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  1. Article ; Online: The Staying Power of Pharyngeal Gonorrhea: Implications for Public Health and Antimicrobial Resistance.

    Adamson, Paul C / Klausner, Jeffrey D

    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

    2021  Volume 73, Issue 4, Page(s) 583–585

    MeSH term(s) Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/therapeutic use ; Drug Resistance, Bacterial/drug effects ; Gonorrhea/drug therapy ; Gonorrhea/epidemiology ; Humans ; Neisseria gonorrhoeae/drug effects ; Public Health
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2021-03-08
    Publishing country United States
    Document type Editorial ; Research Support, N.I.H., Extramural ; Comment
    ZDB-ID 1099781-7
    ISSN 1537-6591 ; 1058-4838
    ISSN (online) 1537-6591
    ISSN 1058-4838
    DOI 10.1093/cid/ciab074
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  2. Article ; Online: Diagnostic Tests for Detecting Chlamydia trachomatis and Neisseria gonorrhoeae in Rectal and Pharyngeal Specimens.

    Adamson, Paul C / Klausner, Jeffrey D

    Journal of clinical microbiology

    2021  Volume 60, Issue 4, Page(s) e0021121

    Abstract: ... for the detection of C. trachomatis and N. gonorrhoeae infections owing to their high sensitivity and specificity ... patient populations. Routine screening for C. trachomatis in pharyngeal specimens is not recommended ... to determine the potential benefits and costs associated with increased screening for rectal and pharyngeal C ...

    Abstract Chlamydia trachomatis and Neisseria gonorrhoeae are two of the most often reported bacterial infections in the United States. The rectum and oropharynx are important anatomic sites of infection and can contribute to ongoing transmission. Nucleic acid amplification tests (NAATs) are the mainstays for the detection of C. trachomatis and N. gonorrhoeae infections owing to their high sensitivity and specificity. Several NAATs have been evaluated for testing in rectal and pharyngeal infections. A few assays recently received clearance by the Food and Drug Administration, including one point-of-care test. Those assays can be used for testing in symptomatic individuals, as well as for asymptomatic screening in certain patient populations. Routine screening for C. trachomatis in pharyngeal specimens is not recommended by the Centers for Disease Control and Prevention, though it is often performed due to the use of multiplex assays. While expanding the types of settings for screening and using self-collected rectal and pharyngeal specimens can help to increase access and uptake of testing, additional research is needed to determine the potential benefits and costs associated with increased screening for rectal and pharyngeal C. trachomatis and N. gonorrhoeae infections on a population level.
    MeSH term(s) Chlamydia Infections/diagnosis ; Chlamydia Infections/microbiology ; Chlamydia trachomatis/genetics ; Diagnostic Tests, Routine ; Gonorrhea/diagnosis ; Gonorrhea/microbiology ; Humans ; Neisseria gonorrhoeae/genetics ; Nucleic Acid Amplification Techniques ; Rectum/microbiology ; Sensitivity and Specificity
    Language English
    Publishing date 2021-11-03
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, N.I.H., Extramural
    ZDB-ID 390499-4
    ISSN 1098-660X ; 0095-1137
    ISSN (online) 1098-660X
    ISSN 0095-1137
    DOI 10.1128/JCM.00211-21
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  3. Article ; Online: Machine learning to predict ceftriaxone resistance using single nucleotide polymorphisms within a global database of

    Ha, Sung Min / Lin, Eric Y / Klausner, Jeffrey D / Adamson, Paul C

    Microbiology spectrum

    2023  Volume 11, Issue 6, Page(s) e0170323

    Abstract: Importance: Antimicrobial resistance ... ...

