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Article ; Online: Venovenous extracorporeal membrane oxygenation for COVID-19 associated severe respiratory failure: Case series from a Hungarian tertiary centre.

Zöllei, Éva / Rudas, László / Hankovszky, Péter / Korsós, Anita / Pálfi, Alexandra / Varga, Zoltán / Tomozi, László / Hegedüs, Zoltán / Bari, Gábor / Lobozárné Szivós, Brigitta / Kiszel, Attila / Babik, Barna

Perfusion

2023 , Page(s) 2676591231160272

Abstract: Introduction: Venovenous extracorporeal membrane oxygenation (V-V ECMO) is recommended for the support of patients with severe COVID-19 associated severe respiratory failure (SRF). We report the characteristics and outcome of COVID-19 patients supported ...

Abstract	Introduction: Venovenous extracorporeal membrane oxygenation (V-V ECMO) is recommended for the support of patients with severe COVID-19 associated severe respiratory failure (SRF). We report the characteristics and outcome of COVID-19 patients supported with V-V ECMO in a Hungarian centre. Methods: We retrospectively collected data on all patients admitted with proven SARS CoV-2 infection who received V-V ECMO support between March 2021 and May 2022. Results: Eighteen patients were placed on ECMO during this period, (5 women, age (mean ± SD) 44 ± 10 years, APACHE II score (median (interquartile range)) 12 (10-14.5)). Before ECMO support, they had been hospitalised for 6 (4-11) days. Fifteen patients received noninvasive ventilation for 4 (2-8) days, two patients had high flow nasal oxygen therapy, for one day each. They had already been intubated for 2.5 (1-6) days. Prone position was applied in 15 cases. On the day before ECMO initiation the Lung Injury Score was 3.25 (3-3.26), the PaO Conclusions: During the last three waves of the COVID-19 pandemic, we achieved a 56% ICU and a 50% hospital survival rate at our low volume centre.
Language	English
Publishing date	2023-03-13
Publishing country	England
Document type	Journal Article
ZDB-ID	645038-6
ISSN	1477-111X ; 0267-6591
ISSN (online)	1477-111X
ISSN	0267-6591
DOI	10.1177/02676591231160272
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Article ; Online: Use of capnography to verify emergency ventilator sharing in the COVID-19 era.

Korsós, Anita / Peták, Ferenc / Südy, Roberta / Schranc, Álmos / Fodor, Gergely H / Babik, Barna

Respiratory physiology & neurobiology

2020 Volume 285, Page(s) 103611

Abstract: Exacerbation of COVID-19 pandemic may lead to acute shortage of ventilators, which may require shared use of ventilator as a lifesaving concept. Two model lungs were ventilated with one ventilator to i) test the adequacy of individual tidal volumes via ... ...

Abstract	Exacerbation of COVID-19 pandemic may lead to acute shortage of ventilators, which may require shared use of ventilator as a lifesaving concept. Two model lungs were ventilated with one ventilator to i) test the adequacy of individual tidal volumes via capnography, ii) assess cross-breathing between lungs, and iii) offer a simulation-based algorithm for ensuring equal tidal volumes. Ventilation asymmetry was induced by placing rubber band around one model lung, and the uneven distribution of tidal volumes (VT) was counterbalanced by elevating airflow resistance (HR) contralaterally. VT, end-tidal CO
MeSH term(s)	COVID-19/diagnosis ; COVID-19/therapy ; Capnography/standards ; Computer Simulation ; Emergency Medical Services ; Humans ; Lung/physiopathology ; Models, Anatomic ; Models, Biological ; Point-of-Care Testing/standards ; Respiration, Artificial/instrumentation ; Respiration, Artificial/standards ; Respiratory Function Tests
Language	English
Publishing date	2020-12-24
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2077867-3
ISSN	1878-1519 ; 1569-9048
ISSN (online)	1878-1519
ISSN	1569-9048
DOI	10.1016/j.resp.2020.103611
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Article ; Online: Importance of the imaging techniques in the management of COVID-19-infected patients

Lovas, András / Hankovszky, Péter / Korsós, Anita / Kupcsulik, Szilvia / Molnár, Tamás / Szabó, Zsolt / Babik, Barna

Orvosi hetilap

2020 Volume 161, Issue 17, Page(s) 672–677

Abstract: Critical-care physicians are facing a challenging process in healthcare due to the overwhelming case number of hypoxic respiratory failure patients. Pneumonia has an utmost importance in the primary pathomechanism of the development of critical illness ... ...

