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Article: Adhesion Studies during Generative Hybridization of Textile-Reinforced Thermoplastic Composites via Additive Manufacturing.

Maier, Johanna / Vogel, Christian / Lebelt, Tobias / Geske, Vinzenz / Behnisch, Thomas / Modler, Niels / Gude, Maik

2021 Volume 14, Issue 14

Abstract: Generative hybridization enables the efficient production of lightweight structures by combining classic manufacturing processes with additive manufacturing technologies. This type of functionalization process allows components with high geometric ... ...

Abstract	Generative hybridization enables the efficient production of lightweight structures by combining classic manufacturing processes with additive manufacturing technologies. This type of functionalization process allows components with high geometric complexity and high mechanical properties to be produced efficiently in small series without the need for additional molds. In this study, hybrid specimens were generated by additively depositing PA6 (polyamide 6) via fused layer modeling (FLM) onto continuous woven fiber GF/PA6 (glass fiber/polyamide 6) flat preforms. Specifically, the effects of surface pre-treatment and process-induced surface interactions were investigated using optical microscopy for contact angle measurements as well as laser profilometry and thermal analytics. The bonding characteristic at the interface was evaluated via quasi-static tensile pull-off tests. Results indicate that both the bond strength and corresponding failure type vary with pre-treatment settings and process parameters during generative hybridization. It is shown that both the base substrate temperature and the FLM nozzle distance have a significant influence on the adhesive tensile strength. In particular, it can be seen that surface activation by plasma can significantly improve the specific adhesion in generative hybridization.
Language	English
Publishing date	2021-07-12
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2487261-1
ISSN	1996-1944
ISSN	1996-1944
DOI	10.3390/ma14143888
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Hydrogen permeability of thermoplastic composites and liner systems for future mobility applications

Condé-Wolter, Jan / Ruf, Michael G. / Liebsch, Alexander / Lebelt, Tobias / Koch, Ilja / Drechsler, Klaus / Gude, Maik

Composites Part A. 2023 Apr., v. 167 p.107446-

2023

Abstract: High pressure hydrogen permeation tests were carried out and specific permeation rates of various thermoplastic matrix materials have been measured as well as of continuous fiber reinforced thermoplastic composites (PA6, PA12, PA410, PPA, PPS), ... ...

Abstract	High pressure hydrogen permeation tests were carried out and specific permeation rates of various thermoplastic matrix materials have been measured as well as of continuous fiber reinforced thermoplastic composites (PA6, PA12, PA410, PPA, PPS), considering non-crimp and crimp textile architectures. Furthermore, liners based on thermoplastic high barrier films made of EVOH were applied on PA6 composites and their effect on permeation rate were investigated. All samples were accompanied by pressure tightness tests and micrographs to determine manufacturing effects, microstructure, porosity and additional defects like microcracks. Experiments show that thermoplastic composites can reach low permeation rate as long as a damage-free microstructure is ensured. Furthermore, the influence of the matrix material can be assessed, whereby the influence of the textile architecture can only be roughly estimated and is considered to be small. EVOH layers show remarkable barrier properties and are easy to integrate into the composite structure.
Keywords	fabrics ; hydrogen ; microstructure ; permeability ; porosity ; thermoplastics ; Hydrogen permeation ; Thermoplastic composites ; Liner ; EVOH
Language	English
Dates of publication	2023-04
Publishing place	Elsevier Ltd
Document type	Article ; Online
Note	Use and reproduction
ZDB-ID	2012223-8
ISSN	1359-835X
ISSN	1359-835X
DOI	10.1016/j.compositesa.2023.107446
Database	NAL-Catalogue (AGRICOLA)

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Article: Simultaneous detection and quantification of six equine cytokines in plasma using a fluorescent microsphere immunoassay (FMIA).

Hall, Sarah A / Stucke, Diana / Morrone, Beatrice / Lebelt, Dirk / Zanella, Adroaldo J

MethodsX

2015 Volume 2, Page(s) 241–248

Abstract: Cytokines are cell signalling proteins that mediate a number of different physiological responses. They are also biomarkers for inflammatory conditions and potential diagnostic references for diseases. Until recently, simultaneous quantification of ... ...

