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Article ; Online: A novel approach to modeling epidemic vulnerability, applied to Aedes aegypti-vectored diseases in Perú.

Meisner, Julianne / Frisbie, Lauren A / Munayco, César V / García, Patricia J / Cárcamo, César P / Morin, Cory W / Pigott, David M / Rabinowitz, Peter M

BMC infectious diseases

2021 Volume 21, Issue 1, Page(s) 846

Abstract: Background: A proactive approach to preventing and responding to emerging infectious diseases is critical to global health security. We present a three-stage approach to modeling the spatial distribution of outbreak vulnerability to Aedes aegypti- ... ...

Abstract	Background: A proactive approach to preventing and responding to emerging infectious diseases is critical to global health security. We present a three-stage approach to modeling the spatial distribution of outbreak vulnerability to Aedes aegypti-vectored diseases in Perú. Methods: Extending a framework developed for modeling hemorrhagic fever vulnerability in Africa, we modeled outbreak vulnerability in three stages: index case potential (stage 1), outbreak receptivity (stage 2), and epidemic potential (stage 3), stratifying scores on season and El Niño events. Subsequently, we evaluated the validity of these scores using dengue surveillance data and spatial models. Results: We found high validity for stage 1 and 2 scores, but not stage 3 scores. Vulnerability was highest in Selva Baja and Costa, and in summer and during El Niño events, with index case potential (stage 1) being high in both regions but outbreak receptivity (stage 2) being generally high in Selva Baja only. Conclusions: Stage 1 and 2 scores are well-suited to predicting outbreaks of Ae. aegypti-vectored diseases in this setting, however stage 3 scores appear better suited to diseases with direct human-to-human transmission. To prevent outbreaks, measures to detect index cases should be targeted to both Selva Baja and Costa, while Selva Baja should be prioritized for healthcare system strengthening. Successful extension of this framework from hemorrhagic fevers in Africa to an arbovirus in Latin America indicates its broad utility for outbreak and pandemic preparedness and response activities.
MeSH term(s)	Aedes ; Animals ; Arboviruses ; Dengue/epidemiology ; Dengue/prevention & control ; Epidemics ; Humans ; Insect Vectors ; Mosquito Vectors
Language	English
Publishing date	2021-08-21
Publishing country	England
Document type	Journal Article
ISSN	1471-2334
ISSN (online)	1471-2334
DOI	10.1186/s12879-021-06530-9
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Article ; Online: Madrid Newborn Sickle Cell Disease Cohort: clinical outcomes, stroke prevention and survival.

García-Morin, Marina / Bardón-Cancho, Eduardo J / Beléndez, Cristina / Dulín, Elena / Blanco-Soto, Paula / Puertas-López, Carolina / Prieto-Medina, Mar / Cervera-Bravo, Áurea / Llorente-Otones, Lucía / Pérez-Alonso, Vanesa / San-Román, Sonsoles / Vecilla-Rivelles, Cruz / López-Rubio, Montserrat / Sebastián, Elena / Bellón, José M / Cela, Elena

Annals of hematology

2023 Volume 103, Issue 2, Page(s) 373–383

Abstract: In May 2003, Madrid established the universal newborn screening (NBS) for sickle cell disease (SCD). However, there are no studies resembling the evolution of a SCD neonate cohort followed according to national guidelines in Spain. The aim of this study ... ...

