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  1. Article ; Online: Multiple sclerosis: is it all black and white in optical coherence tomography?

    Aly, Lilian / Korn, Thomas

    Brain : a journal of neurology

    2018  Volume 141, Issue 11, Page(s) 3088–3091

    MeSH term(s) African Americans ; Atrophy ; Brain ; Humans ; Longitudinal Studies ; Multiple Sclerosis ; Tomography, Optical Coherence ; United States
    Language English
    Publishing date 2018-10-19
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 80072-7
    ISSN 1460-2156 ; 0006-8950
    ISSN (online) 1460-2156
    ISSN 0006-8950
    DOI 10.1093/brain/awy269
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  2. Article ; Online: COVID-19 distresses the depressed while schizophrenic patients are unimpressed: A study on psychiatric inpatients.

    Hölzle, Patricia / Aly, Lilian / Frank, Wolfgang / Förstl, Hans / Frank, Andreas

    Psychiatry research

    2020  Volume 291, Page(s) 113175

    Keywords covid19
    Language English
    Publishing date 2020-06-05
    Publishing country Ireland
    Document type Letter
    ZDB-ID 445361-x
    ISSN 1872-7123 ; 1872-7506 ; 0925-4927 ; 0165-1781
    ISSN (online) 1872-7123 ; 1872-7506
    ISSN 0925-4927 ; 0165-1781
    DOI 10.1016/j.psychres.2020.113175
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  3. Article ; Online: Rapamycin rescues loss of function in blood-brain barrier-interacting Tregs.

    Baeten, Paulien / Hamad, Ibrahim / Hoeks, Cindy / Hiltensperger, Michael / Van Wijmeersch, Bart / Popescu, Veronica / Aly, Lilian / Somers, Veerle / Korn, Thomas / Kleinewietfeld, Markus / Hellings, Niels / Broux, Bieke

    JCI insight

    2024  Volume 9, Issue 7

    Abstract: In autoimmunity, FOXP3+ Tregs skew toward a proinflammatory, nonsuppressive phenotype and are, therefore, unable to control the exaggerated autoimmune response. This largely affects the success of autologous Treg therapy, which is currently under ... ...

    Abstract In autoimmunity, FOXP3+ Tregs skew toward a proinflammatory, nonsuppressive phenotype and are, therefore, unable to control the exaggerated autoimmune response. This largely affects the success of autologous Treg therapy, which is currently under investigation for autoimmune diseases, including multiple sclerosis (MS). There is a need to ensure in vivo Treg stability before successful application of Treg therapy. Using genetic fate-mapping mice, we demonstrate that inflammatory, cytokine-expressing exFOXP3 T cells accumulate in the CNS during experimental autoimmune encephalomyelitis. In a human in vitro model, we discovered that interaction with inflamed blood-brain barrier endothelial cells (BBB-ECs) induces loss of function by Tregs. Transcriptome and cytokine analysis revealed that in vitro migrated Tregs have disrupted regenerative potential and a proinflammatory Th1/17 signature, and they upregulate the mTORC1 signaling pathway. In vitro treatment of migrated human Tregs with the clinically approved mTORC1 inhibitor rapamycin restored suppression. Finally, flow cytometric analysis indicated an enrichment of inflammatory, less-suppressive CD49d+ Tregs in the cerebrospinal fluid of people with MS. In summary, interaction with BBB-ECs is sufficient to affect Treg function, and transmigration triggers an additive proinflammatory phenotype switch. These insights help improve the efficacy of autologous Treg therapy of MS.
    MeSH term(s) Humans ; Mice ; Animals ; Sirolimus/pharmacology ; Blood-Brain Barrier/metabolism ; T-Lymphocytes, Regulatory ; Endothelial Cells/metabolism ; Autoimmune Diseases ; Cytokines/metabolism ; Multiple Sclerosis/drug therapy ; Mechanistic Target of Rapamycin Complex 1/metabolism
    Chemical Substances Sirolimus (W36ZG6FT64) ; Cytokines ; Mechanistic Target of Rapamycin Complex 1 (EC 2.7.11.1)
    Language English
    Publishing date 2024-04-08
    Publishing country United States
    Document type Journal Article
    ISSN 2379-3708
    ISSN (online) 2379-3708
    DOI 10.1172/jci.insight.167457
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  4. Article ; Online: Aquaporin-4 prevents exaggerated astrocytosis and structural damage in retinal inflammation.

    Maisam Afzali, Ali / Stüve, Lasse / Pfaller, Monika / Aly, Lilian / Steiger, Katja / Knier, Benjamin / Korn, Thomas

    Journal of molecular medicine (Berlin, Germany)

    2022  Volume 100, Issue 6, Page(s) 933–946

    Abstract: Aquaporin-4 (AQP4) is the molecular target of the immune response in neuromyelitis optica (NMO) that leads to severe structural damage in the central nervous system (CNS) and in the retina. Conversely, AQP4 might be upregulated in astrocytes as a ... ...

