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Book ; Thesis: Epitope Mapping von Antikörpern bei Hämophilie B

Hoehl, Sebastian

2014

Author's details	vorgelegt von Sebastian Hoehl
Language	German
Size	IX, 80 Seiten, Illustrationen, Diagramme
Publishing place	Frankfurt am Main
Publishing country	Germany
Document type	Book ; Thesis
Thesis / German Habilitation thesis	Dissertation, Johann Wolfgang Goethe-Universität Frankfurt am Main, 2015
HBZ-ID	HT018882073
Database	Catalogue ZB MED Medicine, Health

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Article: Neuronale Dynamiken sozialer Interaktion in der frühen Kindheit

Höhl, Stefanie

Psychologie in Österreich

2023 Volume 43, Issue 2, Page(s) 115–122

Abstract: Neu entwickelte mobile Geräte zur Erfassung von Gehirnaktivitäten sowie innovative Analysemethoden ermöglichen ungeahnte Einblicke in die neuronalen Dynamiken von Säuglingen und Kleinkindern während sie mit ihren Bezugspersonen interagieren. Der ... ...

Title translation	Neural dynamics of social interactions in early childhood
Abstract	Neu entwickelte mobile Geräte zur Erfassung von Gehirnaktivitäten sowie innovative Analysemethoden ermöglichen ungeahnte Einblicke in die neuronalen Dynamiken von Säuglingen und Kleinkindern während sie mit ihren Bezugspersonen interagieren. Der vorliegende Beitrag bietet einen Überblick über das neu entstehende Forschungsfeld des Hyperscannings in der Entwicklungsforschung, d. h. der gleichzeitigen Messung der Gehirnaktivitäten von zwei oder mehr Personen, die an einer sozialen Interaktion beteiligt sind. Es werden Befunde zusammengefasst, die belegen, dass Kleinkinder und ihre Bezugspersonen ihre Gehirnaktivitäten während sozialer Interaktionen spontan synchronisieren. Verschiedene Arten der Kommunikation, vom Blickkontakt bis hin zu Vokalisierung und Berührung, scheinen die neuronale Synchronisation zu unterstützen. Forschungen mit Erwachsenen deuten darauf hin, dass neuronale Synchronisation die Kommunikation und die gegenseitige Verhaltensvorhersage fördert, was darauf schließen lässt, dass sie auch eine wichtige Rolle beim frühen Spracherwerb und beim sozialen Lernen spielen könnte.
Keywords	Attachment Behavior ; Bezugspersonen ; Bildgebende Verfahren ; Bindungsverhalten ; Biological Neural Networks ; Biologische Neuronale Netze ; Early Childhood Development ; Eltern-Kind-Kommunikation ; Entwicklung in der frühen Kindheit ; Language Development ; Neuroimaging ; Parent Child Communication ; Significant Others ; Social Interaction ; Soziale Interaktion ; Sprachentwicklung ; Synchronizität ; Synchrony
Language	German
Document type	Article
ISSN	1025-1839
ISSN	1025-1839
Database	PSYNDEX

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Article ; Online: Recalling ancestral SARS-CoV-2 variants: is it an original sin with benefits?

Hoehl, Sebastian / Ciesek, Sandra

The Lancet. Infectious diseases

2023 Volume 23, Issue 3, Page(s) 272–273

MeSH term(s)	Humans ; COVID-19 ; SARS-CoV-2 ; Antibodies, Viral ; Antibodies, Neutralizing
Chemical Substances	Antibodies, Viral ; Antibodies, Neutralizing
Language	English
Publishing date	2023-01-30
Publishing country	United States
Document type	Journal Article
ZDB-ID	2061641-7
ISSN	1474-4457 ; 1473-3099
ISSN (online)	1474-4457
ISSN	1473-3099
DOI	10.1016/S1473-3099(23)00007-5
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Article ; Online: Tissue Level Profiling of SARS-CoV-2 antivirals in mice to predict their effects: comparing Remdesivir’s active metabolite GS-441 524 vs. the clinically failed Hydroxychloroquine

Scherf-Clavel, Oliver / Kaczmarek, Edith / Kinzig, Martina / Friedl, Bettina / Feja, Malte / Höhl, Rainer / Nau, Roland / Holzgrabe, Ulrike / Gernert, Manuela / Richter, Franziska / Sörgel, Fritz

bioRxiv

Abstract: Background and Objectives Remdesivir and hydroxychloroquine are or were among the most promising therapeutic options to tackle the current SARS-CoV-2 pandemic. Besides the use of the prodrug remdesivir itself, the direct administration of GS-441 524, the ...