Abstract	In May 2003, Madrid established the universal newborn screening (NBS) for sickle cell disease (SCD). However, there are no studies resembling the evolution of a SCD neonate cohort followed according to national guidelines in Spain. The aim of this study is to describe the morbimortality and the stroke prevention programme in patients diagnosed by SCD NBS in Madrid. This is a multicentre, observational, prospective cohort study between 2003 and 2018; 187 patients diagnosed with SCD were included (151 HbSS, 6 HbSβ
MeSH term(s)	Child ; Humans ; Infant, Newborn ; Acute Chest Syndrome ; Anemia, Sickle Cell/therapy ; Anemia, Sickle Cell/drug therapy ; Hemoglobin, Sickle ; Hydroxyurea/therapeutic use ; Prospective Studies ; Stroke/epidemiology ; Stroke/etiology ; Stroke/prevention & control ; Infant ; Child, Preschool ; Adolescent
Chemical Substances	Hemoglobin, Sickle ; Hydroxyurea (X6Q56QN5QC)
Language	English
Publishing date	2023-11-18
Publishing country	Germany
Document type	Observational Study ; Multicenter Study ; Journal Article
ZDB-ID	1064950-5
ISSN	1432-0584 ; 0939-5555 ; 0945-8077
ISSN (online)	1432-0584
ISSN	0939-5555 ; 0945-8077
DOI	10.1007/s00277-023-05539-1
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Article ; Online: Development of castration resistance in prostate cancer patients treated with luteinizing hormone-releasing hormone analogues (LHRHa): results of the ANARESISTANCE study.

Angulo, J C / Ciria Santos, J P / Gómez-Caamaño, A / Poza de Celis, R / González Sala, J L / García Garzón, J M / Galán-Llopis, J A / Pérez Sampietro, M / Perrot, V / Planas Morin, J

World journal of urology

2022 Volume 40, Issue 10, Page(s) 2459–2466

Abstract: Purpose: Evaluate the percentage of patients with prostate cancer treated with luteinizing hormone-releasing hormone analogues (LHRHa) that develop castration resistance after a follow-up period of 3 years. The secondary objective is to evaluate the ... ...

Abstract	Purpose: Evaluate the percentage of patients with prostate cancer treated with luteinizing hormone-releasing hormone analogues (LHRHa) that develop castration resistance after a follow-up period of 3 years. The secondary objective is to evaluate the variables potentially related to the progression to castration resistant prostate cancer (CRPC). Methods: A post-authorization, nation-wide, multicenter, prospective, observational, and longitudinal study that included 416 patients treated with LHRHa between 2012 and 2017 is presented. Patients were followed for 3 years or until development of CRPC, thus completing a per-protocol population of 350 patients. A Cox regression analysis was carried out to evaluate factors involved in progression to CRPC. Results: After 3 years of treatment with LHRHa 18.2% of patients developed CRPC. In contrast, in the subgroup analysis, 39.6% of the metastatic patients developed CRPC, compared with 8.8% of the non-metastatic patients. The patients with the highest risk of developing CRPC were those with a nadir prostate-specific antigen (PSA) > 2 ng/ml (HR 21.6; 95% CI 11.7-39.8; p < 0.001) and those receiving concomitant medication, most commonly bicalutamide (HR 1.8; 95% CI 1-3.1, p = 0.0431). Conclusions: The proportion of metastatic patients developing CRPC after 3 years of treatment with LHRHa is consistent with what has been previously described in the literature. In addition, this study provides new findings on CRPC in non-metastatic patients. Concomitant medication and nadir PSA are statistically significant predictive factors for the time to diagnosis of CRPC, the nadir PSA being the strongest predictor.
MeSH term(s)	Androgen Antagonists/therapeutic use ; Castration ; Gonadotropin-Releasing Hormone ; Humans ; Longitudinal Studies ; Male ; Prospective Studies ; Prostate-Specific Antigen ; Prostatic Neoplasms/drug therapy ; Prostatic Neoplasms, Castration-Resistant/diagnosis ; Prostatic Neoplasms, Castration-Resistant/drug therapy
Chemical Substances	Androgen Antagonists ; Gonadotropin-Releasing Hormone (33515-09-2) ; Prostate-Specific Antigen (EC 3.4.21.77)
Language	English
Publishing date	2022-09-04
Publishing country	Germany
Document type	Journal Article ; Multicenter Study ; Observational Study
ZDB-ID	380333-8
ISSN	1433-8726 ; 0724-4983
ISSN (online)	1433-8726
ISSN	0724-4983
DOI	10.1007/s00345-022-04108-x
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Article ; Online: Bromocriptine for the treatment of postoperative cerebellar mutism syndrome in pediatric patients: Three case reports.

