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Article: Feasibility study on the introduction of Micro-CT technology for the identification of

Chen, Kehong / Chen, Gong / Zhuang, Zhelong / Luo, Shouhua / Liu, Jiaming / Liu, Guorong

2024 Volume 15, Page(s) 1347316

Abstract: Background: ...

Abstract	Background:
Language	English
Publishing date	2024-02-28
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2587355-6
ISSN	1663-9812
ISSN	1663-9812
DOI	10.3389/fphar.2024.1347316
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Associations of advanced liver fibrosis with heart failure with preserved ejection fraction in type 2 diabetic patients according to obesity and metabolic goal achievement status.

Jiang, Wangyan / Liu, Zhelong / Liu, Shaohua / Du, Tingting

Frontiers in endocrinology

2023 Volume 14, Page(s) 1183075

Abstract: Background: Heart failure with preserved ejection fraction (HFpEF), a major cause of morbidity and mortality in patients with type 2 diabetes mellitus (T2DM), is frequently coexisted with obesity, poor glycemic, blood pressure (BP), and/or lipid control. ...

Abstract	Background: Heart failure with preserved ejection fraction (HFpEF), a major cause of morbidity and mortality in patients with type 2 diabetes mellitus (T2DM), is frequently coexisted with obesity, poor glycemic, blood pressure (BP), and/or lipid control. We aimed to investigate the associations of nonalcoholic fatty liver disease (NAFLD) and its advanced fibrosis with HFpEF according to obesity, glycated hemoglobin A1c (HbA1c), BP, and low-density lipoprotein cholesterol (LDL-C) goal achievement status in T2DM patients. Methods: A total of 2,418 T2DM patients who were hospitalized were cross-sectionally assessed. Liver fibrosis was evaluated by non-invasive biomarkers. Logistic regression analysis was used to evaluate the independent and combined associations of fibrosis status and diabetic care goal attainments with HFpEF risk. Results: Simple steatosis was not associated with HFpEF risk compared with patients without steatosis, while advanced liver fibrosis was found to have significantly higher odds for HFpEF risk (odds ratio,1.59; 95% confidence interval, 1.22-2.08). Advanced fibrosis in NAFLD was significantly associated with an increased risk of HFpEF, regardless of obesity status, HbA1c, BP, and LDL-C goal achievement status. P values for the interactions between fibrosis status and HbA1c control status, fibrosis status and BP control status, fibrosis status and LDL-C control status, and fibrosis status and body mass index (BMI) status on HFpEF risk were 0.021, 0.13, 0.001, and 0.23, respectively. Conclusion: In patients with T2DM, advanced hepatic fibrosis was significantly associated with HFpEF risk, irrespective of obesity status, HbA1c, BP, and LDL-C goal attainment status. Further, HbA1c and LDL-C goal attainment status modified this association.
MeSH term(s)	Humans ; Diabetes Mellitus, Type 2/complications ; Non-alcoholic Fatty Liver Disease/complications ; Heart Failure/complications ; Stroke Volume/physiology ; Glycated Hemoglobin ; Cholesterol, LDL ; Goals ; Liver Cirrhosis/complications ; Obesity/complications
Chemical Substances	Glycated Hemoglobin ; Cholesterol, LDL
Language	English
Publishing date	2023-10-24
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2592084-4
ISSN	1664-2392
ISSN	1664-2392
DOI	10.3389/fendo.2023.1183075
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Article ; Online: Sarcopenia as an important determinant for adverse outcomes in patients with pyogenic liver abscess

Li Liu / Shaohua Liu / Meng Hao / Song Hu / Tian Yu / Yunkai Yang / Zhelong Liu

PeerJ, Vol 11, p e

2023 Volume 16055

Abstract: Background Low muscle mass/sarcopenia has been associated with poor prognosis in many diseases, but its clinical significance in pyogenic liver abscess (PLA) remains unclear. The purpose of this study is to investigate the relationship between muscle ... ...

