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Article ; Online: Long-term outcomes of tailored stromal expansion with refractive lenticule for crosslinking thin corneas.

Sachdev, Gitansha S / Thulasidas, Mithun / Sachdev, Mahipal S

2023 Volume 72, Issue 1, Page(s) 94–97

Abstract: Purpose: To assess the long-term safety and stability of visual outcomes following the modified technique of collagen crosslinking (CXL) using refractive lenticule in eyes with thin corneas (<400 µm) and progressive keratoconus.: Setting: A tertiary ... ...

Abstract	Purpose: To assess the long-term safety and stability of visual outcomes following the modified technique of collagen crosslinking (CXL) using refractive lenticule in eyes with thin corneas (<400 µm) and progressive keratoconus. Setting: A tertiary eye care hospital in India. Design: Prospective, interventional case series. Methods: Eyes with progressive keratoconus and thin corneas (<400 µm) underwent CXL with intraoperative stromal augmentation using a refractive lenticule obtained from small-incision lenticule extraction (SMILE). Preoperative and postoperative evaluation (3 months, and then yearly thereafter) included corneal tomography (Oculus Pentacam), uncorrected and corrected distance visual acuity (UDVA and CDVA, respectively), manifest refraction, and endothelial cell count (specular microscopy), and adverse events, if any, were noted. The patients were followed up for a period of 5 years. Results: Seven eyes were included in the analysis. Mean corneal flattening of -4.29 D was noted from preoperative maximum keratometry (P = 0.018). An improvement in UDVA and CDVA of 0.38 logarithm of minimum angle of resolution (logMAR) and 0.36 logMAR, respectively, was noted at 5 years postoperative visit. Four eyes demonstrated a gain of two lines in CDVA. Mean spherical equivalent improved from -6.85 D preoperatively to -6.05 D at 5 years postoperatively. Clear demarcation line was noted between 230 to 270 µm on anterior segment optical coherence topography. No significant endothelial cell loss was noted postoperatively. Conclusion: Long-term outcomes demonstrated safety and disease stability following lenticule-assisted CXL.
MeSH term(s)	Humans ; Keratoconus/diagnosis ; Keratoconus/drug therapy ; Keratoconus/surgery ; Prospective Studies ; Corneal Stroma/surgery ; Corneal Stroma/metabolism ; Photosensitizing Agents/therapeutic use ; Riboflavin/therapeutic use ; Corneal Topography ; Cornea/surgery ; Cornea/metabolism ; Cross-Linking Reagents/pharmacology ; Cross-Linking Reagents/therapeutic use
Chemical Substances	Photosensitizing Agents ; Riboflavin (TLM2976OFR) ; Cross-Linking Reagents
Language	English
Publishing date	2023-12-22
Publishing country	India
Document type	Journal Article
ZDB-ID	187392-1
ISSN	1998-3689 ; 0301-4738
ISSN (online)	1998-3689
ISSN	0301-4738
DOI	10.4103/IJO.IJO_762_23
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Zs.B 329: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Zs.MO 598: Show issues

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Article ; Online: Past antihypertensive medication use is associated with lower levels of small vessel disease and lower Aβ plaque stage in the brains of older individuals.

Affleck, Andrew J / Sachdev, Perminder S / Halliday, Glenda M

Neuropathology and applied neurobiology

2023 Volume 49, Issue 4, Page(s) e12922

Abstract: Aims: This study assesses the association of antihypertensive medication use on the severities of neuropathological cerebrovascular disease (CVD excluding lobar infarction) in older individuals.: Methods: Clinical and neuropathological data were ... ...