    Abstract Aquaporin-4 (AQP4) is the molecular target of the immune response in neuromyelitis optica (NMO) that leads to severe structural damage in the central nervous system (CNS) and in the retina. Conversely, AQP4 might be upregulated in astrocytes as a compensatory event in multiple sclerosis. Thus, the functional relevance of AQP4 in neuroinflammation needs to be defined. Here, we tested the role of AQP4 in the retina in MOG(35-55)-induced experimental autoimmune encephalomyelitis (EAE) using optical coherence tomography (OCT), OCT angiography, immunohistology, flow cytometry, and gene expression analysis in wild-type and Aqp4
    MeSH term(s) Albumins/metabolism ; Animals ; Aquaporin 4/genetics ; Aquaporin 4/metabolism ; Cicatrix/pathology ; Encephalomyelitis, Autoimmune, Experimental ; Gliosis/metabolism ; Gliosis/pathology ; Inflammation/metabolism ; Mice ; Retina/metabolism
    Chemical Substances Albumins ; Aquaporin 4
    Language English
    Publishing date 2022-05-10
    Publishing country Germany
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1223802-8
    ISSN 1432-1440 ; 0946-2716
    ISSN (online) 1432-1440
    ISSN 0946-2716
    DOI 10.1007/s00109-022-02202-6
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  5. Book ; Thesis: Characterization of JC virus-specific CD4+ T cell epitopes in healthy individuals

    Aly, Lilian Marlene

    2013  

    Author's details vorgelegt von Lilian Marlene Aly
    Language English
    Size Bl. 3393 - 3408, 25 Bl., Ill., graph. Darst.
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Univ., FB Medizin, Diss.--Hamburg, 2014
    Note Enth. 1 Zeitschriftenart.
    Database Former special subject collection: coastal and deep sea fishing

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  6. Article: COVID-19 distresses the depressed while schizophrenic patients are unimpressed: A study on psychiatric inpatients

    Hölzle, Patricia / Aly, Lilian / Frank, Wolfgang / Förstl, Hans / Frank, Andreas

    Psychiatry Res

    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #548200
    Database COVID19

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  7. Article ; Online: COVID-19 distresses the depressed while schizophrenic patients are unimpressed

    Hölzle, Patricia / Aly, Lilian / Frank, Wolfgang / Förstl, Hans / Frank, Andreas

    Psychiatry Research

    A study on psychiatric inpatients

    2020  Volume 291, Page(s) 113175

    Keywords Biological Psychiatry ; Psychiatry and Mental health ; covid19
    Language English
    Publisher Elsevier BV
    Publishing country us
    Document type Article ; Online
    ZDB-ID 445361-x
    ISSN 1872-7123 ; 1872-7506 ; 0925-4927 ; 0165-1781
    ISSN (online) 1872-7123 ; 1872-7506
    ISSN 0925-4927 ; 0165-1781
    DOI 10.1016/j.psychres.2020.113175
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: Association of retinal vessel pathology and brain atrophy in relapsing-remitting multiple sclerosis.

    Romahn, Eva Feodora / Wiltgen, Tun / Bussas, Matthias / Aly, Lilian / Wicklein, Rebecca / Noll, Christina / Berthele, Achim / Dehmelt, Vera / Mardin, Christian / Zimmer, Claus / Korn, Thomas / Hemmer, Bernhard / Kirschke, Jan S / Mühlau, Mark / Knier, Benjamin

    Frontiers in immunology

    2023  Volume 14, Page(s) 1284986

    Abstract: Background: Optical coherence tomography angiography (OCTA) allows non-invasive assessment of retinal vessel structures. Thinning and loss of retinal vessels is evident in eyes of patients with multiple sclerosis (MS) and might be associated with a ... ...

