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  1. Article ; Online: Die neue EU-Trinkwasserrichtlinie.

    Lippitsch, C

    Osterreichische Wasser- und Abfallwirtschaft

    2020  Volume 72, Issue 11-12, Page(s) 498–500

    Abstract: After more than two years of negotiations, the new EU Drinking Water Directive is due to be published in mid-December 2020. Quite a few new provisions will be introduced, such as new chemical and physical parameters, the mandatory implementation of a ... ...

    Title translation The new EU Drinking Water Directive.
    Abstract After more than two years of negotiations, the new EU Drinking Water Directive is due to be published in mid-December 2020. Quite a few new provisions will be introduced, such as new chemical and physical parameters, the mandatory implementation of a risk assessment on three levels, minimum hygiene requirements for materials in contact with drinking water or access to drinking water for all. The resulting extension of responsibilities compared to the current Directive poses challenges for many Member States. Following intensive discussions at European level, these have to continue now at national level.
    Language German
    Publishing date 2020-11-25
    Publishing country Austria
    Document type English Abstract ; Journal Article
    ZDB-ID 1186984-7
    ISSN 1613-7566 ; 0945-358X
    ISSN (online) 1613-7566
    ISSN 0945-358X
    DOI 10.1007/s00506-020-00725-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Development and evaluation of a software system for medical students to teach and practice anamnestic interviews with virtual patient avatars.

    Lippitsch, Antonia / Steglich, Jonas / Ludwig, Christiane / Kellner, Juliane / Hempel, Linn / Stoevesandt, Dietrich / Thews, Oliver

    Computer methods and programs in biomedicine

    2023  Volume 244, Page(s) 107964

    Abstract: Background and objectives: Taking a medical history is a core competence of the diagnostic process. At the beginning of their study medical students need to learn and practice the necessary techniques, initially focusing on good structuring and ... ...

    Abstract Background and objectives: Taking a medical history is a core competence of the diagnostic process. At the beginning of their study medical students need to learn and practice the necessary techniques, initially focusing on good structuring and completeness. For this purpose, an interactive software system (ViPATalk) was developed in which the student can train to pose questions to virtual patient avatars in free conversation. At the end, the student receives feedback on the completeness of the questioning and an explanation of the essential items. The use of this software was compared to the traditional format of student role play in a randomized trial.
    Methods: The central component of ViPATalk is a chatbot based on the AI language AIML, which generates an appropriate answer based on keywords in the student's question. To enable a realistic use, the student can enter the question via microphone (speech-to-text) and the answer generated by the chatbot is presented as a short video sequence, where the avatar is generated from a real image. Here, the transition between the sequences is seamless, resulting in a continuous movement of the avatar during the conversation.
    Results: The learning success by practicing with ViPATalk was tested in an anamnestic interview with actors as simulated patients. The completeness of the conversation was evaluated with regard to numerous aspects and also certain behaviors during the conversation. These results were compared with those after practicing using peer role play.
    Conclusions: It was found that practicing with ViPATalk was mostly equivalent to the students' role play. In the subsequent survey of the students, the wish was expressed that the ViPATalk software should also be used as an online tool for self-study and that there should be more cases for practicing.
    MeSH term(s) Humans ; Avatar ; Students, Medical ; Education, Medical, Undergraduate/methods ; Software ; Learning
    Language English
    Publishing date 2023-12-01
    Publishing country Ireland
    Document type Journal Article
    ZDB-ID 632564-6
    ISSN 1872-7565 ; 0169-2607
    ISSN (online) 1872-7565
    ISSN 0169-2607
    DOI 10.1016/j.cmpb.2023.107964
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    Zs.B 521: Show issues Location:
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  3. Conference proceedings: Anamneseerhebung in einem virtuellen Environment: Möglichkeiten eines Online-Unterrichts mittels Computeravatar

    Lippitsch, Antonia / Stoevesandt, Dietrich / Ludwig, Christiane / Kellner, Juliane / Steglich, Jonas / Thews, Oliver

    2022  , Page(s) V3.2

    Event/congress 15. Internationales SkillsLab Symposium 2021; sine loco [digital]; 2021
    Keywords Medizin, Gesundheit
    Publishing date 2022-03-11
    Publisher German Medical Science GMS Publishing House; Düsseldorf
    Document type Conference proceedings
    DOI 10.3205/21isls31
    Database German Medical Science

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  4. Article ; Online: Plasmacytoid dendritic cell depletion modifies FoxP3+ T cell homeostasis and the clinical course of bacterial pneumonia in mice.

