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Article: Beta-variant recombinant booster vaccine elicits broad cross-reactive neutralization of SARS-CoV-2 including Omicron variants.

Planas, Delphine / Peng, Lin / Zheng, Lingyi / Guivel-Benhassine, Florence / Staropoli, Isabelle / Porrot, Françoise / Bruel, Timothée / Bhiman, Jinal N / Bonaparte, Matthew / Savarino, Stephen / de Bruyn, Guy / Chicz, Roman M / Moore, Penny L / Schwartz, Olivier / Sridhar, Saranya

Heliyon

2024 Volume 10, Issue 5, Page(s) e27033

Abstract: Background: SARS-CoV-2 Omicron lineage contains variants with multiple sequence mutations relative to the ancestral strain particularly in the viral spike gene. These mutations are associated inter alia with loss of neutralization sensitivity to sera ... ...

Abstract	Background: SARS-CoV-2 Omicron lineage contains variants with multiple sequence mutations relative to the ancestral strain particularly in the viral spike gene. These mutations are associated inter alia with loss of neutralization sensitivity to sera generated by immunization with vaccines targeting ancestral strains or prior infection with circulating (non-Omicron) variants. Here we present a comparison of vaccine formulation elicited cross neutralization responses using two different assay readouts from a subpopulation of a Phase II/III clinical trial. Methods: Human sera from a Phase II/III trial (NCT04762680) was collected and evaluated for neutralizing responses to SARS-CoV-2 spike antigen protein vaccines formulated with AS03 adjuvant, following a primary series of two-doses of ancestral strain vaccine in individuals who were previously unvaccinated or as an ancestral or variant strain booster vaccine among individuals previously vaccinated with the mRNA BNT162b2 vaccine. Results: We report that a neutralizing response to Omicron BA.1 is induced by the two-dose primary series in 89% of SARS-CoV-2-seronegative individuals. A booster dose of each vaccine formulation raises neutralizing antibody titers that effectively neutralizes Omicron BA.1 and BA.4/5 variants. Responses are highest after the monovalent Beta variant booster and similar in magnitude to human convalescent plasma titers. Conclusion: The findings of this study suggest the possibility to generate greater breadth of cross-neutralization to more recently emerging viral variants through use of a diverged spike vaccine in the form of a Beta variant booster vaccine.
Language	English
Publishing date	2024-02-28
Publishing country	England
Document type	Journal Article
ZDB-ID	2835763-2
ISSN	2405-8440
ISSN	2405-8440
DOI	10.1016/j.heliyon.2024.e27033
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Upregulation of PTPRC and Interferon Response Pathways in HIV-1 Seroconverters Prior to Infection.

Li, Yunqi / Lefebvre, Francois / Nakku-Joloba, Edith / Ronald, Allan / Gray, Glenda / de Bruyn, Guy / Kiarie, James / Celum, Connie / Cameron, Mark J / Lingappa, Jairam R / Mackelprang, Romel D

The Journal of infectious diseases

2023 Volume 227, Issue 5, Page(s) 714–719

Abstract: Human immunodeficiency virus 1 (HIV-1) exposed seronegative (HESN) individuals may have unique characteristics that alter susceptibility to HIV-1 infection. However, identifying truly exposed HESN is challenging. We utilized stored data and biospecimens ... ...

Abstract	Human immunodeficiency virus 1 (HIV-1) exposed seronegative (HESN) individuals may have unique characteristics that alter susceptibility to HIV-1 infection. However, identifying truly exposed HESN is challenging. We utilized stored data and biospecimens from HIV-1 serodifferent couple cohorts, in which couples' HIV-1 exposures were quantified based on unprotected sex frequency and viral load of the partner with HIV-1. We compared peripheral blood gene expression between 15 HESN and 18 seroconverters prior to infection. We found PTPRC (encoding CD45 antigen) and interferon-response pathways had significantly higher expression among individuals who went on to become seropositive and thus may be a signature for increased acquisition risk.
MeSH term(s)	Humans ; HIV-1 ; Interferons/genetics ; Up-Regulation ; Leukocyte Common Antigens ; HIV Infections
Chemical Substances	Interferons (9008-11-1) ; Leukocyte Common Antigens (EC 3.1.3.48) ; PTPRC protein, human (EC 3.1.3.48)
Language	English
Publishing date	2023-01-14
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	3019-3
ISSN	1537-6613 ; 0022-1899
ISSN (online)	1537-6613
ISSN	0022-1899
DOI	10.1093/infdis/jiac498
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Article ; Online: Sonotype‐level responses of Afrotropical hipposiderid bats to local‐scale effects of rainforest structure