Abstract	Aims: This study assesses the association of antihypertensive medication use on the severities of neuropathological cerebrovascular disease (CVD excluding lobar infarction) in older individuals. Methods: Clinical and neuropathological data were retrieved for 149 autopsy cases >75 years old with or without CVD or Alzheimer's disease and no other neuropathological diagnoses. Clinical data included hypertension status, hypertension diagnosis, antihypertensive medication use, antihypertensive medication dose (where available) and clinical dementia rating (CDR). Neuropathological CVD severity was evaluated for differences with anti-hypertensive medication usage. Results: Antihypertensive medication use was associated with less severe white matter small vessel disease (SVD, mainly perivascular dilatation and rarefaction), with a 5.6-14.4 times greater likelihood of less severe SVD if medicated. No significant relationship was detected between infarction (presence, type, number and size), lacunes or cerebral amyloid angiopathy and antihypertensive medication use. Only increased white matter rarefaction/oedema and not perivascular dilation was associated with Alzheimer's pathology, with a 4.3 times greater likelihood of reduced Aβ progression through the brain if white matter rarefaction severity was none or mild. Antihypertensive medication use was associated with reduced Aβ progression but only in those with moderate to severe white matter SVD. Conclusions: This histopathological study provides further evidence that antihypertensive medication use in older individuals is associated with white matter SVD and not with other CVD pathologies. This is mainly due to a reduction in white matter perivascular dilation and rarefaction/oedema. Even in those with moderate to severe white matter SVD, antihypertensive medication use reduced rarefaction and Aβ propagation through the brain.
MeSH term(s)	Humans ; Aged ; Antihypertensive Agents/therapeutic use ; Brain/pathology ; Alzheimer Disease/pathology ; Cerebral Amyloid Angiopathy/pathology ; White Matter/pathology ; Leukoencephalopathies/pathology ; Hypertension/complications ; Hypertension/drug therapy ; Hypertension/pathology ; Infarction/complications ; Infarction/pathology ; Cerebral Small Vessel Diseases/complications ; Cerebral Small Vessel Diseases/drug therapy ; Cerebral Small Vessel Diseases/pathology ; Magnetic Resonance Imaging
Chemical Substances	Antihypertensive Agents
Language	English
Publishing date	2023-07-10
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
ZDB-ID	80371-6
ISSN	1365-2990 ; 0305-1846
ISSN (online)	1365-2990
ISSN	0305-1846
DOI	10.1111/nan.12922
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Zs.A 1241: Show issues

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Article ; Online: Nodal band-off-diagonal superconductivity in twisted graphene superlattices.

Christos, Maine / Sachdev, Subir / Scheurer, Mathias S

Nature communications

2023 Volume 14, Issue 1, Page(s) 7134

Abstract: The superconducting state and mechanism are among the least understood phenomena in twisted graphene systems. Recent tunneling experiments indicate a transition between nodal and gapped pairing with electron filling, which is not naturally understood ... ...

Abstract	The superconducting state and mechanism are among the least understood phenomena in twisted graphene systems. Recent tunneling experiments indicate a transition between nodal and gapped pairing with electron filling, which is not naturally understood within current theory. We demonstrate that the coexistence of superconductivity and flavor polarization leads to pairing channels that are guaranteed by symmetry to be entirely band-off-diagonal, with a variety of consequences: most notably, the pairing invariant under all symmetries can have Bogoliubov Fermi surfaces in the superconducting state with protected nodal lines, or may be fully gapped, depending on parameters, and the band-off-diagonal chiral p-wave state exhibits transitions between gapped and nodal regions upon varying the doping. We demonstrate that band-off-diagonal pairing can be the leading state when only phonons are considered, and is also uniquely favored by fluctuations of a time-reversal-symmetric intervalley coherent order motivated by recent experiments. Consequently, band-off-diagonal superconductivity allows for the reconciliation of several key experimental observations in graphene moiré systems.
Language	English
Publishing date	2023-11-06
Publishing country	England
Document type	Journal Article
ZDB-ID	2553671-0
ISSN	2041-1723 ; 2041-1723
ISSN (online)	2041-1723
ISSN	2041-1723
DOI	10.1038/s41467-023-42471-4
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Article: Recent advances in label-free optical, electrochemical, and electronic biosensors for glioma biomarkers.

Saha, Soumyadeep / Sachdev, Manoj / Mitra, Sushanta K

Biomicrofluidics

2023 Volume 17, Issue 1, Page(s) 11502

Abstract: Gliomas are the most commonly occurring primary brain tumor with poor prognosis and high mortality rate. Currently, the diagnostic and monitoring options for glioma mainly revolve around imaging techniques, which often provide limited information and ... ...

Abstract	Gliomas are the most commonly occurring primary brain tumor with poor prognosis and high mortality rate. Currently, the diagnostic and monitoring options for glioma mainly revolve around imaging techniques, which often provide limited information and require supervisory expertise. Liquid biopsy is a great alternative or complementary monitoring protocol that can be implemented along with other standard diagnosis protocols. However, standard detection schemes for sampling and monitoring biomarkers in different biological fluids lack the necessary sensitivity and ability for real-time analysis. Lately, biosensor-based diagnostic and monitoring technology has attracted significant attention due to several advantageous features, including high sensitivity and specificity, high-throughput analysis, minimally invasive, and multiplexing ability. In this review article, we have focused our attention on glioma and presented a literature survey summarizing the diagnostic, prognostic, and predictive biomarkers associated with glioma. Further, we discussed different biosensory approaches reported to date for the detection of specific glioma biomarkers. Current biosensors demonstrate high sensitivity and specificity, which can be used for point-of-care devices or liquid biopsies. However, for real clinical applications, these biosensors lack high-throughput and multiplexed analysis, which can be achieved via integration with microfluidic systems. We shared our perspective on the current state-of-the-art different biosensor-based diagnostic and monitoring technologies reported and the future research scopes. To the best of our knowledge, this is the first review focusing on biosensors for glioma detection, and it is anticipated that the review will offer a new pathway for the development of such biosensors and related diagnostic platforms.
Language	English
Publishing date	2023-02-22
Publishing country	United States
Document type	Journal Article ; Review
ISSN	1932-1058
ISSN	1932-1058
DOI	10.1063/5.0135525
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Article ; Online: Radiosensitization of IDH-Mutated Gliomas through ZMYND8 - a Pathway to Improved Outcomes.