Title translation	[A képalkotó diagnosztika jelentősége a COVID–19-fertőzött betegek ellátásában]
Abstract	Critical-care physicians are facing a challenging process in healthcare due to the overwhelming case number of hypoxic respiratory failure patients. Pneumonia has an utmost importance in the primary pathomechanism of the development of critical illness in the COVID-19 patients. Thus, imaging techniques are situated in the frontline to aim the diagnostic decision-making, to follow up the progress and to evaluate the possible complications. Reviewing the available literature, so far the common chest CT, chest X-ray and chest wall ultrasound features are presented, and recommendations are pronounced for the indications of the different modalities. At the initial phase, the atypical presentations of the virus infection are multiplex, peripheral ground glass opacities situated in the right lower lobe of the lung evolving rapidly into a bilateral involvement of the middle and basal zones. Along with the progression, the ratio of the consolidation is increasing subsequently deteriorating into fibrosis with reticular pattern. Chest ultrasound performed at the bedside has a paramount importance to reduce the possible number of health-care worker contacts in consequence of the strict and special infection control orders established on account of the SARS-CoV-2 pandemia. Orv Hetil. 2020; 161(17): 672–677.
MeSH term(s)	Betacoronavirus ; COVID-19 ; COVID-19 Testing ; Clinical Laboratory Techniques ; Coronavirus Infections/diagnosis ; Coronavirus Infections/diagnostic imaging ; Disease Progression ; Humans ; Pandemics ; Pneumonia, Viral/diagnostic imaging ; Point-of-Care Systems ; Radiography, Thoracic ; SARS-CoV-2 ; Tomography, X-Ray Computed ; Ultrasonography
Keywords	covid19
Language	Hungarian
Publishing date	2020-04-01
Publishing country	Hungary
Document type	Journal Article ; Review
ZDB-ID	123879-6
ISSN	1788-6120 ; 0030-6002
ISSN (online)	1788-6120
ISSN	0030-6002
DOI	10.1556/650.2020.31814
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Article ; Online: Diagnostic consideration and bedside estimation of the prognosis in COVID-19 patients

Korsós, Anita / Kupcsulik, Szilvia / Lovas, András / Hankovszky, Péter / Molnár, Tamás / Szabó, Zsolt / Babik, Barna

Orvosi hetilap

2020 Volume 161, Issue 17, Page(s) 667–671

Abstract: In December 2019, a cluster of pneumonia cases of unknown origin occured in Wuhan, China. The identified infective agent is a novel corona virus called “severe acute respiratory syndrome coronavirus 2” (SARS-CoV-2) and the respiratory disease caused by ... ...