    Abstract Background: Optical coherence tomography angiography (OCTA) allows non-invasive assessment of retinal vessel structures. Thinning and loss of retinal vessels is evident in eyes of patients with multiple sclerosis (MS) and might be associated with a proinflammatory disease phenotype and worse prognosis. We investigated whether changes of the retinal vasculature are linked to brain atrophy and disability in MS.
    Material and methods: This study includes one longitudinal observational cohort (n=79) of patients with relapsing-remitting MS. Patients underwent annual assessment of the expanded disability status scale (EDSS), timed 25-foot walk, symbol digit modalities test (SDMT), retinal optical coherence tomography (OCT), OCTA, and brain MRI during a follow-up duration of at least 20 months. We investigated intra-individual associations between changes in the retinal architecture, vasculature, brain atrophy and disability. Eyes with a history of optic neuritis (ON) were excluded.
    Results: We included 79 patients with a median disease duration of 12 (interquartile range 2 - 49) months and a median EDSS of 1.0 (0 - 2.0). Longitudinal retinal axonal and ganglion cell loss were linked to grey matter atrophy, cortical atrophy, and volume loss of the putamen. We observed an association between vessel loss of the superficial vascular complex (SVC) and both grey and white matter atrophy. Both observations were independent of retinal ganglion cell loss. Moreover, patients with worsening of the EDSS and SDMT revealed a pronounced longitudinal rarefication of the SVC and the deep vascular complex.
    Discussion: ON-independent narrowing of the retinal vasculature might be linked to brain atrophy and disability in MS. Our findings suggest that retinal OCTA might be a new tool for monitoring neurodegeneration during MS.
    MeSH term(s) Humans ; Atrophy ; Brain/diagnostic imaging ; Brain/pathology ; Central Nervous System Diseases/pathology ; Multiple Sclerosis/pathology ; Multiple Sclerosis, Relapsing-Remitting/pathology ; Neurodegenerative Diseases/pathology ; Optic Neuritis/diagnostic imaging ; Optic Neuritis/pathology ; Retina/diagnostic imaging ; Retina/pathology ; Retinal Vessels/diagnostic imaging ; Retinal Vessels/pathology ; Longitudinal Studies
    Language English
    Publishing date 2023-11-28
    Publishing country Switzerland
    Document type Observational Study ; Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2023.1284986
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  9. Book ; Online ; Thesis: Characterization of JC virus-specific CD4+ T cell epitopes in healthy individuals

    Aly, Lilian Marlene / Martin, Roland

    2014  

    Title variant Charakterisierung JC Virus-spezifischer CD4+ T Zell Epitope in Gesunden
    Author's details Lilian Marlene Aly. Betreuer: Roland Martin
    Language English
    Size Online-Ressource
    Publisher Staats- und Universitätsbibliothek Hamburg
    Publishing place Hamburg
    Document type Book ; Online ; Thesis
    Thesis / German Habilitation thesis Univ. Hamburg, FB Medizin, Diss.--Hamburg, 2014
    Database Former special subject collection: coastal and deep sea fishing

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  10. Article ; Online: Technical Variations and Considerations around OAGB in IFSO-APC and IFSO-MENAC Chapters, an Expert Survey.

    Kermansaravi, Mohammad / Shahmiri, Shahab Shahabi / Kow, Lilian / Gawdat, Khaled / Abbas, Syed Imran / Aly, Ahmad / Bashir, Ahmad / Bhandari, Mohit / Haddad, Ashraf / ElFawal, Mohamad Hayssam / Inam, Atif / Kasama, Kazunori / Kim, Sang Hyun / Kular, Kuldeepak Singh / Lakdawala, Muffazal / Layani, Laurent Abram / Lee, Wei-Jei / Pazouki, Abdolreza / Prasad, Arun /
    Safadi, Bassem / Wang, Cunchuan / Yang, Wah / Adib, Reza / Jazi, Amir Hossein Davarpanah / Shabbir, Asim

    Obesity surgery

    2024  

    Abstract: Objective: This study aimed to evaluate the technical variations of one-anastomosis gastric bypass (OAGB) among IFSO-APC and MENAC experts.: Background: The multitude of technical variations and patient selection challenges among metabolic and ... ...

    Abstract Objective: This study aimed to evaluate the technical variations of one-anastomosis gastric bypass (OAGB) among IFSO-APC and MENAC experts.
    Background: The multitude of technical variations and patient selection challenges among metabolic and bariatric surgeons worldwide necessitates a heightened awareness of these issues. Understanding different perspectives and viewpoints can empower surgeons performing OAGB to adapt their techniques, leading to improved outcomes and reduced complications.
    Methods: The scientific team of IFSO-APC, consisting of skilled bariatric and metabolic surgeons specializing in OAGB, conducted a confidential online survey. The survey aimed to assess technical variations and considerations related to OAGB within the IFSO-APC and IFSO-MENAC chapters. A total of 85 OAGB experts participated in the survey, providing their responses through a 35-question online format. The survey took place from January 1, 2024, to February 15, 2024.
    Results: Most experts do not perform OAGB for children and adolescents younger than 18 years. Most experts create the gastric pouch over a 36-40-F bougie and prefer to create a gastrojejunostomy, at the posterior wall of the gastric pouch. An anti-reflux suture during OAGB is performed in all patients by 51.8% of experts. Most experts set a common limb length of > 4 m in revisional and conversional OAGBs to prevent nutritional complications.
    Conclusion: The ongoing debate among metabolic and bariatric surgeons regarding the technical variations and patient selection in OAGB remains a significant point of discussion. This survey demonstrated the variations in technical aspects and patient selection for OAGB among MBS surgeons in the IFSO-APC and IFSO-MENAC chapters. Standardizing the OAGB technique is crucial to ensure optimal safety and efficacy in this procedure.
    Language English
    Publishing date 2024-04-25
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1070827-3
    ISSN 1708-0428 ; 0960-8923
    ISSN (online) 1708-0428
    ISSN 0960-8923
    DOI 10.1007/s11695-024-07239-9
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