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Article ; Online: Initial Upper Palaeolithic material culture by 45,000 years ago at Shiyu in northern China.

Nature ecology & evolution

2024 Volume 8, Issue 3, Page(s) 552–563

Abstract: ... in China dating to 43-41 ka. Here we describe an IUP assemblage from Shiyu in northern China, dating to ∼45 ... ka. Shiyu contains a stone tool assemblage produced by Levallois and Volumetric Blade Reduction ... tool and a shaped graphite disc. Shiyu exhibits a set of advanced cultural behaviours, and together ...

Abstract	The geographic expansion of Homo sapiens populations into southeastern Europe occurred by ∼47,000 years ago (∼47 ka), marked by Initial Upper Palaeolithic (IUP) technology. H. sapiens was present in western Siberia by ∼45 ka, and IUP industries indicate early entries by ∼50 ka in the Russian Altai and 46-45 ka in northern Mongolia. H. sapiens was in northeastern Asia by ∼40 ka, with a single IUP site in China dating to 43-41 ka. Here we describe an IUP assemblage from Shiyu in northern China, dating to ∼45 ka. Shiyu contains a stone tool assemblage produced by Levallois and Volumetric Blade Reduction methods, the long-distance transfer of obsidian from sources in China and the Russian Far East (800-1,000 km away), increased hunting skills denoted by the selective culling of adult equids and the recovery of tanged and hafted projectile points with evidence of impact fractures, and the presence of a worked bone tool and a shaped graphite disc. Shiyu exhibits a set of advanced cultural behaviours, and together with the recovery of a now-lost human cranial bone, the record supports an expansion of H. sapiens into eastern Asia by about 45 ka.
MeSH term(s)	Humans ; Fossils ; China ; Europe ; Skull ; Anthropology, Cultural
Language	English
Publishing date	2024-01-18
Publishing country	England
Document type	Journal Article
ISSN	2397-334X
ISSN (online)	2397-334X
DOI	10.1038/s41559-023-02294-4
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Article ; Online: Understanding the Formation and Growth of New Atmospheric Particles at the Molecular Level through Laboratory Molecular Beam Experiments.

Wang, Yadong / Zhan, Shiyu / Hu, Yongjun / Chen, Xi / Yin, Shi

ChemPlusChem

2024 , Page(s) e202400108

Abstract: Atmospheric new particle formation (NPF), which exerts comprehensive implications for climate, air quality and human health, has received extensive attention. From molecule to cluster is the initial and most important stage of the nucleation process of ... ...

Abstract	Atmospheric new particle formation (NPF), which exerts comprehensive implications for climate, air quality and human health, has received extensive attention. From molecule to cluster is the initial and most important stage of the nucleation process of atmospheric new particles. However, due to the complexity of the nucleation process and limitations of experimental characterization techniques, there is still a great uncertainty in understanding the nucleation mechanism at the molecular level. Laboratory-based molecular beam methods can experimentally implement the generation and growth of typical atmospheric gas-phase nucleation precursors to nanoscale clusters, characterize the key physical and chemical properties of clusters such as structure and composition, and obtain a series of their physicochemical parameters, including association rate coefficients, electron binding energy, pickup cross section and pickup probability and so on. These parameters can quantitatively illustrate the physicochemical properties of the cluster, and evaluate the effect of different gas phase nucleation precursors on the formation and growth of atmospheric new particles. We review the present literatures on atmospheric cluster formation and reaction employing the experimental method of laboratory molecular beam. The experimental apparatuses were classified and summarized from three aspects of cluster generation, growth and detection processes. Focus of this review is on the properties of nucleation clusters involving different precursor molecules of water, sulfuric acid, nitric acid and N
Language	English
Publishing date	2024-03-18
Publishing country	Germany
Document type	Journal Article ; Review
ISSN	2192-6506
ISSN (online)	2192-6506
DOI	10.1002/cplu.202400108
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Article: Study on Radiation Shielding Properties of New Barium-Doped Zinc Tellurite Glass.

Yin, Shiyu / Wang, Hao / Li, Aifeng / Ma, Zhongjian / He, Yintong

Materials (Basel, Switzerland)

2022 Volume 15, Issue 6

Abstract: This study aimed to investigate the effect of ... ...

Abstract	This study aimed to investigate the effect of BaF
Language	English
Publishing date	2022-03-13
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2487261-1
ISSN	1996-1944
ISSN	1996-1944
DOI	10.3390/ma15062117
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Article ; Online: Long-term night shift work, genetic predisposition, and risk of incident asthma: a prospective cohort study.