Title translation	[Diagnosztikus lépések és a betegség prognózisának becslése COVID–19-fertőzött betegeken]
Abstract	In December 2019, a cluster of pneumonia cases of unknown origin occured in Wuhan, China. The identified infective agent is a novel corona virus called “severe acute respiratory syndrome coronavirus 2” (SARS-CoV-2) and the respiratory disease caused by this agent aquired the name “coronavirus disease 2019” (COVID-19). In March 2020, the World Health Organization (WHO) declared the novel coronavirus outbreak a pandemic. We reviewed the international literature regarding the novel coronavirus outbreak. Here below, we focus mainly on the diagnostic issues of COVID-19 and on the estimation of the prognosis. We detail the relevant anamnestic factors and initial examination results which serve as basics for the clinical suspicion of COVID-19. We also focus on the proper method of microbiological sampling and the relevant informations regarding diagnostic tests like the gold standard real-time reverse transcriptase polymerase chain reaction (RT-PCR) for SARS-CoV-2. We also cite the current national epidemiologic regulations of testing for novel coronavirus. In the last section, we emphasize the importance and the potential way of early identification of high-risk patients. The COVID-19 pandemic may cause substantial epidemiological and healthcare burden even in Hungary. In addition to the epidemiologic interventions aiming the deceleration of the outbreak, the early identification and the correct hospital treatment remain key issues since these may influence mortality. The chances of the critically ill patients could be improved solely by a high-quality and careful critical care. It is prudent to meet the experiences of colleagues working hard with these patients in the already heavily infected countries. Orv Hetil. 2020; 161(17): 667–671.
MeSH term(s)	Betacoronavirus/genetics ; Betacoronavirus/isolation & purification ; COVID-19 ; COVID-19 Testing ; COVID-19 Vaccines ; China ; Clinical Laboratory Techniques ; Coronavirus Infections/diagnosis ; Critical Illness ; Humans ; Hungary ; Pandemics ; Pneumonia, Viral/diagnosis ; Prognosis ; Real-Time Polymerase Chain Reaction ; Risk Assessment ; SARS-CoV-2
Chemical Substances	COVID-19 Vaccines ; Covid-19 aAPC vaccine
Keywords	covid19
Language	Hungarian
Publishing date	2020-04-01
Publishing country	Hungary
Document type	Journal Article ; Review
ZDB-ID	123879-6
ISSN	1788-6120 ; 0030-6002
ISSN (online)	1788-6120
ISSN	0030-6002
DOI	10.1556/650.2020.31815
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Article ; Online: Respiratory consequences of obesity and diabetes

Kovács, Barbara Nóra / Südy, Roberta / Peták, Ferenc / Balogh, Ádám László / Fodor, H Gergely / Tolnai, József / Korsós, Anita / Schranc, Álmos / Lengyel, Csaba / Babik, Barna

Orvosi hetilap

2022 Volume 163, Issue 2, Page(s) 63–73

Title translation	Az elhízás és a cukorbetegség légzőrendszeri következményei
MeSH term(s)	Diabetes Mellitus ; Humans ; Obesity/complications
Language	Hungarian
Publishing date	2022-01-09
Publishing country	Hungary
Document type	Journal Article
ZDB-ID	123879-6
ISSN	1788-6120 ; 0030-6002
ISSN (online)	1788-6120
ISSN	0030-6002
DOI	10.1556/650.2022.32335
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Article ; Online: A képalkotó diagnosztika jelentősége a COVID–19-fertőzött betegek ellátásában

Lovas, András / Hankovszky, Péter / Korsós, Anita / Kupcsulik, Szilvia / Molnár, Tamás / Szabó, Zsolt / Babik, Barna

2020

Keywords	covid19
Language	Hungarian
Publishing country	hu
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Diagnosztikus lépések és a betegség prognózisának becslése COVID–19-fertőzött betegeken

Korsós, Anita / Kupcsulik, Szilvia / Lovas, András / Hankovszky, Péter / Molnár, Tamás / Szabó, Zsolt / Babik, Barna

2020

Keywords	covid19
Language	Hungarian
Publishing country	hu
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Obesity and diabetes: similar respiratory mechanical but different gas exchange defects.

Südy, Roberta / Peták, Ferenc / Kiss, Liliána / Balogh, Ádám L / Fodor, Gergely H / Korsós, Anita / Schranc, Álmos / Babik, Barna

American journal of physiology. Lung cellular and molecular physiology

2020 Volume 320, Issue 3, Page(s) L368–L376

Abstract: Diabetes mellitus increases smooth muscle tone and causes tissue remodeling, affecting elastin and collagen. Although the lung is dominated by these elements, diabetes is expected to modify the airway function and respiratory tissue mechanics. Therefore, ...

