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Article ; Online: Round window application of an active middle ear implant (AMEI) system in congenital oval window atresia.

Zhao, Shouqin / Gong, Shusheng / Han, Demin / Zhang, Hua / Ma, Xiaobo / Li, Yi / Chen, Xueqing / Ren, Ran / Li, Yuling

2016 Volume 136, Issue 1, Page(s) 23–33

Abstract: ... the surgical technique and auditory outcome of an active middle ear implant (AMEI) system used in patients ... ranging in age from 5.5 to 25 years, average 12.5 years) were implanted with an AMEI (Vibrant Soundbridge ...

Abstract	Conclusion: Application of the Vibrant Soundbridge to the round window (RW) membrane can be utilized as an efficient therapy for congenital oval window (OW) atresia. Objective: To report the surgical technique and auditory outcome of an active middle ear implant (AMEI) system used in patients with congenital OW atresia. Methods: Nine subjects with congenital OW atresia (six males and three females, ranging in age from 5.5 to 25 years, average 12.5 years) were implanted with an AMEI (Vibrant Soundbridge) at the round window (RW-Vibroplasty). Five cases were diagnosed as having isolated congenital OW atresia while four patients presented with combined external/middle ear malformation. Results: An improvement of 30 dB in average pure-tone air conduction thresholds (0.5-4 kHz) was achieved, with the high frequencies showing greater results. The subjects achieved postoperative speech recognition scores of 80-100% on the Computerized Mandarin Speech Test System (CMSTS) sentence test. Bone conduction thresholds were confirmed as stable in all subjects postoperatively. Decline in auditory benefit was noticed in two subjects, who then underwent revision surgery. One of these revision surgery patients then experienced stable hearing recovery, while the other patient's hearing declined.
MeSH term(s)	Adolescent ; Audiometry, Pure-Tone ; Auditory Threshold ; Bone Conduction ; Child ; Child, Preschool ; Cohort Studies ; Equipment Design ; Female ; Hearing Aids ; Humans ; Male ; Ossicular Prosthesis ; Oval Window, Ear/abnormalities ; Round Window, Ear/surgery ; Treatment Outcome ; Young Adult
Language	English
Publishing date	2016
Publishing country	England
Document type	Journal Article
ISSN	1651-2251
ISSN (online)	1651-2251
DOI	10.3109/00016489.2014.1003091
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Article: Biological and practical implications of genome-wide association study of schizophrenia using Bayesian variable selection.

Rowe, Benazir / Chen, Xiangning / Wang, Zuoheng / Chen, Jingchun / Amei, Amei

NPJ schizophrenia

2019 Volume 5, Issue 1, Page(s) 19

Abstract: Genome-wide association studies (GWAS) have identified over 100 loci associated with schizophrenia. Most of these studies test genetic variants for association one at a time. In this study, we performed GWAS of the molecular genetics of schizophrenia ( ... ...

Abstract	Genome-wide association studies (GWAS) have identified over 100 loci associated with schizophrenia. Most of these studies test genetic variants for association one at a time. In this study, we performed GWAS of the molecular genetics of schizophrenia (MGS) dataset with 5334 subjects using multivariate Bayesian variable selection (BVS) method Posterior Inference via Model Averaging and Subset Selection (piMASS) and compared our results with the previous univariate analysis of the MGS dataset. We showed that piMASS can improve the power of detecting schizophrenia-associated SNPs, potentially leading to new discoveries from existing data without increasing the sample size. We tested SNPs in groups to allow for local additive effects and used permutation test to determine statistical significance in order to compare our results with univariate method. The previous univariate analysis of the MGS dataset revealed no genome-wide significant loci. Using the same dataset, we identified a single region that exceeded the genome-wide significance. The result was replicated using an independent Swedish Schizophrenia Case-Control Study (SSCCS) dataset. Based on the SZGR 2.0 database we found 63 SNPs from the best performing regions that are mapped to 27 genes known to be associated with schizophrenia. Overall, we demonstrated that piMASS could discover association signals that otherwise would need a much larger sample size. Our study has important implication that reanalyzing published datasets with BVS methods like piMASS might have more power to discover new risk variants for many diseases without new sample collection, ascertainment, and genotyping.
Language	English
Publishing date	2019-11-19
Publishing country	United States
Document type	Journal Article
ZDB-ID	2813844-2
ISSN	2334-265X
ISSN	2334-265X
DOI	10.1038/s41537-019-0088-6
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Article ; Online: Intramyocardial dissecting hematoma associated with a coronary sinus diverticulum: a rare cause of chest pain.