Amor-García, Miguel Á / Fernández-Llamazares, Cecilia M / Manrique-Rodríguez, Silvia / Narrillos-Moraza, Álvaro / García-Morín, Marina / Huerta-Aragonés, Jorge / Sanjurjo-Sáez, María

Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners

2020 Volume 27, Issue 7, Page(s) 1753–1757

Abstract: Introduction: Cerebellar mutism syndrome (CMS) is a common complication after posterior fossa tumor resection. It is characterized by a significant lack or loss of speech. Its biological origin remains unclear and there are no standardized treatments. ... ...

Abstract	Introduction: Cerebellar mutism syndrome (CMS) is a common complication after posterior fossa tumor resection. It is characterized by a significant lack or loss of speech. Its biological origin remains unclear and there are no standardized treatments. However, bromocriptine seems to be a possible treatment for this condition. Case report: In this paper, we present three cases of pediatric patients (4, 5, and 17-year old) who developed CMS after posterior fossa tumor surgery. They were treated with bromocriptine to improve neurological symptoms.Management and outcome: Bromocriptine was started at a low dose and was progressively increased to reach the minimum effective dose. After four months of treatment, a normal and fluid speech was observed in the three patients. No discontinuation due to adverse events were reported. Discussion: Bromocriptine has shown to be an effective and safe treatment for CMS in pediatric patients after posterior fossa tumor resection.
MeSH term(s)	Bromocriptine/therapeutic use ; Cerebellar Neoplasms/drug therapy ; Cerebellar Neoplasms/surgery ; Child ; Humans ; Infratentorial Neoplasms ; Medulloblastoma ; Mutism/drug therapy ; Mutism/etiology ; Postoperative Complications/drug therapy
Chemical Substances	Bromocriptine (3A64E3G5ZO)
Language	English
Publishing date	2020-12-25
Publishing country	England
Document type	Case Reports ; Journal Article
ZDB-ID	1330764-2
ISSN	1477-092X ; 1078-1552
ISSN (online)	1477-092X
ISSN	1078-1552
DOI	10.1177/1078155220982046
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Article ; Online: Productos homeopáticos: la importancia de una correcta información.

López Sanguos, C / García Morín, M / Vázquez López, P

Anales de pediatria (Barcelona, Spain : 2003)

2014 Volume 80, Issue 5, Page(s) 333

Title translation	Homeopathic products: the importance of correct information.
MeSH term(s)	Atropa belladonna/poisoning ; Humans ; Infant ; Information Dissemination ; Male ; Materia Medica/poisoning
Chemical Substances	Materia Medica
Language	Spanish
Publishing date	2014-05
Publishing country	Spain
Document type	Case Reports ; Letter
ISSN	1695-9531
ISSN (online)	1695-9531
DOI	10.1016/j.anpedi.2013.10.012
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Article ; Online: Association between neuroimaging findings and neurological sequelae in patients with congenital cytomegalovirus infection.

Escobar Castellanos, M / de la Mata Navazo, S / Carrón Bermejo, M / García Morín, M / Ruiz Martín, Y / Saavedra Lozano, J / Miranda Herrero, M C / Barredo Valderrama, E / Castro de Castro, P / Vázquez López, M

Neurologia (Barcelona, Spain)

2021 Volume 37, Issue 2, Page(s) 122–129

Abstract: Background: Congenital cytomegalovirus (CMV) infection is an important cause of disability. There is little evidence on the prognostic value of lesions identified in neuroimaging studies.: Aim: The study aimed to assess the severity of lesions ... ...

