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Article ; Online: Short-term dietary magnesium deficiency downregulates the expression of bone formation-related genes in rats.

Katsumata, Shinichi / Matsuzaki, Hiroshi

2024 Volume 36, Issue 3, Page(s) 23–29

Abstract: Dietary magnesium deficiency increases osteoclastic bone resorption and decreases osteoblastic bone formation. Increased bone resorption due to dietary magnesium deficiency can be explained by increased expression of the receptor activator of nuclear ... ...

Abstract	Dietary magnesium deficiency increases osteoclastic bone resorption and decreases osteoblastic bone formation. Increased bone resorption due to dietary magnesium deficiency can be explained by increased expression of the receptor activator of nuclear factor kB ligand. However, the detailed mechanisms underlying decreased bone formation remain unclear. Thus, in the present study, to determine the mechanism underlying decreased bone formation induced by dietary magnesium deficiency, we investigated the effects of short-term dietary magnesium deficiency on the mRNA expression of genes related to bone formation in rats. Male Wistar rats were fed a control or magnesium-deficient diet for eight days. The mRNA expression level of Runx2, Sp7, Bglap, Alpl, Col1a1, Igf1, and Bmp2 in the femur was significantly lower in magnesium-deficient rats than in control rats. These results suggest that short-term dietary magnesium deficiency decreases the gene expression of insulin-like growth factor-1 and bone morphogenetic protein 2, which, in turn, decreases osteoblastic bone formation through the downregulation of osteoblastogenesis-related gene expression.
MeSH term(s)	Rats ; Male ; Animals ; Magnesium Deficiency/genetics ; Magnesium Deficiency/metabolism ; Osteogenesis/genetics ; Magnesium/metabolism ; Rats, Wistar ; Bone Resorption/metabolism ; RNA, Messenger
Chemical Substances	Magnesium (I38ZP9992A) ; RNA, Messenger
Language	English
Publishing date	2024-03-12
Publishing country	England
Document type	Journal Article
ZDB-ID	1036384-1
ISSN	1952-4021 ; 0953-1424
ISSN (online)	1952-4021
ISSN	0953-1424
DOI	10.1684/mrh.2023.0518
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Zs.A 2658: Show issues

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Article ; Online: Discovery of pyridachlometyl: A new class of pyridazine fungicides.

Manabe, Akio / Ikegami, Hiroshi / Morishita, Hiroshi / Matsuzaki, Yuichi

Bioorganic & medicinal chemistry

2023 Volume 88-89, Page(s) 117332

Abstract: Pyridachlometyl is a unique pyridazine fungicide with a novel mode of action. Herein, we describe the pathway for the invention of pyridachlometyl. First, we identified a diphenyl-imidazo[1,2-a]pyrimidine as our proprietary lead with potent fungicidal ... ...

Abstract	Pyridachlometyl is a unique pyridazine fungicide with a novel mode of action. Herein, we describe the pathway for the invention of pyridachlometyl. First, we identified a diphenyl-imidazo[1,2-a]pyrimidine as our proprietary lead with potent fungicidal activity. Then, aiming to simplify the chemical structure, we applied judicious estimations to explore monocyclic heterocycles as pharmacophores. This enabled the identification of a novel class of tetrasubstituted pyridazine compounds with potent fungicidal activity, likely retaining the same mode of action as the aforementioned compounds. The findings indicated bioisosteric similarity between diphenyl-imidazo[1,2-a]pyrimidine and pyridazine. Further structure-activity and mammalian safety investigations of pyridazine compounds resulted in the discovery of pyridachlometyl as a candidate for commercial development.
MeSH term(s)	Animals ; Fungicides, Industrial/pharmacology ; Fungicides, Industrial/chemistry ; Biphenyl Compounds ; Pyrimidines/pharmacology ; Pyridazines/pharmacology ; Pyridazines/chemistry ; Structure-Activity Relationship ; Mammals
Chemical Substances	Fungicides, Industrial ; diphenyl (2L9GJK6MGN) ; Biphenyl Compounds ; Pyrimidines ; Pyridazines
Language	English
Publishing date	2023-05-16
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1161284-8
ISSN	1464-3391 ; 0968-0896
ISSN (online)	1464-3391
ISSN	0968-0896
DOI	10.1016/j.bmc.2023.117332
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Zs.A 3815: Show issues

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Article ; Online: Treadmill Exercise Suppresses Histological Progression of Disuse Atrophy in Articular Cartilage in Rat Knee Joints during Hindlimb Suspension.