Abstract	Background Low muscle mass/sarcopenia has been associated with poor prognosis in many diseases, but its clinical significance in pyogenic liver abscess (PLA) remains unclear. The purpose of this study is to investigate the relationship between muscle mass and prognosis of patients with PLA. Methods A total of 154 adult patients with PLA hospitalized at Tongji Hospital (Wuhan, Hubei, China) between October 2011 and June 2021 were included in this retrospective analysis. Muscle-fat related indicators were measured by computed tomography (CT) images at the third lumbar vertebra (L3) level. The data of patients between the sarcopenia group and non-sarcopenia group were compared. Multivariate logistic regression and receiver operating characteristic (ROC) curve analyses were performed. Results The skeletal muscle index (SMI) was independently associated with adverse outcomes (95% CI [0.649–0.954], P = 0.015) of PLA in multivariate logistic regression analysis. This conclusion held true in sex-specific subgroup analysis. ROC analysis indicated that SMI may predict adverse outcomes in both male (area under the ROC curve [AUC], 0.718; cut-off, 52.59; P < 0.001) and female (AUC, 0.714; cut-off, 38.39; P = 0.017) patient populations. Conclusions Sarcopenia serves as an independent risk factor for poor prognosis in PLA and patients with sarcopenia may be more prone to adverse outcomes.
Keywords	Pyogenic liver abscess ; Sarcopenia ; Muscle mass ; Body composition ; Prognosis ; Retrospective ; Medicine ; R ; Biology (General) ; QH301-705.5
Subject code	610
Language	English
Publishing date	2023-10-01T00:00:00Z
Publisher	PeerJ Inc.
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Sarcopenia as an important determinant for adverse outcomes in patients with pyogenic liver abscess.

Liu, Li / Liu, Shaohua / Hao, Meng / Hu, Song / Yu, Tian / Yang, Yunkai / Liu, Zhelong

PeerJ

2023 Volume 11, Page(s) e16055

Abstract: Background: Low muscle mass/sarcopenia has been associated with poor prognosis in many diseases, but its clinical significance in pyogenic liver abscess (PLA) remains unclear. The purpose of this study is to investigate the relationship between muscle ... ...

Abstract	Background: Low muscle mass/sarcopenia has been associated with poor prognosis in many diseases, but its clinical significance in pyogenic liver abscess (PLA) remains unclear. The purpose of this study is to investigate the relationship between muscle mass and prognosis of patients with PLA. Methods: A total of 154 adult patients with PLA hospitalized at Tongji Hospital (Wuhan, Hubei, China) between October 2011 and June 2021 were included in this retrospective analysis. Muscle-fat related indicators were measured by computed tomography (CT) images at the third lumbar vertebra (L3) level. The data of patients between the sarcopenia group and non-sarcopenia group were compared. Multivariate logistic regression and receiver operating characteristic (ROC) curve analyses were performed. Results: The skeletal muscle index (SMI) was independently associated with adverse outcomes (95% CI [0.649-0.954], Conclusions: Sarcopenia serves as an independent risk factor for poor prognosis in PLA and patients with sarcopenia may be more prone to adverse outcomes.
MeSH term(s)	Adult ; Humans ; Male ; Female ; Sarcopenia/complications ; Liver Abscess, Pyogenic/diagnostic imaging ; Retrospective Studies ; Muscle, Skeletal/diagnostic imaging ; Prognosis
Language	English
Publishing date	2023-10-04
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2703241-3
ISSN	2167-8359 ; 2167-8359
ISSN (online)	2167-8359
ISSN	2167-8359
DOI	10.7717/peerj.16055
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Article ; Online: Reinforced Computer-aided Framework for Diagnosing Thyroid Cancer.