Mande, Claude / Kirkpatrick, Lucinda / Van Cakenberghe, Victor / Bruyn, Luc de / Laudisoit, Anne / Gembu, Guy‐Crispin / Verheyen, Erik

African Journal of Ecology. 2023 Dec., v. 61, no. 4 p.829-839

2023

Abstract: Bats exhibit a variety of life‐history traits that can serve as valuable surrogate metrics of terrestrial ecosystem health. Here, we investigate how sonotype activity of hipposiderid bats covaries with habitat structure at finer spatial scales. We ... ...

Abstract	Bats exhibit a variety of life‐history traits that can serve as valuable surrogate metrics of terrestrial ecosystem health. Here, we investigate how sonotype activity of hipposiderid bats covaries with habitat structure at finer spatial scales. We recorded passive echolocation calls and measured key habitat attributes in six rainforests in the Lomami and Yangambi landscapes, Democratic Republic of the Congo. Using bat passes as a measure of sonotype activity, we clustered echolocation calls based on call structure similarity to control for within‐sonotype variation in activity. Over 432 h of recording, we detected 370 passes matching a hipposiderid sonotype in three subgroups, recovering eight potential species. Open habitats negatively affected sonotype activity in the Hipposideros subgroup, which was associated with higher echolocation frequencies. Indeed, activity peaked in the early evening when mean post‐sunset temperature was above the nocturnal average and declined until early morning when mean temperatures dropped below the nightly average. All habitat variables were marginally correlated with the activity of the Doryrhina subgroup, whereas Macronycteris was more active in open habitats. Our findings indicate a probable flexibility of habitat use in lower echolocating bats and point to three possible foraging guilds that modulate hipposiderid bat responses to habitat structure.
Keywords	Afrotropical region ; Hipposideros ; echolocation ; environmental health ; habitat preferences ; habitats ; life history ; rain forests ; temperature ; terrestrial ecosystems ; Democratic Republic of the Congo
Language	English
Dates of publication	2023-12
Size	p. 829-839.
Publishing place	John Wiley & Sons, Ltd
Document type	Article ; Online
Note	JOURNAL ARTICLE
ZDB-ID	2019879-6
ISSN	1365-2028 ; 0141-6707
ISSN (online)	1365-2028
ISSN	0141-6707
DOI	10.1111/aje.13182
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Drivers affecting habitat use in Afrotropical hipposiderid and pteropodid bats

Mande, Claude / Van Cakenberghe, Victor / Kirkpatrick, Lucinda / Laudisoit, Anne / Bruyn, Luc de / Gembu, Guy‐Crispin / Verheyen, Erik

Biotropica. 2023 Sept., v. 55, no. 5 p.920-932

2023

Abstract: Assessing how bats respond to habitat attributes requires an integrative approach to reliably predict direct community‐level effects. We focused on hipposiderid and pteropodid bats because of their diverse resource use patterns, body size ranges, and ... ...

Abstract	Assessing how bats respond to habitat attributes requires an integrative approach to reliably predict direct community‐level effects. We focused on hipposiderid and pteropodid bats because of their diverse resource use patterns, body size ranges, and dispersal abilities. We combined an array of bat species‐level characteristics with key forest stand characteristics that may covary with habitat use. Twelve stations were sampled in the Lomami and Yangambi landscapes, Democratic Republic of the Congo. We investigated whether species‐level flight ability of bats and forest stand characteristics can affect bat commuting flights and community‐level estimates of both species detection and habitat occupancy. We captured bats for 108 trap‐nights. Three sampling events (early evening, middle of the night, and early morning) were replicated for each survey night. Hipposiderids showed an early evening flight peak, while flight activity of pteropodids was constant throughout the night, but increased around the middle of the night. Species capture probability decreased with higher wing loading in hipposiderids and was negatively correlated with higher wing aspect ratio in pteropodids. Forest occupancy of hipposiderids increased along the gradient towards waterways, while pteropodid occurrence was not directly linked to measured forest stand variables. This suggests a consequence of habitat patterns at larger spatial scales, which would need clarifying through additional data collection. We discuss these findings in terms of resource‐use strategies of clutter‐tolerant and clutter‐intolerant species. We argue that the occurrence of specific bat species and their habitat use patterns can serve as surrogate measures of ecosystem health.
Keywords	Afrotropical region ; Hipposideridae ; body size ; data collection ; environmental health ; flight ; forest stands ; forests ; habitat preferences ; habitats ; probability ; surveys ; Democratic Republic of the Congo
Language	English
Dates of publication	2023-09
Size	p. 920-932.
Publishing place	John Wiley & Sons, Ltd
Document type	Article ; Online
Note	JOURNAL ARTICLE
ZDB-ID	2052061-X
ISSN	1744-7429 ; 0006-3606
ISSN (online)	1744-7429
ISSN	0006-3606
DOI	10.1111/btp.13242
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Article: Intensive Therapy of the Lower Limbs and the Trunk in Children with Bilateral Spastic Cerebral Palsy: Comparing a Qualitative Functional and a Functional Approach.

