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  1. Article: A few questions to Prof Dr Kenneth W. Witwer, Johns Hopkins University. Kenneth W. Witwer is an associate professor of molecular and comparative pathobiology and neurology at the Johns Hopkins University School of Medicine in Baltimore, Maryland, United States. He received his PhD from Johns Hopkins University School of Medicine in 2010. In 2011, Ken joined the faculty at Johns Hopkins, and he assumed a tenure-track position in 2012. His research focusses on EVs and RNA in HIV disease of the central nervous system. Ken has served as Secretary General of ISEV.

    Witwer, Kenneth W.

    Trillium extracellular vesicles

    2023  Volume 5, Issue 1, Page(s) 8

    Language English
    Document type Article
    ZDB-ID 2988015-4
    ISSN 2698-8739
    Database Current Contents Medicine

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 7194: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: On your MARCKS, get set, deliver: Engineering extracellular vesicles.

    Witwer, Kenneth W

    Molecular therapy : the journal of the American Society of Gene Therapy

    2021  Volume 29, Issue 5, Page(s) 1664–1665

    MeSH term(s) Extracellular Vesicles
    Language English
    Publishing date 2021-04-22
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 2010592-7
    ISSN 1525-0024 ; 1525-0016
    ISSN (online) 1525-0024
    ISSN 1525-0016
    DOI 10.1016/j.ymthe.2021.04.013
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5640: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Letter by Halushka and Witwer Regarding Article, "Circulating MicroRNA-122-5p Is Associated With a Lack of Improvement in Left Ventricular Function After Transcatheter Aortic Valve Replacement and Regulates Viability of Cardiomyocytes Through Extracellular Vesicles".

    Halushka, Marc K / Witwer, Kenneth W

    Circulation

    2023  Volume 147, Issue 4, Page(s) e64–e65

    MeSH term(s) Humans ; Ventricular Function, Left/physiology ; Transcatheter Aortic Valve Replacement ; Circulating MicroRNA ; Myocytes, Cardiac ; Aortic Valve/surgery ; Aortic Valve Stenosis/surgery ; Extracellular Vesicles ; Treatment Outcome ; Severity of Illness Index ; Stroke Volume/physiology ; MicroRNAs
    Chemical Substances Circulating MicroRNA ; MIRN122 microRNA, human ; MicroRNAs
    Language English
    Publishing date 2023-01-23
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 80099-5
    ISSN 1524-4539 ; 0009-7322 ; 0069-4193 ; 0065-8499
    ISSN (online) 1524-4539
    ISSN 0009-7322 ; 0069-4193 ; 0065-8499
    DOI 10.1161/CIRCULATIONAHA.122.061834
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ui IV Zs.60: Show issues Location:
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: The evolving paradigm of extracellular vesicles in intercellular signaling and delivery of therapeutic RNAs.

    Morris, Kevin V / Witwer, Kenneth W

    Molecular therapy : the journal of the American Society of Gene Therapy

    2022  Volume 30, Issue 7, Page(s) 2393–2394

    MeSH term(s) Cell Communication ; Extracellular Vesicles ; RNA ; Signal Transduction
    Chemical Substances RNA (63231-63-0)
    Language English
    Publishing date 2022-05-28
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 2010592-7
    ISSN 1525-0024 ; 1525-0016
    ISSN (online) 1525-0024
    ISSN 1525-0016
    DOI 10.1016/j.ymthe.2022.05.015
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5640: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: MISEV2023: An updated guide to EV research and applications.

    Welsh, Joshua A / Goberdhan, Deborah C / O'Driscoll, Lorraine / Théry, Clotilde / Witwer, Kenneth W

    Journal of extracellular vesicles

    2024  Volume 13, Issue 2, Page(s) e12416

    Language English
    Publishing date 2024-02-23
    Publishing country United States
    Document type Editorial
    ZDB-ID 2683797-3
    ISSN 2001-3078 ; 2001-3078
    ISSN (online) 2001-3078
    ISSN 2001-3078
    DOI 10.1002/jev2.12416
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: L1CAM-associated extracellular vesicles: A systematic review of nomenclature, sources, separation, and characterization.

    Gomes, Dimitria E / Witwer, Kenneth W

    Journal of extracellular biology

    2022  Volume 1, Issue 3

    Abstract: When released into biological fluids like blood or saliva, brain extracellular vesicles (EVs) might provide a window into otherwise inaccessible tissue, contributing useful biomarkers of neurodegenerative and other central nervous system (CNS) diseases. ... ...

    Abstract When released into biological fluids like blood or saliva, brain extracellular vesicles (EVs) might provide a window into otherwise inaccessible tissue, contributing useful biomarkers of neurodegenerative and other central nervous system (CNS) diseases. To enrich for brain EVs in the periphery, however, cell-specific EV surface markers are needed. The protein that has been used most frequently to obtain EVs of putative neuronal origin is the transmembrane L1 cell adhesion molecule (L1CAM/CD171). In this systematic review, we examine the existing literature on L1CAM and EVs, including investigations of both neurodegenerative disease and cancer through the lens of the minimal information for studies of EVs (MISEV), specifically in the domains of nomenclature usage, EV sources, and EV separation and characterization. Although numerous studies have reported L1CAM-associated biomarker signatures that correlate with disease, interpretation of these results is complicated since L1CAM expression is not restricted to neurons and is also upregulated during cancer progression. A recent study has suggested that L1CAM epitopes are present in biofluids mostly or entirely as cleaved, soluble protein. Our findings on practices and trends in L1CAM-mediated EV separation, enrichment, and characterization yield insights that may assist with interpreting results, evaluating rigor, and suggesting avenues for further exploration.
    Language English
    Publishing date 2022-04-05
    Publishing country United States
    Document type Journal Article
    ISSN 2768-2811
    ISSN (online) 2768-2811
    DOI 10.1002/jex2.35
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Non-Invasive imaging of extracellular vesicles: Quo vaditis in vivo?