    Abstract Importance: Antimicrobial resistance in
    MeSH term(s) Humans ; Ceftriaxone/pharmacology ; Ceftriaxone/therapeutic use ; Neisseria gonorrhoeae/genetics ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/therapeutic use ; Polymorphism, Single Nucleotide ; Drug Resistance, Bacterial/genetics ; Microbial Sensitivity Tests ; Gonorrhea/drug therapy
    Chemical Substances Ceftriaxone (75J73V1629) ; Anti-Bacterial Agents
    Language English
    Publishing date 2023-10-31
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2807133-5
    ISSN 2165-0497 ; 2165-0497
    ISSN (online) 2165-0497
    ISSN 2165-0497
    DOI 10.1128/spectrum.01703-23
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  4. Article ; Online: Endofungal Mycetohabitans rhizoxinica Bacteremia Associated with Rhizopus microsporus Respiratory Tract Infection.

    Yang, Shangxin / Anikst, Victoria / Adamson, Paul C

    Emerging infectious diseases

    2022  Volume 28, Issue 10, Page(s) 2091–2095

    Abstract: We report Mycetohabitans rhizoxinica bacteremia in a 65-year-old woman in California, USA, who was undergoing chimeric antigen receptor T-cell therapy for multiple myeloma. Acute brain infarction and pneumonia developed; Rhizopus microsporus mold was ... ...

    Abstract We report Mycetohabitans rhizoxinica bacteremia in a 65-year-old woman in California, USA, who was undergoing chimeric antigen receptor T-cell therapy for multiple myeloma. Acute brain infarction and pneumonia developed; Rhizopus microsporus mold was isolated from tracheal suction. Whole-genome sequencing confirmed bacteria in blood as genetically identical to endofungal bacteria inside the mold.
    MeSH term(s) Aged ; Bacteremia ; Burkholderia ; Burkholderiaceae ; Fungi ; Humans ; Mucormycosis/diagnosis ; Receptors, Chimeric Antigen ; Respiratory Tract Infections ; Rhizopus/genetics ; Symbiosis
    Chemical Substances Receptors, Chimeric Antigen
    Language English
    Publishing date 2022-10-17
    Publishing country United States
    Document type Case Reports ; Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 1380686-5
    ISSN 1080-6059 ; 1080-6040
    ISSN (online) 1080-6059
    ISSN 1080-6040
    DOI 10.3201/eid2810.220507
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Legislation to Increase Accessibility to Direct-to-Consumer Tests in California.

    Doan, Thuan-Huong Pearl / Adamson, Paul C / Klausner, Jeffrey D

    Sexually transmitted diseases

    2021  Volume 49, Issue 1, Page(s) e37

    MeSH term(s) California ; Humans
    Language English
    Publishing date 2021-06-14
    Publishing country United States
    Document type Letter ; Research Support, N.I.H., Extramural ; Comment
    ZDB-ID 435191-5
    ISSN 1537-4521 ; 0148-5717
    ISSN (online) 1537-4521
    ISSN 0148-5717
    DOI 10.1097/OLQ.0000000000001570
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  6. Article ; Online: Applying molecular algorithms to predict decreased susceptibility to ceftriaxone from a report of strains of Neisseria gonorrhoeae in Amsterdam, the Netherlands.

    Lin, Eric Y / Adamson, Paul C / Klausner, Jeffrey D

    The Journal of antimicrobial chemotherapy

    2021  Volume 77, Issue 2, Page(s) 534–536

    MeSH term(s) Algorithms ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/therapeutic use ; Ceftriaxone/pharmacology ; Gonorrhea/drug therapy ; Humans ; Microbial Sensitivity Tests ; Neisseria gonorrhoeae/genetics ; Netherlands
    Chemical Substances Anti-Bacterial Agents ; Ceftriaxone (75J73V1629)
    Language English
    Publishing date 2021-11-06
    Publishing country England
    Document type Letter ; Research Support, N.I.H., Extramural
    ZDB-ID 191709-2
    ISSN 1460-2091 ; 0305-7453
    ISSN (online) 1460-2091
    ISSN 0305-7453
    DOI 10.1093/jac/dkab389
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    Zs.MO 124: Show issues

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  7. Article ; Online: Discovery of a novel sub-lineage of multi-drug resistant Shigella flexneri in Southern California.

