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  1. Article ; Online: Sympathetic Skin Response in Ulnar Neuropathy at the Elbow.

    Mondelli, Mauro / Aretini, Alessandro

    Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society

    2022  Volume 41, Issue 3, Page(s) 271–277

    Abstract: Introduction: The sympathetic skin response (SSR) reflects the function of sudomotor sympathetic unmyelinated fibers. This study evaluates SSR abnormalities in ulnar neuropathy at the elbow (UNE).: Methods: Sympathetic skin response was obtained ... ...

    Abstract Introduction: The sympathetic skin response (SSR) reflects the function of sudomotor sympathetic unmyelinated fibers. This study evaluates SSR abnormalities in ulnar neuropathy at the elbow (UNE).
    Methods: Sympathetic skin response was obtained after electrical stimulation of the glabella recording simultaneously from the hand palm (P), third digit (M3) and fifth digit ipsilateral (U5) and contralateral (cU5) to the side of UNE. Ten consecutive SSRs were recorded from each recording side of all participants.
    Results: The authors enrolled 31 patients (mean age 54.3 ± 11.4 years) and 25 subjects of a control group (mean age 52.6 ± 11.3 years). The mean of the areas and the area of the largest response of U5-SSR were significantly lower in the patients (106.9 ± 68.9 and 127.8 ± 79.7 μV/s, respectively) than in control group (161.8 ± 116.6 and 197.2 ± 143.3 μV/s, respectively) and in the affected than in the unaffected sides of the patients (155.3 ± 84.8 and 197.7 ± 103.3 μV/s, respectively); there were no differences in U5-SSR latencies and P-SSR and M3-SSR parameters. U5-SSR mean areas and U5-SSR largest area were reduced in 29% and 26% of patients, respectively. The differences between patients and control group and the number of patients with U5-SSR abnormalities increased when the ratios of M3/U5-SSR and U5/cU5-SSR areas were considered. U5-SSR area was related to UNE clinical severity and to some parameters of the ulnar nerve conduction velocity and cutaneous silent period.
    Conclusions: Sympathetic skin response is useful to demonstrate abnormalities of sympathetic fibers even if UNE patients do not complain for sympathetic symptoms. The SSR abnormalities were evident only if electrophysiological damage of myelinated fibers was moderate or severe.
    MeSH term(s) Humans ; Adult ; Middle Aged ; Aged ; Elbow ; Skin/innervation ; Ulnar Neuropathies ; Hand ; Electric Stimulation ; Sympathetic Nervous System ; Galvanic Skin Response ; Neural Conduction/physiology
    Language English
    Publishing date 2022-11-02
    Publishing country United States
    Document type Journal Article
    ZDB-ID 605640-4
    ISSN 1537-1603 ; 0736-0258
    ISSN (online) 1537-1603
    ISSN 0736-0258
    DOI 10.1097/WNP.0000000000000963
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  2. Article ; Online: Cutaneous silent period in ulnar neuropathy at the elbow.

    Mondelli, Mauro / Aretini, Alessandro

    Muscle & nerve

    2021  Volume 65, Issue 2, Page(s) 225–232

    Abstract: Introduction/aims: The cutaneous silent period (CSP) reflects the function of A-delta sensory fibers. There are few studies on CSP in nerve entrapment syndromes. This study aims to evaluate the neurophysiological abnormalities of small-diameter sensory ... ...

