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Article: Editorial: Reproductive Events in Women With Mood Disorders: Advances in Knowledge and Management.

Rosso, Gianluca / Chandra, Prabha S

2021 Volume 12, Page(s) 767983

Language	English
Publishing date	2021-11-30
Publishing country	Switzerland
Document type	Editorial
ZDB-ID	2564218-2
ISSN	1664-0640
ISSN	1664-0640
DOI	10.3389/fpsyt.2021.767983
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Article ; Online: Efficacy and suitability of adding short-term psychodynamic psychotherapy (STPP) to pharmacotherapy in patients with depressive disorders: a systematic review.

Di Salvo, Gabriele / Perotti, Camilla / Ricci, Valerio / Maina, Giuseppe / Rosso, Gianluca

Trends in psychiatry and psychotherapy

2024

Abstract: Introduction: Recent guidelines on depressive disorders suggest a combination of antidepressants and psychotherapy in case of moderate to severe symptomatology. While cognitive behavioral therapy and interpersonal therapy are the most investigated ... ...

Abstract	Introduction: Recent guidelines on depressive disorders suggest a combination of antidepressants and psychotherapy in case of moderate to severe symptomatology. While cognitive behavioral therapy and interpersonal therapy are the most investigated interventions, psychodynamic psychotherapies have been less explored. Objective: The aim of this paper is to systematically review literature data on the efficacy of shortterm psychodynamic psychotherapy (STPP) in combination with antidepressants in the treatment of depressive disorders, focusing both on short and on long-term results and on potential moderators that could influence its effectiveness. Methods: The systematic review was conducted using the PRISMA guidelines. Databases searched were PubMed, Ovid, Scopus, and Cochrane Library, from inception to August 2023. Results: Adding STPP to medications in the first six months of treatment didn't influence remission rates, but improved acceptability, work adjustment, interpersonal relationships, social role functioning, hospitalization rates and cost-effectiveness. After 12 months, a significant difference in remission rates arised, favouring combined therapy. In a long-term perspective, adding STPP to pharmacotherapy reduced the recurrence rate by almost 50%. STPP has proven to be more effective in longer depressive episodes, in more severe depressions and in patients with a childhood abuse history. Instead, STPP had no impact on major depressive disorder with comorbid Obsessive-Compulsive Disorder (OCD). Conclusions: Combining STPP with antidepressants appeared to be helpful both in a short-term and in a long-term perspective. Still, there are few rigorous studies with large samples and further research is needed to identify which subgroups of patients may benefit more from STPP.
Language	English
Publishing date	2024-04-30
Publishing country	Brazil
Document type	Journal Article
ZDB-ID	2708374-3
ISSN	2238-0019 ; 2238-0019
ISSN (online)	2238-0019
ISSN	2238-0019
DOI	10.47626/2237-6089-2023-0764
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Article: Paliperidone Palmitate: A Breakthrough Treatment for Schizophrenia? A Review on Patient Adherence Levels, Healthcare Resource Utilization and Costs.

Bramante, Stefano / Di Salvo, Gabriele / Maina, Giuseppe / Rosso, Gianluca

Neuropsychiatric disease and treatment

2023 Volume 19, Page(s) 519–530

Abstract: International guidelines suggest long-term antipsychotic therapies for treating schizophrenia; however, medication compliance remains a critical issue in schizophrenia. Paliperidone palmitate (PP) is a second-generation antipsychotic long-acting ... ...

Abstract	International guidelines suggest long-term antipsychotic therapies for treating schizophrenia; however, medication compliance remains a critical issue in schizophrenia. Paliperidone palmitate (PP) is a second-generation antipsychotic long-acting injectable (SGA-LAI) approved for the treatment of schizophrenia. To date, the majority of studies on PP compliance patterns did not use specific instruments to assess medications' adherence, have been performed in not naturalistic samples and present partially overlapping populations. We conducted a systematic review in which we aimed to review the current knowledge on PP-LAI adherence levels and to describe healthcare resource utilisation and costs related to PP-LAI treatment. The evaluation has been conducted by searching in different databases (PubMed, Ovid, Scopus, and Cochrane Library) from inception to September 2022. Our findings suggest that paliperidone palmitate should be considered a good treatment strategy for patients affected by schizophrenia: PP showed both a good efficacy and tolerability and better adherence patterns and more favourable healthcare resource utilisation and costs, compared to OA.
Language	English
Publishing date	2023-03-07
Publishing country	New Zealand
Document type	Journal Article ; Review
ZDB-ID	2186503-6
ISSN	1178-2021 ; 1176-6328
ISSN (online)	1178-2021
ISSN	1176-6328
DOI	10.2147/NDT.S374696
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Article ; Online: Assessing Adult ADHD Through Objective Neuropsychological Measures: A Critical Overview.

