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Article: Health Literacy of Children and Adolescents with Inflammatory Bowel Disease (IBD) and Parents of IBD Patients-Coping and Information Needs.

Kaul, Kalina / Schumann, Stefan / Sander, Cornelia / Däbritz, Jan / de Laffolie, Jan

2024 Volume 11, Issue 4

Abstract: Background: The number of children and adolescents with inflammatory bowel disease (IBD) is increasing. Many chronically ill children and adolescents have low health literacy. Patient empowerment (PE) enables positive changes and control over one's ... ...

Abstract	Background: The number of children and adolescents with inflammatory bowel disease (IBD) is increasing. Many chronically ill children and adolescents have low health literacy. Patient empowerment (PE) enables positive changes and control over one's disease through specific activities, information, and counseling. The CEDNA (IBD Needs Assessment) Survey aimed to provide the necessary data to improve PE in pediatric IBD (PIBD). Methods: Questionnaires were distributed to adolescent IBD patients and parents of children and adolescents with IBD throughout Germany. The answers were given anonymously. Based on the available data, a subgroup analysis was conducted in relation to the age of the patients and the period since diagnosis. For the parents' responses, the same age groups were analyzed for comparison with the patients' responses. Results: From October 2021 to April 2022, 2810 questionnaires were distributed and 1158 questionnaires were completed ( Conclusions: The analysis of all findings according to the patient's age structure and duration since diagnosis can be used to enable age-appropriate communication at certain stages of the disease. This tailored information should increase patients' health literacy, improve their management of the disease, and reduce the burden on their families.
Language	English
Publishing date	2024-04-17
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2732685-8
ISSN	2227-9067
ISSN	2227-9067
DOI	10.3390/children11040481
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: New Insights on CD8

Casalegno Garduño, Rosaely / Däbritz, Jan

Frontiers in immunology

2021 Volume 12, Page(s) 738762

Abstract: ... ...

Abstract	CD8
MeSH term(s)	Animals ; CD8-Positive T-Lymphocytes/immunology ; CD8-Positive T-Lymphocytes/metabolism ; Colitis, Ulcerative/immunology ; Colitis, Ulcerative/metabolism ; Colitis, Ulcerative/pathology ; Colitis, Ulcerative/therapy ; Crohn Disease/immunology ; Crohn Disease/metabolism ; Crohn Disease/pathology ; Crohn Disease/therapy ; Cytotoxicity, Immunologic ; Humans ; Immunity, Mucosal ; Immunologic Memory ; Immunotherapy ; Inflammation Mediators/metabolism ; Interleukin-17/metabolism ; Intestinal Mucosa/immunology ; Intestinal Mucosa/metabolism ; Intestinal Mucosa/pathology ; Lymphocyte Activation ; Phenotype
Chemical Substances	Inflammation Mediators ; Interleukin-17
Language	English
Publishing date	2021-10-11
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2021.738762
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Book ; Thesis: Nachweis von K-ras-Mutationen im peripheren Blut und Gewebe von Patienten mit Pankreaskarzinom mittels Echtzeit-PCR

Däbritz, Jan

2006

Author's details	von Jan Däbritz
Language	German
Size	97 Bl. : graph. Darst.
Publishing country	Germany
Document type	Book ; Thesis
Thesis / German Habilitation thesis	Berlin, Humboldt-Univ., Diss., 2006
HBZ-ID	HT014831428
Database	Catalogue ZB MED Medicine, Health

In stock of ZB MED Cologne/Königswinter

Shelf mark	Loan status	Location
2006 E 1338	order for loan	Magazin

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Article ; Online: Pathophysiological Concepts and Management of Pulmonary Manifestation of Pediatric Inflammatory Bowel Disease.

Schmid, Florian / Chao, Cho-Ming / Däbritz, Jan

International journal of molecular sciences

2022 Volume 23, Issue 13

Abstract: Pulmonary manifestation (PM) of inflammatory bowel disease (IBD) in children is a rare condition. The exact pathogenesis is still unclear, but several explanatory concepts were postulated and several case reports in children were published. We performed ... ...

