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Book ; Online: Biblical Theology of prayer in the Old Testament

Coetsee, Albert J / Viljoen, Francois / Haynes, Matthew / Firth, David G / Dekker, Jaap / Rochester, Kathleen M / Snyman, Fanie / Moretsi, Lekgetho H / van Rooy, Herrie / Ho, Edward / Kotzé, Gideon R / Nel, Marius / Floor, Sebastian J / Jonker, Louis C / Coetsee, Albert J

(Reformed Theology in Africa Series)

2023

Series title	Reformed Theology in Africa Series
Keywords	Christianity ; Biblical Theology ; prayer ; Old Testament ; praise ; worship ; confession ; lament
Language	English
Size	1 electronic resource (258 pages)
Publisher	AOSIS
Publishing place	Cape Town
Document type	Book ; Online
Note	English
HBZ-ID	HT030648325
ISBN	9781779952738 ; 1779952732
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Book ; Online: Haarzell-Leukämie (HZL)

Wörmann, Bernhard / Dietrich, Sascha / Ho, Anthony Dick / Jöhrens, Korinna / Le Coutre, Philipp / Seifert, Marc / Rummel, Mathias / Staber, Philipp / Zenz, Thorsten

Leitlinie : Empfehlungen der Fachgesellschaft zur Diagnostik und Therapie hämatologischer und onkologischer Erkrankungen

(Onkopedia Leitlinien)

2020

Abstract: Die Haarzell-Leukämie (HZL) ist eine seltene lymphoproliferative Erkrankung. Etwa 95% der Patienten haben eine klassische HZL, bis zu 5% die HZL-Variante. Klinisch ist die klassische HZL durch Zytopenien, Splenomegalie, Allgemeinsymptome und einen ... ...

Institution	Deutsche Gesellschaft für Hämatologie und Medizinische Onkologie Österreichische Gesellschaft für Hämatologie & Medizinische Onkologie Schweizerische Gesellschaft für Hämatologie
Author's details	Deutsche Gesellschaft für Hämatologie und Medizinische Onkologie, Österreichische Gesellschaft für Hämatologie & Medizinische Onkologie, SGH/SSH ; Autoren: Bernhard Wörmann, Sascha Dietrich, Anthony D. Ho, Korinna Jöhrens, Philipp le Coutre, Marc Seifert, Mathias J. Rummel, Philipp Bernhard Staber, Thorsten Zenz ; Vorherige Autoren: Max Solenthaler, Michael Steurer
Series title	Onkopedia Leitlinien
Abstract	Die Haarzell-Leukämie (HZL) ist eine seltene lymphoproliferative Erkrankung. Etwa 95% der Patienten haben eine klassische HZL, bis zu 5% die HZL-Variante. Klinisch ist die klassische HZL durch Zytopenien, Splenomegalie, Allgemeinsymptome und einen langsamen Verlauf charakterisiert. Die Therapie mit Purin-Analoga erzielt Remissionsraten >95%. Weitere wirksame Arzneimittel sind monoklonale Antikörper, BRAF-Inhibitoren, Interferon alpha, Zytostatika und ein Antikörperkonjugat. Die Haarzell-Leukämie ist eine chronische Erkrankung. Die mediane Überlebenszeit liegt über 20 Jahre. Bei gutem Ansprechen auf die Therapie hat die Mehrzahl der Patienten eine fast normale Lebenserwartung.
Subject code	610
Language	German
Size	1 Online-Ressource (21 Seiten), Diagramme
Edition	Stand: September 2020
Publisher	DGHO Deutsche Gesellschaft für Hämatologie und Medizinische Onkologie e.V
Publishing place	Berlin
Publishing country	Germany
Document type	Book ; Online
HBZ-ID	HT021146750
DOI	10.4126/FRL01-006430340
Database	Repository for Life Sciences

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Article ; Online: Disaggregating Asian-American Mortality in Drug-Related Overdoses and Behavioral Disorders: A Cross-Sectional Study.

Zhu, David T / Zhong, Anthony / Ho, Winnie J / Tamang, Suzanne

Journal of racial and ethnic health disparities

2024

Abstract: Asian Americans have been historically underrepresented in the national drug overdose discourse due to their lower substance use and overdose rates compared to other racial/ethnic groups. However, aggregated analyses fail to capture the vast diversity ... ...

