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  1. Book ; Online ; E-Book: Lanzkowsky's manual of pediatric hematology and oncology

    Fish, Jonathan D. / Lipton, Jeffrey M. / Lanzkowsky, Philip

    2022  

    Title variant Manual of pediatric hematology and oncology
    Author's details managing editor: Jonathan D. Fish ; editors: Jeffrey M. Lipton, Philip Lanzkowsky
    Keywords Electronic books
    Language English
    Size 1 Online-Ressource (xxxviii, 796 Seiten), Illustrationen, Diagramme
    Edition Seventh edition
    Publisher Elsevier Academic Press
    Publishing place London
    Publishing country Great Britain
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT021214218
    ISBN 978-0-323-99760-7 ; 9780128216712 ; 0-323-99760-0 ; 0128216719
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article ; Online: Understanding complex disease-related mechanisms: Rational therapies for Diamond-Blackfan anaemia.

    Lipton, Jeffrey M

    British journal of haematology

    2024  

    Abstract: The rich history surrounding Diamond-Blackfan anaemia (DBA), originally described in 1938 as congenital hypoplastic ... ...

    Abstract The rich history surrounding Diamond-Blackfan anaemia (DBA), originally described in 1938 as congenital hypoplastic anaemia
    Language English
    Publishing date 2024-03-14
    Publishing country England
    Document type Journal Article
    ZDB-ID 80077-6
    ISSN 1365-2141 ; 0007-1048
    ISSN (online) 1365-2141
    ISSN 0007-1048
    DOI 10.1111/bjh.19404
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Book ; Online ; E-Book: Lanzkowsky's manual of pediatric hematology and oncology

    Lanzkowsky, Philip / Lipton, Jeffrey M. / Fish, Jonathan D.

    2016  

    Title variant Manual of pediatric hematology and oncology
    Author's details edited by Philip Lanzkowsky, MBChB, MD, ScD (Honoris Causa), FRCP, DCH, FAAP; Jeffrey M. Lipton, MD, PhD; Jonathan D. Fish, MD
    Keywords Pediatric hematology ; Tumors in children
    Subject code 618.9215
    Language English
    Size 1 Online-Ressource (xxxvi, 751 Seiten)
    Edition Sixth edition
    Publisher Elsevier AP
    Publishing place Amsterdam
    Publishing country Netherlands
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT018996968
    ISBN 978-0-12-801674-9 ; 9780128013687 ; 0-12-801674-4 ; 0128013680
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  4. Article ; Online: Defending the island against excess heme.

    Blanc, Lionel / Lipton, Jeffrey M

    Blood

    2022  Volume 139, Issue 23, Page(s) 3359–3360

    MeSH term(s) Animals ; Erythroid Cells ; Erythropoiesis ; Heme ; Humans ; Mice ; Mice, Inbred DBA
    Chemical Substances Heme (42VZT0U6YR)
    Language English
    Publishing date 2022-06-09
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 80069-7
    ISSN 1528-0020 ; 0006-4971
    ISSN (online) 1528-0020
    ISSN 0006-4971
    DOI 10.1182/blood.2022016341
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Inherited thrombocytopenia and Occam's razor.

    Lipton, Jeffrey M

    Blood

    2017  Volume 130, Issue 7, Page(s) 839–840

    MeSH term(s) Humans ; Thrombocytopenia
    Language English
    Publishing date 2017-08-15
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 80069-7
    ISSN 1528-0020 ; 0006-4971
    ISSN (online) 1528-0020
    ISSN 0006-4971
    DOI 10.1182/blood-2017-06-789131
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  6. Article ; Online: A Review of the Therapeutic Role of Bosutinib in Chronic Myeloid Leukemia.

    Kantarjian, Hagop M / Jabbour, Elias J / Lipton, Jeffrey H / Castagnetti, Fausto / Brümmendorf, Tim H

    Clinical lymphoma, myeloma & leukemia

    2024  Volume 24, Issue 5, Page(s) 285–297

    Abstract: The development of the BCR::ABL1 tyrosine kinase inhibitors (TKIs) has transformed Philadelphia chromosome (Ph)-positive chronic myeloid leukemia (CML) from a fatal disease to an often-indolent illness that, when managed effectively, can restore a life ... ...