Abstract	Background: Congenital cytomegalovirus (CMV) infection is an important cause of disability. There is little evidence on the prognostic value of lesions identified in neuroimaging studies. Aim: The study aimed to assess the severity of lesions detected with brain MRI and transfontanellar ultrasound and their relationship with long-term neurological deficits. Patients and methods: We performed a retrospective, analytical, observational study of 36 patients with congenital CMV infection. Neuroimaging studies were reviewed and classified according to the modified Noyola' scale. Imaging findings were compared with neurological alterations in the patients' most recent follow-up evaluation at the paediatric neurology department. Results: Thirty-six patients were studied (transfontanellar ultrasound: 30; brain MRI: 29). Twenty of 30 patients showed ultrasound abnormalities; of these, 11 showed alterations on brain MR images (P = .04) and 10 had neurological impairment (P = .008). Transfontanellar ultrasound had a sensitivity of 83.3%, 90% CI: 58-100 and a specificity of 44.4%, 90% CI: 18.7-70.2 for predicting neurological sequelae. Brain MRI displayed abnormalities in 20 of 29 patients, of whom 16 had neurological impairment (P < .001). MRI had a sensitivity of 94%, 95% CI: 80-100 and a specificity of 66.6%, 95% CI: 36-97.5 for predicting neurological sequelae. Modified Noyola' scale values > 2 were correlated with psychomotor retardation (P < .001). Conclusions: Our findings validate previous studies reporting a statistical significant correlation between the extension of neuroimaging lesions and severity of neurological deficits.
MeSH term(s)	Brain Diseases ; Child ; Cytomegalovirus Infections/complications ; Cytomegalovirus Infections/congenital ; Cytomegalovirus Infections/diagnostic imaging ; Humans ; Magnetic Resonance Imaging ; Neuroimaging ; Retrospective Studies
Language	English
Publishing date	2021-09-14
Publishing country	Spain
Document type	Journal Article ; Observational Study
ZDB-ID	2654369-2
ISSN	2173-5808 ; 2173-5808
ISSN (online)	2173-5808
ISSN	2173-5808
DOI	10.1016/j.nrleng.2018.11.011
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Article ; Online: Bacteriemia recurrente relacionada con catéter por Cupriavidus pauculus.

Luna Arana, Carmen / García-Morín, Marina / Sánchez Carrillo, Carlos / Rincón-López, Elena

Andes pediatrica : revista Chilena de pediatria

2022 Volume 93, Issue 2, Page(s) 259–264

Abstract: Catheter-related bacteriemia by Cupriavidus spp. is a rare condition with very few cases reported in the literature. Most of them occurred in immunocompromised patients.: Objective: To report a case of recurrent catheter-related bacteriemia by ... ...

Title translation	Recurrent Cupriavidus Pauculus catheter-related bacteremia.
Abstract	Catheter-related bacteriemia by Cupriavidus spp. is a rare condition with very few cases reported in the literature. Most of them occurred in immunocompromised patients. Objective: To report a case of recurrent catheter-related bacteriemia by Cupriavidus pauculus in an immunocompromised infant in order to analyze possible therapeutic options, especially in relation to the need or not for central venous catheter (CVC) removal. Clinical case: 22-month-old infant with B-cell acute lymphoblas tic leukemia (ALL) in reinduction phase, CVC carrier. He presented to the Emergency Room with fever without focus on examination. Blood tests were performed (without increase of acute phase reactants) and differential blood cultures (peripheral and CVC). He was hospitalized and empirical antibiotic therapy was started with intravenous fourth-generation cephalosporin (cefepime). After 24 hours, blood cultures were positive for Cupriavidus pauculus, growing first in the CVC culture. We maintained cefepime, adding catheter lock therapy with ciprofloxacin. Afterward, the infection was resolved, allowing us to keep the CVC. Seven months later, in the context of fever, Cupriavidus pauculus was again identified in CVC blood culture. We decided this time to remove the catheter, in addition to the administration of intravenous cefepime. The patient has not presented new episodes nine months after de removal of the CVC. Conclusion: Catheter-related bacteremia by Cupriavidus is a rare condition in children that usually occurs in immunocompromised patients. Catheter lock therapy associated with systemic antibiotics could be a safe option in patients with difficult CVC re moval. However, if persistent colonization of the CVC is suspected, it may be necessary to remove it.
MeSH term(s)	Bacteremia/drug therapy ; Bacteremia/etiology ; Cefepime ; Central Venous Catheters/adverse effects ; Child ; Cupriavidus ; Gram-Negative Facultatively Anaerobic Rods ; Humans ; Infant ; Male
Chemical Substances	Cefepime (807PW4VQE3)
Language	Spanish
Publishing date	2022-06-23
Publishing country	Chile
Document type	Case Reports ; Journal Article
ISSN	2452-6053
ISSN (online)	2452-6053
DOI	10.32641/andespediatr.v93i2.3921
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Article ; Online: The effect of weather and climate on dengue outbreak risk in Peru, 2000-2018: A time-series analysis.

