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  1. Article ; Online: An in situ hybridization study of syndecan family during the late stages of developing mouse molar tooth germ.

    Fujikawa, Kaoru / Nonaka, Naoko / Wang, Xiaofang / Shibata, Shunichi

    Anatomical science international

    2022  Volume 97, Issue 4, Page(s) 358–368

    Abstract: Expression of syndecan-1, 2, 3, and 4 mRNAs during the late stages of tooth germ formation was investigated by in situ hybridization, using [ ...

    Abstract Expression of syndecan-1, 2, 3, and 4 mRNAs during the late stages of tooth germ formation was investigated by in situ hybridization, using [
    MeSH term(s) Animals ; Gene Expression Regulation, Developmental ; In Situ Hybridization ; Mice ; RNA, Messenger/metabolism ; Syndecan-1/genetics ; Syndecan-1/metabolism ; Syndecan-2/metabolism ; Syndecan-3/metabolism ; Tooth Germ/metabolism
    Chemical Substances RNA, Messenger ; Syndecan-1 ; Syndecan-3 ; Syndecan-2 (149769-25-5)
    Language English
    Publishing date 2022-02-04
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 2079994-9
    ISSN 1447-073X ; 1447-6959 ; 0022-7722
    ISSN (online) 1447-073X
    ISSN 1447-6959 ; 0022-7722
    DOI 10.1007/s12565-022-00647-w
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    Zs.A 219: Show issues Location:
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  2. Article ; Online: Hereditary Congenital Methemoglobinemia Diagnosed at the Age of 79 Years: A Case Report.

    Nakata, Marohito / Yokota, Naoko / Tabata, Kazuhiko / Morikawa, Takuya / Shibata, Hiroki / Kenzaka, Tsuneaki

    Medicina (Kaunas, Lithuania)

    2023  Volume 59, Issue 3

    Abstract: ... ...

    Abstract Background
    MeSH term(s) Humans ; Female ; Aged ; Middle Aged ; Methemoglobinemia/diagnosis ; Methemoglobinemia/genetics ; Methemoglobinemia/congenital ; Methemoglobin/analysis ; Cytochrome-B(5) Reductase/genetics ; Cyanosis/genetics
    Chemical Substances Methemoglobin (9008-37-1) ; Cytochrome-B(5) Reductase (EC 1.6.2.2)
    Language English
    Publishing date 2023-03-20
    Publishing country Switzerland
    Document type Case Reports
    ZDB-ID 2188113-3
    ISSN 1648-9144 ; 1010-660X
    ISSN (online) 1648-9144
    ISSN 1010-660X
    DOI 10.3390/medicina59030615
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  3. Article ; Online: SLC23A3 is a renal hypoxanthine transporter.

    Hosoyamada, Makoto / Tomioka, Naoko H / Watanabe, Tamaki / Yasuno, Nobuhiro / Uchida, Shunya / Shibata, Shigeru

    Nucleosides, nucleotides & nucleic acids

    2022  , Page(s) 1–8

    Abstract: LLC-PK1 renal cells show ... ...

    Abstract LLC-PK1 renal cells show Na
    Language English
    Publishing date 2022-01-30
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2008956-9
    ISSN 1532-2335 ; 1525-7770
    ISSN (online) 1532-2335
    ISSN 1525-7770
    DOI 10.1080/15257770.2022.2028826
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  4. Article: [Pharmacological actions of anifrolumab (Saphnelo

    Ueha, Takeshi / Kusuda, Masaki / Shibata, Shoko / Hirata, Masako / Ozaki, Naoko

    Nihon yakurigaku zasshi. Folia pharmacologica Japonica

    2022  Volume 157, Issue 4, Page(s) 271–279

    Abstract: Systemic lupus erythematosus (SLE) is an autoimmune disease which causes damaging inflammation in multiple organs via the accumulation of immune complexes. SLE pathogenesis is associated with type I interferons (IFNs), which are central and reflective of ...

