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  1. Artikel ; Online: Retraction Note: Dickkopf-1 contributes to hepatocellular carcinoma tumorigenesis by activating the Wnt/β-catenin signaling pathway.

    Zhang, Rui / Lin, Hao-Ming / Broering, Ruth / Shi, Xiang-de / Yu, Xian-Huan / Xu, Lei-Bo / Wu, Wen-Rui / Liu, Chao

    Signal transduction and targeted therapy

    2023  Band 8, Heft 1, Seite(n) 181

    Sprache Englisch
    Erscheinungsdatum 2023-05-05
    Erscheinungsland England
    Dokumenttyp Retraction of Publication
    ZDB-ID 2886872-9
    ISSN 2059-3635 ; 2095-9907
    ISSN (online) 2059-3635
    ISSN 2095-9907
    DOI 10.1038/s41392-023-01475-8
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: Complete response of recurrent perihilar cholangiocarcinoma following sintilimab combined with lenvatinib plus S-1: a case report and review of literature.

    Liu, Qin-Qin / Yu, Xian-Huan / Tang, Qi-Bin / Chen, Dong / Zhang, Rui / Liu, Chao / Shi, Xiang-de

    Anti-cancer drugs

    2023  Band 35, Heft 1, Seite(n) 81–85

    Abstract: Perihilar cholangiocarcinoma is a refractory malignancy with an unfavorable prognosis and a high probability of recurrence. Systemic chemotherapy is critical for palliative treatment, but effective therapeutic strategies for perihilar cholangiocarcinoma ... ...

    Abstract Perihilar cholangiocarcinoma is a refractory malignancy with an unfavorable prognosis and a high probability of recurrence. Systemic chemotherapy is critical for palliative treatment, but effective therapeutic strategies for perihilar cholangiocarcinoma after first-line chemotherapy failure are scarce. Here, we introduced a sustained benefit following sintilimab combined with lenvatinib plus S-1 in a patient with recurrent perihilar cholangiocarcinoma. A 52-year-old female patient was admitted to our hospital due to yellow skin and sclera, and further radiological examination revealed perihilar cholangiocarcinoma. The patient underwent surgery and histopathological results confirmed moderately differentiated adenocarcinoma with metastatic lymph nodes. Postoperative adjuvant chemotherapy with gemcitabine and S-1 was given. One year after surgery, the patient experienced hepatic recurrence. Then, she received radiofrequency ablation combined with gemcitabine and cisplatin. Unfortunately, radiological assessment revealed progressive disease with multiple liver metastases after treatment. Subsequently, she received sintilimab combined with lenvatinib plus S-1 and the lesions were completely regressed following 14 cycles of combination therapy. The patient recovered well without disease recurrence at the last follow-up. Sintilimab combined with lenvatinib plus S-1 may be an alternative therapeutic option for chemotherapy-refractory perihilar cholangiocarcinoma, and further evaluation in a larger number of patients is needed.
    Mesh-Begriff(e) Female ; Humans ; Middle Aged ; Klatskin Tumor/drug therapy ; Klatskin Tumor/pathology ; Klatskin Tumor/surgery ; Gemcitabine ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Cholangiocarcinoma/drug therapy ; Cholangiocarcinoma/pathology ; Pathologic Complete Response ; Bile Ducts, Intrahepatic/pathology ; Bile Ducts, Intrahepatic/surgery ; Bile Duct Neoplasms/drug therapy ; Bile Duct Neoplasms/surgery ; Bile Duct Neoplasms/pathology
    Chemische Substanzen Gemcitabine ; sintilimab (8FU7FQ8UPK) ; lenvatinib (EE083865G2)
    Sprache Englisch
    Erscheinungsdatum 2023-04-28
    Erscheinungsland England
    Dokumenttyp Review ; Case Reports ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1065301-6
    ISSN 1473-5741 ; 0959-4973
    ISSN (online) 1473-5741
    ISSN 0959-4973
    DOI 10.1097/CAD.0000000000001519
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel ; Online: Real-world experience of postoperative adjuvant chemoimmunotherapy in patients with perihilar cholangiocarcinoma at high risk of recurrence.

    Liu, Qin-Qin / Shi, Xiang-de / Ye, Yan-Fang / Tang, Qi-Bin / Lin, Hao-Ming / Yu, Xian-Huan / Zhang, Rui / Liu, Chao

    Cancer immunology, immunotherapy : CII

    2023  Band 72, Heft 6, Seite(n) 1753–1761

    Abstract: Background: This study aimed to assess whether postoperative adjuvant chemoimmunotherapy could lead to better clinical outcomes for high-risk patients with perihilar cholangiocarcinoma (pCCA).: Methods: In the cohort study, we retrospectively ... ...