    Lippitsch, Anne / Baal, Nelli / Chukovetskyi, Yuri / Cunningham, Sarah / Michel, Gabriela / Dietert, Kristina / Gurtner, Corinne / Gruber, Achim D / Bein, Gregor / Hackstein, Holger

    Journal of leukocyte biology

    2019  Volume 106, Issue 4, Page(s) 977–985

    Abstract: Plasmacytoid dendritic cells (pDC) are critical to antiviral defense because of their high production of type I IFNs; less is known regarding their functions in bacterial infection. Moreover, pDC are involved in immunomodulation. A stable pool of ... ...

    Abstract Plasmacytoid dendritic cells (pDC) are critical to antiviral defense because of their high production of type I IFNs; less is known regarding their functions in bacterial infection. Moreover, pDC are involved in immunomodulation. A stable pool of regulatory T cells (Treg) is crucial for maintaining immune homeostasis. However, interactions between pDC and Treg regarding the regulation of Treg homeostasis are understudied. By using BDCA2-DTR mice as a systemic pDC depletion model, we identified increased steady-state numbers of FoxP3
    MeSH term(s) Animals ; Antigens, CD/metabolism ; Antigens, Differentiation, T-Lymphocyte/metabolism ; Biomarkers/metabolism ; Cytokines/metabolism ; Dendritic Cells/immunology ; Forkhead Transcription Factors/metabolism ; Homeostasis ; Inflammation Mediators/metabolism ; Klebsiella pneumoniae/physiology ; Lectins, C-Type/metabolism ; Lung/immunology ; Lung/pathology ; Mice, Inbred C57BL ; Pneumonia, Bacterial/immunology ; Pneumonia, Bacterial/microbiology ; Pneumonia, Bacterial/pathology ; T-Lymphocytes/immunology
    Chemical Substances Antigens, CD ; Antigens, Differentiation, T-Lymphocyte ; Biomarkers ; CD69 antigen ; Cytokines ; Forkhead Transcription Factors ; Foxp3 protein, mouse ; Inflammation Mediators ; Lectins, C-Type
    Language English
    Publishing date 2019-07-02
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 605722-6
    ISSN 1938-3673 ; 0741-5400
    ISSN (online) 1938-3673
    ISSN 0741-5400
    DOI 10.1002/JLB.3AB0119-014RR
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 603: Show issues Location:
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  5. Article ; Online: Ability of an orally administered lactobacilli preparation to improve the quality of the neovaginal microflora in male to female transsexual women.

    Kaufmann, Ulrike / Domig, Konrad J / Lippitsch, Christina I / Kraler, Manuel / Marschalek, Julian / Kneifel, Wolfgang / Kiss, Herbert / Petricevic, Ljubomir

    European journal of obstetrics, gynecology, and reproductive biology

    2014  Volume 172, Page(s) 102–105

    Abstract: ... compared with an increase by 1600±100CFU in the control group (p<0.0001). When measured by real-time PCR (c ...