van Tittelboom, Vanessa / Heyrman, Lieve / De Cat, Josse / Algoet, Patrick / Peeters, Nicky / Alemdaroğlu-Gürbüz, Ipek / Plasschaert, Frank / Van Herpe, Katrin / Molenaers, Guy / De Bruyn, Nele / Deschepper, Ellen / Desloovere, Kaat / Calders, Patrick / Feys, Hilde / Van den Broeck, Christine

Journal of clinical medicine

2023 Volume 12, Issue 12

Abstract: Few studies have examined the effect of intensive therapy on gross motor function and trunk control in children with cerebral palsy (CP). This study evaluated the effects of an intensive burst of therapy on the lower limbs and trunk by comparing ... ...

Abstract	Few studies have examined the effect of intensive therapy on gross motor function and trunk control in children with cerebral palsy (CP). This study evaluated the effects of an intensive burst of therapy on the lower limbs and trunk by comparing qualitative functional and functional approaches. This study was designed as a quasi-randomized, controlled, and evaluator-blinded trial. Thirty-six children with bilateral spastic CP (mean age = 8 y 9 mo; Gross Motor Function Classification II and III) were randomized into functional (
Language	English
Publishing date	2023-06-15
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm12124078
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Article ; Online: Comparative population genomics of manta rays has global implications for management.

Humble, Emily / Hosegood, Jane / Carvalho, Gary / de Bruyn, Mark / Creer, Simon / Stevens, Guy M W / Armstrong, Amelia / Bonfil, Ramon / Deakos, Mark / Fernando, Daniel / Froman, Niv / Peel, Lauren R / Pollett, Stephen / Ponzo, Alessandro / Stewart, Joshua D / Wintner, Sabine / Ogden, Rob

Molecular ecology

2023

Abstract: Understanding population connectivity and genetic diversity is of fundamental importance to conservation. However, in globally threatened marine megafauna, challenges remain due to their elusive nature and wide-ranging distributions. As overexploitation ... ...

Abstract	Understanding population connectivity and genetic diversity is of fundamental importance to conservation. However, in globally threatened marine megafauna, challenges remain due to their elusive nature and wide-ranging distributions. As overexploitation continues to threaten biodiversity across the globe, such knowledge gaps compromise both the suitability and effectiveness of management actions. Here, we use a comparative framework to investigate genetic differentiation and diversity of manta rays, one of the most iconic yet vulnerable groups of elasmobranchs on the planet. Despite their recent divergence, we show how oceanic manta rays (Mobula birostris) display significantly higher heterozygosity than reef manta rays (Mobula alfredi) and that M. birostris populations display higher connectivity worldwide. Through inferring modes of colonization, we reveal how both contemporary and historical forces have likely influenced these patterns, with important implications for population management. Our findings highlight the potential for fisheries to disrupt population dynamics at both local and global scales and therefore have direct relevance for international conservation of marine species.
Language	English
Publishing date	2023-11-23
Publishing country	England
Document type	Journal Article
ZDB-ID	1126687-9
ISSN	1365-294X ; 0962-1083
ISSN (online)	1365-294X
ISSN	0962-1083
DOI	10.1111/mec.17220
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Article: Chemically diverse activity-based probes with unexpected inhibitory mechanisms targeting trypsin-like serine proteases.

Ramos-Llorca, Alba / Decraecker, Lisse / Cacheux, Valérie M Y / Zeiburlina, Irena / De Bruyn, Michelle / Battut, Louise / Moreno-Cinos, Carlos / Ceradini, Davide / Espinosa, Eric / Dietrich, Gilles / Berg, Maya / De Meester, Ingrid / Van Der Veken, Pieter / Boeckxstaens, Guy / Lambeir, Anne-Marie / Denadai-Souza, Alexandre / Augustyns, Koen

Frontiers in chemistry

2023 Volume 10, Page(s) 1089959

Abstract: Activity-based probes (ABP) are molecules that bind covalently to the active form of an enzyme family, making them an attractive tool for target and biomarker identification and drug discovery. The present study describes the synthesis and biochemical ... ...