Abstract	Diabetes mellitus increases smooth muscle tone and causes tissue remodeling, affecting elastin and collagen. Although the lung is dominated by these elements, diabetes is expected to modify the airway function and respiratory tissue mechanics. Therefore, we characterized the respiratory function in patients with diabetes with and without associated obesity. Mechanically ventilated patients with normal body shapes were divided into the control nondiabetic (
MeSH term(s)	Aged ; Aged, 80 and over ; Diabetes Mellitus/metabolism ; Diabetes Mellitus/pathology ; Diabetes Mellitus/physiopathology ; Female ; Humans ; Lung Compliance ; Male ; Middle Aged ; Obesity/metabolism ; Obesity/pathology ; Obesity/physiopathology ; Prospective Studies ; Pulmonary Gas Exchange ; Respiration, Artificial ; Respiratory Mechanics
Language	English
Publishing date	2020-12-02
Publishing country	United States
Document type	Clinical Trial ; Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1013184-x
ISSN	1522-1504 ; 1040-0605
ISSN (online)	1522-1504
ISSN	1040-0605
DOI	10.1152/ajplung.00439.2020
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Article: [A képalkotó diagnosztika jelentosége a COVID19-fertozött betegek ellátásában]/ Importance of the imaging techniques in the management of COVID-19-infected patients

Lovas, András / Hankovszky, Péter / Korsós, Anita / Kupcsulik, Szilvia / Molnár, Tamás / Szabó, Zsolt / Babik, Barna

Orv Hetil

Abstract	Critical-care physicians are facing a challenging process in healthcare due to the overwhelming case number of hypoxic respiratory failure patients. Pneumonia has an utmost importance in the primary pathomechanism of the development of critical illness in the COVID-19 patients. Thus, imaging techniques are situated in the frontline to aim the diagnostic decision-making, to follow up the progress and to evaluate the possible complications. Reviewing the available literature, so far the common chest CT, chest X-ray and chest wall ultrasound features are presented, and recommendations are pronounced for the indications of the different modalities. At the initial phase, the atypical presentations of the virus infection are multiplex, peripheral ground glass opacities situated in the right lower lobe of the lung evolving rapidly into a bilateral involvement of the middle and basal zones. Along with the progression, the ratio of the consolidation is increasing subsequently deteriorating into fibrosis with reticular pattern. Chest ultrasound performed at the bedside has a paramount importance to reduce the possible number of health-care worker contacts in consequence of the strict and special infection control orders established on account of the SARS-CoV-2 pandemia. Orv Hetil. 2020; 161(17): 672677.
Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #32324360
Database	COVID19

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Article: [Diagnosztikus lépések és a betegség prognózisának becslése COVID19-fertozött betegeken]/ Diagnostic consideration and bedside estimation of the prognosis in COVID-19 patients

Korsós, Anita / Kupcsulik, Szilvia / Lovas, András / Hankovszky, Péter / Molnár, Tamás / Szabó, Zsolt / Babik, Barna

Orv Hetil

Abstract: In December 2019, a cluster of pneumonia cases of unknown origin occured in Wuhan, China. The identified infective agent is a novel corona virus called "severe acute respiratory syndrome coronavirus 2" (SARS-CoV-2) and the respiratory disease caused by ... ...

Abstract	In December 2019, a cluster of pneumonia cases of unknown origin occured in Wuhan, China. The identified infective agent is a novel corona virus called "severe acute respiratory syndrome coronavirus 2" (SARS-CoV-2) and the respiratory disease caused by this agent aquired the name "coronavirus disease 2019" (COVID-19). In March 2020, the World Health Organization (WHO) declared the novel coronavirus outbreak a pandemic. We reviewed the international literature regarding the novel coronavirus outbreak. Here below, we focus mainly on the diagnostic issues of COVID-19 and on the estimation of the prognosis. We detail the relevant anamnestic factors and initial examination results which serve as basics for the clinical suspicion of COVID-19. We also focus on the proper method of microbiological sampling and the relevant informations regarding diagnostic tests like the gold standard real-time reverse transcriptase polymerase chain reaction (RT-PCR) for SARS-CoV-2. We also cite the current national epidemiologic regulations of testing for novel coronavirus. In the last section, we emphasize the importance and the potential way of early identification of high-risk patients. The COVID-19 pandemic may cause substantial epidemiological and healthcare burden even in Hungary. In addition to the epidemiologic interventions aiming the deceleration of the outbreak, the early identification and the correct hospital treatment remain key issues since these may influence mortality. The chances of the critically ill patients could be improved solely by a high-quality and careful critical care. It is prudent to meet the experiences of colleagues working hard with these patients in the already heavily infected countries. Orv Hetil. 2020; 161(17): 667671.
Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #216081
Database	COVID19

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