    Kamau, Edwin / Adamson, Paul C / Crandall, John / Mukhopadhyay, Rituparna / Yang, Shangxin

    International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases

    2023  Volume 132, Page(s) 1–3

    Abstract: Clustered outbreaks of multi-drug resistant (MDR) Shigella are on the rise among men who have sex with men (MSM). Identification of MDR sub-lineages is critical for clinical management and public health interventions. Here, we describe a novel MDR sub- ... ...

    Abstract Clustered outbreaks of multi-drug resistant (MDR) Shigella are on the rise among men who have sex with men (MSM). Identification of MDR sub-lineages is critical for clinical management and public health interventions. Here, we describe a novel MDR sub-lineage of Shigella flexneri isolated from an MSM patient without a travel history in Southern California. Detailed genomic characterization of this novel strain would serve as a reference to aid monitoring and future outbreak investigation of MDR Shigella among MSM.
    MeSH term(s) Male ; Humans ; Shigella flexneri/genetics ; Homosexuality, Male ; Dysentery, Bacillary/drug therapy ; Dysentery, Bacillary/epidemiology ; Sexual and Gender Minorities ; Shigella ; California/epidemiology ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/therapeutic use
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2023-03-28
    Publishing country Canada
    Document type Journal Article
    ZDB-ID 1331197-9
    ISSN 1878-3511 ; 1201-9712
    ISSN (online) 1878-3511
    ISSN 1201-9712
    DOI 10.1016/j.ijid.2023.03.039
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    Zs.A 4516: Show issues Location:
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  8. Article: Prevalence and Factors Associated With Antigen Test Positivity Following SARS-CoV-2 Infection Among Health Care Workers in Los Angeles.

    Adamson, Paul C / Currier, Judith S / Uslan, Daniel Z / Garner, Omai B

    Open forum infectious diseases

    2022  Volume 9, Issue 10, Page(s) ofac462

    Abstract: Surges of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections among health care workers (HCWs) have led to critical staffing shortages. From January 4 to February 4, 2022, we implemented a return-to-work antigen testing program for ... ...

    Abstract Surges of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections among health care workers (HCWs) have led to critical staffing shortages. From January 4 to February 4, 2022, we implemented a return-to-work antigen testing program for HCWs, and 870 HCWs participated. Antigen test positivity was 60.5% for those ≤5 days from symptom onset or positive polymerase chain reaction (PCR), and 47.4% were positive at day 7. Antigen positivity was associated with receiving a booster vaccination and being ≤6 days from symptom onset or PCR test, but not age or a symptomatic infection. Rapid antigen testing can be a useful tool to guide return-to-work and isolation precautions for HCWs following infection.
    Language English
    Publishing date 2022-10-19
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2757767-3
    ISSN 2328-8957
    ISSN 2328-8957
    DOI 10.1093/ofid/ofac462
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  9. Article ; Online: Reliability of Genetic Alterations in Predicting Ceftriaxone Resistance in Neisseria gonorrhoeae Globally.

    Lin, Eric Yu / Adamson, Paul C / Ha, Sung-Min / Klausner, Jeffrey D

    Microbiology spectrum

    2022  Volume 10, Issue 2, Page(s) e0206521

    Abstract: Antimicrobial resistance in N. gonorrhoeae is increasing globally, and ceftriaxone is the recommended treatment for empirical therapy in most settings. Developing molecular assays to detect decreased ceftriaxone susceptibility is critical. Using ... ...