    Arifin, Dian R / Witwer, Kenneth W / Bulte, Jeff W M

    Journal of extracellular vesicles

    2023  Volume 11, Issue 7, Page(s) e12241

    Abstract: Extracellular vesicles (EVs) are lipid-bilayer delimited vesicles released by nearly all cell types that serve as mediators of intercellular signalling. Recent evidence has shown that EVs play a key role in many normal as well as pathological cellular ... ...

    Abstract Extracellular vesicles (EVs) are lipid-bilayer delimited vesicles released by nearly all cell types that serve as mediators of intercellular signalling. Recent evidence has shown that EVs play a key role in many normal as well as pathological cellular processes. EVs can be exploited as disease biomarkers and also as targeted, cell-free therapeutic delivery and signalling vehicles for use in regenerative medicine and other clinical settings. Despite this potential, much remains unknown about the in vivo biodistribution and pharmacokinetic profiles of EVs after administration into living subjects. The ability to non-invasively image exogeneous EVs, especially in larger animals, will allow a better understanding of their in vivo homing and retention patterns, blood and tissue half-life, and excretion pathways, all of which are needed to advance clinical diagnostic and/or therapeutic applications of EVs. We present the current state-of-the-art methods for labeling EVs with various diagnostic contrast agents and tracers and the respective imaging modalities that can be used for their in vivo visualization: magnetic resonance imaging (MRI), X-ray computed tomography (CT) imaging, magnetic particle imaging (MPI), single-photon emission computed tomography (SPECT), positron emission tomography (PET), and optical imaging (fluorescence and bioluminescence imaging). We review here the strengths and weaknesses of each of these EV imaging approaches, with special emphasis on clinical translation.
    MeSH term(s) Animals ; Extracellular Vesicles/metabolism ; Humans ; Optical Imaging ; Tissue Distribution
    Language English
    Publishing date 2023-05-01
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2683797-3
    ISSN 2001-3078 ; 2001-3078
    ISSN (online) 2001-3078
    ISSN 2001-3078
    DOI 10.1002/jev2.12241
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Alternative miRNAs? Human sequences misidentified as plant miRNAs in plant studies and in human plasma.

    Witwer, Kenneth W

    F1000Research

    2018  Volume 7, Page(s) 244

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2018-02-28
    Publishing country England
    Document type Journal Article
    ZDB-ID 2699932-8
    ISSN 2046-1402
    ISSN 2046-1402
    DOI 10.12688/f1000research.14060.1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Extracellular vesicles versus synthetic nanoparticles for drug delivery.

    Witwer, Kenneth W / Wolfram, Joy

    Nature reviews. Materials

    2021  Volume 6, Issue 2, Page(s) 103–106

    Abstract: Cell-released biological nanoparticles, including extracellular vesicles (EVs), are emerging drug carriers with high complexity. EV-based drug delivery has the potential to efficiently exploit intrinsic mechanisms for molecular transport in the body. ... ...

    Abstract Cell-released biological nanoparticles, including extracellular vesicles (EVs), are emerging drug carriers with high complexity. EV-based drug delivery has the potential to efficiently exploit intrinsic mechanisms for molecular transport in the body. Integrating the expanding knowledge of EV biology and manufacturing with clinical insights from synthetic nanoparticles is likely to substantially advance the field of drug delivery.
    Language English
    Publishing date 2021-01-07
    Publishing country England
    Document type Journal Article
    ISSN 2058-8437
    ISSN 2058-8437
    DOI 10.1038/s41578-020-00277-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Blebs and former blebs: From surface protrusions to extracellular vesicles in cancer signalling, anoikis resistance and beyond.

    Di Vizio, Dolores / Schoppet, Melanie / Weeraratna, Ashani / Witwer, Kenneth W

    Journal of extracellular biology

    2023  Volume 2, Issue 10

    Abstract: Associations between plasma membrane blebbing and metastatic progression have been widely reported. There are also reports of increased extracellular vesicle release from cancer cells. Yet the ties between these closely related phenomena are incompletely ...

    Abstract Associations between plasma membrane blebbing and metastatic progression have been widely reported. There are also reports of increased extracellular vesicle release from cancer cells. Yet the ties between these closely related phenomena are incompletely understood. In this commentary, we remark on a recent finding on cellular membrane blebs in melanoma signaling. We discuss possible implications for cancer biology and draw parallels to knowns and unknowns in the relationships of extracellular vesicles and cancer progression.
    Language English
    Publishing date 2023-10-19
    Publishing country United States
    Document type Journal Article
    ISSN 2768-2811
    ISSN (online) 2768-2811
    DOI 10.1002/jex2.112
    Database MEDical Literature Analysis and Retrieval System OnLINE

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