    Abstract Background: This study aimed to assess whether postoperative adjuvant chemoimmunotherapy could lead to better clinical outcomes for high-risk patients with perihilar cholangiocarcinoma (pCCA).
    Methods: In the cohort study, we retrospectively reviewed patients who received surgical resection for pCCA with curative intent from January 2018 to December 2021 at the Sun Yat-sen Memorial Hospital. The patients at high risk for relapse were further analyzed. Among them, 20 patients received adjuvant chemoimmunotherapy, 28 patients received adjuvant chemotherapy, and 33 patients received surgery alone. The oncological outcomes and drug-associated adverse events were evaluated.
    Results: The 2-year overall survival (OS) rates in patients treated with adjuvant chemoimmunotherapy, adjuvant chemotherapy, and surgery alone were 80.0%, 49.4% and 22.6%, respectively. Univariable and multivariable Cox analyses showed that the treatment regimen and TNM stage were associated with adverse OS. Adjuvant chemoimmunotherapy led to an increase in OS compared with adjuvant chemotherapy [hazard ratio (HR) = 3.253; 95% confidence interval (CI) 1.072-9.870; P = 0.037] or surgery alone (HR = 7.560; 95% CI 2.508-22.785; P < 0.001). The median recurrence-free survival was 22.0 months for the adjuvant chemoimmunotherapy group, 17.0 months for the adjuvant chemotherapy group, and 13.2 months for the surgery alone group (P = 0.177); these differences were not significant. The chemoimmunotherapy group was associated with more frequent hematological side effects than the chemotherapy group, but the difference was not statistically significant.
    Conclusion: Postoperative adjuvant chemoimmunotherapy for resected pCCA patients showed improved OS compared with adjuvant chemotherapy or surgery alone, and further prospectively randomized controlled trials are necessary to validate these results.
    Mesh-Begriff(e) Humans ; Adjuvants, Immunologic ; Bile Duct Neoplasms/surgery ; Chemotherapy, Adjuvant/methods ; Cholangiocarcinoma ; Cohort Studies ; Klatskin Tumor/surgery ; Neoplasm Recurrence, Local ; Retrospective Studies
    Chemische Substanzen Adjuvants, Immunologic
    Sprache Englisch
    Erscheinungsdatum 2023-01-17
    Erscheinungsland Germany
    Dokumenttyp Journal Article
    ZDB-ID 195342-4
    ISSN 1432-0851 ; 0340-7004
    ISSN (online) 1432-0851
    ISSN 0340-7004
    DOI 10.1007/s00262-022-03362-7
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel ; Online: Retraction Note

    Rui Zhang / Hao-Ming Lin / Ruth Broering / Xiang-de Shi / Xian-huan Yu / Lei-bo Xu / Wen-rui Wu / Chao Liu

    Signal Transduction and Targeted Therapy, Vol 8, Iss 1, Pp 1-

    Dickkopf-1 contributes to hepatocellular carcinoma tumorigenesis by activating the Wnt/β-catenin signaling pathway

    2023  Band 1

    Schlagwörter Medicine ; R ; Biology (General) ; QH301-705.5
    Sprache Englisch
    Erscheinungsdatum 2023-05-01T00:00:00Z
    Verlag Nature Publishing Group
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  5. Artikel: [Status of Heavy Metal in Organic Fertilizers in Main Tea Growing Regions of China].

    Yi, Xiao-Yun / Fang, Li / Yang, Xiang-de / Ma, Li-Feng / Liu, Mei-Ya / Zhang, Qun-Feng / Ni, Kang / Shi, Yuan-Zhi

    Huan jing ke xue= Huanjing kexue

    2022  Band 43, Heft 10, Seite(n) 4613–4621

    Abstract: To provide guidance for the safe use of organic fertilizers and improve soil quality and tea safety, it is necessary to conduct systematic analyses of the heavy metal content of organic fertilizers applied in the main tea producing areas of China. In ... ...

    Abstract To provide guidance for the safe use of organic fertilizers and improve soil quality and tea safety, it is necessary to conduct systematic analyses of the heavy metal content of organic fertilizers applied in the main tea producing areas of China. In this study, we analyzed the heavy metal contents in organic fertilizer samples collected from 2017 to 2019. The risks of collected organic fertilizers from different areas and sources were calculated. The results showed that the average concentrations of
    Mesh-Begriff(e) Animals ; Brassica napus ; Brassica rapa ; Cadmium/analysis ; Chickens ; China ; Environmental Monitoring/methods ; Fabaceae ; Fertilizers/analysis ; Lead/analysis ; Manure/analysis ; Mercury/analysis ; Metals, Heavy/analysis ; Sheep ; Soil ; Soil Pollutants/analysis ; Glycine max ; Swine ; Tea
    Chemische Substanzen Fertilizers ; Manure ; Metals, Heavy ; Soil ; Soil Pollutants ; Tea ; Cadmium (00BH33GNGH) ; Lead (2P299V784P) ; Mercury (FXS1BY2PGL)
    Sprache Chinesisch
    Erscheinungsdatum 2022-10-12
    Erscheinungsland China
    Dokumenttyp Journal Article
    ISSN 0250-3301
    ISSN 0250-3301
    DOI 10.13227/j.hjkx.202107120
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  6. Buch: Fan dui wang ming tou xiang zhu yi lu xian de dou zheng