    Abstract Introduction/aims: The cutaneous silent period (CSP) reflects the function of A-delta sensory fibers. There are few studies on CSP in nerve entrapment syndromes. This study aims to evaluate the neurophysiological abnormalities of small-diameter sensory fibers in ulnar neuropathy at the elbow (UNE) by means of CSP.
    Methods: We consecutively evaluated UNE patients at one electrodiagnostic laboratory. The CSP was obtained upon stimulating the fifth (D5) and third digits, recording from the first dorsal interosseous (FDI) and abductor pollicis brevis (APB) muscles.
    Results: We enrolled 37 UNE patients (mean age 55.4 ± 11.2 y) and 30 controls (mean age 51.2 ± 11.1 y). The combinations of the D5-APB and D5-FDI mean onset latencies of CSP were significantly more prolonged in patients (83.7 ± 6.8 and 84.5 ± 8 ms, respectively) than in controls (78.2 ± 8.1 and 79.4 ± 7.6 ms, respectively). The D5-FDI duration of CSP was shorter in patients (52.2 ± 8.3 ms) than in controls (55.8 ± 7 ms). The mean of the onset latencies of D5-FDI and D5-APB was related to the clinical severity (P = .013 and .0025, respectively). D5-APB and D5-FDI onset latencies were more prolonged and the duration was shorter in the UNE group with absent ulnar sensory nerve action potentials (SNAPs) and axonal motor damage than in patients with preserved SNAPs and with demyelinating damage.
    Discussion: CSP was able to demonstrate abnormalities of small-diameter myelinated sensory fibers. This damage was directly related to UNE severity and to axonal damage of motor fibers. Absence of a sensory large-diameter fiber response did not exclude preserved residual small fiber conduction.
    MeSH term(s) Adult ; Aged ; Elbow ; Elbow Joint ; Humans ; Middle Aged ; Nerve Compression Syndromes ; Neural Conduction/physiology ; Ulnar Nerve ; Ulnar Neuropathies/diagnosis
    Language English
    Publishing date 2021-11-16
    Publishing country United States
    Document type Journal Article
    ZDB-ID 438353-9
    ISSN 1097-4598 ; 0148-639X
    ISSN (online) 1097-4598
    ISSN 0148-639X
    DOI 10.1002/mus.27452
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  3. Article: Determining the widths of the maxillary anterior teeth for esthetics: comparison of the Mondelli and Albers formulas, esthetic proportion, and golden ratio.

    Garrido, Lorena Mello Alcântara / Magalhães, Ana Paula Rodrigues / Mamani, Mauro Elisban Díaz / Mondelli, José

    General dentistry

    2024  Volume 72, Issue 3, Page(s) 26–32

    Abstract: ... of the maxillary incisors to the actual dimensions of natural teeth. The Mondelli formula 1 (MF1), Mondelli formula ...

    Abstract The purpose of this study was to compare various formulas for idealized proportions of the maxillary incisors to the actual dimensions of natural teeth. The Mondelli formula 1 (MF1), Mondelli formula 2 (MF2), Albers formula (AF), esthetic proportion (EP) for width and height of anterior teeth, and golden ratio (GR) were calculated for a total of 50 dental students (30 women and 20 men) who participated in the study. The following measurements were obtained directly in the participant's mouth with a digital caliper: the mesiodistal and incisogingival dimensions of the maxillary central incisors, lateral incisors, and canines; the intercanine distance; and the smile width. The participants were photographed, and the smile width was also measured on the photographs. The MF1 and MF2 were each calculated twice, using both direct measurements and photographic measurements. The projected central incisor widths calculated using the MF1, MF2, and AF were compared among themselves and against the actual measurements using analysis of variance and Fisher test for multiple comparisons (α = 0.05). The EP and GR were analyzed using descriptive statistics. There was a statistically significant difference between all of the widths projected by the formulas and the actual widths of the central incisors (P < 0.05). Whether calculated from a direct or a photographic measurement, the incisor widths projected by the MF1 and MF2 were statistically similar to each other (P > 0.05). The EP values were similar to those reported in the literature. Only 2% of the participants had an incisor width ratio (central incisor/lateral incisor) that matched the GR of 1.618, while 86% fell within the range of 1.2 to 1.4. Overall, the proportions calculated with the MF1, MF2, AF, EP, and GR did not exactly match the actual dimensions of natural teeth. The formulas and the proportions available in the literature can assist in esthetic planning, but the individual characteristics of each patient and expertise of the dentist should guide treatment for each case.
    MeSH term(s) Male ; Humans ; Female ; Maxilla ; Esthetics, Dental ; Odontometry ; Incisor ; Smiling ; Cuspid
    Language English
    Publishing date 2024-04-19
    Publishing country United States
    Document type Journal Article
    ZDB-ID 603650-8
    ISSN 0363-6771
    ISSN 0363-6771
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  4. Article ; Online: Electrophysiological Study of the Tibial Nerve Across the Tarsal Tunnel in Distal Symmetric Diabetic Polyneuropathy.