Takahashi, Ikufumi / Matsuzaki, Taro / Kuroki, Hiroshi / Hoso, Masahiro

Cartilage

2023 Volume 14, Issue 4, Page(s) 482–491

Abstract: Objective: The purpose of this study was to determine the preventive effects of treadmill exercise or physiological loading on disuse atrophy in the rat knee joint cartilage and bone during hindlimb suspension.: Design: Twenty male rats were divided ... ...

Abstract	Objective: The purpose of this study was to determine the preventive effects of treadmill exercise or physiological loading on disuse atrophy in the rat knee joint cartilage and bone during hindlimb suspension. Design: Twenty male rats were divided into 4 experimental groups, including the control, hindlimb suspension, physiological loading, and treadmill walking groups. Histological changes in the articular cartilage and bone of the tibia were histomorphometrically and immunohistochemically evaluated 4 weeks after the intervention. Results: Compared with the control group, the hindlimb suspension group showed thinning of cartilage thickness, decreased matrix staining, and decreased proportion of noncalcified layers. Cartilage thinning, decreased matrix staining, and decreased noncalcified layers were suppressed in the treadmill walking group. The physiological loading group exhibited no significant suppression of cartilage thinning or decreased noncalcified layers, but the decreased matrix staining was significantly suppressed. No significant prevention of bone mass loss or changes in subchondral bone thickness were detected after physiological loading or treadmill walking. Conclusion: Disuse atrophy of the articular cartilage caused by unloading conditions could be prevented by treadmill walking in rat knee joints.
MeSH term(s)	Rats ; Male ; Animals ; Cartilage, Articular/pathology ; Hindlimb Suspension ; Knee Joint ; Tibia/pathology ; Muscular Disorders, Atrophic/pathology
Language	English
Publishing date	2023-02-17
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2515870-3
ISSN	1947-6043 ; 1947-6035
ISSN (online)	1947-6043
ISSN	1947-6035
DOI	10.1177/19476035231154510
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Article ; Online: Mechanical Characterization of Mucus on Intestinal Tissues by Atomic Force Microscopy.

Horikiri, Momoka / Taniguchi, Mugen / Yoshikawa, Hiroshi Y / Okumura, Ryu / Matsuzaki, Takahisa

Methods in molecular biology (Clifton, N.J.)

2024 Volume 2763, Page(s) 403–414

Abstract: Mucus is part of the innate immune system that defends the mucosa against microbiota and other infectious threats. The mechanical characteristics of mucus, such as viscosity, elasticity, and lubricity, are critically involved in its barrier function. ... ...

Abstract	Mucus is part of the innate immune system that defends the mucosa against microbiota and other infectious threats. The mechanical characteristics of mucus, such as viscosity, elasticity, and lubricity, are critically involved in its barrier function. However, assessing the mechanical properties of mucus remains challenging because of technical limitations. Thus, a new approach that characterizes the mechanical properties of mucus on colonic tissues needs to be developed. Here, we describe a novel strategy to characterize the ex vivo mechanical properties of mucus on colonic tissues using atomic force microscopy. This description includes the preparation of the mouse colon sample, AFM calibration, and determining the elasticity (Young's modulus, E [kPa]) of the mucus layer in the colon.
MeSH term(s)	Animals ; Mice ; Microscopy, Atomic Force ; Elasticity ; Elastic Modulus
Language	English
Publishing date	2024-02-13
Publishing country	United States
Document type	Journal Article
ISSN	1940-6029
ISSN (online)	1940-6029
DOI	10.1007/978-1-0716-3670-1_35
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Article ; Online: Histological and immunohistochemical analyses of articular cartilage during onset and progression of pre- and early-stage osteoarthritis in a rodent model.

Takahashi, Ikufumi / Takeda, Keisuke / Toyama, Tadashi / Matsuzaki, Taro / Kuroki, Hiroshi / Hoso, Masahiro

Scientific reports

2024 Volume 14, Issue 1, Page(s) 10568

Abstract: Early diagnosis and treatment of pre- and early-stage osteoarthritis (OA) is important. However, the cellular and cartilaginous changes occurring during these stages remain unclear. We investigated the histological and immunohistochemical changes over ... ...