    Shi, Feng

    (Zhong guo xian dai shi cong shu ; 中国現代史丛书)

    1976  

    Körperschaft Zhongguo gong chan dang
    Verfasserangabe Shi feng bian xie
    Serientitel Zhong guo xian dai shi cong shu
    中国現代史丛书
    Schlagwörter China
    Sprache Chinesisch
    Umfang 2, 106 pages, 19 cm
    Ausgabenhinweis Di 1 ban
    Verlag Shang hai ren min chu ban she
    Erscheinungsort Shang hai
    Dokumenttyp Buch
    Anmerkung Includes bibliographical references
    Datenquelle Ehemaliges Sondersammelgebiet Küsten- und Hochseefischerei

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  7. Artikel ; Online: Cathepsin-facilitated invasion of BMI1-high hepatocellular carcinoma cells drives bile duct tumor thrombi formation

    Lei-Bo Xu / Yu-Fei Qin / Liangping Su / Cheng Huang / Qiuping Xu / Rui Zhang / Xiang-De Shi / Ruipu Sun / Jiali Chen / Zhixiao Song / Xue Jiang / Lihuan Shang / Gang Xiao / Xiangzhan Kong / Chao Liu / Ping-Pui Wong

    Nature Communications, Vol 14, Iss 1, Pp 1-

    2023  Band 18

    Abstract: Abstract Bile duct tumor thrombosis (BDTT) is a complication mostly observed in patients with advanced hepatocellular carcinoma (HCC), causing jaundice and associated with poor clinical outcome. However, its underlying molecular mechanism is unclear. ... ...

    Abstract Abstract Bile duct tumor thrombosis (BDTT) is a complication mostly observed in patients with advanced hepatocellular carcinoma (HCC), causing jaundice and associated with poor clinical outcome. However, its underlying molecular mechanism is unclear. Here, we develop spontaneous preclinical HCC animal models with BDTT to identify the role of BMI1 expressing tumor initiating cells (BMI1high TICs) in inducing BDTT. BMI1 overexpression transforms liver progenitor cells into BMI1high TICs, which possess strong tumorigenicity and increased trans-intrahepatic biliary epithelial migration ability by secreting lysosomal cathepsin B (CTSB). Orthotopic liver implantation of BMI1high TICs into mice generates tumors and triggers CTSB mediated bile duct invasion to form tumor thrombus, while CTSB inhibitor treatment prohibits BDTT and extends mouse survival. Clinically, the elevated serum CTSB level determines BDTT incidence in HCC patients. Mechanistically, BMI1 epigenetically up-regulates CTSB secretion in TICs by repressing miR-218-1-3p expression. These findings identify a potential diagnostic and therapeutic target for HCC patients with BDTT.
    Schlagwörter Science ; Q
    Sprache Englisch
    Erscheinungsdatum 2023-11-01T00:00:00Z
    Verlag Nature Portfolio
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  8. Artikel ; Online: Cathepsin-facilitated invasion of BMI1-high hepatocellular carcinoma cells drives bile duct tumor thrombi formation.

    Xu, Lei-Bo / Qin, Yu-Fei / Su, Liangping / Huang, Cheng / Xu, Qiuping / Zhang, Rui / Shi, Xiang-De / Sun, Ruipu / Chen, Jiali / Song, Zhixiao / Jiang, Xue / Shang, Lihuan / Xiao, Gang / Kong, Xiangzhan / Liu, Chao / Wong, Ping-Pui

    Nature communications

    2023  Band 14, Heft 1, Seite(n) 7033

    Abstract: Bile duct tumor thrombosis (BDTT) is a complication mostly observed in patients with advanced hepatocellular carcinoma (HCC), causing jaundice and associated with poor clinical outcome. However, its underlying molecular mechanism is unclear. Here, we ... ...