    Mondelli, Mauro / Aretini, Alessandro / Ginanneschi, Federica

    American journal of physical medicine & rehabilitation

    2021  Volume 101, Issue 2, Page(s) 152–159

    Abstract: Objective: The aim of the study was to demonstrate abnormalities of motor conduction of the tibial nerve across the tarsal tunnel in type 2 diabetes.: Design: One hundred twenty-four consecutive patients (mean age = 66.6 yrs, 62.1% male) with distal ... ...

    Abstract Objective: The aim of the study was to demonstrate abnormalities of motor conduction of the tibial nerve across the tarsal tunnel in type 2 diabetes.
    Design: One hundred twenty-four consecutive patients (mean age = 66.6 yrs, 62.1% male) with distal symmetric diabetic polyneuropathy clinically diagnosed were prospectively enrolled. Nerve conduction studies of deep peroneal, tibial, superficial peroneal, medial plantar, and sural nerves and standard needle electromyography in the lower limbs were performed. Demographic, anthropometric, and clinical findings were collected.
    Results: Motor conduction velocity of the tibial nerve across tarsal tunnel was slowed in 60.5% of patients; another 4% showed conduction block across tarsal tunnel without reduction of motor conduction velocity. Overall percentage of abnormalities across tarsal tunnel (64.5%) exceeds that of the sensory conduction velocities of proximal sural and superficial peroneal nerves. Abnormal tibial motor conduction velocity across tarsal tunnel represents the most common abnormality among all motor nerve conduction study parameters and significantly correlates with hemoglobin level, diabetic neuropathic index score, and diabetic complications frequency.
    Conclusions: Tibial conduction abnormalities across tarsal tunnel are the most sensitive motor parameter in distal symmetric diabetic polyneuropathy, second only to conduction abnormalities of sensory/mixed distal nerves of the feet. The use of nerve conduction studies across tarsal tunnel of the tibial nerve may be useful in the electrophysiological protocol to confirm the diagnosis of distal symmetric diabetic polyneuropathy.
    MeSH term(s) Aged ; Diabetes Mellitus, Type 2/complications ; Diabetes Mellitus, Type 2/physiopathology ; Diabetic Neuropathies/diagnosis ; Diabetic Neuropathies/physiopathology ; Electromyography/methods ; Female ; Humans ; Male ; Neural Conduction ; Prospective Studies ; Tarsal Tunnel Syndrome/diagnosis ; Tarsal Tunnel Syndrome/etiology ; Tibial Nerve/diagnostic imaging
    Language English
    Publishing date 2021-04-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 219390-5
    ISSN 1537-7385 ; 0002-9491 ; 0894-9115
    ISSN (online) 1537-7385
    ISSN 0002-9491 ; 0894-9115
    DOI 10.1097/PHM.0000000000001769
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  5. Article ; Online: The effects of anthropometric and demographic factors on conduction parameters of the ulnar nerve: Multivariate analysis.

    Mondelli, Mauro / Vinciguerra, Claudia / Aretini, Alessandro / Ginanneschi, Federica

    Neuroscience letters

    2020  Volume 734, Page(s) 135107

    Abstract: The objective of the study is to investigate the effects of age, height, gender, body mass index (BMI), waist-to-hip ratio (WHR), arm and elbow measures on ulnar nerve conduction. We enrolled 261 "disease-free" subjects. We analyzed motor conduction ... ...