Abstract	Early diagnosis and treatment of pre- and early-stage osteoarthritis (OA) is important. However, the cellular and cartilaginous changes occurring during these stages remain unclear. We investigated the histological and immunohistochemical changes over time between pre- and early-stage OA in a rat model of traumatic injury. Thirty-six male rats were divided into two groups, control and OA groups, based on destabilization of the medial meniscus. Histological and immunohistochemical analyses of articular cartilage were performed on days 1, 3, 7, 10, and 14 postoperatively. Cell density of proteins associated with cartilage degradation increased from postoperative day one. On postoperative day three, histological changes, including chondrocyte death, reduced matrix staining, and superficial fibrillation, were observed. Simultaneously, a compensatory increase in matrix staining was observed. The Osteoarthritis Research Society International score increased from postoperative day seven, indicating thinner cartilage. On postoperative day 10, the positive cell density decreased, whereas histological changes progressed with fissuring and matrix loss. The proteoglycan 4-positive cell density increased on postoperative day seven. These findings will help establish an experimental model and clarify the mechanism of the onset and progression of pre- and early-stage traumatic OA.
MeSH term(s)	Animals ; Cartilage, Articular/pathology ; Cartilage, Articular/metabolism ; Male ; Rats ; Osteoarthritis/pathology ; Osteoarthritis/metabolism ; Disease Models, Animal ; Disease Progression ; Immunohistochemistry ; Chondrocytes/metabolism ; Chondrocytes/pathology ; Rats, Sprague-Dawley ; Proteoglycans/metabolism
Chemical Substances	Proteoglycans
Language	English
Publishing date	2024-05-08
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-024-61502-8
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Article ; Online: Decomposing predictability to identify dominant causal drivers in complex ecosystems.

Suzuki, Kenta / Matsuzaki, Shin-Ichiro S / Masuya, Hiroshi

Proceedings of the National Academy of Sciences of the United States of America

2022 Volume 119, Issue 42, Page(s) e2204405119

Abstract: Ecosystems are complex systems of various physical, biological, and chemical processes. Since ecosystem dynamics are composed of a mixture of different levels of stochasticity and nonlinearity, handling these data is a challenge for existing methods of ... ...

Abstract	Ecosystems are complex systems of various physical, biological, and chemical processes. Since ecosystem dynamics are composed of a mixture of different levels of stochasticity and nonlinearity, handling these data is a challenge for existing methods of time series-based causal inferences. Here, we show that, by harnessing contemporary machine learning approaches, the concept of Granger causality can be effectively extended to the analysis of complex ecosystem time series and bridge the gap between dynamical and statistical approaches. The central idea is to use an ensemble of fast and highly predictive artificial neural networks to select a minimal set of variables that maximizes the prediction of a given variable. It enables decomposition of the relationship among variables through quantifying the contribution of an individual variable to the overall predictive performance. We show how our approach, EcohNet, can improve interaction network inference for a mesocosm experiment and simulated ecosystems. The application of the method to a long-term lake monitoring dataset yielded interpretable results on the drivers causing cyanobacteria blooms, which is a serious threat to ecological integrity and ecosystem services. Since performance of EcohNet is enhanced by its predictive capabilities, it also provides an optimized forecasting of overall components in ecosystems. EcohNet could be used to analyze complex and hybrid multivariate time series in many scientific areas not limited to ecosystems.
MeSH term(s)	Causality ; Ecosystem ; Lakes ; Machine Learning ; Neural Networks, Computer
Language	English
Publishing date	2022-10-10
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	209104-5
ISSN	1091-6490 ; 0027-8424
ISSN (online)	1091-6490
ISSN	0027-8424
DOI	10.1073/pnas.2204405119
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Zs.A 1148: Show issues

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Article ; Online: Noninvasive total counting of cultured cells using a home-use scanner with a pattern sheet.

Mizuno, Mitsuru / Maeda, Yoshitaka / Sanami, Sho / Matsuzaki, Takahisa / Yoshikawa, Hiroshi Y / Ozeki, Nobutake / Koga, Hideyuki / Sekiya, Ichiro

iScience

2024 Volume 27, Issue 3, Page(s) 109170

Abstract: The inherent variability in cell culture techniques hinders their reproducibility. To address this issue, we introduce a comprehensive cell observation device. This new approach enhances the features of existing home-use scanners by implementing a ... ...

Abstract	The inherent variability in cell culture techniques hinders their reproducibility. To address this issue, we introduce a comprehensive cell observation device. This new approach enhances the features of existing home-use scanners by implementing a pattern sheet. Compared with fluorescent staining, our method over- or underestimated the cell count by a mere 5%. The proposed technique showcased a strong correlation with conventional methodologies, displaying R
Language	English
Publishing date	2024-02-09
Publishing country	United States
Document type	Journal Article
ISSN	2589-0042
ISSN (online)	2589-0042
DOI	10.1016/j.isci.2024.109170
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Article ; Online: Editorial Comment to Importance of considering interest in sex when evaluating satisfaction after robot-assisted radical prostatectomy.