Xie, Jiajun / Chen, Amei / Ma, Zelan / Xu, Xiangdong / Wei, Xinhua

Internal and emergency medicine

2022 Volume 18, Issue 2, Page(s) 667–669

MeSH term(s)	Humans ; Coronary Sinus/diagnostic imaging ; Myocardial Infarction ; Chest Pain/complications ; Hematoma/complications ; Hematoma/diagnostic imaging ; Diverticulum/complications ; Diverticulum/diagnostic imaging
Language	English
Publishing date	2022-09-30
Publishing country	Italy
Document type	Journal Article
ZDB-ID	2454173-4
ISSN	1970-9366 ; 1828-0447
ISSN (online)	1970-9366
ISSN	1828-0447
DOI	10.1007/s11739-022-03111-9
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Article ; Online: Exercise-Diet Therapy Combined with Insulin Aspart Injection for the Treatment of Gestational Diabetes Mellitus

Amei Mu / Yan’e Chen / Yongmei Lv / Wenxing Wang

Computational and Mathematical Methods in Medicine, Vol

A Study on Clinical Effect and Its Impact

2022 Volume 2022

Abstract: Objective. To explore the clinical effect and impact of exercise-diet therapy combined with Insulin Aspart Injection on gestational diabetes mellitus (GDM). Methods. The objects of study were patients with pregestational diabetes mellitus (PGDM) and 62 ... ...

Abstract	Objective. To explore the clinical effect and impact of exercise-diet therapy combined with Insulin Aspart Injection on gestational diabetes mellitus (GDM). Methods. The objects of study were patients with pregestational diabetes mellitus (PGDM) and 62 patients with GDM who were diagnosed by oral glucose tolerance test (OGTT) and insulin release test from February 2017 to February 2019. According to the severity of the disease, enrolled patients were informed to have appropriate exercise and diet control or Insulin Aspart Injection on this basis until the completion of delivery. By using 50 pregnant women with normal glucose as the control, the fasting plasma glucose (FPG), 1-hour postprandial glucose (1hPG), 2-hour postprandial glucose (2hPG), nocturnal glucose, and glycosylated hemoglobin (HbA1c) levels were compared between the PGDM group and the GDM group before and after treatment; besides, further comparison was made in terms of glucose compliance rate, islet B-cell secretory function, and insulin resistance after treatment. The pregnant women were examined by B-ultrasound at 24 and 26 weeks of gestation to check if the fetus had abnormalities in the central nervous system and the heart. Further B-ultrasound examination was performed at 32 and 37 weeks of gestation to check the problems such as polyhydramnios and stillbirth. In addition, a comparative analysis was carried out in terms of the adverse pregnancy outcomes and complications, associated with the comparison of the results after treatment with control group. Results. After treatment, the levels of FPG, 1hPG, 2hPG, nocturnal glucose, and HbA1c were decreased in the PGDM group and GDM group than those before treatment, especially in the GDM group, with significant difference still when compared with the control group (P<0.05). Statistical analysis revealed that the blood glucose compliance rate in the GDM group was higher than that in the PGDM group, showing a better therapeutic effect. Fasting insulin (FINS) and homeostasis model assessment ...
Keywords	Computer applications to medicine. Medical informatics ; R858-859.7
Subject code	796
Language	English
Publishing date	2022-01-01T00:00:00Z
Publisher	Hindawi Limited
Document type	Article ; Online
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Article ; Online: Exercise-Diet Therapy Combined with Insulin Aspart Injection for the Treatment of Gestational Diabetes Mellitus: A Study on Clinical Effect and Its Impact.

Mu, Amei / Chen, Yan'e / Lv, Yongmei / Wang, Wenxing

Computational and mathematical methods in medicine

2022 Volume 2022, Page(s) 4882061

Abstract: Objective: To explore the clinical effect and impact of exercise-diet therapy combined with Insulin Aspart Injection on gestational diabetes mellitus (GDM).: Methods: The objects of study were patients with pregestational diabetes mellitus (PGDM) and ...