Abstract	Pulmonary manifestation (PM) of inflammatory bowel disease (IBD) in children is a rare condition. The exact pathogenesis is still unclear, but several explanatory concepts were postulated and several case reports in children were published. We performed a systematic Medline search between April 1976 and April 2022. Different pathophysiological concepts were identified, including the shared embryological origin, "miss-homing" of intestinal based neutrophils and T lymphocytes, inflammatory triggering via certain molecules (tripeptide proline-glycine-proline, interleukin 25), genetic factors and alterations in the microbiome. Most pediatric IBD patients with PM are asymptomatic, but can show alterations in pulmonary function tests and breathing tests. In children, the pulmonary parenchyma is more affected than the airways, leading histologically mainly to organizing pneumonia. Medication-associated lung injury has to be considered in pulmonary symptomatic pediatric IBD patients treated with certain agents (i.e., mesalamine, sulfasalazine or infliximab). Furthermore, the risk of pulmonary embolism is generally increased in pediatric IBD patients. The initial treatment of PM is based on corticosteroids, either inhaled for the larger airways or systemic for smaller airways and parenchymal disease. In summary, this review article summarizes the current knowledge about PM in pediatric IBD patients, focusing on pathophysiological and clinical aspects.
MeSH term(s)	Child ; Humans ; Inflammatory Bowel Diseases/complications ; Inflammatory Bowel Diseases/diagnosis ; Infliximab/therapeutic use ; Lung ; Mesalamine ; Proline
Chemical Substances	Mesalamine (4Q81I59GXC) ; Proline (9DLQ4CIU6V) ; Infliximab (B72HH48FLU)
Language	English
Publishing date	2022-06-30
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms23137287
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: GM-CSF and the role of myeloid regulatory cells in the pathogenesis and treatment of Crohn's disease.

Däbritz, Jan

Molecular and cellular pediatrics

2015 Volume 2, Issue 1, Page(s) 12

Abstract: Background: Intestinal monocytes/macrophages sustain the intestinal immune homeostasis and might be an attractive therapeutic target for the management of inflammatory bowel disease (IBD). Granulocyte macrophage colony-stimulating factor (GM-CSF) exerts ...

Abstract	Background: Intestinal monocytes/macrophages sustain the intestinal immune homeostasis and might be an attractive therapeutic target for the management of inflammatory bowel disease (IBD). Granulocyte macrophage colony-stimulating factor (GM-CSF) exerts beneficial effects on intestinal inflammation and promotes signal transducer and activator of transcription 3 (STAT3)-mediated expansion of myeloid-derived suppressor cells (MDSCs). However, the full action mechanism of GM-CSF, and especially whether monocytes mediate its therapeutic effects in vivo, had not been previously elucidated. Conclusions: This review article summarizes recent developments in the immunology of mucosal diseases and describes new aspects of the role of myeloid regulatory cells in IBD and the function of GM-CSF in maintaining the intestinal immune homeostasis in Crohn's disease (CD). This review article highlights the exploration of stimulating in addition to suppressive therapies for patients with IBD and underpins that myeloid regulatory cells might become a promising novel cell-based therapeutic option.
Language	English
Publishing date	2015-12-01
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2785551-X
ISSN	2194-7791
ISSN	2194-7791
DOI	10.1186/s40348-015-0024-4
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Predicting complications in pediatric Crohn's disease patients followed in CEDATA-GPGE registry.

Klamt, Juliane / de Laffolie, Jan / Wirthgen, Elisa / Stricker, Sebastian / Däbritz, Jan

Frontiers in pediatrics

2023 Volume 11, Page(s) 1043067

Abstract: Background: Complications of Crohn's disease (CD) often impair patients' quality of life. It is necessary to predict and prevent these complications (surgery, stricturing [B2]/penetrating [B3] disease behavior, perianal disease, growth retardation and ... ...