Abstract	Activity-based probes (ABP) are molecules that bind covalently to the active form of an enzyme family, making them an attractive tool for target and biomarker identification and drug discovery. The present study describes the synthesis and biochemical characterization of novel activity-based probes targeting trypsin-like serine proteases. We developed an extensive library of activity-based probes with "clickable" affinity tags and a diaryl phosphonate warhead. A wide diversity was achieved by including natural amino acid analogs as well as basic polar residues as side chains. A detailed enzymatic characterization was performed in a panel of trypsin-like serine proteases. Their inhibitory potencies and kinetic profile were examined, and their IC
Language	English
Publishing date	2023-01-05
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2711776-5
ISSN	2296-2646
ISSN	2296-2646
DOI	10.3389/fchem.2022.1089959
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Article ; Online: Circumcision reduced the risk of contracting HIV infection in young sexually active Kenyan men.

de Bruyn, Guy

Evidence-based medicine

2007 Volume 12, Issue 4, Page(s) 104

Language	English
Publishing date	2007-08
Publishing country	England
Document type	Comment ; Journal Article
ZDB-ID	1324346-9
ISSN	1473-6810 ; 1356-5524
ISSN (online)	1473-6810
ISSN	1356-5524
DOI	10.1136/ebm.12.4.104
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Article ; Online: Cofactors that may influence vaccine responses.

de Bruyn, Guy

Current opinion in HIV and AIDS

2010 Volume 5, Issue 5, Page(s) 404–408

Abstract: Purpose of review: This review summarizes recent developments related to cofactors that may influence response to vaccination.: Recent findings: The unexpected increased HIV acquisition among vaccinees in the Step trial with prior exposure to ... ...

Abstract	Purpose of review: This review summarizes recent developments related to cofactors that may influence response to vaccination. Recent findings: The unexpected increased HIV acquisition among vaccinees in the Step trial with prior exposure to adenovirus type 5 (Ad5) led to several studies trying to understand whether an underlying biological risk factor may have been responsible for this observation. Demographic factors and genetic background of the human populations in HIV vaccine trials remain a source of potential variation in responses observed in vaccine trials, yet empirical data remain limited on the impact of those factors. Coinfections, particularly those that may modulate the immune response, are a further concern for HIV vaccine trialists, with recent data providing further insight into effects of coinfections on innate and adaptive immunity and vaccine responses. Summary: Individuals and human populations display variation in response to vaccination. Key explanatory variables for this variation include host factors, such as host genetics, and environmental factors, such as prior exposure to the vaccine vector, coinfection with other pathogens, and demographic factors. This review will outline some of the recent developments investigating the role of various cofactors on vaccine responses, with a particular emphasis on studies of HIV vaccines.
MeSH term(s)	AIDS Vaccines/immunology ; Clinical Trials as Topic ; Demography ; Genetic Variation ; Humans ; Treatment Outcome
Chemical Substances	AIDS Vaccines
Language	English
Publishing date	2010-09-01
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Review
ZDB-ID	2502511-9
ISSN	1746-6318 ; 1746-630X
ISSN (online)	1746-6318
ISSN	1746-630X
DOI	10.1097/COH.0b013e32833d1fca
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Article: Diarrhea in adults (acute).

De Bruyn, Guy

American family physician

2008 Volume 78, Issue 4, Page(s) 503–504

MeSH term(s)	Acute Disease ; Adult ; Anti-Bacterial Agents/therapeutic use ; Anti-Ulcer Agents/therapeutic use ; Antidiarrheals/therapeutic use ; Combined Modality Therapy ; Diarrhea/epidemiology ; Diarrhea/etiology ; Diarrhea/therapy ; Evidence-Based Medicine ; Fluid Therapy/methods ; Humans ; Loperamide/therapeutic use ; Prognosis
Chemical Substances	Anti-Bacterial Agents ; Anti-Ulcer Agents ; Antidiarrheals ; Loperamide (6X9OC3H4II)
Language	English
Publishing date	2008-08-15
Publishing country	United States
Document type	Journal Article
ZDB-ID	412694-4
ISSN	0002-838X ; 0572-3612
ISSN	0002-838X ; 0572-3612
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