    Abstract The objective of the study is to investigate the effects of age, height, gender, body mass index (BMI), waist-to-hip ratio (WHR), arm and elbow measures on ulnar nerve conduction. We enrolled 261 "disease-free" subjects. We analyzed motor conduction velocity (MCV) in across elbow (AE) and forearm tracts, and sensory conduction velocity in 4th, 5th digit-wrist tracts (U4, U5) and in dorsal ulnar cutaneous nerve (DUC). We calculated the amplitudes of sensory and motor potentials (CMAPa and SNAPa), % of CMAPa drop AE, MCV drop and distal motor latency (DML). Univariate and multivariate analyses were performed. We estimated the predictive equations. The median nerve was examined for comparison. Age was negatively correlated with all conduction parameters. Forearm and AE MCV, % of CMAPa drop, DML, U4 and U5 SCV also depended upon height. Females had higher U4 and U5 SNAPa than males. BMI showed inverse relationship with U4 and U5 SNAPa. DUC parameters depended upon BMI and arm length. Similar trends were observed for the median nerve. "Normative" ulnar conduction parameters should be adjusted for demographic and anthropometric measures to improve diagnostic sensitivity.
    MeSH term(s) Action Potentials/physiology ; Adult ; Age Factors ; Body Height ; Body Mass Index ; Elbow ; Electrophysiology/standards ; Female ; Humans ; Male ; Middle Aged ; Neural Conduction/physiology ; Reference Values ; Ulnar Nerve/physiology ; Waist-Hip Ratio
    Language English
    Publishing date 2020-05-30
    Publishing country Ireland
    Document type Journal Article
    ZDB-ID 194929-9
    ISSN 1872-7972 ; 0304-3940
    ISSN (online) 1872-7972
    ISSN 0304-3940
    DOI 10.1016/j.neulet.2020.135107
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  6. Article ; Online: Risk factors of asymptomatic reduction of motor conduction velocity of the ulnar nerve across the elbow.

    Mondelli, Mauro / Ciaramirato, Palma / Greco, Giuseppe / Pitocchi, Ester / Sicurelli, Francesco / Vinciguerra, Claudia

    Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology

    2021  Volume 43, Issue 3, Page(s) 2065–2072

    Abstract: Introduction: The aim of the study was to check the risk factors for subjects with motor conduction velocity (MCV) reduction of the ulnar nerve across the elbow without symptoms/signs of ulnar neuropathy at the elbow (UNE) using a database of a previous ...

    Abstract Introduction: The aim of the study was to check the risk factors for subjects with motor conduction velocity (MCV) reduction of the ulnar nerve across the elbow without symptoms/signs of ulnar neuropathy at the elbow (UNE) using a database of a previous multicenter case-control study on UNE patients.
    Methods: From the previous database, we extracted all asymptomatic UNE (A-UNE) and matched for age and sex with a control and UNE groups with a ratio of 1:2. Anthropometric factors were measured and all participants filled in a questionnaire on demographic, lifestyle factors, and medical history. One-sample proportion test and univariate and multivariate logistic regression analyses were performed.
    Results: We enrolled 64 A-UNE, 124 UNE, and 124 controls (mean age 53 years). There were more males with A-UNE than females (74.2%). The predominantly or exclusively concerned side of A-UNE was the right. Logistic regression showed that A-UNE was associated with diabetes (OR = 2.99, 95% CI = 1.21-7.39) and width of cubital groove (CGW) (OR = 0.89, 95%  CI = 0.81-0.97).
    Discussion: Risk factors for A-UNE are different from UNE. The prevalence of right side in A-UNE was not due to particular elbow postures. Diabetes is a risk factor, probably because MCV reduction of the ulnar nerve across the elbow was an early manifestation of asymptomatic polyneuropathy in diabetes. A-UNE is associated with narrow CGW as already demonstrated in UNE, even if the OR was higher in UNE than in A-UNE. Only future longitudinal studies will be able to check whether the A-UNE subjects develop symptoms and signs of true mononeuropathy with time.
    MeSH term(s) Case-Control Studies ; Elbow/innervation ; Electrodiagnosis ; Female ; Humans ; Male ; Middle Aged ; Neural Conduction/physiology ; Risk Factors ; Ulnar Nerve ; Ulnar Neuropathies/etiology
    Language English
    Publishing date 2021-09-09
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 2016546-8
    ISSN 1590-3478 ; 1590-1874
    ISSN (online) 1590-3478
    ISSN 1590-1874
    DOI 10.1007/s10072-021-05584-6
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  7. Article ; Online: Relations between sensory symptoms, touch sensation, and sensory neurography in the assessment of the ulnar neuropathy at the elbow.