    Abstract Bile duct tumor thrombosis (BDTT) is a complication mostly observed in patients with advanced hepatocellular carcinoma (HCC), causing jaundice and associated with poor clinical outcome. However, its underlying molecular mechanism is unclear. Here, we develop spontaneous preclinical HCC animal models with BDTT to identify the role of BMI1 expressing tumor initiating cells (BMI1
    Mesh-Begriff(e) Humans ; Animals ; Mice ; Carcinoma, Hepatocellular/metabolism ; Liver Neoplasms/metabolism ; Cathepsins ; Bile Duct Neoplasms/pathology ; Thrombosis/pathology ; Polycomb Repressive Complex 1/genetics ; MicroRNAs/genetics
    Chemische Substanzen Cathepsins (EC 3.4.-) ; BMI1 protein, human ; Polycomb Repressive Complex 1 (EC 2.3.2.27) ; MIRN218 microRNA, human ; MicroRNAs
    Sprache Englisch
    Erscheinungsdatum 2023-11-03
    Erscheinungsland England
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-023-42930-y
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  9. Artikel ; Online: Activation of the Notch1-c-myc-VCAM1 signalling axis initiates liver progenitor cell-driven hepatocarcinogenesis and pulmonary metastasis.

    Wu, Wen-Rui / Shi, Xiang-De / Zhang, Fa-Peng / Zhu, Ke / Zhang, Rui / Yu, Xian-Huan / Qin, Yu-Fei / He, Shun-Peng / Fu, Hou-Wei / Zhang, Lei / Zeng, Hong / Zhu, Man-Sheng / Xu, Lei-Bo / Wong, Ping-Pui / Liu, Chao

    Oncogene

    2022  Band 41, Heft 16, Seite(n) 2340–2356

    Abstract: The cellular origin of hepatocellular carcinomas (HCC) and the role of Notch1 signalling in HCC initiation are controversial. Herein, we establish Notch1 as a regulator of HCC development and progression. Clinically, high Notch1 expression correlates ... ...

    Abstract The cellular origin of hepatocellular carcinomas (HCC) and the role of Notch1 signalling in HCC initiation are controversial. Herein, we establish Notch1 as a regulator of HCC development and progression. Clinically, high Notch1 expression correlates with enhanced cancer progression, elevated lung metastasis, increased cancer stem cell (CSC)-like cells' gene signature expression, and poor overall survival in HCC patients. Notch1 intracellular domain (N1ICD) overexpression spontaneously transforms rat liver progenitor cells (LPC) into CSC-like cells (WB
    Mesh-Begriff(e) Animals ; Carcinogenesis/genetics ; Carcinoma, Hepatocellular/pathology ; Cell Line, Tumor ; Humans ; Liver Neoplasms/pathology ; Lung Neoplasms/genetics ; Rats ; Receptor, Notch1/metabolism ; Stem Cells/metabolism
    Chemische Substanzen NOTCH1 protein, human ; Notch1 protein, rat ; Receptor, Notch1
    Sprache Englisch
    Erscheinungsdatum 2022-03-07
    Erscheinungsland England
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 639046-8
    ISSN 1476-5594 ; 0950-9232
    ISSN (online) 1476-5594
    ISSN 0950-9232
    DOI 10.1038/s41388-022-02246-5
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  10. Artikel ; Online: Dickkopf-1 contributes to hepatocellular carcinoma tumorigenesis by activating the Wnt/β-catenin signaling pathway.

    Zhang, Rui / Lin, Hao-Ming / Broering, Ruth / Shi, Xiang-de / Yu, Xian-Huan / Xu, Lei-Bo / Wu, Wen-Rui / Liu, Chao

    Publikation ZURÜCKGEZOGEN

    Signal transduction and targeted therapy

    2019  Band 4, Seite(n) 54

    Abstract: Dysregulation of dickkopf-related protein 1 (DKK1) expression has been reported in a variety of human cancers. We previously reported that DKK1 was upregulated in hepatocellular carcinoma (HCC). However, the role of DKK1 in HCC remains unclear. This ... ...

    Abstract Dysregulation of dickkopf-related protein 1 (DKK1) expression has been reported in a variety of human cancers. We previously reported that DKK1 was upregulated in hepatocellular carcinoma (HCC). However, the role of DKK1 in HCC remains unclear. This study aimed to investigate the clinical significance and biological functions of DKK1 in HCC. The expression of DKK1 was examined in cirrhotic and HCC tissues by immunohistochemistry and quantitative real-time polymerase chain reaction (qRT-PCR). DKK1 was silenced or overexpressed in HCC cell lines, and in vitro and in vivo studies were performed. Immunohistochemistry revealed that DKK1 was weakly expressed in cirrhotic tissues (8/22, 36.4%) but upregulated in HCC tissues (48/53, 90.6%, cohort 1). Significant upregulation of DKK1 was observed in 57.6% (19/33, cohort 2) of HCC tissues by qRT-PCR, and the expression of DKK1 was associated with tumor size (
    Sprache Englisch
    Erscheinungsdatum 2019-12-06
    Erscheinungsland England
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't ; Retracted Publication
    ZDB-ID 2886872-9
    ISSN 2059-3635 ; 2095-9907
    ISSN (online) 2059-3635
    ISSN 2095-9907
    DOI 10.1038/s41392-019-0082-5
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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