Abstract	Cytokines are cell signalling proteins that mediate a number of different physiological responses. They are also biomarkers for inflammatory conditions and potential diagnostic references for diseases. Until recently, simultaneous quantification of cytokine profiles had not been possible. Now however, fluorescent microsphere immunoassays (FMIA) are able to measure multiple cytokines in a single sample. The following pro-inflammatory and anti-inflammatory cytokines were quantified in equine plasma and serum samples: interleukin (IL)-2, IL-4, IL-6, IL-10, interferon (IFN)-γ, tumor necrosis factor (TNF)-α. •The objective of this study was to quantify six equine cytokines simultaneously using the BioPlex(®) 200 system in equine EDTA-plasma and serum.•It demonstrates an increased number of detectable cytokines over published studies.•This technology has the advantage of reduced sample volume and assay time compared to traditional sandwich ELISAs.
Language	English
Publishing date	2015-04-25
Publishing country	Netherlands
Document type	Journal Article
ISSN	2215-0161
ISSN	2215-0161
DOI	10.1016/j.mex.2015.04.002
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Article ; Online: Survivin, caspase-3 and MIB-1 expression in astrocytic tumors of various grades.

Lebelt, Agnieszka / Rutkowski, Robert / Och, Waldemar / Jaczun, Kamil / Dziemiańczyk-Pakieła, Dorota / Milewski, Robert / Mariak, Zenon / Reszeć, Joanna

Advances in medical sciences

2016 Volume 61, Issue 2, Page(s) 237–243

Abstract: Purpose: Gliomas are the most common primary brain tumors. The etiology is still unclear and the progression from low to high-grade gliomas is frequent. The molecular mechanisms are quite established, however the heterogeneity of glioblastomas force the ...

Abstract	Purpose: Gliomas are the most common primary brain tumors. The etiology is still unclear and the progression from low to high-grade gliomas is frequent. The molecular mechanisms are quite established, however the heterogeneity of glioblastomas force the scientist to look for the new therapeutic targets. The aim of the study was to evaluate the caspase-3 and survivin expression in correlation with MIB-1 expression in gliomas of various grade to assess the apoptosis in gliomas and to determinate new possible targets for the future therapy. Material and methods: We identified 131 patients with a histopathological diagnosis of astrocytic tumors (diffuse astrocytoma, anaplastic astrocytoma and glioblastoma). The evaluation of caspase-3, survivin and MIB-1 expression was done using immunohistochemical methods. Results: Caspase-3 and survivin expression was observed both in low- and high-grade astrocytomas. The differences in expression were the most evident in glioblastoma group. All primary glioblastomas (31 cases) expressed caspase-3. In secondary glioblastoma group only 17 out of 30 specimens were positive for caspase-3. Survivin expression was observed in 80.6% primary glioblastomas and in all examined secondary glioblastomas and the staining was strong and diffuse in all cases. MIB-1 expression was low in diffuse astrocytomas (DA) and ranged between 1 and 5%. In anaplastic astrocytoma group it was ranged between 5 and 10% and the highest percentage of the positive cells was observed in glioblastoma cases and ranged from 10% even to 30%. The most evident MIB-1 expression was observed in the cells surrounding the pathological blood vessels and necrosis. Conclusions: The high incidence of survivin and caspase-3 expression in diffuse and anaplastic astrocytoma cases may suggest, that the regulation between pro- and antiapoptotic proteins may play an important role in tumor growth and progression. The overexpression of survivin and MIB-1 expression in glioblastoma cases also may confirm the theory about the important role of anti-apoptotic and proliferation processes in glioblastoma progression and as such may be potential therapeutic targets.
MeSH term(s)	Aged ; Astrocytoma/metabolism ; Astrocytoma/pathology ; Caspase 3/metabolism ; Female ; Humans ; Inhibitor of Apoptosis Proteins/metabolism ; Male ; Middle Aged ; Neoplasm Grading ; Ubiquitin-Protein Ligases/metabolism
Chemical Substances	BIRC5 protein, human ; Inhibitor of Apoptosis Proteins ; MIB1 ligase, human (EC 2.3.2.27) ; Ubiquitin-Protein Ligases (EC 2.3.2.27) ; Caspase 3 (EC 3.4.22.-)
Language	English
Publishing date	2016-09
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2273668-2
ISSN	1898-4002 ; 1896-1126
ISSN (online)	1898-4002
ISSN	1896-1126
DOI	10.1016/j.advms.2016.02.001
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Book ; Thesis: Untersuchungen zur natürlichen Bornavirus-Infektion im Haupt-Endemiegebiet