    Abstract Antimicrobial resistance in N. gonorrhoeae is increasing globally, and ceftriaxone is the recommended treatment for empirical therapy in most settings. Developing molecular assays to detect decreased ceftriaxone susceptibility is critical. Using PathogenWatch, a public database of N. gonorrhoeae genomes, antibiotic susceptibility data and DNA sequences of different genes associated with ceftriaxone resistance were extracted. That information was used to determine the sensitivity and specificity of different molecular markers and algorithms to predict decreased susceptibility to ceftriaxone. A total of 12,943 N. gonorrhoeae genomes were extracted from the PathogenWatch database, of which 9,540 genomes were used in the analysis. The sensitivity and specificity of specific molecular markers and algorithms were largely consistent with prior reports. Small variation (<10%) in either sensitivity or specificity occurred. Certain algorithms using different molecular markers at various prevalence of decreased ceftriaxone susceptibility identified a potentially clinically useful range of positive and negative predictive values. We validated previously described mutations and algorithms in a large public database containing a global collection of N. gonorrhoeae genomes. Certain mutations and algorithms resulted in sensitivity and specificity values consistent with those of prior studies. Further research is needed to integrate these markers and algorithms into the development of molecular assays to predict decreased ceftriaxone susceptibility.
    MeSH term(s) Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/therapeutic use ; Ceftriaxone/pharmacology ; Drug Resistance, Bacterial/genetics ; Genetic Markers ; Gonorrhea/drug therapy ; Humans ; Microbial Sensitivity Tests ; Mutation ; Neisseria gonorrhoeae/genetics ; Reproducibility of Results
    Chemical Substances Anti-Bacterial Agents ; Genetic Markers ; Ceftriaxone (75J73V1629)
    Language English
    Publishing date 2022-03-29
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2807133-5
    ISSN 2165-0497 ; 2165-0497
    ISSN (online) 2165-0497
    ISSN 2165-0497
    DOI 10.1128/spectrum.02065-21
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Resistance-Guided Therapy for Neisseria gonorrhoeae.

    Allan-Blitz, Lao-Tzu / Adamson, Paul C / Klausner, Jeffrey D

    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

    2022  Volume 75, Issue 9, Page(s) 1655–1660

    Abstract: Antimicrobial-resistant Neisseria gonorrhoeae infections are a threat to public health. Novel strategies for combating such resistance include the development of molecular assays to facilitate real-time prediction of antimicrobial susceptibility. ... ...

    Abstract Antimicrobial-resistant Neisseria gonorrhoeae infections are a threat to public health. Novel strategies for combating such resistance include the development of molecular assays to facilitate real-time prediction of antimicrobial susceptibility. Resistance to ciprofloxacin is determined by the presence of a single mutation at codon 91 of the gyrase A gene; molecular assays to guide therapy are commercially available. Resistance to cefixime is conferred via 1 of 6 critical mutations in either the mosaic penA gene or specific loci in the nonmosaic region. Resistance to ceftriaxone is conferred through mutations in 1 of 4 genes: penA, ponA, penB, and mtr; however, the ability to predict reduced susceptibility based on those genes varies by geographic region. Here, we highlight the work done toward the development of 3 such assays for ciprofloxacin, cefixime, and ceftriaxone, discuss the status of our current understanding and ongoing challenges, and suggest future directions.
    MeSH term(s) Humans ; Neisseria gonorrhoeae/genetics ; Cefixime/pharmacology ; Cefixime/therapeutic use ; Ceftriaxone/pharmacology ; Ceftriaxone/therapeutic use ; Microbial Sensitivity Tests ; Gonorrhea/drug therapy ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/therapeutic use ; Ciprofloxacin/pharmacology ; Ciprofloxacin/therapeutic use ; Drug Resistance, Bacterial/genetics
    Chemical Substances Cefixime (97I1C92E55) ; Ceftriaxone (75J73V1629) ; Anti-Bacterial Agents ; Ciprofloxacin (5E8K9I0O4U)
    Language English
    Publishing date 2022-07-08
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 1099781-7
    ISSN 1537-6591 ; 1058-4838
    ISSN (online) 1537-6591
    ISSN 1058-4838
    DOI 10.1093/cid/ciac371
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