Hu, Bingzhu / Xie, Yujia / Yin, Haoyu / Yang, Shiyu / You, Xiaojie / Ma, Jixuan / Yang, Liangle

QJM : monthly journal of the Association of Physicians

2024

Abstract: Background: Evidence about a potential link between current and lifetime night shift work and risk of incident asthma is insufficient.: Aim: To investigate the association of current and lifetime night shift work with risk of incident asthma, and the ...

Abstract	Background: Evidence about a potential link between current and lifetime night shift work and risk of incident asthma is insufficient. Aim: To investigate the association of current and lifetime night shift work with risk of incident asthma, and the modified effect of genetic susceptibility on this association. Design and methods: We included 253,773 individuals with complete night shift work information in the UK biobank. We calculated the standard polygenetic risk score (PRS) for asthma. The Cox proportional hazard models were conducted to estimate hazard ratios (HRs) and 95% CIs. Results: After multivariable adjustments, we found that current night shift work was associated with an increased risk of incident asthma in a dose-response fashion (P for trend<0.001). Compared with day workers, those working usual/permanent night shifts had a 17% (95% CI: 1.04-1.33) higher risk of asthma incidence. In addition, we observed significant dose-dependent relationships of longer lifetime duration or frequency of night shift work with elevated risk of asthma incidence (all P for trend<0.05). Compared with never night shift workers, those with a duration (≥5 years) or frequency (≥8 nights/month) of night shift work exhibited a 20% (95% CI: 1.03-1.39) or 22% (95% CI: 1.03-1.44) higher risk of incident asthma, respectively. Moreover, the elevated risk of incident asthma related to current and lifetime night shift work exposure was strengthened by high PRS, although no significant shift work-PRS interactions were detected. Conclusion: Both current and lifetime night shift work may increase the risk of incident asthma, regardless of genetic predisposition to asthma.
Language	English
Publishing date	2024-04-10
Publishing country	England
Document type	Journal Article
ZDB-ID	1199985-8
ISSN	1460-2393 ; 0033-5622 ; 1460-2725
ISSN (online)	1460-2393
ISSN	0033-5622 ; 1460-2725
DOI	10.1093/qjmed/hcae068
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Article ; Online: Targeting PRL phosphatases in hematological malignancies.

Xiao, Shiyu / Chen, Hongxia / Bai, Yunpeng / Zhang, Zhong-Yin / Liu, Yan

Expert opinion on therapeutic targets

2024

Abstract: Introduction: Phosphatase of regenerating liver (PRL) family proteins, also known as protein tyrosine phosphatase 4A (PTP4A), have been implicated in many types of cancers. The PRL family of phosphatases consists of three members, PRL1, PRL2, and PRL3. ... ...

Abstract	Introduction: Phosphatase of regenerating liver (PRL) family proteins, also known as protein tyrosine phosphatase 4A (PTP4A), have been implicated in many types of cancers. The PRL family of phosphatases consists of three members, PRL1, PRL2, and PRL3. PRLs have been shown to harbor oncogenic potentials and are highly expressed in a variety of cancers. Given their roles in cancer progression and metastasis, PRLs are potential targets for anticancer therapies. However, additional studies are needed to be performed to fully understand the roles of PRLs in blood cancers. Areas covered: In this review, we will summarize recent studies of PRLs in normal and malignant hematopoiesis, the role of PRLs in regulating various signaling pathways, and the therapeutic potentials of targeting PRLs in hematological malignancies. We will also discuss how to improve current PRL inhibitors for cancer treatment. Expert opinion: Although PRL inhibitors show promising therapeutic effects in preclinical studies of different types of cancers, moving PRL inhibitors from bench to bedside is still challenging. More potent and selective PRL inhibitors are needed to target PRLs in hematological malignancies and improve treatment outcomes.
Language	English
Publishing date	2024-04-23
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2055208-7
ISSN	1744-7631 ; 1472-8222
ISSN (online)	1744-7631
ISSN	1472-8222
DOI	10.1080/14728222.2024.2344695
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Article: Isolation and Identification of the Causal Agent of Top Rot and the Genetic Architecture of Resistance in Maize.

Liu, Huanhuan / Zhao, Chunyue / Wang, Yan / Ye, Shiyu / He, Yonghui / Hu, Qinying / Yin, Zhitong

Plant disease

2023 Volume 107, Issue 9, Page(s) 2799–2807

Abstract: In maize ( ...