Lebelt, Jochen

1995

Author's details	eingereicht von Jochen Lebelt
Language	Undetermined
Size	150 S, Ill., graph. Darst., Kt
Document type	Book ; Thesis
Thesis / German Habilitation thesis	@Leipzig, Univ., Diss. : 1995
Database	Special collection on veterinary medicine and general parasitology

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Article ; Online: Simultaneous detection and quantification of six equine cytokines in plasma using a fluorescent microsphere immunoassay (FMIA)

Sarah A. Hall / Diana Stucke / Beatrice Morrone / Dirk Lebelt / Adroaldo J. Zanella

MethodsX, Vol 2, Iss C, Pp 241-

2015 Volume 248

Abstract	Cytokines are cell signalling proteins that mediate a number of different physiological responses. They are also biomarkers for inflammatory conditions and potential diagnostic references for diseases. Until recently, simultaneous quantification of cytokine profiles had not been possible. Now however, fluorescent microsphere immunoassays (FMIA) are able to measure multiple cytokines in a single sample. The following pro-inflammatory and anti-inflammatory cytokines were quantified in equine plasma and serum samples: interleukin (IL)-2, IL-4, IL-6, IL-10, interferon (IFN)-γ, tumor necrosis factor (TNF)-α. • The objective of this study was to quantify six equine cytokines simultaneously using the BioPlex® 200 system in equine EDTA-plasma and serum. • It demonstrates an increased number of detectable cytokines over published studies. • This technology has the advantage of reduced sample volume and assay time compared to traditional sandwich ELISAs.
Keywords	Fluorescent microsphere immunoassay (FMIA) ; Science ; Q
Subject code	610
Language	English
Publishing date	2015-01-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Simultaneous detection and quantification of six equine cytokines in plasma using a fluorescent microsphere immunoassay (FMIA)

Hall, Sarah A / Adroaldo J. Zanella / Beatrice Morrone / Diana Stucke / Dirk Lebelt

MethodsX. 2015, v. 2

2015

Abstract	Cytokines are cell signalling proteins that mediate a number of different physiological responses. They are also biomarkers for inflammatory conditions and potential diagnostic references for diseases. Until recently, simultaneous quantification of cytokine profiles had not been possible. Now however, fluorescent microsphere immunoassays (FMIA) are able to measure multiple cytokines in a single sample. The following pro-inflammatory and anti-inflammatory cytokines were quantified in equine plasma and serum samples: interleukin (IL)-2, IL-4, IL-6, IL-10, interferon (IFN)-γ, tumor necrosis factor (TNF)-α.•The objective of this study was to quantify six equine cytokines simultaneously using the BioPlex® 200 system in equine EDTA-plasma and serum.•It demonstrates an increased number of detectable cytokines over published studies.•This technology has the advantage of reduced sample volume and assay time compared to traditional sandwich ELISAs.
Keywords	biomarkers ; blood serum ; cell communication ; enzyme-linked immunosorbent assay ; fluorescence ; horses ; interferon-gamma ; interleukin-10 ; interleukin-4 ; interleukin-6 ; microparticles ; physiological response ; proteins ; tumor necrosis factor-alpha
Language	English
Size	p. 241-248.
Publishing place	Elsevier B.V.
Document type	Article
ISSN	2215-0161
DOI	10.1016/j.mex.2015.04.002
Database	NAL-Catalogue (AGRICOLA)

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Article: Die Verteilung des Bornavirus in natürlich infizierten Tieren mit klinischer Erkrankung.

Lebelt, J / Hagenau, K

Berliner und Munchener tierarztliche Wochenschrift

1996 Volume 109, Issue 5, Page(s) 178–183

Abstract: Borna disease (BD) is a naturally occurring enzootic encephalomyelitis of horses and sheep. The aetiological agent, Borna disease virus (BDV) is an unclassified, neurotropic, negative stranded RNA virus. The study aimed at providing further information ... ...