Abstract	Objective: To explore the clinical effect and impact of exercise-diet therapy combined with Insulin Aspart Injection on gestational diabetes mellitus (GDM). Methods: The objects of study were patients with pregestational diabetes mellitus (PGDM) and 62 patients with GDM who were diagnosed by oral glucose tolerance test (OGTT) and insulin release test from February 2017 to February 2019. According to the severity of the disease, enrolled patients were informed to have appropriate exercise and diet control or Insulin Aspart Injection on this basis until the completion of delivery. By using 50 pregnant women with normal glucose as the control, the fasting plasma glucose (FPG), 1-hour postprandial glucose (1hPG), 2-hour postprandial glucose (2hPG), nocturnal glucose, and glycosylated hemoglobin (HbA1c) levels were compared between the PGDM group and the GDM group before and after treatment; besides, further comparison was made in terms of glucose compliance rate, islet B-cell secretory function, and insulin resistance after treatment. The pregnant women were examined by B-ultrasound at 24 and 26 weeks of gestation to check if the fetus had abnormalities in the central nervous system and the heart. Further B-ultrasound examination was performed at 32 and 37 weeks of gestation to check the problems such as polyhydramnios and stillbirth. In addition, a comparative analysis was carried out in terms of the adverse pregnancy outcomes and complications, associated with the comparison of the results after treatment with control group. Results: After treatment, the levels of FPG, 1hPG, 2hPG, nocturnal glucose, and HbA1c were decreased in the PGDM group and GDM group than those before treatment, especially in the GDM group, with significant difference still when compared with the control group ( Conclusion: Exercise-diet therapy combined with Insulin Aspart Injection can effectively control the blood glucose level of pregnant patients with GDM, improve the pregnancy outcome to a certain extent, and ensure the health of pregnant women and fetus, which is worthy of clinical application.
MeSH term(s)	Blood Glucose/analysis ; Diabetes, Gestational/drug therapy ; Diet ; Female ; Glycated Hemoglobin A/analysis ; Glycated Hemoglobin A/therapeutic use ; Humans ; Insulin ; Insulin Aspart/therapeutic use ; Insulin Resistance ; Polyhydramnios ; Pregnancy ; Stillbirth
Chemical Substances	Blood Glucose ; Glycated Hemoglobin A ; Insulin ; Insulin Aspart (D933668QVX)
Language	English
Publishing date	2022-07-28
Publishing country	United States
Document type	Journal Article
ZDB-ID	2252430-7
ISSN	1748-6718 ; 1748-670X ; 1027-3662
ISSN (online)	1748-6718
ISSN	1748-670X ; 1027-3662
DOI	10.1155/2022/4882061
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Article ; Online: Prevalence and Molecular Characterization of Methicillin-Resistant Staphylococci Recovered from Public Shared Bicycles in China.

Xu, Zhen / Chen, Liqin / Chen, Xiaowei / Tang, Amei / Huang, Dengmin / Pan, Qin / Fang, Zhongze

International journal of environmental research and public health

2022 Volume 19, Issue 8

Abstract: Millions of public shared bicycles (PSBs) have been launched in China, and PSBs are a potential reservoir of antimicrobial-resistant staphylococci. However, no national data to elucidate the dissemination, antimicrobial resistance and genotypes of ... ...

Abstract	Millions of public shared bicycles (PSBs) have been launched in China, and PSBs are a potential reservoir of antimicrobial-resistant staphylococci. However, no national data to elucidate the dissemination, antimicrobial resistance and genotypes of staphylococci has been recovered from public shared bicycles located in different cities in China. Antimicrobial susceptibility, SCC
MeSH term(s)	Anti-Bacterial Agents/pharmacology ; Humans ; Methicillin Resistance/genetics ; Methicillin-Resistant Staphylococcus aureus/genetics ; Microbial Sensitivity Tests ; Prevalence ; Staphylococcal Infections/epidemiology ; Staphylococcus/genetics ; Staphylococcus epidermidis/genetics
Chemical Substances	Anti-Bacterial Agents
Language	English
Publishing date	2022-04-08
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2175195-X
ISSN	1660-4601 ; 1661-7827
ISSN (online)	1660-4601
ISSN	1661-7827
DOI	10.3390/ijerph19084492
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Article ; Online: Structural connectivity from DTI to predict mild cognitive impairment in de novo Parkinson’s disease

Xiaofei Huang / Qing He / Xiuhang Ruan / Yuting Li / Zhanyu Kuang / Mengfan Wang / Riyu Guo / Shuwen Bu / Zhaoxiu Wang / Shaode Yu / Amei Chen / Xinhua Wei

NeuroImage: Clinical, Vol 41, Iss , Pp 103548- (2024)

1481

Abstract: Background: Early detection of Parkinson's disease (PD) patients at high risk for mild cognitive impairment (MCI) can help with timely intervention. White matter structural connectivity is considered an early and sensitive indicator of neurodegenerative ... ...