Dostal, Tia / Meisner, Julianne / Munayco, César / García, Patricia J / Cárcamo, César / Pérez Lu, Jose Enrique / Morin, Cory / Frisbie, Lauren / Rabinowitz, Peter M

PLoS neglected tropical diseases

2022 Volume 16, Issue 6, Page(s) e0010479

Abstract: Background: Dengue fever is the most common arboviral disease in humans, with an estimated 50-100 million annual infections worldwide. Dengue fever cases have increased substantially in the past four decades, driven largely by anthropogenic factors ... ...

Abstract	Background: Dengue fever is the most common arboviral disease in humans, with an estimated 50-100 million annual infections worldwide. Dengue fever cases have increased substantially in the past four decades, driven largely by anthropogenic factors including climate change. More than half the population of Peru is at risk of dengue infection and due to its geography, Peru is also particularly sensitive to the effects of El Niño Southern Oscillation (ENSO). Determining the effect of ENSO on the risk for dengue outbreaks is of particular public health relevance and may also be applicable to other Aedes-vectored viruses. Methods: We conducted a time-series analysis at the level of the district-month, using surveillance data collected from January 2000 to September 2018 from all districts with a mean elevation suitable to survival of the mosquito vector (<2,500m), and ENSO and weather data from publicly-available datasets maintained by national and international agencies. We took a Bayesian hierarchical modeling approach to address correlation in space, and B-splines with four knots per year to address correlation in time. We furthermore conducted subgroup analyses by season and natural region. Results: We detected a positive and significant effect of temperature (°C, RR 1.14, 95% CI 1.13, 1.15, adjusted for precipitation) and ENSO (ICEN index: RR 1.17, 95% CI 1.15, 1.20; ONI index: RR 1.04, 95% CI 1.02, 1.07) on outbreak risk, but no evidence of a strong effect for precipitation after adjustment for temperature. Both natural region and season were found to be significant effect modifiers of the ENSO-dengue effect, with the effect of ENSO being stronger in the summer and the Selva Alta and Costa regions, compared with winter and Selva Baja and Sierra regions. Conclusions: Our results provide strong evidence that temperature and ENSO have significant effects on dengue outbreaks in Peru, however these results interact with region and season, and are stronger for local ENSO impacts than remote ENSO impacts. These findings support optimization of a dengue early warning system based on local weather and climate monitoring, including where and when to deploy such a system and parameterization of ENSO events, and provide high-precision effect estimates for future climate and dengue modeling efforts.
MeSH term(s)	Animals ; Bayes Theorem ; Dengue/epidemiology ; Disease Outbreaks ; El Nino-Southern Oscillation ; Humans ; Peru/epidemiology ; Weather
Language	English
Publishing date	2022-06-30
Publishing country	United States
Document type	Journal Article ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2429704-5
ISSN	1935-2735 ; 1935-2735
ISSN (online)	1935-2735
ISSN	1935-2735
DOI	10.1371/journal.pntd.0010479
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Book ; Online: A Global Multi-Source Tropical Cyclone Precipitation (MSTCP) Dataset

Morin, Gabriel / Boudreault, Mathieu / García-Franco, Jorge Luis

eISSN: 1866-3516

2023

Abstract: Tropical cyclone precipitation (TCP) has significant impacts on coastal communities through its modulation of flood event frequency as well as the water supply in many regions of the world. Satellite estimates provide our most reliable observations of ... ...