    Abstract The development of the BCR::ABL1 tyrosine kinase inhibitors (TKIs) has transformed Philadelphia chromosome (Ph)-positive chronic myeloid leukemia (CML) from a fatal disease to an often-indolent illness that, when managed effectively, can restore a life expectancy close to that of the normal population. Bosutinib is a second-generation TKI approved for adults with Ph-positive CML in chronic phase, accelerated phase, or blast phase that is resistant or intolerant to prior therapy, and for newly diagnosed Ph-positive chronic phase CML. This review details the efficacy of bosutinib for the treatment of CML in the first- and second-line settings, as well as in third- and later-line settings for high-risk patients resistant or intolerant to at least 2 TKIs. It also outlines bosutinib studies that provide evidence for dose-optimization strategies that can be used to improve efficacy and effectively manage adverse events. The studies that provide evidence for specific patient populations benefiting particularly from bosutinib dose-optimization strategies are also discussed. The well-established, long-term side-effect profile and the potential to make dose adjustments with bosutinib make it an appropriate treatment option for patients with CML. Bosutinib has demonstrated a positive impact on health-related quality of life and an important role in the long-term treatment of patients with CML.
    MeSH term(s) Humans ; Aniline Compounds/therapeutic use ; Aniline Compounds/pharmacology ; Nitriles/therapeutic use ; Nitriles/pharmacology ; Quinolines/therapeutic use ; Quinolines/pharmacology ; Leukemia, Myelogenous, Chronic, BCR-ABL Positive/drug therapy ; Protein Kinase Inhibitors/therapeutic use ; Protein Kinase Inhibitors/pharmacology ; Antineoplastic Agents/therapeutic use ; Antineoplastic Agents/pharmacology ; Treatment Outcome
    Chemical Substances bosutinib (5018V4AEZ0) ; Aniline Compounds ; Nitriles ; Quinolines ; Protein Kinase Inhibitors ; Antineoplastic Agents
    Language English
    Publishing date 2024-01-12
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2540992-X
    ISSN 2152-2669 ; 2152-2650
    ISSN (online) 2152-2669
    ISSN 2152-2650
    DOI 10.1016/j.clml.2024.01.005
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Curing sickle cell disease: Mission accomplished?

    Lipton, Jeffrey M

    Pediatric blood & cancer

    2015  Volume 62, Issue 7, Page(s) 1129–1130

    MeSH term(s) Anemia, Sickle Cell/therapy ; Female ; Fetal Blood ; Hematopoietic Stem Cell Transplantation ; Histocompatibility Testing ; Humans ; Male ; Tissue Donors/supply & distribution
    Language English
    Publishing date 2015-07
    Publishing country United States
    Document type Comment ; Journal Article
    ZDB-ID 2131448-2
    ISSN 1545-5017 ; 1545-5009
    ISSN (online) 1545-5017
    ISSN 1545-5009
    DOI 10.1002/pbc.25497
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Defects in Bone and Bone Marrow in Inherited Anemias: the Chicken or the Egg.

    Willimann, Rachel / Chougar, Christina / Wolfe, Lawrence C / Blanc, Lionel / Lipton, Jeffrey M

    Current osteoporosis reports

    2023  Volume 21, Issue 5, Page(s) 527–539

    Abstract: Purpose of review: Recently, there has been an increasing number of studies on the crosstalk between the bone and the bone marrow and how it pertains to anemia. Here, we discuss four heritable clinical syndromes contrasting those in which anemia affects ...

