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  1. Article ; Online: M

    Moran, Sean P / Dickerson, Jonathan W / Cho, Hyekyung P / Xiang, Zixiu / Maksymetz, James / Remke, Daniel H / Lv, Xiaohui / Doyle, Catherine A / Rajan, Deepa H / Niswender, Colleen M / Engers, Darren W / Lindsley, Craig W / Rook, Jerri M / Conn, P Jeffrey

    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology

    2018  Volume 43, Issue 8, Page(s) 1763–1771

    Abstract: Highly selective positive allosteric modulators (PAMs) of the M ...

    Abstract Highly selective positive allosteric modulators (PAMs) of the M
    MeSH term(s) Allosteric Regulation ; Animals ; CHO Cells ; Cholinergic Agents/pharmacology ; Cricetulus ; Excitatory Postsynaptic Potentials/drug effects ; Excitatory Postsynaptic Potentials/physiology ; Male ; Mice, Inbred C57BL ; Nootropic Agents/pharmacology ; Prefrontal Cortex/drug effects ; Prefrontal Cortex/physiology ; Pyramidal Cells/drug effects ; Pyramidal Cells/physiology ; Rats ; Rats, Sprague-Dawley ; Receptor, Muscarinic M1/agonists ; Receptor, Muscarinic M1/genetics ; Receptor, Muscarinic M1/metabolism ; Recognition (Psychology)/drug effects ; Tissue Culture Techniques
    Chemical Substances Cholinergic Agents ; Nootropic Agents ; Receptor, Muscarinic M1
    Language English
    Publishing date 2018-03-14
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 639471-1
    ISSN 1740-634X ; 0893-133X
    ISSN (online) 1740-634X
    ISSN 0893-133X
    DOI 10.1038/s41386-018-0033-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2379: Show issues Location:
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  2. Article ; Online: M

    Maksymetz, James / Joffe, Max E / Moran, Sean P / Stansley, Branden J / Li, Brianna / Temple, Kayla / Engers, Darren W / Lawrence, J Josh / Lindsley, Craig W / Conn, P Jeffrey

    Biological psychiatry

    2019  Volume 85, Issue 12, Page(s) 989–1000

    Abstract: ... tools to assess the involvement of M: Results: M: Conclusions: M ...

    Abstract Background: The prefrontal cortex (PFC) integrates information from multiple inputs to exert top-down control allowing for appropriate responses in a given context. In psychiatric disorders such as posttraumatic stress disorder, PFC hyperactivity is associated with inappropriate fear in safe situations. We previously reported a form of muscarinic acetylcholine receptor (mAChR)-dependent long-term depression in the PFC that we hypothesize is involved in appropriate fear responding and could serve to reduce cortical hyperactivity following stress. However, it is unknown whether this long-term depression occurs at fear-related inputs.
    Methods: Using optogenetics with extracellular and whole-cell electrophysiology, we assessed the effect of mAChR activation on the synaptic strength of specific PFC inputs. We used selective pharmacological tools to assess the involvement of M
    Results: M
    Conclusions: M
    MeSH term(s) Animals ; Basolateral Nuclear Complex/physiology ; Conditioning, Classical ; Extinction, Psychological/physiology ; Fear/physiology ; Hippocampus/physiology ; Long-Term Synaptic Depression ; Mediodorsal Thalamic Nucleus/physiology ; Mice, Inbred C57BL ; Neural Pathways/physiology ; Neurons/physiology ; Prefrontal Cortex/physiology ; Receptor, Muscarinic M1/physiology ; Stress Disorders, Post-Traumatic/physiopathology ; Synaptic Transmission/physiology
    Chemical Substances Receptor, Muscarinic M1
    Language English
    Publishing date 2019-03-07
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 209434-4
    ISSN 1873-2402 ; 0006-3223
    ISSN (online) 1873-2402
    ISSN 0006-3223
    DOI 10.1016/j.biopsych.2019.02.020
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 720: Show issues Location:
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  3. Article ; Online: m

    Tong, Jiyu / Cao, Guangchao / Zhang, Ting / Sefik, Esen / Amezcua Vesely, Maria Carolina / Broughton, James P / Zhu, Shu / Li, Huabin / Li, Bin / Chen, Lei / Chang, Howard Y / Su, Bing / Flavell, Richard A / Li, Hua-Bing