Xie, Xia / Tian, Yuanyishu / Ota, Kaoru / Dong, Mianxiong / Liu, Zhelong / Jin, Hai / Yao, Dezhong

IEEE/ACM transactions on computational biology and bioinformatics

2023 Volume PP

Abstract: Thyroid cancer is the most pervasive disease in the endocrine system and is getting extensive attention. The most prevalent method for an early check is ultrasound examination. Traditional research mainly concentrates on promoting the performance of ... ...

Abstract	Thyroid cancer is the most pervasive disease in the endocrine system and is getting extensive attention. The most prevalent method for an early check is ultrasound examination. Traditional research mainly concentrates on promoting the performance of processing a single ultrasound image using deep learning. However, the complex situation of patients and nodules often makes the model dissatisfactory in terms of accuracy and generalization. Imitating the diagnosis process in reality, a practical diagnosis-oriented computer-aided diagnosis (CAD) framework towards thyroid nodules is proposed, using collaborative deep learning and reinforcement learning. Under the framework, the deep learning model is trained collaboratively with multiparty data; afterward classification results are fused by a reinforcement learning agent to decide the final diagnosis result. Within the architecture, multiparty collaborative learning with privacy-preserving on large-scale medical data brings robustness and generalization, and diagnostic information is modeled as a Markov decision process (MDP) to get final precise diagnosis results. Moreover, the framework is scalable and capable of containing more diagnostic information and multiple sources to pursue a precise diagnosis. A practical dataset of two thousand thyroid ultrasound images is collected and labeled for collaborative training on classification tasks. The simulated experiments have shown the advancement of the framework in promising performance.
Language	English
Publishing date	2023-03-02
Publishing country	United States
Document type	Journal Article
ISSN	1557-9964
ISSN (online)	1557-9964
DOI	10.1109/TCBB.2023.3251323
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Article ; Online: Secular trends in the prevalence of abdominal obesity among Chinese adults with normal weight, 1993–2015

Xingxing Sun / Zhelong Liu / Tingting Du

Scientific Reports, Vol 11, Iss 1, Pp 1-

2021 Volume 9

Abstract: Abstract A considerable chronic disease burden existed in people with normal body mass index (BMI), it is imperative to study the prevailing trends in abdominal obesity among Chinese people with normal BMI. Hence, we aimed to analyze updated prevalence ... ...

Abstract	Abstract A considerable chronic disease burden existed in people with normal body mass index (BMI), it is imperative to study the prevailing trends in abdominal obesity among Chinese people with normal BMI. Hence, we aimed to analyze updated prevalence data on abdominal obesity trends among Chinese adults with a normal BMI. We used data from the China Health and Nutrition Survey (CHNS) conducted between 1993 and 2015. Abdominal obesity is defined as waist circumference (WC) ≥ 90 cm for men and ≥ 80 cm for women following the International Diabetes Federation recommendations for Asians. Over the 23-year period, the age-standardized mean WC values showed a significant increasing trend among Chinese adults with BMI < 25 kg/m2, with the mean value increased from 74.0 cm to 78.5 cm (P for trend < 0.0001). During the period of 1993–2015, the age-standardized prevalence of abdominal obesity increased from 12.1 to 26.0% (P for trend < 0.0001). Significant increases were observed in both sexes, all age groups, rural and urban residents, and all educational attainment groups (all P for trends < 0.0001), with a greater relative increase noted among men, younger participants, and rural residents. Similar significant trends were noted when a more stringent BMI < 23 kg/m2 cut point (Asian cut point) was applied. A low magnitude of overlap existed between abdominal obesity and general obesity, irrespective of the criteria used. The mean WC and the prevalence of abdominal obesity among Chinese adults with normal BMI increased continuously from 1993 to 2015. The upward trends were noted in both sexes, all age groups, rural and urban regions, and all educational attainment groups. Our estimates emphasize the importance of adding WC in addition to BMI as measures to monitor obesity prevalence.
Keywords	Medicine ; R ; Science ; Q
Subject code	796
Language	English
Publishing date	2021-08-01T00:00:00Z
Publisher	Nature Portfolio
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Sarcopenia modifies the associations of nonalcoholic fatty liver disease with all-cause and cardiovascular mortality among older adults

Xingxing Sun / Zhelong Liu / Fuqiong Chen / Tingting Du

Scientific Reports, Vol 11, Iss 1, Pp 1-

2021 Volume 10

Abstract: Abstract The contribution of nonalcoholic fatty liver disease (NAFLD) to all-cause and cardiovascular mortality remains controversial. Sarcopenia, a measure of muscle mass, strength and function, may identify which persons are most at risk for adverse ... ...