Rosso, Gianluca / Portaluppi, Caterina / Teobaldi, Elena / Di Salvo, Gabriele / Maina, Giuseppe

Journal of attention disorders

2023 Volume 27, Issue 7, Page(s) 786–794

Abstract: Objective: This review examines the role of neuropsychological tests in the diagnostic assessment of adult ADHD, focusing on their ability to discriminate individuals with ADHD from those with other psychiatric conditions.: Method: PubMed, Embase, ... ...

Abstract	Objective: This review examines the role of neuropsychological tests in the diagnostic assessment of adult ADHD, focusing on their ability to discriminate individuals with ADHD from those with other psychiatric conditions. Method: PubMed, Embase, and PsycINFO were searched for eligible peer-reviewed studies from inception to September 2022. Results: Ten studies were included. Among the objective measures analyzed, Continuous Performance Tests were the only capable to reliably distinguish individuals with ADHD from other psychiatric patients, in a combined approach with clinical interview instruments. The other objective tests showed mixed and inconsistent results. Conclusion: This finding suggest that further studies are needed to develop objective measures more tailored to the core symptoms of ADHD, in order to improve the discriminatory ability of the tests and help the clinicians in the complex differential diagnosis between ADHD and other psychiatric disorders.
MeSH term(s)	Humans ; Adult ; Attention Deficit Disorder with Hyperactivity/diagnosis ; Attention Deficit Disorder with Hyperactivity/psychology ; Neuropsychological Tests ; Diagnosis, Differential
Language	English
Publishing date	2023-04-11
Publishing country	United States
Document type	Review ; Journal Article
ZDB-ID	2004350-8
ISSN	1557-1246 ; 1087-0547
ISSN (online)	1557-1246
ISSN	1087-0547
DOI	10.1177/10870547231167564
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Article ; Online: Cariprazine Augmentation in Treatment-Resistant Bipolar Depression: Data from a Retrospective Observational Study.

Teobaldi, Elena / Pessina, Enrico / Martini, Azzurra / Cattaneo, Carlo Ignazio / De Berardis, Domenico / Martiadis, Vassilis / Maina, Giuseppe / Rosso, Gianluca

Current neuropharmacology

2024

Abstract: Background: Treatment-resistant bipolar depression is one of the leading problems in psychiatry with serious consequences on patients functioning, quality of life and resource utilization. Despite this, there is a lack of consensus on diagnostic ... ...

Abstract	Background: Treatment-resistant bipolar depression is one of the leading problems in psychiatry with serious consequences on patients functioning, quality of life and resource utilization. Despite this, there is a lack of consensus on diagnostic criteria and treatment algorithms. Objective: The objective of the present study is to assess the acute effectiveness and tolerability of cariprazine in the management of treatment resistant bipolar depression. Methods: This is a four weeks retrospective multicentric observational study on patients with treatment resistant bipolar depression receiving cariprazine in augmentation to the current treatment. Cariprazine dosage changed during the follow-up period according to clinical judgment. Since data followed a non-normal distribution, non-parametric tests were used to pursue the analysis. The effectiveness of cariprazine was assessed through the mean change in Hamilton Depression rating scale (HAM-D) scores from baseline to endpoint. For missing values, a "Last Observation Carried Forward" approach was applied. Results: Fifty-one patients were enrolled. Four patients (7.8%) discontinued cariprazine mainly due to adverse events. Mean cariprazine dose was 1.7 mg/day. The mean HAM-D score decreased significantly from baseline (T0) to week 4 (T4) at each evaluation point. Fourty-five.one per cent of the patients benefited of cariprazine add-on strategy: 23.5% achieved a clinical response and 21.6% were remitters. Among the completers, 70.6% experienced at least one adverse event. All side effects were mild to moderate. Conclusion: Cariprazine seems to be an effective and well tolerated option in the management of patients with treatment resistant bipolar depression.
Language	English
Publishing date	2024-01-29
Publishing country	United Arab Emirates
Document type	Journal Article
ZDB-ID	2192352-8
ISSN	1875-6190 ; 1570-159X
ISSN (online)	1875-6190
ISSN	1570-159X
DOI	10.2174/1570159X22666240129095852
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Article: Correlates of long duration of untreated illness (DUI) in patients with bipolar disorder: results of an observational study.