Abstract	Background: Early detection of Parkinson's disease (PD) patients at high risk for mild cognitive impairment (MCI) can help with timely intervention. White matter structural connectivity is considered an early and sensitive indicator of neurodegenerative disease. Objectives: To investigate whether baseline white matter structural connectivity features from diffusion tensor imaging (DTI) of de novo PD patients can help predict PD-MCI conversion at an individual level using machine learning methods. Methods: We included 90 de novo PD patients who underwent DTI and 3D T1-weighted imaging. Elastic net-based feature consensus ranking (ENFCR) was used with 1000 random training sets to select clinical and structural connectivity features. Linear discrimination analysis (LDA), support vector machine (SVM), K-nearest neighbor (KNN) and naïve Bayes (NB) classifiers were trained based on features selected more than 500 times. The area under the ROC curve (AUC), accuracy (ACC), sensitivity (SEN) and specificity (SPE) were used to evaluate model performance. Results: A total of 57 PD patients were classified as PD-MCI nonconverters, and 33 PD patients were classified as PD-MCI converters. The models trained with clinical data showed moderate performance (AUC range: 0.62–0.68; ACC range: 0.63–0.77; SEN range: 0.45–0.66; SPE range: 0.64–0.84). Models trained with structural connectivity (AUC range, 0.81–0.84; ACC range, 0.75–0.86; SEN range, 0.77–0.91; SPE range, 0.71–0.88) performed similar to models that were trained with both clinical and structural connectivity data (AUC range, 0.81–0.85; ACC range, 0.74–0.85; SEN range, 0.79–0.91; SPE range, 0.70–0.89). Conclusions: Baseline white matter structural connectivity from DTI is helpful in predicting future MCI conversion in de novo PD patients.
Keywords	Parkinson’s disease ; Mild cognitive impairment ; Structural connectivity ; Diffusion tensor imaging ; Machine learning ; Computer applications to medicine. Medical informatics ; R858-859.7 ; Neurology. Diseases of the nervous system ; RC346-429
Subject code	610
Language	English
Publishing date	2024-01-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
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Article ; Online: Epidemiology of acute hepatitis C and hepatitis C virus-related cirrhosis in reproductive-age women, 1990-2019: An analysis of the Global Burden of Disease study.

Zou, Yanzheng / Yue, Ming / Ye, Xiangyu / Wang, Yifan / Ma, Xinyan / Zhang, Amei / Xia, Xueshan / Chen, Hongbo / Yu, Rongbin / Yang, Sheng / Huang, Peng

Journal of global health

2024 Volume 14, Page(s) 4077

Abstract: Background: The current study uniquely focuses on the global incidence and temporal trends of acute hepatitis C (AHC) and hepatitis C virus (HCV)-related cirrhosis among women of reproductive age (15-49 years) from 1990-2019. The risk of vertical ... ...