Abstract	Abstract The contribution of nonalcoholic fatty liver disease (NAFLD) to all-cause and cardiovascular mortality remains controversial. Sarcopenia, a measure of muscle mass, strength and function, may identify which persons are most at risk for adverse effects of NAFLD. We aimed to test the hypothesis that sarcopenia modifies the associations between NAFLD and all-cause and cardiovascular mortality. A total of 2446 older adults (≥ 60 years) from the third National Health and Nutrition Examination Survey were enrolled. Their mortality data were linked to death certificates in the National Death Index. Sarcopenia was defined as having low skeletal muscle mass together with slow gait speed, which captures both muscle mass and muscle function. Ultrasound tests were used for the assessment of hepatic steatosis. During follow-up (median 16.8 years), 1530 older subjects died from any cause, of which 379 were cardiovascular-related. All-cause and cardiovascular mortality rates were 4.31 and 1.07 per 100 person-years, respectively. In a multivariate model, using participants without NAFLD and sarcopenia as the reference group, individuals with both NAFLD and sarcopenia had 1.69 times [95% confidence interval (CI) 1.23–2.31] and 2.17 times (95% CI 1.33–3.54) higher risks of all-cause and cardiovascular mortality, respectively. However, NAFLD persons without sarcopenia had hazard ratios for all-cause and cardiovascular mortality similar to those of the reference group. Sarcopenia modified the associations of NAFLD with all-cause and cardiovascular mortality. Sarcopenia may identify older adults who are at the highest risk for adverse outcomes associated with NAFLD.
Keywords	Medicine ; R ; Science ; Q
Subject code	310
Language	English
Publishing date	2021-08-01T00:00:00Z
Publisher	Nature Portfolio
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Targeted delivery of MerTK protein via cell membrane engineered nanoparticle enhances efferocytosis and attenuates atherosclerosis in diabetic ApoE

Qiu, Shuo / Liu, Jiahan / Chen, Jianmei / Li, Yangni / Bu, Te / Li, Zhelong / Zhang, Liang / Sun, Wenqi / Zhou, Tian / Hu, Wei / Yang, Guodong / Yuan, Lijun / Duan, Yunyou / Xing, Changyang

Journal of nanobiotechnology

2024 Volume 22, Issue 1, Page(s) 178

Abstract: Background: Clearance of apoptotic cells by efferocytosis is crucial for prevention of atherosclerosis progress, and impaired efferocytosis contributes to the aggravated atherosclerosis.: Results: In this study, we found that diabetic ApoE: ... ...

Abstract	Background: Clearance of apoptotic cells by efferocytosis is crucial for prevention of atherosclerosis progress, and impaired efferocytosis contributes to the aggravated atherosclerosis. Results: In this study, we found that diabetic ApoE Conclusions: Our study indicates that MerTK decrease in macrophages contributes to the aggravated atherosclerosis in diabetic ApoE
MeSH term(s)	Humans ; Animals ; Mice ; Efferocytosis ; HEK293 Cells ; Cell Membrane ; Atherosclerosis ; Protein-Tyrosine Kinases ; Apolipoproteins E/genetics ; Magnetic Iron Oxide Nanoparticles ; Diabetes Mellitus
Chemical Substances	Protein-Tyrosine Kinases (EC 2.7.10.1) ; Apolipoproteins E
Language	English
Publishing date	2024-04-13
Publishing country	England
Document type	Journal Article
ZDB-ID	2100022-0
ISSN	1477-3155 ; 1477-3155
ISSN (online)	1477-3155
ISSN	1477-3155
DOI	10.1186/s12951-024-02463-y
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Article ; Online: Secular trends in the prevalence of abdominal obesity among Chinese adults with normal weight, 1993-2015.