Abstract	Background: Complications of Crohn's disease (CD) often impair patients' quality of life. It is necessary to predict and prevent these complications (surgery, stricturing [B2]/penetrating [B3] disease behavior, perianal disease, growth retardation and hospitalization). Our study investigated previously suggested and additional predictors by analyzing data of the CEDATA-GPGE registry. Methods: Pediatric patients (< 18 years) diagnosed with CD with follow up data in the registry were included in the study. Potential risk factors for the selected complications were evaluated by performing Kaplan-Meier survival curves and cox regression models. Results: For the complication surgery, the potential risk factors older age, B3 disease, severe perianal disease and initial therapy with corticosteroids at the time of diagnosis were identified. Older age, initial therapy with corticosteroids, low weight-for-age, anemia and emesis predict B2 disease. Low weight-for-age and severe perianal disease were risk factors for B3 disease. Low weight-for-age, growth retardation, older age, nutritional therapy, and extraintestinal manifestations (EIM) of the skin were identified as risk factors for growth retardation during the disease course. High disease activity and treatment with biologicals were predictors for hospitalization. As risk factors for perianal disease, the factors male sex, corticosteroids, B3 disease, a positive family history and EIM of liver and skin were identified. Conclusion: We confirmed previously suggested predictors of CD course and identified new ones in one of the largest registries of pediatric CD patients. This may help to better stratify patients' according to their individual risk profile and choose appropriate treatment strategies.
Language	English
Publishing date	2023-02-15
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2711999-3
ISSN	2296-2360
ISSN	2296-2360
DOI	10.3389/fped.2023.1043067
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: A Nationwide Survey on Patient Empowerment in Pediatric Inflammatory Bowel Disease in Germany.

Kaul, Kalina / Schumann, Stefan / Sander, Cornelia / Däbritz, Jan / de Laffolie, Jan

Children (Basel, Switzerland)

2023 Volume 10, Issue 12

Abstract: Background: The incidence/prevalence of pediatric inflammatory bowel disease (IBD) is increasing. IBD places a significant burden on young patients during important developmental stages and affects their families. Children and adolescents with IBD ... ...

Abstract	Background: The incidence/prevalence of pediatric inflammatory bowel disease (IBD) is increasing. IBD places a significant burden on young patients during important developmental stages and affects their families. Children and adolescents with IBD require increased support from health care services. However, little is known about the additional support needed and how to provide it. Therefore, a large survey was conducted with a focus on patient empowerment. Methods: For the anonymous survey, called CEDNA, a patient questionnaire for adolescents with IBD and a questionnaire for parents of children and adolescents with IBD were made available throughout Germany (distributed n = 2810). Questions covered various aspects of coping with the disease, utilization of care, use and need of information and communication services, and how information should be provided. Results: From October 2021 to April 2022, 1158 (n = 708 parents (61.1%), n = 450 patients (38.9%)) questionnaires were completed. The results show a deficit in pediatric IBD care and revealed a large gap in knowledge about core IBD topics (e.g., 74.8% of patients feel poorly informed about transition, 62.4% know little about patient organizations and self-help groups, and 54.7% have little information about preventive health measures), indicating a low level of health literacy among affected children and adolescents. Conclusion: Pediatric IBD poses significant challenges for patients, their families, and healthcare teams. By empowering patients and families, and providing targeted information and communication tailored to the age of the child or adolescent and the needs of the parents, care can be improved and better adapted to the needs of patients. Actions would include providing quality information online through scientific societies and patient organizations and facilitating self-management in adolescents.
Language	English
Publishing date	2023-12-09
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2732685-8
ISSN	2227-9067
ISSN	2227-9067
DOI	10.3390/children10121904
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Granulocyte macrophage colony-stimulating factor and the intestinal innate immune cell homeostasis in Crohn's disease.

Däbritz, Jan

American journal of physiology. Gastrointestinal and liver physiology

2014 Volume 306, Issue 6, Page(s) G455–65

Abstract: Current literature consolidates the view of Crohn's disease (CD) as a form of immunodeficiency highlighting dysregulation of intestinal innate immunity in the pathogenesis of CD. Intestinal macrophages derived from blood monocytes play a key role in ... ...

