metabolism ; RNA, Transfer/genetics ; RNA, Transfer/metabolism ; Riboswitch/physiology
Chemical Substances	Bacterial Proteins ; RNA, Bacterial ; Riboswitch ; RNA, Transfer (9014-25-9) ; Isoleucine-tRNA Ligase (EC 6.1.1.5)
Language	English
Publishing date	2015-01-27
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	209104-5
ISSN	1091-6490 ; 0027-8424
ISSN (online)	1091-6490
ISSN	0027-8424
DOI	10.1073/pnas.1424175112
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