Abstract	Asian Americans have been historically underrepresented in the national drug overdose discourse due to their lower substance use and overdose rates compared to other racial/ethnic groups. However, aggregated analyses fail to capture the vast diversity among Asian-American subgroups, obscuring critical disparities. We conducted a cross-sectional study between 2018 and 2021 examining Asian-American individuals within the CDC WONDER database with drug overdoses as the underlying cause of death (n = 3195; ICD-10 codes X40-X44, X60-X64, X85, and Y10-Y14) or psychoactive substance-related mental and behavioral disorders as one of multiple causes of death (n = 15,513; ICD-10 codes F10-F19). Proportional mortality ratios were calculated, comparing disaggregated Asian-American subgroups to the reference group (Asian Americans as a single aggregate group). Z-tests identified significant differences between subgroups. Compared to the reference group (0.99%), drug overdose deaths were less prevalent among Japanese (0.46%; p < 0.001), Chinese (0.47%; p < 0.001), and Filipino (0.82%; p < 0.001) subgroups, contrasting with a higher prevalence among Asian Indian (1.20%; p < 0.001), Vietnamese (1.35%; p < 0.001), Korean (1.36%; p < 0.001), and other Asian (1.79%; p < 0.001) subgroups. Similarly, compared to the reference group (4.80%), deaths from mental and behavioral disorders were less prevalent among Chinese (3.18%; p < 0.001), Filipino (4.52%; p < 0.001), and Asian Indian (4.56%; p < 0.001) subgroups, while more prevalent among Korean (5.60%; p < 0.001), Vietnamese (5.64%; p < 0.001), Japanese (5.81%; p < 0.001), and other Asian (6.14%; p < 0.001) subgroups. Disaggregated data also revealed substantial geographical variations in these deaths obscured by aggregated analyses. Our findings revealed pronounced intra-racial disparities, underscoring the importance of data disaggregation to inform targeted clinical and public health interventions.
Language	English
Publishing date	2024-03-26
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2760524-3
ISSN	2196-8837 ; 2197-3792
ISSN (online)	2196-8837
ISSN	2197-3792
DOI	10.1007/s40615-024-01983-5
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: The effects of puberty and sex on adolescent white matter development: A systematic review.

Piekarski, David J / Colich, Natalie L / Ho, Tiffany C

Developmental cognitive neuroscience

2023 Volume 60, Page(s) 101214

Abstract: Adolescence, the transition between childhood and adulthood, is characterized by rapid brain development in white matter (WM) that is attributed in part to rising levels in adrenal and gonadal hormones. The extent to which pubertal hormones and related ... ...

Abstract	Adolescence, the transition between childhood and adulthood, is characterized by rapid brain development in white matter (WM) that is attributed in part to rising levels in adrenal and gonadal hormones. The extent to which pubertal hormones and related neuroendocrine processes explain sex differences in WM during this period is unclear. In this systematic review, we sought to examine whether there are consistent associations between hormonal changes and morphological and microstructural properties of WM across species and whether these effects are sex-specific. We identified 90 (75 human, 15 non-human) studies that met inclusion criteria for our analyses. While studies in human adolescents show notable heterogeneity, results broadly demonstrate that increases in gonadal hormones across pubertal development are associated with macro- and microstructural changes in WM tracts that are consistent with the sex differences found in non-human animals, particularly in the corpus callosum. We discuss limitations of the current state of the science and recommend important future directions for investigators in the field to consider in order to advance our understanding of the neuroscience of puberty and to promote forward and backward translation across model organisms.
MeSH term(s)	Humans ; Animals ; Male ; Female ; Adolescent ; Child ; White Matter ; Puberty ; Gonadal Hormones ; Sex Characteristics ; Neurosciences ; Brain
Chemical Substances	Gonadal Hormones
Language	English
Publishing date	2023-02-10
Publishing country	Netherlands
Document type	Systematic Review ; Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2572271-2
ISSN	1878-9307 ; 1878-9307
ISSN (online)	1878-9307
ISSN	1878-9307
DOI	10.1016/j.dcn.2023.101214
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Noninvasive focal transgene delivery with viral neuronal tracers in the marmoset monkey.

Parks, T Vincenza / Szczupak, Diego / Choi, Sang-Ho / Schaeffer, David J

Cell reports methods

2024 Volume 4, Issue 2, Page(s) 100709

Abstract: We establish a reliable method for selectively delivering adeno-associated viral vectors (AAVs) across the blood-brain barrier (BBB) in the marmoset without the need for neurosurgical injection. We focally perturbed the BBB (∼1 × 2 mm) in area 8aD of the ...