    Ginanneschi, Federica / Aretini, Alessandro / Mondelli, Mauro

    Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology

    2018  Volume 130, Issue 2, Page(s) 199–206

    Abstract: Objectives: To evaluate sensitivity, specificity and predictive values of sensory findings in ulnar neuropathy at the elbow (UNE), differences according to UNE localization and pathophysiology, and relation between the sites of sensory symptoms, ... ...

    Abstract Objectives: To evaluate sensitivity, specificity and predictive values of sensory findings in ulnar neuropathy at the elbow (UNE), differences according to UNE localization and pathophysiology, and relation between the sites of sensory symptoms, abnormal evaluation of sensation and neurographic findings of ulnar sensory nerve.
    Methods: Hand diagram and Semmes-Weinstein monofilaments were used for clinical evaluation in four ulnar hand territories. Sensory neurography was measured in the fourth and fifth digits-wrist segments (U5) and in the dorsal ulnar cutaneous nerve.
    Results: We enrolled 75 idiopathic UNE cases and 180 controls. Symptoms in the fifth digit, reduction of touch sensation and U5 sensory nerve action potential amplitude (SNAPa) had the highest sensitivity, specificity and predictivity in UNE diagnosis. The normal/abnormal sensory clinical findings of the fifth digit matched with normal/abnormal U5 SNAP more than the matching of sensory parameters in the other ulnar hand sites. Sensory anomalies were more frequent in predominantly axonal than demyelinating UNE. There were no differences according to UNE location.
    Conclusion: Sensory anomalies of the fifth digit are constant findings in UNE more than anomalies of the other ulnar nerve hand regions.
    Significance: Probably the fascicles from fifth digit are the most liable to damage at elbow.
    MeSH term(s) Adolescent ; Adult ; Aged ; Elbow Joint/innervation ; Elbow Joint/physiology ; Electromyography/methods ; Female ; Humans ; Male ; Middle Aged ; Prospective Studies ; Sensory Thresholds/physiology ; Touch/physiology ; Ulnar Nerve/physiology ; Ulnar Neuropathies/diagnosis ; Ulnar Neuropathies/physiopathology ; Young Adult
    Language English
    Publishing date 2018-12-09
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1463630-x
    ISSN 1872-8952 ; 0921-884X ; 1388-2457
    ISSN (online) 1872-8952
    ISSN 0921-884X ; 1388-2457
    DOI 10.1016/j.clinph.2018.11.020
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  8. Article ; Online: Impact of carpal tunnel syndrome on ulnar nerve at wrist: Systematic review.

    Ginanneschi, Federica / Mondelli, Mauro / Cioncoloni, David / Rossi, Alessandro

    Journal of electromyography and kinesiology : official journal of the International Society of Electrophysiological Kinesiology

    2018  Volume 40, Page(s) 32–38

    Abstract: Considerable debate exists in the literature about possible anomalies of ulnar nerve at wrist in carpal tunnel syndrome (CTS). We systematically reviewed the literature about electrophysiologic and morphologic changes of ulnar nerve at wrist in CTS. We ... ...