    Abstract Objective: Lactobacilli have been found in the neovagina of very low numbers of transsexual women. We undertook this study to determine whether an orally administered preparation of four lactobacilli strains exerts some measurable effect on the neovaginal microflora of female transsexuals.
    Study design: 60 male to female transsexual women with penile linked neovagina were randomised into two groups. Women in the intervention group (n=33) received oral probiotic capsules and women in the control group (n=27) placebo in for 7 days. Swabs of the neovagina were taken before and after the therapy.
    Results: Comparing the first and second swabs, we observed a significant improvement of the Nugent score in the intervention group 16 (48.5%) vs. low improvement in control group 4 (14.8%) (p<0.006). The neovaginal microflora was significantly enriched with lactobacilli after oral supplementation compared to placebo. In the intervention group, an increase by 10,000±600 colony forming units (CFU) of presumptive lactobacilli was observed, compared with an increase by 1600±100CFU in the control group (p<0.0001). When measured by real-time PCR (c/ml), lactobacilli increased by 1400±100c/ml in the intervention group and 300±100c/ml in the control group (p<0.0001).
    Conclusion: There was an improvement of vaginal lactobacilli microflora after of oral supplementation with lactobacilli strains in transsexual women.
    MeSH term(s) Administration, Oral ; Adult ; Colony Count, Microbial ; Female ; Humans ; Lactobacillus ; Male ; Microbiota ; Middle Aged ; Probiotics/therapeutic use ; Sex Reassignment Surgery ; Transgender Persons ; Treatment Outcome ; Vagina/microbiology
    Language English
    Publishing date 2014-01
    Publishing country Ireland
    Document type Journal Article ; Randomized Controlled Trial
    ZDB-ID 190605-7
    ISSN 1872-7654 ; 0301-2115 ; 0028-2243
    ISSN (online) 1872-7654
    ISSN 0301-2115 ; 0028-2243
    DOI 10.1016/j.ejogrb.2013.10.019
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  6. Article ; Online: Prospectively defined murine mesenchymal stem cells inhibit Klebsiella pneumoniae-induced acute lung injury and improve pneumonia survival.

    Hackstein, Holger / Lippitsch, Anne / Krug, Philipp / Schevtschenko, Inna / Kranz, Sabine / Hecker, Matthias / Dietert, Kristina / Gruber, Achim D / Bein, Gregor / Brendel, Cornelia / Baal, Nelli

    Respiratory research

    2015  Volume 16, Page(s) 123

    Abstract: Background: Numerous studies have described the immunosuppressive capacity of mesenchymal stem cells (MSC) but these studies use mixtures of heterogeneous progenitor cells for in vitro expansion. Recently, multipotent MSC have been prospectively ... ...

    Abstract Background: Numerous studies have described the immunosuppressive capacity of mesenchymal stem cells (MSC) but these studies use mixtures of heterogeneous progenitor cells for in vitro expansion. Recently, multipotent MSC have been prospectively identified in murine bone marrow (BM) on the basis of PDFGRa(+) SCA1(+) CD45(-) TER119(-) (PαS) expression but the immunomodulatory capacity of these MSC is unknown.
    Methods: We isolated PαS MSC by high-purity FACS sorting of murine BM and after in vitro expansion we analyzed the in vivo immunomodulatory activity during acute pneumonia. PαS MSC (1 × 10(6)) were applied intratracheally 4 h after acute respiratory Klebsiella pneumoniae induced infection.
    Results: PαS MSC treatment resulted in significantly reduced alveolitis and protein leakage in comparison to mock-treated controls. PαS MSC-treated mice exhibited significantly reduced alveolar TNF-α and IL-12p70 expression, while IL-10 expression was unaffected. Dissection of respiratory dendritic cell (DC) subsets by multiparameter flow cytometry revealed significantly reduced lung DC infiltration and significantly reduced CD86 costimulatory expression on lung CD103(+) DC in PαS MSC-treated mice. In the post-acute phase of pneumonia, PαS MSC-treated animals exhibited significantly reduced respiratory IL-17(+) CD4(+) T cells and IFN-γ(+) CD4(+) T cells. Moreover, PαS MSC treatment significantly improved overall pneumonia survival and did not increase bacterial load.
    Conclusion: In this study we demonstrated for the first time the feasibility and in vivo immunomodulatory capacity of prospectively defined MSC in pneumonia.
    MeSH term(s) Acute Lung Injury/immunology ; Acute Lung Injury/metabolism ; Acute Lung Injury/microbiology ; Acute Lung Injury/prevention & control ; Animals ; Biomarkers/metabolism ; CD4-Positive T-Lymphocytes/immunology ; CD4-Positive T-Lymphocytes/microbiology ; Cell Separation/methods ; Cells, Cultured ; Dendritic Cells/immunology ; Dendritic Cells/microbiology ; Disease Models, Animal ; Feasibility Studies ; Flow Cytometry ; Inflammation Mediators/metabolism ; Klebsiella Infections/immunology ; Klebsiella Infections/metabolism ; Klebsiella Infections/microbiology ; Klebsiella Infections/surgery ; Klebsiella pneumoniae/immunology ; Klebsiella pneumoniae/pathogenicity ; Lung/immunology ; Lung/metabolism ; Lung/microbiology ; Mesenchymal Stem Cell Transplantation ; Mesenchymal Stromal Cells/immunology ; Mesenchymal Stromal Cells/metabolism ; Mice, Inbred C57BL ; Phenotype ; Pneumonia, Bacterial/immunology ; Pneumonia, Bacterial/metabolism ; Pneumonia, Bacterial/microbiology ; Pneumonia, Bacterial/surgery ; Time Factors
    Chemical Substances Biomarkers ; Inflammation Mediators
    Language English
    Publishing date 2015-10-06
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2041675-1
    ISSN 1465-993X ; 1465-9921
    ISSN (online) 1465-993X
    ISSN 1465-9921
    DOI 10.1186/s12931-015-0288-1
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  7. Book: Multiplication as parallel as possible