Abstract	We establish a reliable method for selectively delivering adeno-associated viral vectors (AAVs) across the blood-brain barrier (BBB) in the marmoset without the need for neurosurgical injection. We focally perturbed the BBB (∼1 × 2 mm) in area 8aD of the frontal cortex in four adult marmoset monkeys using low-intensity transcranial focused ultrasound aided by microbubbles. Within an hour of opening the BBB, either AAV2 or AAV9 was delivered systemically via tail-vein injection. In all four marmosets, fluorescence-encoded neurons were observed at the site of BBB perturbation, with AAV2 showing a sparse distribution of transduced neurons when compared to AAV9. The results are compared to direct intracortical injections of anterograde tracers into area 8aD and similar (albeit sparser) long-range connectivity was observed. With evidence of transduced neurons specific to the region of BBB opening as well as long-distance tracing, we establish a framework for focal noninvasive transgene delivery to the marmoset brain.
MeSH term(s)	Animals ; Callithrix ; Brain/physiology ; Blood-Brain Barrier ; Transgenes ; Neurons
Language	English
Publishing date	2024-02-14
Publishing country	United States
Document type	Journal Article
ISSN	2667-2375
ISSN (online)	2667-2375
DOI	10.1016/j.crmeth.2024.100709
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: The Adatom Concentration Profile: A Paradigm for Understanding Two-Dimensional MoS

Xu, Jiangang / Srolovitz, David J / Ho, Derek

ACS nano

2021 Volume 15, Issue 4, Page(s) 6839–6848

Abstract: The two-dimensional (2D) transition metal dichalcogenide (TMD) ... ...

Abstract	The two-dimensional (2D) transition metal dichalcogenide (TMD) MoS
Language	English
Publishing date	2021-03-22
Publishing country	United States
Document type	Journal Article
ISSN	1936-086X
ISSN (online)	1936-086X
DOI	10.1021/acsnano.0c10474
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Proportion of Physicians Who Treat Patients With Greater Social and Clinical Risk and Physician Inclusion in Medicare Advantage Networks.

Gong, Jung Ho / Johnston, Kenton J / Meyers, David J

JAMA health forum

2023 Volume 4, Issue 7, Page(s) e231991

Abstract: Importance: Medicare Advantage (MA) plans are expanding rapidly, now serving 50% of all Medicare enrollees. Little is known about how inclusion rates of physicians in MA plan networks vary by the social and clinical risks of their patients.: Objective! ...

Abstract	Importance: Medicare Advantage (MA) plans are expanding rapidly, now serving 50% of all Medicare enrollees. Little is known about how inclusion rates of physicians in MA plan networks vary by the social and clinical risks of their patients. Objective: To examine the association of physicians caring for patients with higher levels of social and clinical risk in traditional Medicare (TM) with the likelihood of inclusion in MA plan networks. Design, setting, and participants: This cross-sectional study evaluated the number of patients of physicians participating in TM Part B in 2019. The data analysis was conducted between June 2022 and March 2023. Exposures: Quintiles of the proportion of patients who were dually eligible for Medicare and Medicaid and average beneficiary hierarchical condition category (HCC) score (a measure of a patient's chronic disease burden that is used in risk adjustment and MA plan payment, where higher scores indicate higher risk) in the Part B TM program. Main outcomes and measures: The main outcomes were the proportion of MA plans and enrollees for which physicians were in network. Results: The analysis sample included 259 932 physicians billing Medicare Part B in 2019. After adjusting for physician, patient, and county characteristics, physicians with the highest quintile of patients with dual eligibility were associated with a lower likelihood of being included in MA plans and being in network with MA enrollees than the lowest quintile physicians (MA inclusion rate, -3.0% [95% CI, -3.2% to -2.8%]; P < .001; in-network enrollee proportion, -6.5% [95% CI, -7.0% to -6.0%]; P < .001). Similarly, physicians with the highest quintile HCC score were associated with a lower likelihood of being included in MA plans and being in network with MA enrollees than the lowest quintile physicians (MA inclusion rate, -7.5% [95% CI, -7.9% to -7.2%]; P < .001; in-network enrollee proportion, -18.7% [95% CI, -19.5% to -18.1%]; P < .001). Physicians in medical specialties in the highest clinical risk group (highest quintile HCC score) were associated with a significantly lower likelihood of being in network with MA enrollees than those in the lowest clinical risk group (in-network enrollee proportion, -20.4% [95% CI, -21.1% to -19.8%]; P < .001). Conclusions and relevance: This cross-sectional study of physicians participating in TM Part B in 2019 found that physicians with higher numbers of patients with social and medical risks in TM were significantly less likely to be associated with MA plans.
MeSH term(s)	Aged ; Humans ; United States ; Medicare Part C ; Cross-Sectional Studies ; Medicaid ; Risk Adjustment ; Physicians
Language	English
Publishing date	2023-07-07
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ISSN	2689-0186
ISSN (online)	2689-0186
DOI	10.1001/jamahealthforum.2023.1991
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Assessment of a Price Index for Hospital Outpatient Department Services Using Commercial Claims Data in Massachusetts.