    Cell research

    2018  Volume 28, Issue 2, Page(s) 253–256

    MeSH term(s) Adenosine/analogs & derivatives ; Adenosine/genetics ; Adenosine/metabolism ; Animals ; Autoimmune Diseases/etiology ; CD4-Positive T-Lymphocytes/metabolism ; Cell Proliferation ; Gene Expression Regulation ; Male ; Methylation ; Methyltransferases/metabolism ; Mice ; Mice, Knockout ; Sequence Analysis, RNA ; T-Lymphocytes, Regulatory/metabolism
    Chemical Substances N-methyladenosine (CLE6G00625) ; Methyltransferases (EC 2.1.1.-) ; Mettl3 protein, mouse (EC 2.1.1.-) ; Adenosine (K72T3FS567)
    Language English
    Publishing date 2018-01-05
    Publishing country England
    Document type Letter
    ZDB-ID 1319303-x
    ISSN 1748-7838 ; 1001-0602
    ISSN (online) 1748-7838
    ISSN 1001-0602
    DOI 10.1038/cr.2018.7
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    Zs.A 5283: Show issues Location:
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  4. Article ; Online: m

    Ke, Shengdong / Pandya-Jones, Amy / Saito, Yuhki / Fak, John J / Vågbø, Cathrine Broberg / Geula, Shay / Hanna, Jacob H / Black, Douglas L / Darnell, James E / Darnell, Robert B

    Genes & development

    2017  Volume 31, Issue 10, Page(s) 990–1006

    Abstract: Understanding the biologic role ... ...

    Abstract Understanding the biologic role of
    MeSH term(s) Animals ; Chromatin/metabolism ; Cytoplasm/metabolism ; Embryonic Stem Cells ; Exons/genetics ; Gene Knockout Techniques ; HeLa Cells ; Humans ; Introns/genetics ; Methylation ; Methyltransferases/genetics ; Methyltransferases/metabolism ; Mice ; RNA Precursors/metabolism ; RNA Splicing ; RNA, Messenger/metabolism
    Chemical Substances Chromatin ; RNA Precursors ; RNA, Messenger ; Methyltransferases (EC 2.1.1.-) ; Mettl3 protein, mouse (EC 2.1.1.-)
    Language English
    Publishing date 2017-05-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 806684-x
    ISSN 1549-5477 ; 0890-9369
    ISSN (online) 1549-5477
    ISSN 0890-9369
    DOI 10.1101/gad.301036.117
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2292: Show issues Location:
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    Zs.MG 54: Show issues

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  5. Article ; Online: m

    Li, Hua-Bing / Tong, Jiyu / Zhu, Shu / Batista, Pedro J / Duffy, Erin E / Zhao, Jun / Bailis, Will / Cao, Guangchao / Kroehling, Lina / Chen, Yuanyuan / Wang, Geng / Broughton, James P / Chen, Y Grace / Kluger, Yuval / Simon, Matthew D / Chang, Howard Y / Yin, Zhinan / Flavell, Richard A

    Nature

    2017  Volume 548, Issue 7667, Page(s) 338–342

    Abstract: ... ...

    Abstract N
    MeSH term(s) Adenosine/analogs & derivatives ; Adenosine/metabolism ; Adoptive Transfer ; Animals ; Cell Differentiation ; Cell Proliferation ; Colitis/prevention & control ; DNA-Binding Proteins/deficiency ; Disease Models, Animal ; Female ; Homeostasis ; Interleukin-7/immunology ; Male ; Methylation ; Methyltransferases/deficiency ; Mice ; RNA Stability ; RNA, Messenger/chemistry ; RNA, Messenger/metabolism ; STAT5 Transcription Factor/metabolism ; Signal Transduction ; Suppressor of Cytokine Signaling 1 Protein/genetics ; Suppressor of Cytokine Signaling 3 Protein/genetics ; Suppressor of Cytokine Signaling Proteins/genetics ; Suppressor of Cytokine Signaling Proteins/metabolism ; T-Lymphocytes/cytology ; T-Lymphocytes/immunology ; T-Lymphocytes/metabolism
    Chemical Substances DNA-Binding Proteins ; Interleukin-7 ; RNA, Messenger ; Rag2 protein, mouse ; STAT5 Transcription Factor ; Socs1 protein, mouse ; Socs3 protein, mouse ; Suppressor of Cytokine Signaling 1 Protein ; Suppressor of Cytokine Signaling 3 Protein ; Suppressor of Cytokine Signaling Proteins ; cytokine inducible SH2-containing protein ; N-methyladenosine (CLE6G00625) ; Methyltransferases (EC 2.1.1.-) ; Mettl3 protein, mouse (EC 2.1.1.-) ; Adenosine (K72T3FS567)
    Language English
    Publishing date 2017-08-09
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 120714-3
    ISSN 1476-4687 ; 0028-0836
    ISSN (online) 1476-4687
    ISSN 0028-0836
    DOI 10.1038/nature23450
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 26: Show issues Location:
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    Zs.MG 9: Show issues
    Zs.MO 244: Show issues