Abstract	Background and Objectives Remdesivir and hydroxychloroquine are or were among the most promising therapeutic options to tackle the current SARS-CoV-2 pandemic. Besides the use of the prodrug remdesivir itself, the direct administration of GS-441 524, the resulting main metabolite of remdesivir, could be advantageous and even more effective. All substances were not originally developed for the treatment of COVID-19 and especially for GS-441 524 little is known about its pharmacokinetic and physical-chemical properties. To justify the application of new or repurposed drugs in humans, pre-clinical in vivo animal models are mandatory to investigate relevant PK and PD properties and their relationship to each other. In this study, an adapted mouse model was chosen to demonstrate its suitability to provide sufficient information on the model substances GS-441 524 and HCQ regarding plasma concentration and distribution into relevant tissues a prerequisite for treatment effectiveness. Methods GS-441 524 and HCQ were administered intravenously as a single injection to male mice. Blood and organ samples were taken at several time points and drug concentrations were quantified in plasma and tissue homogenates by two liquid chromatography/tandem mass spectrometry methods. In vitro experiments were conducted to investigate the degradation of remdesivir in human plasma and blood. All pharmacokinetic analyses were performed with R Studio using non-compartmental analysis. Results High tissue to plasma ratios for GS-441 524 and HCQ were found, indicating a significant distribution into the examined tissue, except for the central nervous system and fat. For GS-441 524, measured tissue concentrations exceeded the reported in vitro EC50 values by more than 10-fold and in consideration of its high efficacy against feline infectious peritonitis, GS-441 524 could indeed be effective against SARS-CoV-2 in vivo. For HCQ, relatively high in vitro EC50 values are reported, which were not reached in all tissues. Facing its slow tissue distribution, HCQ might not lead to sufficient tissue saturation for a reliable antiviral effect. Conclusion The mouse model was able to characterise the PK and tissue distribution of both model substances and is a suitable tool to investigate early drug candidates against SARS-CoV-2. Furthermore, we could demonstrate a high tissue distribution of GS-441 524 even if not administered as the prodrug remdesivir.
Keywords	covid19
Publisher	BioRxiv; WHO
Document type	Article ; Online
DOI	10.1101/2020.09.16.299537
Database	COVID19

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Article ; Online: The development of visual categorization based on high-level cues.

Peykarjou, Stefanie / Hoehl, Stefanie / Pauen, Sabina

Child development

2023 Volume 95, Issue 2, Page(s) e122–e138

Abstract: This study investigated the development of rapid visual object categorization. N = 20 adults (Experiment 1), N = 21 five to six-year-old children (Experiment 2), and N = 140 four-, seven-, and eleven-month-old infants (Experiment 3; all predominantly ... ...

Abstract	This study investigated the development of rapid visual object categorization. N = 20 adults (Experiment 1), N = 21 five to six-year-old children (Experiment 2), and N = 140 four-, seven-, and eleven-month-old infants (Experiment 3; all predominantly White, 81 females, data collected in 2013-2020) participated in a fast periodic visual stimulation electroencephalographic task. Similar categorization of animal and furniture stimuli emerged in children and adults, with responses much reduced by phase-scrambling (R
MeSH term(s)	Child ; Adult ; Infant ; Female ; Animals ; Humans ; Pattern Recognition, Visual/physiology ; Cues ; Electroencephalography ; Photic Stimulation
Language	English
Publishing date	2023-10-03
Publishing country	United States
Document type	Journal Article
ZDB-ID	215602-7
ISSN	1467-8624 ; 0009-3920
ISSN (online)	1467-8624
ISSN	0009-3920
DOI	10.1111/cdev.14015
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Article ; Online: Your turn, my turn. Neural synchrony in mother-infant proto-conversation.

Nguyen, Trinh / Zimmer, Lucie / Hoehl, Stefanie

Philosophical transactions of the Royal Society of London. Series B, Biological sciences

2023 Volume 378, Issue 1875, Page(s) 20210488

Abstract: Even before infants utter their first words, they engage in highly coordinated vocal exchanges with their caregivers. During these so-called proto-conversations, caregiver-infant dyads use a presumably universal communication structure-turn-taking, which ...