Abstract	Background: The current study uniquely focuses on the global incidence and temporal trends of acute hepatitis C (AHC) and hepatitis C virus (HCV)-related cirrhosis among women of reproductive age (15-49 years) from 1990-2019. The risk of vertical transmission and adverse perinatal outcomes associated with HCV infection underscores the importance of prioritising these women in HCV prevention efforts. Methods: Leveraging the Global Burden of Disease 2019 data, we calculated age-standardised incidence rates (ASIR) and assessed temporal trends via the average annual percent change from joinpoint regression. The age-period-cohort model was employed to understand further the effects of age, period, and birth cohort. Results: Over the 30 years, global incidences of AHC and HCV-related cirrhosis in reproductive-age women increased by 46.45 and 72.74%, respectively. The ASIR of AHC was highest in low sociodemographic index regions but showed a declining trend. Conversely, the ASIR of HCV-related cirrhosis displayed unfavourable trends in low, low-middle, and high sociodemographic index regions. Special attention is necessary for sub-Saharan Africa, high-income North America, Eastern Europe, and Central Asia due to their high incidence rates or increasing trends of AHC and HCV-related cirrhosis. Notably, the age-period-cohort model suggests a recent resurgence in AHC and HCV-related cirrhosis risk. Conclusions: The current study is the first to thoroughly evaluate the trends of AHC and HCV-related cirrhosis among reproductive-age women, shedding light on previously unexplored aspects of HCV epidemiology. Our findings identify critical areas where health care systems must adapt to the changing dynamics of HCV infection. The detailed stratification by region and nation further enables the development of localised prevention and treatment strategies.
MeSH term(s)	Pregnancy ; Humans ; Female ; Adolescent ; Young Adult ; Adult ; Middle Aged ; Hepacivirus ; Global Burden of Disease ; Hepatitis C/complications ; Hepatitis C/epidemiology ; Liver Cirrhosis/epidemiology ; Liver Cirrhosis/etiology ; Incidence ; Global Health
Language	English
Publishing date	2024-04-19
Publishing country	Scotland
Document type	Journal Article
ZDB-ID	2741629-X
ISSN	2047-2986 ; 2047-2986
ISSN (online)	2047-2986
ISSN	2047-2986
DOI	10.7189/jogh.14.04077
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Article ; Online: Association between residential greenspace and mental health among cancer survivors in Shanghai, China.

Li, Ruijia / Liu, Mengying / Song, Jie / Xu, Yuan / He, Amei / Hu, Xiaojing / Yang, Shanshi / Ding, Gang / Chen, Minxing / Jin, Chunlin

Environmental research

2023 Volume 238, Issue Pt 2, Page(s) 117155

Abstract: Background: Living near and enjoying visually green landscapes is associated with better mental health, but evidence focusing on vulnerable populations (such as cancer survivors) is sparse. The purpose of this study was to explore the association ... ...

Abstract	Background: Living near and enjoying visually green landscapes is associated with better mental health, but evidence focusing on vulnerable populations (such as cancer survivors) is sparse. The purpose of this study was to explore the association between residential greenspace and anxiety and depressive symptoms among cancer survivors in Shanghai, China. Methods: In total, 4195 cancer survivors participated in this study from the 2022 Shanghai Cancer Patient Needs Survey. The estimation of residential greenspaces was based on Normalized Difference Vegetation Index (NDVI) and Enhanced Vegetation Index (EVI). The presence and severity of depressive and anxiety symptoms were assessed by using the Patient Health Questionnaire-2 (PHQ-2) and Generalized Anxiety Disorder-2 (GAD-2). The relation between mental health and green space was assessed using the Generalized Additive Model (GAM) after controlling for relevant individual covariates and contextual characteristics. Results: The prevalence of anxiety and depression in cancer survivors was 36.2% and 28.3% respectively. After multivariate adjustment, each increase in inter-quartile range (IQR) for NDVI in the 250 m buffer (NDVI Conclusions: Higher levels of residential green space are associated with lower risk of depression and anxiety disorders. Our findings will fill the gap in the relationship between green space and mental health among cancer survivors in urban China, and provide new evidence for garden afforestation, community planning and policy-making. To better understand this association, more longitudinal studies are necessary to investigate the mechanisms involved.
MeSH term(s)	Young Adult ; Humans ; Adolescent ; Mental Health ; Parks, Recreational ; Cancer Survivors ; China ; Longitudinal Studies ; Neoplasms
Language	English
Publishing date	2023-09-27
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	205699-9
ISSN	1096-0953 ; 0013-9351
ISSN (online)	1096-0953
ISSN	0013-9351
DOI	10.1016/j.envres.2023.117155
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Article ; Online: Letter to the Editor. Is gender a factor in long-term outcomes after radiosurgery for vestibular schwannoma?

Wang, Lishi / Ren, Mingji / Chen, Amei / Gu, Weikuan

Journal of neurosurgery

2017 Volume 126, Issue 6, Page(s) 2057–2058

MeSH term(s)	Hearing ; Hearing Tests ; Humans ; Neuroma, Acoustic/surgery ; Radiosurgery
Language	English
Publishing date	2017-03-24
Publishing country	United States
Document type	Letter ; Comment
ZDB-ID	3089-2
ISSN	1933-0693 ; 0022-3085
ISSN (online)	1933-0693
ISSN	0022-3085
DOI	10.3171/2016.10.JNS162623
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