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  6. Article ; Online: The m

    Weng, Hengyou / Huang, Feng / Yu, Zhaojin / Chen, Zhenhua / Prince, Emily / Kang, Yalin / Zhou, Keren / Li, Wei / Hu, Jiacheng / Fu, Chen / Aziz, Tursunjan / Li, Hongzhi / Li, Jingwen / Yang, Ying / Han, Li / Zhang, Subo / Ma, Yuelong / Sun, Mingli / Wu, Huizhe /
    Zhang, Zheng / Wunderlich, Mark / Robinson, Sean / Braas, Daniel / Hoeve, Johanna Ten / Zhang, Bin / Marcucci, Guido / Mulloy, James C / Zhou, Keda / Tao, Hong-Fang / Deng, Xiaolan / Horne, David / Wei, Minjie / Huang, Huilin / Chen, Jianjun

    Cancer cell

    2022  Volume 40, Issue 12, Page(s) 1566–1582.e10

    Abstract: ... ...

    Abstract N
    MeSH term(s) Humans ; Glutamine/metabolism ; Leukemia, Myeloid, Acute/drug therapy ; Leukemia, Myeloid, Acute/genetics ; Leukemia, Myeloid, Acute/metabolism ; RNA Stability ; Prognosis ; Minor Histocompatibility Antigens ; Amino Acid Transport System ASC/genetics ; Amino Acid Transport System ASC/metabolism ; RNA-Binding Proteins/genetics ; RNA-Binding Proteins/metabolism
    Chemical Substances Glutamine (0RH81L854J) ; SLC1A5 protein, human ; Minor Histocompatibility Antigens ; Amino Acid Transport System ASC ; IGF2BP2 protein, human ; RNA-Binding Proteins
    Language English
    Publishing date 2022-10-27
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 2078448-X
    ISSN 1878-3686 ; 1535-6108
    ISSN (online) 1878-3686
    ISSN 1535-6108
    DOI 10.1016/j.ccell.2022.10.004
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    Zs.A 5650: Show issues Location:
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    Zs.MG 104: Show issues

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  7. Article ; Online: The m

    Xiao, Yiren / Thakkar, Kaushik N / Zhao, Hongjuan / Broughton, James / Li, Yang / Seoane, Jose A / Diep, Anh N / Metzner, Thomas J / von Eyben, Rie / Dill, David L / Brooks, James D / Curtis, Christina / Leppert, John T / Ye, Jiangbin / Peehl, Donna M / Giaccia, Amato J / Sinha, Subarna / Rankin, Erinn B

    Proceedings of the National Academy of Sciences of the United States of America

    2020  Volume 117, Issue 35, Page(s) 21441–21449

    Abstract: ... transcriptomic data. Using this approach, we identified a synthetic lethal interaction between VHL and the m ...