Sachdev, Sean / Dmello, Crismita / Sonabend, Adam M

Clinical cancer research : an official journal of the American Association for Cancer Research

2023 Volume 29, Issue 9, Page(s) 1648–1650

Abstract: Isocitrate dehydrogenase 1-mutant (IDH1m) gliomas are recalcitrant tumors for which radiotherapy remains a standard treatment. A recent study identified ZMYND8 as a key mediator of radioresistance for IDH1m gliomas, and pharmacologic targeting of this ... ...

Abstract	Isocitrate dehydrogenase 1-mutant (IDH1m) gliomas are recalcitrant tumors for which radiotherapy remains a standard treatment. A recent study identified ZMYND8 as a key mediator of radioresistance for IDH1m gliomas, and pharmacologic targeting of this pathway may heighten radiotherapy-induced tumor response, providing a prospect of improved clinical outcomes. See related article by Carney et al., p. 1763.
MeSH term(s)	Humans ; Isocitrate Dehydrogenase/genetics ; Isocitrate Dehydrogenase/metabolism ; Brain Neoplasms/genetics ; Brain Neoplasms/radiotherapy ; Brain Neoplasms/metabolism ; MYND Domains ; Mutation ; Glioma/genetics ; Glioma/radiotherapy ; Glioma/metabolism
Chemical Substances	Isocitrate Dehydrogenase (EC 1.1.1.41) ; IDH1 protein, human (EC 1.1.1.42.)
Language	English
Publishing date	2023-02-21
Publishing country	United States
Document type	Editorial ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Comment
ZDB-ID	1225457-5
ISSN	1557-3265 ; 1078-0432
ISSN (online)	1557-3265
ISSN	1078-0432
DOI	10.1158/1078-0432.CCR-23-0018
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Zs.A 4223: Show issues

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Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

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Article: Perioperative Lignocaine Intravenous Infusion (PLIV) in Maxillofacial Surgeries: Risk and Safety Considerations and Management.

Tirupathi, Sunnypriyatham / Afnan, Lamea / Sachdev, Muskaan

Journal of maxillofacial and oral surgery

2023 Volume 23, Issue 2, Page(s) 448–449

Language	English
Publishing date	2023-08-26
Publishing country	India
Document type	Journal Article
ZDB-ID	2502352-4
ISSN	0974-942X ; 0972-8279
ISSN (online)	0974-942X
ISSN	0972-8279
DOI	10.1007/s12663-023-02003-5
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Article: Comparison of a single-dose vectored thermal pulsation procedure with 5-day course of daily oral azithromycin for meibomian gland dysfunction.

Kodavoor, Shreesha Kumar / Jayashri, M / Patekar, Komal Bhimrao / Ramamurthy, Shreyas / Sachdev, Gitansha

Oman journal of ophthalmology

2024 Volume 17, Issue 1, Page(s) 102–107

Abstract: Purpose: This study aims at comparing the efficacy of a single-dose vectored thermal pulsation (VTP) procedure versus 5 days once daily oral azithromycin in patients with meibomian gland disease (MGD) by measuring the symptomatology and ocular surface ... ...

Abstract	Purpose: This study aims at comparing the efficacy of a single-dose vectored thermal pulsation (VTP) procedure versus 5 days once daily oral azithromycin in patients with meibomian gland disease (MGD) by measuring the symptomatology and ocular surface parameters. Materials and methods: The study was conducted as a prospective, nonrandomized, comparative study over a period of 17 months at a tertiary care center. In this study, 60 patients with MGD were enrolled after they gave their informed consent according to the inclusion-exclusion criteria and were divided into two groups, 30 each in the azithromycin group and the VTP, i.e., the LipiFlow group. One group was treated with oral azithromycin for 5 days and the other group was given LipiFlow treatment. Postprocedure, follow-up was done for 2 weeks, 3 months, and 6 months. Results: A statistically significant difference was noted in the score Standard Patient Evaluation of Eye Dryness questionnaire after 3 months of treatment in both the azithromycin and LipiFlow group ( Conclusion: Both oral azithromycin and LipiFlow treatment are effective in patients with MGD. The effect of LipiFlow treatment lasted longer as compared to azithromycin. The efficacy of azithromycin in resolving the symptoms of MGD was greater compared to LipiFlow in the initial 2 weeks of treatment. However, the effect deteriorated in the subsequent follow-up at 3 months and 6 months.
Language	English
Publishing date	2024-02-21
Publishing country	India
Document type	Journal Article
ZDB-ID	2484272-2
ISSN	0974-7842 ; 0974-620X
ISSN (online)	0974-7842
ISSN	0974-620X
DOI	10.4103/ojo.ojo_114_22
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Article ; Online: Structural Survey of Antigen Recognition by Synthetic Human Antibodies.