    Abstract Considerable debate exists in the literature about possible anomalies of ulnar nerve at wrist in carpal tunnel syndrome (CTS). We systematically reviewed the literature about electrophysiologic and morphologic changes of ulnar nerve at wrist in CTS. We carried out a comprehensive search using PubMed from 1963 through October 2017. Data were extracted and the quality of the included studies was evaluated. Twenty-eight studies were selected. Seventy-nine percent of the studies report abnormalities of the ulnar nerve conduction. There was a relation between the median and ulnar nerve conduction in almost all the papers, i.e., conduction impairment of the ulnar nerve increased with increasing severity of median nerve involvement, emerging as a process correlated with damage of the median nerve. Seventy-five percent of ultrasonographic studies report changes of ulnar nerve cross sectional area in CTS. Morphologic and functional changes of the ulnar nerve and/or Guyon canal are reported by 100% of papers addressed to this topic. Several papers quoted in this review have some flaws. The key message of present review is that electrophysiological and morphological changes of the ulnar nerve at the wrist can occur in CTS, although the possibility of an overestimation of the phenomenon needs to be considered.
    MeSH term(s) Carpal Tunnel Syndrome/diagnosis ; Carpal Tunnel Syndrome/physiopathology ; Clinical Trials as Topic/methods ; Humans ; Median Nerve/physiopathology ; Muscle, Skeletal/physiopathology ; Neural Conduction/physiology ; Ulnar Nerve/physiopathology ; Wrist/innervation ; Wrist/physiopathology ; Wrist Joint/innervation ; Wrist Joint/physiopathology
    Language English
    Publishing date 2018-03-20
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1073161-1
    ISSN 1873-5711 ; 1050-6411
    ISSN (online) 1873-5711
    ISSN 1050-6411
    DOI 10.1016/j.jelekin.2018.03.004
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  9. Article ; Online: Diagnostic Accuracy of Sensory Clinical Findings of the Hand Dorsum and of Neurography of the Dorsal Ulnar Cutaneous Nerve in Ulnar Neuropathy at the Elbow.

    Mondelli, Mauro / Ginanneschi, Federica / Aretini, Alessandro

    Archives of physical medicine and rehabilitation

    2018  Volume 100, Issue 5, Page(s) 908–913

    Abstract: Objective: The main objective is to investigate the diagnostic accuracy and the relation of touch sensation and subjective sensory symptoms in the medial aspect of the hand dorsum, and neurography of the dorsal ulnar cutaneous nerve (DUCN) in ulnar ... ...