    Abstract Systemic lupus erythematosus (SLE) is an autoimmune disease which causes damaging inflammation in multiple organs via the accumulation of immune complexes. SLE pathogenesis is associated with type I interferons (IFNs), which are central and reflective of disease activity in SLE. Even before clinical development of disease, genetic and environmental contributions to IFN production lead to abnormal innate and adaptive immune activation. Through the Janus kinase-signal transducer and activator of transcription signaling pathway, IFN play a central role in the immunopathogenicity of SLE. Thus, IFN-blocking therapy may be used to regulate inflammation in individuals with SLE. Food and Drug Administration (FDA)-approved anifrolumab (Saphnelo
    MeSH term(s) Adult ; Antibodies, Monoclonal, Humanized/pharmacology ; Antibodies, Monoclonal, Humanized/therapeutic use ; Humans ; Inflammation ; Interferon Type I/metabolism ; Interferon Type I/therapeutic use ; Lupus Erythematosus, Systemic/drug therapy ; Lupus Erythematosus, Systemic/genetics
    Chemical Substances Antibodies, Monoclonal, Humanized ; Interferon Type I ; anifrolumab (38RL9AE51Q)
    Language Japanese
    Publishing date 2022-03-01
    Publishing country Japan
    Document type Journal Article ; Review
    ZDB-ID 1097532-9
    ISSN 1347-8397 ; 0015-5691
    ISSN (online) 1347-8397
    ISSN 0015-5691
    DOI 10.1254/fpj.22026
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  5. Article ; Online: Acute cataract by a high-intensity focused ultrasound procedure: a case report.

    Ikoma, Toru / Shibata, Teppei / Shibata, Naoko / Mito, Tsuyoshi / Kubo, Eri / Sasaki, Hiroshi

    BMC ophthalmology

    2022  Volume 22, Issue 1, Page(s) 164

    Abstract: Background: We report a case of acute onset of cataract after eyelid rejuvenation tightening with intense focused ultrasound (IFUS) treatment without using a protection device.: Case presentation: A 47-year-old female patient presented at the ... ...

    Abstract Background: We report a case of acute onset of cataract after eyelid rejuvenation tightening with intense focused ultrasound (IFUS) treatment without using a protection device.
    Case presentation: A 47-year-old female patient presented at the outpatient clinic with blurred vision in her left eye immediately after undergoing an eyelid tightening procedure, using IFUS, seven days prior. The patient had decreased vision in her left eye, caused by an acute cataract with several drop-like opacities and a rosette-like posterior subcapsular cataract. One month after her first visit, the patient's visual acuity in her left eye decreased to 20/630. A Swept-Source Anterior Segment optical coherence tomography confirmed that the posterior capsule was not ruptured. The patient underwent uneventful phacoemulsification cataract surgery with intraocular lens implantation, which resulted in full visual recovery.
    Conclusions: This case emphasized the need to evaluate possible ocular side effects, resulting from periocular IFUS without a protection device, including severe cataract requiring surgery.
    MeSH term(s) Cataract/etiology ; Cataract Extraction/adverse effects ; Female ; Humans ; Lens Implantation, Intraocular/adverse effects ; Middle Aged ; Phacoemulsification/adverse effects ; Visual Acuity
    Language English
    Publishing date 2022-04-09
    Publishing country England
    Document type Case Reports ; Journal Article
    ZDB-ID 2050436-6
    ISSN 1471-2415 ; 1471-2415
    ISSN (online) 1471-2415
    ISSN 1471-2415
    DOI 10.1186/s12886-022-02390-2
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  6. Article ; Online: Expression of Syo_1.56 SARP Regulator Unveils Potent Elasnin Derivatives with Antibacterial Activity.

    A Abdelhakim, Islam / Futamura, Yushi / Asami, Yukihiro / Hanaki, Hideaki / Kito, Naoko / Masuda, Sachiko / Shibata, Arisa / Muranaka, Atsuya / Koshino, Hiroyuki / Shirasu, Ken / Osada, Hiroyuki / Ishikawa, Jun / Takahashi, Shunji

    Journal of natural products

    2024  

    Abstract: Actinomycetes are prolific producers of natural products, particularly antibiotics. However, a significant proportion of its biosynthetic gene clusters (BGCs) remain silent under typical laboratory conditions. This limits the effectiveness of ... ...