Abstract	Current literature consolidates the view of Crohn's disease (CD) as a form of immunodeficiency highlighting dysregulation of intestinal innate immunity in the pathogenesis of CD. Intestinal macrophages derived from blood monocytes play a key role in sustaining the innate immune homeostasis in the intestine, suggesting that the monocyte/macrophage compartment might be an attractive therapeutic target for the management of CD. Granulocyte macrophage colony-stimulating factor (GM-CSF) is a hematopoietic growth factor that also promotes myeloid cell activation, proliferation, and differentiation. GM-CSF has a protective effect in human CD and mouse models of colitis. However, the role of GM-CSF in immune and inflammatory reactions in the intestine is not well defined. Beneficial effects exerted by GM-CSF during intestinal inflammation could relate to modulation of the mucosal barrier function in the intestine, including epithelial cell proliferation, survival, restitution, and immunomodulatory actions. The aim of this review is to summarize potential mechanistic roles of GM-CSF in intestinal innate immune cell homeostasis and to highlight its central role in maintenance of the intestinal immune barrier in the context of immunodeficiency in CD.
MeSH term(s)	Animals ; Autoantibodies/immunology ; Colitis/pathology ; Colitis/physiopathology ; Crohn Disease/immunology ; Disease Models, Animal ; Granulocyte-Macrophage Colony-Stimulating Factor/immunology ; Granulocyte-Macrophage Colony-Stimulating Factor/physiology ; Granulocyte-Macrophage Colony-Stimulating Factor/therapeutic use ; Homeostasis ; Humans ; Immunity, Innate/genetics ; Immunity, Innate/immunology ; Inflammation/immunology ; Inflammation/pathology ; Intestinal Mucosa/pathology ; Intestines/immunology ; Intestines/pathology ; Macrophages/immunology ; Mice ; Receptors, Granulocyte-Macrophage Colony-Stimulating Factor/physiology
Chemical Substances	Autoantibodies ; Receptors, Granulocyte-Macrophage Colony-Stimulating Factor ; Granulocyte-Macrophage Colony-Stimulating Factor (83869-56-1)
Language	English
Publishing date	2014-03
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	603840-2
ISSN	1522-1547 ; 0193-1857
ISSN (online)	1522-1547
ISSN	0193-1857
DOI	10.1152/ajpgi.00409.2013
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Book ; Online ; Thesis: Individualized somatic classification of newborns based on maternal height and weight

Meyer-Kahrweg, Lena Marie [Verfasser] / Däbritz, Jan [Akademischer Betreuer] / Rochow, Niels [Akademischer Betreuer] / Däbritz, Jan [Gutachter] / Singer, Dominique [Gutachter]

2023

Author's details	Lena Marie Meyer-Kahrweg ; Gutachter: Jan Däbritz, Dominique Singer ; Jan Däbritz, Niels Rochow
Keywords	Medizin, Gesundheit ; Medicine, Health
Subject code	sg610
Language	German
Publisher	Universität Greifswald
Publishing place	Greifswald
Document type	Book ; Online ; Thesis
Database	Digital theses on the web

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Article ; Online: Pathophysiological Concepts and Management of Pulmonary Manifestation of Pediatric Inflammatory Bowel Disease

Florian Schmid / Cho-Ming Chao / Jan Däbritz

International Journal of Molecular Sciences, Vol 23, Iss 7287, p

2022 Volume 7287

Abstract	Pulmonary manifestation (PM) of inflammatory bowel disease (IBD) in children is a rare condition. The exact pathogenesis is still unclear, but several explanatory concepts were postulated and several case reports in children were published. We performed a systematic Medline search between April 1976 and April 2022. Different pathophysiological concepts were identified, including the shared embryological origin, “miss-homing” of intestinal based neutrophils and T lymphocytes, inflammatory triggering via certain molecules (tripeptide proline-glycine-proline, interleukin 25), genetic factors and alterations in the microbiome. Most pediatric IBD patients with PM are asymptomatic, but can show alterations in pulmonary function tests and breathing tests. In children, the pulmonary parenchyma is more affected than the airways, leading histologically mainly to organizing pneumonia. Medication-associated lung injury has to be considered in pulmonary symptomatic pediatric IBD patients treated with certain agents (i.e., mesalamine, sulfasalazine or infliximab). Furthermore, the risk of pulmonary embolism is generally increased in pediatric IBD patients. The initial treatment of PM is based on corticosteroids, either inhaled for the larger airways or systemic for smaller airways and parenchymal disease. In summary, this review article summarizes the current knowledge about PM in pediatric IBD patients, focusing on pathophysiological and clinical aspects.
Keywords	children ; molecular ; inflammation ; immunity ; gut–lung axis ; airways ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
Subject code	610
Language	English
Publishing date	2022-06-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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