    Abstract Loss of the von Hippel-Lindau (VHL) tumor suppressor is a hallmark feature of renal clear cell carcinoma. VHL inactivation results in the constitutive activation of the hypoxia-inducible factors (HIFs) HIF-1 and HIF-2 and their downstream targets, including the proangiogenic factors VEGF and PDGF. However, antiangiogenic agents and HIF-2 inhibitors have limited efficacy in cancer therapy due to the development of resistance. Here we employed an innovative computational platform, Mining of Synthetic Lethals (MiSL), to identify synthetic lethal interactions with the loss of VHL through analysis of primary tumor genomic and transcriptomic data. Using this approach, we identified a synthetic lethal interaction between VHL and the m
    MeSH term(s) Alpha-Ketoglutarate-Dependent Dioxygenase FTO/genetics ; Alpha-Ketoglutarate-Dependent Dioxygenase FTO/metabolism ; Amino Acid Transport System ASC/metabolism ; Animals ; Basic Helix-Loop-Helix Transcription Factors/metabolism ; Carcinoma, Renal Cell/genetics ; Carcinoma, Renal Cell/metabolism ; Cell Line, Tumor ; Computer Simulation ; Humans ; Hypoxia-Inducible Factor 1/metabolism ; Kidney Neoplasms/genetics ; Kidney Neoplasms/metabolism ; Mice, Knockout ; Minor Histocompatibility Antigens/metabolism ; Synthetic Lethal Mutations ; Von Hippel-Lindau Tumor Suppressor Protein/genetics
    Chemical Substances Amino Acid Transport System ASC ; Basic Helix-Loop-Helix Transcription Factors ; Hypoxia-Inducible Factor 1 ; Minor Histocompatibility Antigens ; SLC1A5 protein, human ; endothelial PAS domain-containing protein 1 (1B37H0967P) ; Alpha-Ketoglutarate-Dependent Dioxygenase FTO (EC 1.14.11.33) ; FTO protein, human (EC 1.14.11.33) ; Von Hippel-Lindau Tumor Suppressor Protein (EC 2.3.2.27) ; VHL protein, human (EC 6.3.2.-)
    Language English
    Publishing date 2020-08-19
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 209104-5
    ISSN 1091-6490 ; 0027-8424
    ISSN (online) 1091-6490
    ISSN 0027-8424
    DOI 10.1073/pnas.2000516117
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    Zs.A 1148: Show issues Location:
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  8. Article ; Online: Mo' m

    Miller, Linamarie / Shorter, James

    Cell chemical biology

    2024  Volume 31, Issue 1, Page(s) 14–16

    Abstract: CAG-repeat expansions underlie fatal neurodegenerative disorders. In a lodestar study published in a recent issue of Nature, Sun et al. ...

    Abstract CAG-repeat expansions underlie fatal neurodegenerative disorders. In a lodestar study published in a recent issue of Nature, Sun et al.
    MeSH term(s) Humans ; Neurodegenerative Diseases/genetics ; RNA
    Chemical Substances RNA (63231-63-0)
    Language English
    Publishing date 2024-01-14
    Publishing country United States
    Document type Journal Article
    ISSN 2451-9448
    ISSN (online) 2451-9448
    DOI 10.1016/j.chembiol.2023.12.013
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  9. Article: SARS-CoV-2 M

    Chen, Sizhu Amelia / Arutyunova, Elena / Lu, Jimmy / Khan, Muhammad Bashir / Rut, Wioletta / Zmudzinski, Mikolaj / Shahbaz, Shima / Iyyathurai, Jegan / Moussa, Eman W / Turner, Zoe / Bai, Bing / Lamer, Tess / Nieman, James A / Vederas, John C / Julien, Olivier / Drag, Marcin / Elahi, Shokrollah / Young, Howard S / Lemieux, M Joanne

    ACS central science

    2023  Volume 9, Issue 4, Page(s) 696–708

    Abstract: The main protease of SARS-CoV-2 (M ...

    Abstract The main protease of SARS-CoV-2 (M
    Language English
    Publishing date 2023-03-21
    Publishing country United States
    Document type Journal Article
    ISSN 2374-7943
    ISSN 2374-7943
    DOI 10.1021/acscentsci.3c00054
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  10. Article ; Online: Marjorie E.M. Allison.

    Lowe, Gordon / McKillop, James / Gray, Harry

    The journal of the Royal College of Physicians of Edinburgh

    2024  Volume 54, Issue 1, Page(s) 108

    Language English
    Publishing date 2024-01-19
    Publishing country England
    Document type Journal Article
    ZDB-ID 2866363-9
    ISSN 2042-8189 ; 0953-0932
    ISSN (online) 2042-8189
    ISSN 0953-0932
    DOI 10.1177/14782715241227078
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