    Abstract Actinomycetes are prolific producers of natural products, particularly antibiotics. However, a significant proportion of its biosynthetic gene clusters (BGCs) remain silent under typical laboratory conditions. This limits the effectiveness of conventional isolation methods for the discovery of novel natural products. Genetic interventions targeting the activation of silent gene clusters are necessary to address this challenge.
    Language English
    Publishing date 2024-04-23
    Publishing country United States
    Document type Journal Article
    ZDB-ID 304325-3
    ISSN 1520-6025 ; 0163-3864
    ISSN (online) 1520-6025
    ISSN 0163-3864
    DOI 10.1021/acs.jnatprod.4c00259
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  7. Article ; Online: Hereditary Congenital Methemoglobinemia Diagnosed at the Age of 79 Years

    Marohito Nakata / Naoko Yokota / Kazuhiko Tabata / Takuya Morikawa / Hiroki Shibata / Tsuneaki Kenzaka

    Medicina, Vol 59, Iss 615, p

    A Case Report

    2023  Volume 615

    Abstract: Background : Cardiopulmonary disorders are the most common cause of central cyanosis, and methemoglobinemia is often overlooked in the differential diagnosis of patients with central cyanosis. In most cases, methemoglobinemia is acquired and hereditary ... ...

    Abstract Background : Cardiopulmonary disorders are the most common cause of central cyanosis, and methemoglobinemia is often overlooked in the differential diagnosis of patients with central cyanosis. In most cases, methemoglobinemia is acquired and hereditary congenital methemoglobinemia is rare. Only a few case reports of congenital methemoglobinemia can be found in PubMed. To date, only four cases of congenital methemoglobinemia diagnosed after the age of 50 years have been reported. Case Presentation : A 79-year-old Japanese woman presented at our hospital with the chief complaints of dyspnea and cyanosis. She exhibited cyanosis of the lips and extremities, and her SpO 2 was 80%, with oxygen administration at 5 L/min. Blood gas analysis revealed a PaO 2 of 325.4 mmHg and methemoglobin level of 36.9%. The SpO 2 and PaO 2 values were dissociated, and methemoglobin levels were markedly elevated. Genetic analysis revealed a nonsynonymous variant in the gene encoding nicotinamide adenine dinucleotide cytochrome (NADH) B5 reductase 3 ( CYB5R3 ), and the patient was diagnosed with congenital methemoglobinemia. Conclusions : It is important to consider methemoglobinemia in the differential diagnosis of patients with central cyanosis. At 79 years of age, our patient represents the oldest patient with this diagnosis. This report indicates that it is crucial to consider the possibility of methemoglobinemia regardless of the patient’s age.
    Keywords cyanosis ; hereditary congenital methemoglobinemia ; old age ; Medicine (General) ; R5-920
    Subject code 610
    Language English
    Publishing date 2023-03-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: Sleeping Beauty transposon mutagenesis identified genes and pathways involved in inflammation-associated colon tumor development.

    Shimomura, Kana / Hattori, Naoko / Iida, Naoko / Muranaka, Yukari / Sato, Kotomi / Shiraishi, Yuichi / Arai, Yasuhito / Hama, Natsuko / Shibata, Tatsuhiro / Narushima, Daichi / Kato, Mamoru / Takamaru, Hiroyuki / Okamoto, Koji / Takeda, Haruna

    Nature communications

    2023  Volume 14, Issue 1, Page(s) 6514

    Abstract: Chronic inflammation promotes development and progression of colorectal cancer (CRC). To comprehensively understand the molecular mechanisms underlying the development and progression of inflamed CRC, we perform in vivo screening and identify 142 genes ... ...

    Abstract Chronic inflammation promotes development and progression of colorectal cancer (CRC). To comprehensively understand the molecular mechanisms underlying the development and progression of inflamed CRC, we perform in vivo screening and identify 142 genes that are frequently mutated in inflammation-associated colon tumors. These genes include senescence and TGFβ-activin signaling genes. We find that TNFα can induce stemness and activate senescence signaling by enhancing cell plasticity in colonic epithelial cells, which could act as a selective pressure to mutate senescence-related genes in inflammation-associated colonic tumors. Furthermore, we show the efficacy of the Cdk4/6 inhibitor in vivo for inflammation-associated colonic tumors. Finally, we functionally validate that Arhgap5 and Mecom are tumor suppressor genes, providing possible therapeutic targets for CRC. Thus, we demonstrate the importance of the inactivation of senescence pathways in CRC development and progression in an inflammatory microenvironment, which can help progress toward precision medicine.
    MeSH term(s) Humans ; Colorectal Neoplasms/genetics ; Colonic Neoplasms/genetics ; Mutagenesis ; Inflammation/genetics ; Signal Transduction ; Tumor Microenvironment
    Language English
    Publishing date 2023-10-16
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-023-42228-z
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  9. Article ; Online: Raman Microspectroscopy Imaging Analysis of Extracellular Vesicles Biogenesis by Filamentous Fungus Penicilium chrysogenum.