Abstract	In maize (
MeSH term(s)	Zea mays/genetics ; Zea mays/microbiology ; Chromosome Mapping ; Quantitative Trait Loci ; Fusarium/genetics
Language	English
Publishing date	2023-09-19
Publishing country	United States
Document type	Journal Article
ZDB-ID	754182-x
ISSN	0191-2917
ISSN	0191-2917
DOI	10.1094/PDIS-02-23-0276-RE
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Article ; Online: Balancing the Components of Biomass and the Reactivity of Pyrolysis Gas: Biomass-Assisted Recycling of Spent LiCoO

Zhou, Fengyin / Wang, Hongya / Wang, Shiyu / Zhao, Jingjing / Qu, Xin / Wang, Danfeng / Cai, Yuqi / Zheng, Zhiyu / Wang, Dihua / Yin, Huayi

Environmental science & technology

2024 Volume 58, Issue 4, Page(s) 2102–2111

Abstract: Waste biomass is one of the promising feedstocks to supply syngas that can be used as fuels, chemicals, reductants, etc. However, the relationship between the component of biomass and the constituent of pyrolysis gas remains unclear. Here, we study the ... ...

Abstract	Waste biomass is one of the promising feedstocks to supply syngas that can be used as fuels, chemicals, reductants, etc. However, the relationship between the component of biomass and the constituent of pyrolysis gas remains unclear. Here, we study the pyrolysis behaviors of various biomasses and reveal the relationship between the biomass components and gas compositions. Further, different pyrolysis gases are applied for the reduction of spent lithium cobalt oxide (LiCoO
MeSH term(s)	Biomass ; Pyrolysis ; Electric Power Supplies ; Lignin/chemistry ; Recycling ; Gases
Chemical Substances	Lignin (9005-53-2) ; Gases
Language	English
Publishing date	2024-01-18
Publishing country	United States
Document type	Journal Article
ISSN	1520-5851
ISSN (online)	1520-5851
DOI	10.1021/acs.est.3c07279
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Article ; Online: Effects of air pollution control policies on intracerebral hemorrhage mortality among residents in Tianjin, China.

Xu, Jiahui / Yin, Xiaolin / Jiang, Tingting / Wang, Shiyu / Wang, Dezheng

BMC public health

2023 Volume 23, Issue 1, Page(s) 858

Abstract: Background: Exposure to air pollution is an important risk factor for intracerebral hemorrhage (ICH), which is a major cause of death worldwide. However, the relationship between ICH mortality and air quality improvement has been poorly studied. This ... ...

Abstract	Background: Exposure to air pollution is an important risk factor for intracerebral hemorrhage (ICH), which is a major cause of death worldwide. However, the relationship between ICH mortality and air quality improvement has been poorly studied. This study aims to evaluate the impact of the air pollution control policies in the Beijing-Tianjin-Hebei region on ICH mortality among Tianjin residents. Methods: This study used an interrupted time series analysis. We fitted autoregressive integrated moving average (ARIMA) models to assess the changes in ICH deaths before and after the interventions of air pollution control policies based on the data of ICH deaths in Tianjin collected by the Tianjin Center for Disease Control and Prevention. Results: Between 2009 and 2020, there were 63,944 ICH deaths in Tianjin, and there was an overall decreasing trend in ICH mortality. The intervention conducted in June 2014 resulted in a statistically significant (p = 0.03) long-term trend change, reducing the number of deaths from ICH by 0.69 (95% confidence interval [CI]: -1.30 to -0.07) per month. The intervention in October 2017 resulted in a statistically significant (p = 0.04) immediate decrease of 25.74 (95% CI: -50.62 to -0.85) deaths from ICH in that month. The intervention in December 2017 caused a statistically significant (p = 0.04) immediate reduction of 26.58 (95% CI: -52.02 to -1.14) deaths from ICH in that month. The intervention in March 2018 resulted in a statistically significant (p = 0.02) immediate decrease of 30.40 (95% CI: -56.41 to -4.40) deaths from ICH in that month. No significant differences were observed in the changes of male ICH mortality after any of the four interventions. However, female ICH deaths showed statistically significant long-term trend change after the intervention in June 2014 and immediate changes after the interventions in December 2017 and March 2018. Overall, the interventions prevented an estimated 5984.76 deaths due to ICH. Conclusion: During the study period, some interventions of air pollution control policies were significantly associated with the reductions in the number of deaths from ICH among residents in Tianjin. ICH survivors and females were more sensitive to the protective effects of the interventions. Interventions for air pollution control can achieve public health gains in cities with high levels of air pollution.
MeSH term(s)	Humans ; Male ; Female ; Particulate Matter/analysis ; China/epidemiology ; Air Pollution/adverse effects ; Air Pollution/prevention & control ; Air Pollution/analysis ; Beijing ; Cerebral Hemorrhage ; Air Pollutants/adverse effects ; Air Pollutants/analysis ; Environmental Monitoring
Chemical Substances	Particulate Matter ; Air Pollutants
Language	English
Publishing date	2023-05-11
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2041338-5
ISSN	1471-2458 ; 1471-2458
ISSN (online)	1471-2458
ISSN	1471-2458
DOI	10.1186/s12889-023-15735-3
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Article: Niban apoptosis regulator 1 promotes gemcitabine resistance by activating the focal adhesion kinase signaling pathway in bladder cancer.