James, Hannah O / Fonkych, Katya / Nasuti, Laura J / Auerbach, David I

JAMA health forum

2023 Volume 4, Issue 4, Page(s) e230650

MeSH term(s)	Humans ; Outpatients ; Health Care Costs ; Insurance, Health ; Massachusetts ; Hospitals
Language	English
Publishing date	2023-04-07
Publishing country	United States
Document type	Letter
ISSN	2689-0186
ISSN (online)	2689-0186
DOI	10.1001/jamahealthforum.2023.0650
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Turning the world's DNA into new medicines.

Ho, J J David / Dunbar, Kyle L / Naughton, Brian / Harvey, Colin J B

Trends in biotechnology

2022 Volume 40, Issue 6, Page(s) 766–767

MeSH term(s)	DNA/genetics ; Developing Countries
Chemical Substances	DNA (9007-49-2)
Language	English
Publishing date	2022-02-26
Publishing country	England
Document type	Journal Article
ZDB-ID	47474-5
ISSN	1879-3096 ; 0167-7799
ISSN (online)	1879-3096
ISSN	0167-7799
DOI	10.1016/j.tibtech.2022.01.014
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Article ; Online: Biological age is superior to chronological age in predicting hospital mortality of the critically ill.

Ho, Kwok M / Morgan, David J / Johnstone, Mason / Edibam, Cyrus

Internal and emergency medicine

2023 Volume 18, Issue 7, Page(s) 2019–2028

Abstract: Biological age is increasingly recognized as being more accurate than chronological age in determining chronic health outcomes. This study assessed whether biological age, assessed on intensive care unit (ICU) admission, can predict hospital mortality. ... ...

Abstract	Biological age is increasingly recognized as being more accurate than chronological age in determining chronic health outcomes. This study assessed whether biological age, assessed on intensive care unit (ICU) admission, can predict hospital mortality. This retrospective cohort study, conducted in a tertiary multidisciplinary ICU in Western Australia, used the Levine PhenoAge model to estimate each patient's biological age (also called PhenoAge). Each patient's PhenoAge was calibrated to generate a regression residual which was equivalent to biological age unexplained by chronological age in the local context. PhenoAgeAccel was a dichotomized measure of the residuals, and its presence suggested that one was biologically older than the corresponding chronological age. Of the 2950 critically ill adult patients analyzed, 291 died (9.9%) before hospital discharge. Both PhenoAge and its residuals (after regressing on chronological age) had a significantly better ability to differentiate between hospital survivors and non-survivors than chronological age (area under the receiver-operating-characteristic curve 0.648 and 0.654 vs. 0.547 respectively). Being phenotypically older than one's chronological age was associated with an increased risk of mortality (PhenoAgeAccel hazard ratio [HR] 1.997, 95% confidence interval [CI] 1.568-2.542; p = 0.001) in a dose-related fashion and did not reach a plateau until at least a 20-year gap. This adverse association remained significant (adjusted HR 1.386, 95% CI 1.077-1.784; p = 0.011) after adjusted for severity of acute illness and comorbidities. PhenoAgeAccel was more prevalent among those with pre-existing chronic cardiovascular disease, end-stage renal failure, cirrhosis, immune disease, diabetes mellitus, or those treated with immunosuppressive therapy. Being phenotypically older than one's chronological age was more common among those with comorbidities, and this was associated with an increased risk of mortality in a dose-related fashion in the critically ill that was not fully explained by comorbidities and severity of acute illness.
MeSH term(s)	Adult ; Humans ; Hospital Mortality ; Retrospective Studies ; Critical Illness/therapy ; Acute Disease ; Intensive Care Units ; Aging ; Prognosis
Language	English
Publishing date	2023-08-28
Publishing country	Italy
Document type	Journal Article
ZDB-ID	2454173-4
ISSN	1970-9366 ; 1828-0447
ISSN (online)	1970-9366
ISSN	1828-0447
DOI	10.1007/s11739-023-03397-3
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