Di Salvo, Gabriele / Porceddu, Giorgia / Albert, Umberto / Maina, Giuseppe / Rosso, Gianluca

Annals of general psychiatry

2023 Volume 22, Issue 1, Page(s) 12

Abstract: Background: Despite a high number of studies investigating the correlation between long Duration of Untreated Illness (DUI) and poor course of Bipolar Disorder (BD), the results concerning the impact of DUI on some specific factors, such as suicidality ... ...

Abstract	Background: Despite a high number of studies investigating the correlation between long Duration of Untreated Illness (DUI) and poor course of Bipolar Disorder (BD), the results concerning the impact of DUI on some specific factors, such as suicidality and medical comorbidities, are still inconsistent. This cross-sectional observational study aimed at analyzing potential socio-demographic and clinical correlates of long DUI in a large cohort of real-world, well-characterized BD patients. Methods: The socio-demographic and clinical characteristics of 897 patients with BD were collected. The sample was divided for analysis in two groups (short DUI vs long DUI) according to a DUI cutoff of 2 years. Comparisons were performed using χ Results: Six-hundred and sixty patients (75.5%) presented long DUI (> 2 years) and mean DUI was 15.7 years. The LogReg analysis confirmed the association of long DUI with bipolar II disorder (p: 0.016), lower age at onset (p < 0.001), depressive predominant polarity (p: 0.018), depressive polarity onset (p < 0.001), longer duration of illness (p < 0.001), lifetime suicide attempts (p: 0.045) and current medical comorbidities (p: 0.019). Conclusions: The present study confirms the association between long DUI and higher risk of suicide attempts in patients with BD. Moreover, an association between long DUI and higher rates of medical conditions has been found.
Language	English
Publishing date	2023-03-23
Publishing country	England
Document type	Journal Article
ZDB-ID	2090401-0
ISSN	1744-859X ; 1475-2832
ISSN	1744-859X ; 1475-2832
DOI	10.1186/s12991-023-00442-5
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Article ; Online: Prevalence and Correlates of Serotonin Syndrome in Real-World Inpatients.

Di Salvo, Gabriele / Porceddu, Giorgia / Perotti, Camilla / Maina, Giuseppe / Rosso, Gianluca

Journal of clinical psychopharmacology

2023 Volume 44, Issue 1, Page(s) 25–29

Abstract: Background: Serotonin syndrome (SS) is a potentially life-threatening adverse drug reaction due to an increased central and peripheral serotonin activity, which usually presents as a triad of behavioral changes, neuromuscular excitability, and autonomic ...

Abstract	Background: Serotonin syndrome (SS) is a potentially life-threatening adverse drug reaction due to an increased central and peripheral serotonin activity, which usually presents as a triad of behavioral changes, neuromuscular excitability, and autonomic instability. Probably SS is often misdiagnosed, and its symptoms are mistaken for psychiatric symptoms or general medical issues: the true incidence of SS is not clear, and literature concerning potential risk factors is scarce. Our aims were to examine the prevalence of SS in a naturalistic sample of hospitalized patients and to evaluate potential factors related to the risk of developing the condition. Methods: The sample included 133 patients being treated with serotonergic medications admitted to the psychiatric inpatient unit of the San Luigi Gonzaga Hospital. All patients received a medical examination (including a neurological examination) within 24 hours of admission. Serotonin syndrome was diagnosed according to Hunter Criteria. Results: Sixteen patients (12%) were diagnosed with SS. In the subgroup of subjects with SS, we found a higher rate of male patients when compared with subjects with no SS (62.5% vs 33.3%, P = 0.023). Conclusions: SS probably is an underestimated condition, which should be carefully assessed in patients on serotonergic medications. Male gender was the only factor found to be significantly related to a higher risk of developing SS. Further studies on larger samples are needed, to gain more information on possible risk factors and to identify subjects more prone to developing SS, given the potential risk for patients' health.
MeSH term(s)	Humans ; Male ; Serotonin Syndrome/chemically induced ; Serotonin Syndrome/diagnosis ; Serotonin Syndrome/epidemiology ; Inpatients ; Prevalence ; Serotonin Agents/adverse effects ; Risk Factors
Chemical Substances	Serotonin Agents
Language	English
Publishing date	2023-11-29
Publishing country	United States
Document type	Journal Article
ZDB-ID	604631-9
ISSN	1533-712X ; 0271-0749
ISSN (online)	1533-712X
ISSN	0271-0749
DOI	10.1097/JCP.0000000000001798
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Article ; Online: Did COVID-19 early lockdown actually lead to a higher rate of relapses in psychiatric patients?