Title translation	Distribution of Borna disease virus in naturally infected animals with clinical disease.
Abstract	Borna disease (BD) is a naturally occurring enzootic encephalomyelitis of horses and sheep. The aetiological agent, Borna disease virus (BDV) is an unclassified, neurotropic, negative stranded RNA virus. The study aimed at providing further information on BD of naturally infected animals. Samples obtained from 20 animals (18 horses, 1 donkey, 1 sheep) were investigated by a series of virological and molecular biological tests. The highly sensitive reverse transcription-polymerase chain reaction (RT-PCR) method was used to analyze the tissue distribution of BDV-specific RNA. BDV-specific RNA was detected in bulbus olfactorius, nucleus caudatus, hippocampus and cerebral cortex of all infected animals. BDV-RNA was also present in the spinal cord, eye, nasal mucosa, parotide gland, lung, heart, liver, kidney, bladder and ovaries. In addition, BV-specific RNA was also detected in conjunctival fluid, nasal secretions and saliva of two infected animals. By Western Blot assays the highest amounts of BDV antigens were demonstrated in bulbus olfactorius, nucleus caudatus, hippocampus and cerebral cortex.
MeSH term(s)	Animals ; Borna Disease/pathology ; Borna disease virus/isolation & purification ; Brain/pathology ; DNA Probes ; Horse Diseases/pathology ; Horses ; Polymerase Chain Reaction ; RNA, Viral/analysis ; Sheep ; Sheep Diseases/pathology ; Tissue Distribution
Chemical Substances	DNA Probes ; RNA, Viral
Language	German
Publishing date	1996-05
Publishing country	Germany
Document type	English Abstract ; Journal Article
ZDB-ID	5674-1
ISSN	0005-9366
ISSN	0005-9366
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Assessment of S100 protein expression in the epididymis of juvenile and adult European bison.

Czykier, Elżbieta / Zabel, Maciej / Surdyk-Zasada, Joanna / Lebelt, Agnieszka / Klim, Beata

Folia histochemica et cytobiologica

2010 Volume 48, Issue 3, Page(s) 333–338

Abstract: In our study, we decided to compare S100 protein expression in the material obtained from the epididymes of 5- and 12-month-old calves, and adult European bison, and to detect any differences in S100 expression according to the animal age and size of the ...

Abstract	In our study, we decided to compare S100 protein expression in the material obtained from the epididymes of 5- and 12-month-old calves, and adult European bison, and to detect any differences in S100 expression according to the animal age and size of the organ examined. We used the epididymes obtained from 6 adult European bison aged 6-12 years, from 6 at the age of 12 months and 6 calves aged 5 months. Immunocytochemical reactions were performed using the avidin-biotinylated-peroxidase (ABC) technique according to HSU. Specific polyclonal rabbit antiserum against bovine S100 protein (Bio Genex Laboratories) at a dilution at 1:400 was applied. We found the expression of S100 protein in endothelial cells of arteries, veins and lymphatic vessels in all the study animals. At the same time, we found no differences in the expression of S100 protein in vascular endothelial cells. Our observations seem to indicate that S100 expression in endothelial cells of European bison epididymis is not correlated with age or maturity of the organ tested. We found S100 protein in smooth muscle cells of arteries and veins in all European bison specimens examined. Interestingly in the current study, in young 5-month-old sexually immature European bison specimens we observed weaker expression of S100 protein in smooth muscle cells of small vessels as compared to the same cell type both in large vessels in these animals and in small vessels in adult specimens.
MeSH term(s)	Age Factors ; Animals ; Antibodies/immunology ; Arteries/cytology ; Arteries/metabolism ; Biotinylation ; Bison/metabolism ; Cattle ; Endothelial Cells/metabolism ; Endothelium, Vascular/cytology ; Endothelium, Vascular/metabolism ; Epididymis/cytology ; Epididymis/metabolism ; Europe ; Immunohistochemistry ; Lymphatic Vessels/cytology ; Lymphatic Vessels/metabolism ; Male ; Muscle, Smooth, Vascular/cytology ; Muscle, Smooth, Vascular/metabolism ; Organ Size ; Rabbits ; S100 Proteins/immunology ; S100 Proteins/metabolism ; Veins/cytology ; Veins/metabolism
Chemical Substances	Antibodies ; S100 Proteins
Language	English
Publishing date	2010-09-30
Publishing country	Poland
Document type	Comparative Study ; Journal Article
ZDB-ID	605761-5
ISSN	1897-5631 ; 0015-5586 ; 0239-8508
ISSN (online)	1897-5631
ISSN	0015-5586 ; 0239-8508
DOI	10.2478/v10042-10-0020-4
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Article ; Online: Sliding Scale Insulin vs Basal-Bolus Insulin Therapy in Long-Term Care: A 21-Day Randomized Controlled Trial Comparing Efficacy, Safety and Feasibility.