Sun, Xingxing / Liu, Zhelong / Du, Tingting

Scientific reports

2021 Volume 11, Issue 1, Page(s) 16404

Abstract: A considerable chronic disease burden existed in people with normal body mass index (BMI), it is imperative to study the prevailing trends in abdominal obesity among Chinese people with normal BMI. Hence, we aimed to analyze updated prevalence data on ... ...

Abstract	A considerable chronic disease burden existed in people with normal body mass index (BMI), it is imperative to study the prevailing trends in abdominal obesity among Chinese people with normal BMI. Hence, we aimed to analyze updated prevalence data on abdominal obesity trends among Chinese adults with a normal BMI. We used data from the China Health and Nutrition Survey (CHNS) conducted between 1993 and 2015. Abdominal obesity is defined as waist circumference (WC) ≥ 90 cm for men and ≥ 80 cm for women following the International Diabetes Federation recommendations for Asians. Over the 23-year period, the age-standardized mean WC values showed a significant increasing trend among Chinese adults with BMI < 25 kg/m
MeSH term(s)	Adolescent ; Adult ; Aged ; Aged, 80 and over ; Asian People ; Body Mass Index ; China/epidemiology ; Cross-Sectional Studies ; Diabetes Mellitus/epidemiology ; Female ; Health Surveys/methods ; Humans ; Male ; Middle Aged ; Nutrition Surveys/methods ; Obesity, Abdominal/epidemiology ; Prevalence ; Rural Population ; Waist Circumference/physiology ; Young Adult
Language	English
Publishing date	2021-08-12
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-021-95777-y
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Article ; Online: Exosomes in atherosclerosis: performers, bystanders, biomarkers, and therapeutic targets.

Wang, Chen / Li, Zhelong / Liu, Yunnan / Yuan, Lijun

Theranostics

2021 Volume 11, Issue 8, Page(s) 3996–4010

Abstract: Exosomes are nanosized lipid vesicles originating from the endosomal system that carry many macromolecules from their parental cells and play important roles in intercellular communication. The functions and underlying mechanisms of exosomes in ... ...

Abstract	Exosomes are nanosized lipid vesicles originating from the endosomal system that carry many macromolecules from their parental cells and play important roles in intercellular communication. The functions and underlying mechanisms of exosomes in atherosclerosis have recently been intensively studied. In this review, we briefly introduce exosome biology and then focus on advances in the roles of exosomes in atherosclerosis, specifically exosomal changes associated with atherosclerosis, their cellular origins and potential functional cargos, and their detailed impacts on recipient cells. We also discuss the potential of exosomes as biomarkers and drug carriers for managing atherosclerosis.
MeSH term(s)	Atherosclerosis/etiology ; Atherosclerosis/physiopathology ; Atherosclerosis/therapy ; Biomarkers/metabolism ; Blood Platelets/physiology ; Diabetes Mellitus/etiology ; Drug Carriers ; Exosomes/genetics ; Exosomes/physiology ; Humans ; Lipid Metabolism ; Macrophages/physiology ; MicroRNAs/genetics ; Models, Cardiovascular ; Molecular Targeted Therapy ; Obesity/etiology ; Precision Medicine ; Risk Factors
Chemical Substances	Biomarkers ; Drug Carriers ; MicroRNAs
Language	English
Publishing date	2021-02-15
Publishing country	Australia
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	2592097-2
ISSN	1838-7640 ; 1838-7640
ISSN (online)	1838-7640
ISSN	1838-7640
DOI	10.7150/thno.56035
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