Haga, Nobuhiro / Miyazaki, Takeshi / Gunge, Naotaka / Matsuzaki, Hiroshi / Okabe, Yu

International journal of urology : official journal of the Japanese Urological Association

2022 Volume 29, Issue 5, Page(s) 454

MeSH term(s)	Humans ; Male ; Personal Satisfaction ; Prostate ; Prostatectomy ; Robotics ; Seminal Vesicles
Language	English
Publishing date	2022-02-25
Publishing country	Australia
Document type	Journal Article ; Comment
ZDB-ID	1328401-0
ISSN	1442-2042 ; 0919-8172
ISSN (online)	1442-2042
ISSN	0919-8172
DOI	10.1111/iju.14842
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Zs.A 4460: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 278: Show issues

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Article ; Online: Editorial Comment from Dr Haga et al. to Minimal residual membranous urethral length and membranous urethral length predict poor recovery from incontinence after robot-assisted radical prostatectomy and after open radical prostatectomy.

Haga, Nobuhiro / Miyazaki, Takeshi / Gunge, Naotaka / Okabe, Yu / Matsuzaki, Hiroshi

International journal of urology : official journal of the Japanese Urological Association

2022 Volume 29, Issue 12, Page(s) 1523–1524

MeSH term(s)	Male ; Humans ; Robotics ; Prostatectomy/adverse effects ; Urinary Incontinence/etiology ; Urethra/surgery ; Robotic Surgical Procedures/adverse effects ; Recovery of Function
Language	English
Publishing date	2022-09-14
Publishing country	Australia
Document type	Journal Article ; Comment
ZDB-ID	1328401-0
ISSN	1442-2042 ; 0919-8172
ISSN (online)	1442-2042
ISSN	0919-8172
DOI	10.1111/iju.15049
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Zs.MO 278: Show issues

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Article: [A Case of Recurrent Breast Cancer That Was BRCA1 Pathogenic Variant-Positive Successfully Treated with PARP Inhibitor].

Aoyagi, Tomoyoshi / Namura, Maki / Sakata, Haruhito / Tamanuki, Tamaki / Iwai, Mika / Iwata, Kanae / Takahashi, Hidekazu / Matsuzaki, Hiroshi

Gan to kagaku ryoho. Cancer & chemotherapy

2024 Volume 50, Issue 13, Page(s) 1462–1464

Abstract: The patient was a 51-year-old woman at the time of diagnosis of left breast cancer. She underwent a mastectomy and axillary dissection. Pathological findings were invasive ductal carcinoma of the breast, tumor diameter 25 mm, and metastasis in 2 of 16 ... ...

Abstract	The patient was a 51-year-old woman at the time of diagnosis of left breast cancer. She underwent a mastectomy and axillary dissection. Pathological findings were invasive ductal carcinoma of the breast, tumor diameter 25 mm, and metastasis in 2 of 16 removed axillary lymph nodes. The subtype was triple negative. Postoperative chemotherapy was administered, and the patient was followed by follow-up imaging. At the age of 63 years, ultrasonography showed local recurrence, and local mass excision was performed. Genetic abnormalities were suspected since she had a family history of breast cancer, and it was a recurrent case. After genetic counseling, she underwent genetic testing, which revealed a BRCA1 pathogenic variant, so we initiated imaging surveillance. At age 65, a chest CT scan was performed due to respiratory symptoms, and she was diagnosed with multiple lung metastases. Respiratory symptoms improved at the examination 1 month after administration of Poly ADP ribose polymerase(PARP)inhibitor, and the metastatic masses shrank at the CT scan 3 months later. She continues to maintain CR and has no respiratory symptoms at present.
MeSH term(s)	Female ; Humans ; Aged ; Middle Aged ; Breast Neoplasms/drug therapy ; Breast Neoplasms/genetics ; Breast Neoplasms/surgery ; Poly(ADP-ribose) Polymerase Inhibitors/therapeutic use ; Mastectomy ; Neoplasm Recurrence, Local/drug therapy ; Neoplasm Recurrence, Local/surgery ; Antineoplastic Agents/therapeutic use ; BRCA1 Protein/genetics
Chemical Substances	Poly(ADP-ribose) Polymerase Inhibitors ; Antineoplastic Agents ; BRCA1 protein, human ; BRCA1 Protein
Language	Japanese
Publishing date	2024-02-01
Publishing country	Japan
Document type	Case Reports ; English Abstract ; Journal Article
ZDB-ID	604842-0
ISSN	0385-0684
ISSN	0385-0684
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Zs.B 2573: Show issues

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