Abstract	Tropical cyclone precipitation (TCP) has significant impacts on coastal communities through its modulation of flood event frequency as well as the water supply in many regions of the world. Satellite estimates provide our most reliable observations of TCP available globally, however, satellite precipitation estimates were limited because most products only have coverage starting in 1997. In this paper, we present a global dataset of TCP using the newly developed high-resolution Multi-Source Weighted-Ensemble Precipitation, version 2 (MSWEP V2) which spans from January 1979 to date. This Global Multi-Source Tropical Cyclone Precipitation (MSTCP) dataset is comprised of two main files in the format of tables: the main and profile datasets, both from January 1979 to February 2023. The main file provides various TCP statistics per TC track for using the full record from the International Best Track Archive for Climate Stewardship (IBTrACS) dataset, including mean and maximum precipitation rates. The profile dataset comprises the azimuthally averaged precipitation every 10-km away from the center of each storm (until 500 km). The case study of Hurricane Harvey is used to show that MSWEP estimates agree well with another commonly used satellite product. The main statistics of the dataset are analyzed as well, including the differences in the dataset metrics for each of the six TC basins and for each Saffir-Simpson category for storm intensity. The dataset es freely available at: https://zenodo.org/records/10105751 .
Subject code	910
Language	English
Publishing date	2023-11-30
Publishing country	de
Document type	Book ; Online
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Article ; Online: Nurse-led clinical activity in kidney transplantation care in Spain: A cross-sectional observational study.

Pedreira-Robles, Guillermo / Garcimartín, Paloma / Sevilla-Guerra, Sonia / Bach-Pascual, Anna / García-Martínez, Marta / Morín-Fraile, Victoria

Journal of renal care

2023

Abstract: Objectives: To explore the presence of specialist outpatient nursing activity in care for kidney transplant recipients in Spain and to determine the level of competence development of this activity according to the Advanced Practice Nurse model.: ... ...

Abstract	Objectives: To explore the presence of specialist outpatient nursing activity in care for kidney transplant recipients in Spain and to determine the level of competence development of this activity according to the Advanced Practice Nurse model. Design: Descriptive, cross-sectional study. Participants and measurements: All outpatient nurses specialising in renal transplantation in the 39 transplant hospitals in Spain were included. To fulfil the study objectives, an ad hoc questionnaire and the 'Advanced Practice Nurse Role Definition Instrument (IDREPA)' were administered to assess the nurses' level of competence development. Results: Of the facilities included in the study, 25 (64.1%) had posttransplant nursing activity, 13 (33.3%) had pretransplant nursing activity and 11 (28.2%) had nursing activity involving kidney donor candidates. Twenty-seven specialist nurse's offices were identified. The results of the IDREPA reflect the presence of advanced practice in the domains of 'expert care planning' and 'comprehensive care'. Three (11.1%) nurses met all criteria for advanced nursing practice. Conclusion: The results on specialised outpatient nursing activity at the 39 transplantation facilities in Spain indicate a low presence of this type of activity, with an even lower presence of advanced practice nurses. Implications for clinical practice: Management teams should consider investing in the quality of care provided by advanced nurse practice to ensure that suitable treatment is provided and better clinical outcomes are obtained.
Language	English
Publishing date	2023-03-12
Publishing country	United States
Document type	Journal Article
ZDB-ID	2375362-6
ISSN	1755-6686 ; 1755-6678 ; 1019-083X
ISSN (online)	1755-6686
ISSN	1755-6678 ; 1019-083X
DOI	10.1111/jorc.12463
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