Rosso, Gianluca / Teobaldi, Elena / Maina, Giuseppe

Psychiatry research

2020 Volume 291, Page(s) 113204

Keywords	covid19
Language	English
Publishing date	2020-06-08
Publishing country	Ireland
Document type	Letter
ZDB-ID	445361-x
ISSN	1872-7123 ; 1872-7506 ; 0925-4927 ; 0165-1781
ISSN (online)	1872-7123 ; 1872-7506
ISSN	0925-4927 ; 0165-1781
DOI	10.1016/j.psychres.2020.113204
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Article ; Online: Inhaled Loxapine as an Option for Psychomotor Agitation in Complex Patients.

Rosso, Gianluca / Teobaldi, Elena / Maina, Giuseppe

Journal of clinical psychopharmacology

2020 Volume 40, Issue 6, Page(s) 645–647

MeSH term(s)	Adult ; Antipsychotic Agents/adverse effects ; Humans ; Loxapine/adverse effects ; Male ; Middle Aged ; Motor Activity/drug effects ; Psychomotor Agitation/diagnosis ; Psychomotor Agitation/drug therapy ; Psychomotor Agitation/physiopathology ; Psychomotor Agitation/psychology ; Remission Induction ; Treatment Outcome
Chemical Substances	Antipsychotic Agents ; Loxapine (LER583670J)
Language	English
Publishing date	2020-10-15
Publishing country	United States
Document type	Letter ; Observational Study
ZDB-ID	604631-9
ISSN	1533-712X ; 0271-0749
ISSN (online)	1533-712X
ISSN	0271-0749
DOI	10.1097/JCP.0000000000001290
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Article ; Online: The Rational Design of Reducing Organophotoredox Catalysts Unlocks Proton-Coupled Electron-Transfer and Atom Transfer Radical Polymerization Mechanisms.

Bortolato, Tommaso / Simionato, Gianluca / Vayer, Marie / Rosso, Cristian / Paoloni, Lorenzo / Benetti, Edmondo M / Sartorel, Andrea / Lebœuf, David / Dell'Amico, Luca

Journal of the American Chemical Society

2023 Volume 145, Issue 3, Page(s) 1835–1846

Abstract: Photocatalysis has become a prominent tool in the arsenal of organic chemists to develop and (re)imagine transformations. However, only a handful of versatile organic photocatalysts (PCs) are available, hampering the discovery of new reactivities. Here, ... ...

Abstract	Photocatalysis has become a prominent tool in the arsenal of organic chemists to develop and (re)imagine transformations. However, only a handful of versatile organic photocatalysts (PCs) are available, hampering the discovery of new reactivities. Here, we report the design and complete physicochemical characterization of 9-aryl dihydroacridines (9ADA) and 12-aryl dihydrobenzoacridines (12ADBA) as strong reducing organic PCs. Punctual structural variations modulate their molecular orbital distributions and unlock locally or charge-transfer (CT) excited states. The PCs presenting a locally excited state showed better performances in photoredox defunctionalization processes (yields up to 92%), whereas the PCs featuring a CT excited state produced promising results in atom transfer radical polymerization under visible light (up to 1.21
Language	English
Publishing date	2023-01-06
Publishing country	United States
Document type	Journal Article
ZDB-ID	3155-0
ISSN	1520-5126 ; 0002-7863
ISSN (online)	1520-5126
ISSN	0002-7863
DOI	10.1021/jacs.2c11364
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