    Abstract Purpose of review: Recently, there has been an increasing number of studies on the crosstalk between the bone and the bone marrow and how it pertains to anemia. Here, we discuss four heritable clinical syndromes contrasting those in which anemia affects bone growth and development, with those in which abnormal bone development results in anemia, highlighting the multifaceted interactions between skeletal development and hematopoiesis.
    Recent findings: Anemia results from both inherited and acquired disorders caused by either impaired production or premature destruction of red blood cells or blood loss. The downstream effects on bone development and growth in patients with anemia often constitute an important part of their clinical condition. We will discuss the interdependence of abnormal bone development and growth and hematopoietic abnormalities, with a focus on the erythroid lineage. To illustrate those points, we selected four heritable anemias that arise from either defective hematopoiesis impacting the skeletal system (the hemoglobinopathies β-thalassemia and sickle cell disease) versus defective osteogenesis resulting in impaired hematopoiesis (osteopetrosis). Finally, we will discuss recent findings in Diamond Blackfan anemia, an intrinsic disorder of both the erythron and the bone. By focusing on four representative hereditary hematopoietic disorders, this complex relationship between bone and blood should lead to new areas of research in the field.
    MeSH term(s) Humans ; Bone Marrow ; Anemia/genetics ; Hematopoiesis/genetics ; Bone and Bones
    Language English
    Publishing date 2023-07-12
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2186581-4
    ISSN 1544-2241 ; 1544-1873
    ISSN (online) 1544-2241
    ISSN 1544-1873
    DOI 10.1007/s11914-023-00809-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Early Onset Colorectal Cancer: An Emerging Cancer Risk in Patients with Diamond Blackfan Anemia.

    Lipton, Jeffrey M / Molmenti, Christine L S / Desai, Pooja / Lipton, Alexander / Ellis, Steven R / Vlachos, Adrianna

    Genes

    2021  Volume 13, Issue 1

    Abstract: Diamond Blackfan anemia (DBA) is a rare inherited bone marrow failure syndrome, the founding member of a class of disorders known as ribosomopathies. Most cases result from loss of function mutations or deletions in 1 of 23 genes encoding either a small ... ...

    Abstract Diamond Blackfan anemia (DBA) is a rare inherited bone marrow failure syndrome, the founding member of a class of disorders known as ribosomopathies. Most cases result from loss of function mutations or deletions in 1 of 23 genes encoding either a small or large subunit-associated ribosomal protein (RP), resulting in RP haploinsufficiency. DBA is characterized by red cell hypoplasia or aplasia, poor linear growth and congenital anomalies. Small case series and case reports demonstrate DBA to be a cancer predisposition syndrome. Recent analyses from the Diamond Blackfan Anemia Registry of North America (DBAR) have quantified the cancer risk in DBA. These studies reveal the most prevalent solid tumor, presenting in young adults and in children and adolescents, to be colorectal cancer (CRC) and osteogenic sarcoma, respectively. Of concern is that these cancers are typically detected at an advanced stage in patients who, because of their constitutional bone marrow failure, may not tolerate full-dose chemotherapy. Thus, the inability to provide optimal therapy contributes to poor outcomes. CRC screening in individuals over the age of 50 years, and now 45 years, has led to early detection and significant improvements in outcomes for non-DBA patients with CRC. These screening and surveillance strategies have been adapted to detect familial early onset CRC. With the recognition of DBA as a moderately penetrant cancer risk syndrome a rational screening and surveillance strategy will be implemented. The downstream molecular events, resulting from RP haploinsufficiency and leading to cancer, are the subject of significant scientific inquiry.
    MeSH term(s) Anemia, Diamond-Blackfan/complications ; Colorectal Neoplasms/etiology ; Colorectal Neoplasms/metabolism ; Colorectal Neoplasms/pathology ; Early Detection of Cancer/methods ; Humans ; Mutation ; Ribosomal Proteins/genetics ; Risk Factors
    Chemical Substances Ribosomal Proteins
    Language English
    Publishing date 2021-12-26
    Publishing country Switzerland
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2527218-4
    ISSN 2073-4425 ; 2073-4425
    ISSN (online) 2073-4425
    ISSN 2073-4425
    DOI 10.3390/genes13010056
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Heritable cancer: Rounding up the not so usual suspects.

    Lipton, Jeffrey M / Alter, Blanche P

    Pediatric blood & cancer

    2016  Volume 64, Issue 2, Page(s) 219–220

    MeSH term(s) Anemia, Aplastic/genetics ; Bone Marrow Diseases/genetics ; Genetic Predisposition to Disease ; Hemoglobinuria, Paroxysmal/genetics ; Humans ; Neoplasms
    Language English
    Publishing date 2016-10-08
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 2131448-2
    ISSN 1545-5017 ; 1545-5009
    ISSN (online) 1545-5017
    ISSN 1545-5009
    DOI 10.1002/pbc.26190
    Database MEDical Literature Analysis and Retrieval System OnLINE

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