Gorelik, Maryna / Miersch, Shane / Sidhu, Sachdev S

Cold Spring Harbor protocols

2024

Abstract: ... To generate these libraries, the immunological diversity and the antibody framework(s) that supports ...

Abstract	Synthetic antibody libraries have been used extensively to isolate and optimize antibodies. To generate these libraries, the immunological diversity and the antibody framework(s) that supports it outside of the binding regions are carefully designed/chosen to ensure favorable functional and biophysical properties. In particular, minimalist, single-framework synthetic libraries pioneered by our group have yielded a vast trove of antibodies to a broad array of antigens. Here, we review their systematic and iterative development to provide insights into the design principles that make them a powerful tool for drug discovery. In addition, the ongoing accumulation of crystal structures of antigen-binding fragment (Fab)-antigen complexes generated with synthetic antibodies enables a deepening understanding of the structural determinants of antigen recognition and usage of immunoglobulin sequence diversity, which can assist in developing new strategies for antibody and library optimization. Toward this, we also survey here the structural landscape of a comprehensive and unbiased set of 50 distinct complexes derived from these libraries and compare it to a similar set of natural antibodies with the goal of better understanding how each achieves molecular recognition and whether opportunities exist for iterative improvement of synthetic libraries. From this survey, we conclude that despite the minimalist strategies used for design of these synthetic antibody libraries, the overall structural interaction landscapes are highly similar to natural repertoires. We also found, however, some key differences that can help guide the iterative design of new synthetic libraries via the introduction of positionally tailored diversity.
Language	English
Publishing date	2024-04-09
Publishing country	United States
Document type	Journal Article
ISSN	1559-6095
ISSN (online)	1559-6095
DOI	10.1101/pdb.over107759
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Article ; Online: Appearing and disappearing acts of cilia.

Arora, Shashank / Rana, Mausam / Sachdev, Ananya / D'Souza, Jacinta S

Journal of biosciences

2023 Volume 48

Abstract: The past few decades have seen a rise in research on vertebrate cilia and ciliopathy, with interesting collaborations between basic and clinical scientists. This work includes studies on ciliary architecture, composition, evolution, and organelle ... ...

Abstract	The past few decades have seen a rise in research on vertebrate cilia and ciliopathy, with interesting collaborations between basic and clinical scientists. This work includes studies on ciliary architecture, composition, evolution, and organelle generation and its biological role. The human body has cells that harbour any of the following four types of cilia: 9+0 motile, 9+0 immotile, 9+2 motile, and 9+2 immotile. Depending on the type, cilia play an important role in cell/fluid movement, mating, sensory perception, and development. Defects in cilia are associated with a wide range of human diseases afflicting the brain, heart, kidneys, respiratory tract, and reproductive system. These are commonly known as ciliopathies and affect millions of people worldwide. Due to their complex genetic etiology, diagnosis and therapy have remained elusive. Although model organisms like
MeSH term(s)	Animals ; Humans ; Cilia/genetics ; Ciliopathies/genetics ; Cell Movement ; Organelles ; Cell Communication ; Mammals
Language	English
Publishing date	2023-03-16
Publishing country	India
Document type	Review ; Journal Article
ZDB-ID	756157-x
ISSN	0973-7138 ; 0250-5991
ISSN (online)	0973-7138
ISSN	0250-5991
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Zs.A 1907: Show issues

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Article: Desideratum of corroboration-based management for temporomandibular joint disorders: pressing priority in oral surgery.

Bhagat, Bhushan / Bhagat, Shubhangi / Sachdev, Muskaan / Pandey, Narayan Dutt

Journal of the Korean Association of Oral and Maxillofacial Surgeons

2023 Volume 49, Issue 1, Page(s) 53–54

Language	English
Publishing date	2023-03-01
Publishing country	Korea (South)
Document type	Journal Article
ZDB-ID	2763851-0
ISSN	2234-5930 ; 2234-7550
ISSN (online)	2234-5930
ISSN	2234-7550
DOI	10.5125/jkaoms.2023.49.1.53
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