Tong, Shiyu / Yin, Hongling / Fu, Jun / Li, Yangle

Journal of Cancer

2022 Volume 13, Issue 4, Page(s) 1103–1118

Abstract: Although intravesical gemcitabine (GEM) chemotherapy (IGC) can effectively reduce the recurrence risk of non-muscle invasive bladder cancer (NMIBC), the development of GEM resistance may occur and result in cancer recurrence and disease progression. ... ...

Abstract	Although intravesical gemcitabine (GEM) chemotherapy (IGC) can effectively reduce the recurrence risk of non-muscle invasive bladder cancer (NMIBC), the development of GEM resistance may occur and result in cancer recurrence and disease progression. Herein, a label-free proteomics approach was used to characterize the proteomic profiles of primary/post-IGC recurrent NMIBC. A total of 218 proteins were found to be differentially expressed in paired primary and post-IGC recurrent NMIBC. Kyoto Encyclopedia of Genes and Genomes pathway analysis revealed that multiple signaling pathways including "focal adhesion" were highly enriched in recurrent NMIBC. Niban apoptosis regulator 1 (NIBAN1) was identified as the top upregulated protein in recurrent NMIBC. Highly increased NIBAN1 expression was observed in a number of GEM-resistant cancer cell lines and in post-IGC recurrent NMIBC specimens. Manipulation of NIBAN1 expression affected the chemosensitivity to GEM in bladder cancer cell models. Moreover, NIBAN1 also regulated focal adhesion/focal adhesion kinase (FAK) signaling activation in bladder cancer cell lines. Highly elevated FAK (pY397) expression was observed in post-IGC recurrent NMIBC specimens, which was positively correlated with NIBAN1 expression. Knockdown of FAK markedly attenuated GEM resistance in GEM-resistant bladder cancer cells.
Language	English
Publishing date	2022-01-09
Publishing country	Australia
Document type	Journal Article
ZDB-ID	2573318-7
ISSN	1837-9664
ISSN	1837-9664
DOI	10.7150/jca.66248
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Article ; Online: The necessity and appropriate range of the diagnostic "gray zone" of

Yin, Zhihao / Xiao, Shiyu / Tian, Xueli / Yuan, Ziying / Zhou, Liya

Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology Association

2022 Volume 28, Issue 5, Page(s) 385–392

Abstract: Background: The : Methods: Patients with : Results: A total of 208 patients were included, of whom 129 were H. pylori-positive. Sensitivity, specificity, negative predictive value (NPV), and positive predictive value (PPV) of : Conclusions: ... ...

Abstract	Background: The Methods: Patients with Results: A total of 208 patients were included, of whom 129 were H. pylori-positive. Sensitivity, specificity, negative predictive value (NPV), and positive predictive value (PPV) of Conclusions: Accuracy of
MeSH term(s)	Breath Tests/methods ; Helicobacter Infections/diagnosis ; Helicobacter pylori/genetics ; Humans ; Metaplasia ; Sensitivity and Specificity ; Urea/analysis
Chemical Substances	Urea (8W8T17847W)
Language	English
Publishing date	2022-03-03
Publishing country	India
Document type	Journal Article
ZDB-ID	2299174-8
ISSN	1998-4049 ; 1319-3767
ISSN (online)	1998-4049
ISSN	1319-3767
DOI	10.4103/sjg.sjg_638_21
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