    Lippitsch, P / Posch, K.C / Posch, R

    (IIG-Report-Series ; 290)

    1990  

    Author's details P. Lippitsch; K.C. Posch; R. Posch
    Series title IIG-Report-Series ; 290
    Language English
    Size 8 S
    Publisher Inst., TU, Ges
    Publishing place Graz
    Document type Book
    Database Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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  8. Article ; Conference proceedings: Cytology and mRNA expression analysis of fine needle aspirates of nodular thyroid disease

    Karger, S / Engelhardt, C / Herrmann, F / Müller, P / Schmidt, HT / Weiss, CL / Dralle, H / Lippitsch, M / Tannapfel, A / Paschke, R / Führer, D

    Experimental and Clinical Endocrinology & Diabetes

    2005  

    Abstract: Fine needle aspiration cytology is widely advocated as diagnostic tool for pre-operative analysis of thyroid malignancy in patients with scintigraphically cold thyroid nodules (CTN) >10mm size. To assess the contribution of FNAC for differential ... ...

    Event/congress 9th Annual Meeting of the Neuroendocrinology Section of the German Society of Endocrinology (DGE), Münster, 2005
    Abstract Fine needle aspiration cytology is widely advocated as diagnostic tool for pre-operative analysis of thyroid malignancy in patients with scintigraphically cold thyroid nodules (CTN) >10mm size. To assess the contribution of FNAC for differential diagnosis of nodular thyroid disease in daily practice we started a prospective study in 5 thyroid clinics in/around Leipzig, a region with borderline iodine deficiency. 301 FNACs were obtained by 8 different investigators from 244 patients (152 women, 92 men) over a period of 2 years (2002–2004). In addition 37 FNACs were performed intraoperatively. FNACs were reviewed by 3 pathologists with the following diagnoses: 57% benign, 17% follicular neoplasia, 5.2% suspicious, 2.5% malignant, 17.5% non-diagnostic. In addition, an association was noted between the number of thyrocytes/native FNAC smear (+, ++, +++) and the cytological diagnosis of benign (69% +, 29% ++), follicular neoplasia (66% ++, 17% +++), suspicious or malignant FNAC (54%+++, 31% ++) made by the pathologists. A similar correlation was noted for the intraoperatively obtained FNAC for which both cytology and histology were available (14 colloid nodules, 12 follicular adenoma, 3 PTC, 3FTC, 3 autoimmune thyroiditis, 1 Huerthle cell adenoma, 1 lymphoma). When we studied b-actin (house keeping gene) and Tg (thyroid differentiation marker) mRNA expression by real-time PCR, a considerable variation in gene expression/FNAC sample was obtained, challenging the perspective to apply cut-off values for molecular markers in FNA. However there was a trend for lower Tg and higher b-actin expression in FNA samples with follicular or suspicious cytology. In summary, results of FNAC of thyroid nodules in German clinics are in good agreement with results of unselected thyroid nodules reported in the literature. We suggest that besides cytological criteria a high FNA cell yield may not purely represent a “good quality FNA sample“, but may be indicative of a proliferating (follicular) if not transformed thyroid lesion.
    Language English
    Publishing date 2005-03-21
    Publishing place Stuttgart ; New York
    Document type Article ; Conference proceedings
    ZDB-ID 1225416-2
    ISSN 1439-3646 ; 0947-7349
    ISSN (online) 1439-3646
    ISSN 0947-7349
    DOI 10.1055/s-2005-862996
    Database Thieme publisher's database

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