    Abstract Objective: The main objective is to investigate the diagnostic accuracy and the relation of touch sensation and subjective sensory symptoms in the medial aspect of the hand dorsum, and neurography of the dorsal ulnar cutaneous nerve (DUCN) in ulnar neuropathy at the elbow (UNE). Secondary objective is to report the electrophysiological occurrence of anatomical variant of sensory innervation of the medial aspect of the hand dorsum from superficial radial nerve (SRN).
    Design: Prospective, cohort study.
    Setting: Electromyography laboratory.
    Participants: Consecutive participants (N=282), those with UNE (n=81) and those without UNE (n=201), were enrolled.
    Interventions: Not applicable.
    Main outcome measures: Accuracy and agreement between sensory clinical findings of the medial hand dorsum and neurography of DUCN in UNE diagnosis.
    Results: DUCN neurographic and sensory findings had high specificity and relatively low sensitivity. Normal or abnormal sensory nerve action potential (SNAP) of DUCN matched with normal or abnormal touch sensation of the medial aspect of hand dorsum. Abnormal DUCN SNAP was related to the clinical severity of UNE and to the axonal damage of the ulnar nerve. Anatomical variant of the innervation of hand dorsum from SRN was demonstrated in 31 of 564 hands (6.2%) belonging to 26 of 282 participants (9.2%). If the variant was present, DUCN SNAP of the same side was more frequently absent or of low amplitude.
    Conclusions: The utility of DUCN neurography and sensory findings of the medial aspect of the dorsum of the hand is limited in the diagnosis of UNE. However, if DUCN SNAP is absent or low in amplitude, it is advisable to check the presence of the anatomical variant of the innervation of the medial aspect of the hand dorsum from SRN.
    MeSH term(s) Action Potentials ; Adult ; Anatomic Variation/physiology ; Case-Control Studies ; Elbow ; Electromyography ; Female ; Hand/diagnostic imaging ; Hand/innervation ; Humans ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Peripheral Nerves/diagnostic imaging ; Peripheral Nerves/physiopathology ; Prospective Studies ; Sensitivity and Specificity ; Severity of Illness Index ; Touch ; Ulnar Neuropathies/diagnosis ; Ulnar Neuropathies/physiopathology
    Language English
    Publishing date 2018-10-21
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80057-0
    ISSN 1532-821X ; 0003-9993
    ISSN (online) 1532-821X
    ISSN 0003-9993
    DOI 10.1016/j.apmr.2018.09.119
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  10. Article ; Online: Low sensitivity of F-wave in the electrodiagnosis of carpal tunnel syndrome.

    Mondelli, Mauro / Aretini, Alessandro

    Journal of electromyography and kinesiology : official journal of the International Society of Electrophysiological Kinesiology

    2015  Volume 25, Issue 2, Page(s) 247–252

    Abstract: Objective: Previous studies showed "F-wave inversion" (F-INV) as a sensitive method in the electrodiagnosis of early stage of carpal tunnel syndrome (CTS). This study aimed at evaluating the sensitivity and specificity of F-wave and nerve conduction ... ...

    Abstract Objective: Previous studies showed "F-wave inversion" (F-INV) as a sensitive method in the electrodiagnosis of early stage of carpal tunnel syndrome (CTS). This study aimed at evaluating the sensitivity and specificity of F-wave and nerve conduction velocity (NCV) testing in CTS.
    Methods: We consecutively enrolled 244 cases and 108 controls. F-waves analysis included: Fwave minimum and mean latencies, F-wave persistence and chronodispersion, mean-F/CMAP amplitude ratio, F-INV. Specificity and sensitivity of F-waves parameters were calculated in the whole sample of CTS patients and by grouping the patients according to CTS severity. Multivariate logistic regression was also performed using F-INV as a dependent variable.
    Results: In the whole sample the sensitivity of F-mean-INV and of median-ulnar NCV comparative testing was 50.8% and 93.7%, respectively. F-INV sensitivity dropped to 8% in CTS early stage. F-INV could be predicted only by distal motor latency of the median nerve. The sensitivity of all F-wave parameters increased only in the most severe stages of CTS.
    Conclusions: This study does not confirm the electrodiagnostic usefulness of F-INV in early stage of CTS. All F-wave parameters, including F-INV, are much less sensitive than conventional NCV in CTS electrodiagnosis. F-wave does not add further useful information specifically related to CTS.
    MeSH term(s) Adult ; Aged ; Carpal Tunnel Syndrome/diagnosis ; Carpal Tunnel Syndrome/physiopathology ; Electrodiagnosis/methods ; Electrodiagnosis/standards ; Female ; Humans ; Male ; Median Nerve/physiology ; Middle Aged ; Muscle, Skeletal/physiology ; Neural Conduction/physiology ; Prospective Studies
    Language English
    Publishing date 2015-04
    Publishing country England
    Document type Journal Article
    ZDB-ID 1073161-1
    ISSN 1873-5711 ; 1050-6411
    ISSN (online) 1873-5711
    ISSN 1050-6411
    DOI 10.1016/j.jelekin.2014.12.002
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