Dharmarajan, Thiruvinvamalai S / Mahajan, Dheeraj / Zambrano, Annie / Agarwal, Bikash / Fischer, Rachel / Sheikh, Zahra / Skokowska-Lebelt, Anna / Patel, Meenakshi / Wester, Rebecca / Madireddy, Naga P / Pandya, Naushira / Baralatei, Florence T / Vance, Jackie / Norkus, Edward P

Journal of the American Medical Directors Association

2016 Volume 17, Issue 3, Page(s) 206–213

Abstract: Introduction: Sliding scale insulin (SSI) therapy remains a common means of insulin therapy in long-term care (LTC) for the management of type 2 diabetes mellitus, despite current recommendations not supportive of the form of therapy today. Lack of ... ...

Abstract	Introduction: Sliding scale insulin (SSI) therapy remains a common means of insulin therapy in long-term care (LTC) for the management of type 2 diabetes mellitus, despite current recommendations not supportive of the form of therapy today. Lack of randomized trial data on the efficacy and safety of basal-bolus insulin (B-BI) therapy in nursing home residents may have precluded this form of insulin administration in the LTC setting. Our study is a comparison of the efficacy of SSI (control) and B-BI (intervention) therapies during a 21-day intervention trial in older nursing home residents. Methods: Fourteen LTC facilities in the US participated; 110 residents with type 2 diabetes volunteered to participate; 35 failed inclusion criteria, 75 signed informed written consent, and 11 were discharged to home/hospital or withdrew consent; data from 64 participants are reported. Recent fasting blood glucose (FBG), hemoglobin A1c, and chemistries were obtained. Four glucose readings (prior to breakfast, lunch, dinner, and bedtime), oral antiglycemic drug, and insulin doses and changes, and all adverse events/serious adverse events, both those related to glucose control [hypoglycemic (<70 mg/dL) and hyperglycemic (>200 mg/dL) episodes] and those unrelated, were recorded daily. Patients were randomized to either remain on SSI or be shifted to the B-BI group. Results: Nursing home residents 80 ± 8 (standard deviation) years, 66% female participated; Control and Intervention participants had similar age, gender, race distributions, comorbidity, and 3-day average pretrial FBG levels (all P > .05). At study end, B-BI volunteers had significantly lower 3-day average FBG levels vs pretrial (P = .0231) while SSI participants had no change in 3-day average FBG (P > .05). During the trial, participants from both groups had similar rates of hypoglycemia, hyperglycemia, other adverse events, and hospitalizations (serious adverse events) unrelated to glucose control (all P > .05). Conclusions: B-BI therapy produced significantly lower average FBG levels after 21 days compared with SSI therapy; both groups had similar rates of hypo- and hyperglycemia. Switching to B-BI therapy is feasible, safe, and effective in the LTC setting.
MeSH term(s)	Aged ; Aged, 80 and over ; Diabetes Mellitus, Type 2/drug therapy ; Disease Management ; Feasibility Studies ; Female ; Humans ; Hypoglycemia/drug therapy ; Hypoglycemic Agents/administration & dosage ; Insulin, Long-Acting/administration & dosage ; Long-Term Care ; Male ; Patient Safety ; Skilled Nursing Facilities ; Treatment Outcome
Chemical Substances	Hypoglycemic Agents ; Insulin, Long-Acting
Language	English
Publishing date	2016-03-01
Publishing country	United States
Document type	Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
ZDB-ID	2171030-2
ISSN	1538-9375 ; 1525-8610
ISSN (online)	1538-9375
ISSN	1525-8610
DOI	10.1016/j.jamda.2015.08.015
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