    Samuel, Ashok Zachariah / Horii, Shumpei / Nakashima, Takuji / Shibata, Naoko / Ando, Masahiro / Takeyama, Haruko

    Advanced biology

    2022  Volume 6, Issue 6, Page(s) e2101322

    Abstract: The mechanism of production of extracellular vesicles (EVs) and their molecular contents are of great interest due to their diverse roles in biological systems and are far from being completely understood. Even though cellular cargo releases mediated by ... ...

    Abstract The mechanism of production of extracellular vesicles (EVs) and their molecular contents are of great interest due to their diverse roles in biological systems and are far from being completely understood. Even though cellular cargo releases mediated by EVs have been demonstrated in several cases, their role in secondary metabolite production and release remains elusive. In this study, this aspect is investigated in detail using Raman microspectroscopic imaging. Considerable evidence is provided to suggest that the release of antibiotic penicillin by the filamentous fungus Penicillium chrysogenum involves EVs. Further, the study also reveals morphological modifications of the fungal body during biogenesis, changes in cell composition at the locus of biogenesis, and major molecular contents of the released EVs. The results suggest a possible general role of EVs in the release of antibiotics from the producing organisms.
    MeSH term(s) Extracellular Vesicles/metabolism ; Penicillins ; Penicillium chrysogenum/metabolism
    Chemical Substances Penicillins
    Language English
    Publishing date 2022-03-11
    Publishing country Germany
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 2701-0198
    ISSN (online) 2701-0198
    DOI 10.1002/adbi.202101322
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  10. Article ; Online: An autopsy case of sudden unexpected death with Barlow's disease.

    Hata, Yukiko / Tomita, Naoko / Shibata, Atsushi / Yokoyama, Shigeki / Fukahara, Kazuaki / Nishida, Naoki

    Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology

    2022  Volume 61, Page(s) 107462

    Abstract: A 45-year-old man was clinically diagnosed with mitral valve regurgitation 2 years before death. The autopsy showed left ventricular hypertrophy and mitral valve prolapse of the bileaflet with billowing valve and excessively thickened leaflet, the ... ...

    Abstract A 45-year-old man was clinically diagnosed with mitral valve regurgitation 2 years before death. The autopsy showed left ventricular hypertrophy and mitral valve prolapse of the bileaflet with billowing valve and excessively thickened leaflet, the findings of which were consistent with Barlow's disease. Microscopically, destruction of the 3-layer structure of the mitral valve and advanced interstitial fibrosis of the left ventricular wall were evident. Additionally, a marked but limited reduction in conduction fibers was found in the branching point of the left and right branches, as seen in cases of idiopathic complete atrioventricular block. Genetic investigation using whole-exome sequencing showed some genetic variants with uncertain significance. In patients with Barlow's disease, a marked reduction of conduction fibers might be a subtype of sudden cardiac death. The overlap of some arrhythmogenic substrate in the heart may increase the risk of sudden cardiac death with asymptomatic Barlow's disease.
    MeSH term(s) Male ; Humans ; Middle Aged ; Autopsy ; Treatment Outcome ; Mitral Valve Prolapse/complications ; Mitral Valve Prolapse/genetics ; Mitral Valve/pathology ; Death, Sudden, Cardiac/etiology
    Language English
    Publishing date 2022-08-09
    Publishing country United States
    Document type Case Reports
    ZDB-ID 1134600-0
    ISSN 1879-1336 ; 1054-8807
    ISSN (online) 1879-1336
    ISSN 1054-8807
    DOI 10.1016/j.carpath.2022.107462
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