Abstract	Even before infants utter their first words, they engage in highly coordinated vocal exchanges with their caregivers. During these so-called proto-conversations, caregiver-infant dyads use a presumably universal communication structure-turn-taking, which has been linked to favourable developmental outcomes. However, little is known about potential mechanisms involved in early turn-taking. Previous research pointed to interpersonal synchronization of brain activity between adults and preschool-aged children during turn-taking. Here, we assessed caregivers and infants at 4-6 months of age (
MeSH term(s)	Adult ; Child ; Child, Preschool ; Female ; Humans ; Infant ; Mothers ; Communication ; Brain ; Language Development ; Social Interaction
Language	English
Publishing date	2023-03-06
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	208382-6
ISSN	1471-2970 ; 0080-4622 ; 0264-3839 ; 0962-8436
ISSN (online)	1471-2970
ISSN	0080-4622 ; 0264-3839 ; 0962-8436
DOI	10.1098/rstb.2021.0488
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Article ; Online: Theta power relates to infant object encoding in naturalistic mother-infant interactions.

Michel, Christine / Matthes, Daniel / Hoehl, Stefanie

Child development

2023 Volume 95, Issue 2, Page(s) 530–543

Abstract: This study investigates infants' neural and behavioral responses to maternal ostensive signals during naturalistic mother-infant interactions and their effects on object encoding. Mothers familiarized their 9- to 10-month-olds (N = 35, 17 females, mainly ...

Abstract	This study investigates infants' neural and behavioral responses to maternal ostensive signals during naturalistic mother-infant interactions and their effects on object encoding. Mothers familiarized their 9- to 10-month-olds (N = 35, 17 females, mainly White, data collection: 2018-2019) with objects with or without mutual gaze, infant-directed speech, and calling the infant's name. Ostensive signals focused infants' attention on objects and their mothers. Infant theta activity synchronized and alpha activity desynchronized during interactions compared to a nonsocial resting phase (Cohen' d: 0.49-0.75). Yet, their amplitudes were unrelated to maternal ostensive signals. Ostensive signals did not facilitate object encoding. However, higher infant theta power during encoding predicted better subsequent object recognition. Results strengthen the role of theta-band power for early learning processes.
MeSH term(s)	Infant ; Female ; Humans ; Visual Perception/physiology ; Mothers ; Learning ; Communication ; Mother-Child Relations
Language	English
Publishing date	2023-09-15
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	215602-7
ISSN	1467-8624 ; 0009-3920
ISSN (online)	1467-8624
ISSN	0009-3920
DOI	10.1111/cdev.14011
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Article ; Online: Evidence for a dual-process account of over-imitation: Children imitate anti- and prosocial models equally, but prefer prosocial models once they become aware of multiple solutions to a task.

Schleihauf, Hanna / Hoehl, Stefanie

PloS one

2021 Volume 16, Issue 9, Page(s) e0256614

Abstract: Children imitate actions that are perceivably unnecessary to achieve the instrumental goal of an action sequence, a behavior termed over-imitation. It is debated whether this behavior is based on the motivation to follow behavioral norms and affiliate ... ...

Abstract	Children imitate actions that are perceivably unnecessary to achieve the instrumental goal of an action sequence, a behavior termed over-imitation. It is debated whether this behavior is based on the motivation to follow behavioral norms and affiliate with the model or whether it can be interpreted in terms of a behavioral heuristic to copy observed intentional actions without questioning the purpose of each action step. To resolve this question, we tested whether preschool-aged children (N = 89) over-imitate a prosocial model, a helper in a prior third-party moral transgression, but refuse to over-imitate an antisocial model, the perpetrator of the moral transgression. After first observing an inefficient way to extract a reward from a puzzle box from either a perpetrator or a helper, children over-imitated the perpetrator to the same degree as they over-imitated the helper. In a second phase, children were then presented the efficient solution by the respective other model, i.e. the helper or the perpetrator. Over-imitation rates then dropped in both conditions, but remained significantly higher than in a baseline condition only when children had observed the prosocial model demonstrate the inefficient action sequence and the perpetrator performed the efficient solution. In contrast, over-imitation dropped to baseline level when the perpetrator had modelled the inefficient actions and the prosocial model subsequently showed children the efficient solution. In line with a dual-process account of over-imitation, results speak to a strong initial tendency to imitate perceivably irrelevant actions regardless of the model. Imitation behavior is then adjusted according to social motivations after deliberate consideration of different options to attain the goal.
MeSH term(s)	Antisocial Personality Disorder ; Awareness/physiology ; Child ; Child Behavior ; Child Development/physiology ; Child, Preschool ; Female ; Humans ; Imitative Behavior/physiology ; Learning/physiology ; Male ; Motivation/physiology ; Reward ; Social Behavior
Language	English
Publishing date	2021-09-16
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1932-6203
ISSN (online)	1932-6203
DOI	10.1371/journal.pone.0256614
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: An interactionist perspective on the development of coordinated social attention.

Hoehl, Stefanie / Bertenthal, Bennett I

Advances in child development and behavior

2021 Volume 61, Page(s) 1–41

Abstract: Infants' ability to coordinate their attention with other people develops profoundly across the first year of life. Mainly based on experimental research focusing on infants' behavior under highly controlled conditions, developmental milestones were ... ...

Abstract	Infants' ability to coordinate their attention with other people develops profoundly across the first year of life. Mainly based on experimental research focusing on infants' behavior under highly controlled conditions, developmental milestones were identified and explained in the past by prominent theories in terms of the onset of specific cognitive skills. In contrast to this approach, recent longitudinal research challenges this perspective with findings suggesting that social attention develops continuously with a gradual refinement of skills. Informed by these findings, we argue for an interactionist and dynamical systems view that bases observable advances in infant social attention skills on increasingly fine-tuned mutual adjustments in the caregiver-infant dyad, resulting in gradually improving mutual prediction. We present evidence for this view from recent studies leveraging new technologies which afford the opportunity to dynamically track social interactions in real-time. These new technically-sophisticated studies offer unprecedented insights into the dynamic processes of infant-caregiver social attention. It is now possible to track in much greater detail fluctuations over time with regard to object-directed attention as well as social attention and how these processes relate to one another. Encouraged by these initial results and new insights from this interactionist developmental social neuroscience approach, we conclude with a "call to action" in which we advocate for more ecologically valid paradigms for studying social attention as a dynamic and bi-directional process.
MeSH term(s)	Attention ; Humans ; Infant ; Social Skills
Language	English
Publishing date	2021-06-22
Publishing country	United States
Document type	Journal Article
ZDB-ID	140-5
ISSN	0065-2407
ISSN	0065-2407
DOI	10.1016/bs.acdb.2021.05.001
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Article: Development of Down Syndrome Research Over the Last Decades-What Healthcare and Education Professionals Need to Know.

Windsperger, Karin / Hoehl, Stefanie

Frontiers in psychiatry

2021 Volume 12, Page(s) 749046

Abstract: Down syndrome (DS) is the most prevalent neurodevelopmental disorder, with a known genetic cause. Besides facial dysmorphologies and congenital and/or acquired medical conditions, the syndrome is characterized by intellectual disability, accelerated ... ...

Abstract	Down syndrome (DS) is the most prevalent neurodevelopmental disorder, with a known genetic cause. Besides facial dysmorphologies and congenital and/or acquired medical conditions, the syndrome is characterized by intellectual disability, accelerated aging, and an increased likelihood of an early onset Alzheimer's disease in adulthood. These common patterns of DS are derived from the long-held standard in the field of DS research, that describes individuals with DS as a homogeneous group and compares phenotypic outcomes with either neurotypical controls or other neurodevelopmental disorders. This traditional view has changed, as modern research pinpoints a broad variability in both the occurrence and severity of symptoms across DS, arguing for DS heterogeneity and against a single "DS profile." Nevertheless, prenatal counseling does not often prioritize the awareness of potential within-group variations of DS, portraying only a vague picture of the developmental outcomes of children with DS to expectant parents. This mini-review provides a concise update on existent information about the heterogeneity of DS from a full-spectrum developmental perspective, within an interdisciplinary context. Knowledge on DS heterogeneity will not only enable professionals to enhance the quality of prenatal counseling, but also help parents to set targeted early interventions, to further optimize daily functions and the quality of life of their children.
Language	English
Publishing date	2021-12-14
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2564218-2
ISSN	1664-0640
ISSN	1664-0640
DOI	10.3389/fpsyt.2021.749046
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