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  1. Article ; Online: Autophagy researchers: Fu-Cheng Lin, Dalibor Mijaljica, Sovan Sarkar, Teresa Zoladek.

    Lin, Fu-Cheng / Mijaljica, Dalibor / Sarkar, Sovan / Zoladek, Teresa

    Autophagy

    2014  Volume 10, Issue 4, Page(s) 552–555

    MeSH term(s) Australia ; Autophagy ; Cell Biology/history ; China ; Europe ; History, 20th Century ; History, 21st Century ; Humans
    Language English
    Publishing date 2014-01-31
    Publishing country United States
    Document type Biography ; Historical Article
    ZDB-ID 2454135-7
    ISSN 1554-8635 ; 1554-8627
    ISSN (online) 1554-8635
    ISSN 1554-8627
    DOI 10.4161/auto.27977
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    Zs.A 6741: Show issues Location:
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  2. Article ; Online: The necessity of nucleophagic modality.

    Mijaljica, Dalibor / Klionsky, Daniel J

    Autophagy

    2021  Volume 18, Issue 2, Page(s) 443–448

    Abstract: Nucleophagy, the selective subtype of autophagy that predominantly targets only a selected and (nonessential) portion of the nucleus, and rarely the nucleus in its entirety, for degradation, reinforces the paradigm that nucleophagy recycling is a ... ...

    Abstract Nucleophagy, the selective subtype of autophagy that predominantly targets only a selected and (nonessential) portion of the nucleus, and rarely the nucleus in its entirety, for degradation, reinforces the paradigm that nucleophagy recycling is a meticulous and highly delicate process guarded by fail-safe mechanisms. Our goal in this commentary is to encourage autophagy researchers and other scientists to explore nucleophagy blind spots and gain advanced insights into the diverse roles of this process and its selective modality as they pertain to intranuclear quality control and cellular homeostasis. Identifying and deciphering nucleophagic signaling, regulation, molecular mechanism(s) and its mediators, cargo composition and nuclear membrane dynamics under numerous physiological and/or pathological settings will provide important advances in our understanding of this critical type of organelle-selective autophagy.
    MeSH term(s) Autophagy/physiology ; Cell Nucleus/metabolism ; DNA, Ribosomal/metabolism ; Microautophagy ; Nuclear Envelope/metabolism ; Saccharomyces cerevisiae/metabolism
    Chemical Substances DNA, Ribosomal
    Language English
    Publishing date 2021-10-13
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2454135-7
    ISSN 1554-8635 ; 1554-8627
    ISSN (online) 1554-8635
    ISSN 1554-8627
    DOI 10.1080/15548627.2021.1971380
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  3. Article ; Online: Autophagy is the key to making chronic wounds acute in skin wound healing.

    Mijaljica, Dalibor / Spada, Fabrizio / Klionsky, Daniel J / Harrison, Ian P

    Autophagy

    2023  Volume 19, Issue 9, Page(s) 2578–2584

    Abstract: As a highly regulated and dynamically balanced intracellular degradation mechanism, macroautophagy/autophagy plays an essential housekeeping role in different successive stages of skin wound healing; from the homeostasis and inflammatory stages to the ... ...

    Abstract As a highly regulated and dynamically balanced intracellular degradation mechanism, macroautophagy/autophagy plays an essential housekeeping role in different successive stages of skin wound healing; from the homeostasis and inflammatory stages to the proliferative and remodeling stages. Under both progressive and defective skin wound healing conditions, autophagy operates at different levels with a precise extent of activity, at the interface of inflammation, stress signaling and cell metabolism through a complex spatiotemporal cascade of molecular and cellular events. Depending on the wound healing conditions autophagic activity is fine-tuned and differentially modulated at each stage of skin wound healing in order to cope with stage-specific requirements. Here, we postulate that under favorable conditions autophagy may act as the key modulator of skin wound healing by making chronic wounds acute. Enhancing autophagy through the topical application of pro-autophagy biologics in an appropriate hydrating vehicle/moisturizing base such as hydrogels, onto a chronic skin wound may provide moisture and immune modulation, thus contributing to rapid and efficient skin wound healing. A moist environment is more conducive to skin wound healing as it helps to not only accelerate cell proliferation and migration, and extracellular matrix reorganization, but also promotes autophagy and reduces the incidence of inflammation.
    MeSH term(s) Humans ; Proto-Oncogene Proteins c-akt/metabolism ; Phosphatidylinositol 3-Kinases ; Methicillin-Resistant Staphylococcus aureus/metabolism ; Autophagy ; Wound Healing/physiology ; Inflammation
    Chemical Substances Proto-Oncogene Proteins c-akt (EC 2.7.11.1) ; Phosphatidylinositol 3-Kinases (EC 2.7.1.-)
    Language English
    Publishing date 2023-04-11
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2454135-7
    ISSN 1554-8635 ; 1554-8627
    ISSN (online) 1554-8635
    ISSN 1554-8627
    DOI 10.1080/15548627.2023.2194155
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: The heterogeneity and complexity of skin surface lipids in human skin health and disease.

    Mijaljica, Dalibor / Townley, Joshua P / Spada, Fabrizio / Harrison, Ian P

    Progress in lipid research

    2023  Volume 93, Page(s) 101264

    Abstract: The outermost epidermal layer of the skin, the stratum corneum, is not simply a barrier that safeguards skin integrity from external insults and invaders, it is also a delicately integrated interface composed of firm, essentially dead corneocytes and a ... ...

    Abstract The outermost epidermal layer of the skin, the stratum corneum, is not simply a barrier that safeguards skin integrity from external insults and invaders, it is also a delicately integrated interface composed of firm, essentially dead corneocytes and a distinctive lipid matrix. Together, the stratum corneum lipid matrix and sebum lipids derived from sebaceous glands give rise to a remarkably complex but quite unique blend of skin surface lipids that demonstrates tremendous heterogeneity and provides the skin with its indispensable protective coating. The stratum corneum lipid matrix is composed primarily of three major lipid classes: ceramides, non-esterified fatty acids and cholesterol, whereas sebum is a waxy mixture predominantly composed of acylglycerols, wax esters, non-esterified fatty acids, squalene, cholesterol and cholesterol esters. The balance of these skin surface lipids in terms of their relative abundance, composition, molecular organisation and dynamics, and their intricate interactions play a crucial role in the maintenance of healthy skin. For that reason, even minuscule alterations in skin surface lipid properties or overall lipid profile have been implicated in the aetiology of many common skin diseases including atopic dermatitis, psoriasis, xerosis, ichthyosis and acne. Novel lipid-based interventions aimed at correcting the skin surface lipid abnormalities have the potential to repair skin barrier integrity and the symptoms associated with such skin diseases, even though the exact mechanisms of lipid restoration remain elusive.
    MeSH term(s) Humans ; Lipids ; Skin ; Epidermis ; Skin Diseases ; Cholesterol ; Ceramides ; Fatty Acids
    Chemical Substances Lipids ; Cholesterol (97C5T2UQ7J) ; Ceramides ; Fatty Acids
    Language English
    Publishing date 2023-11-06
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 282560-0
    ISSN 1873-2194 ; 0079-6832 ; 0163-7827
    ISSN (online) 1873-2194
    ISSN 0079-6832 ; 0163-7827
    DOI 10.1016/j.plipres.2023.101264
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Se 298: Show issues Location:
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  5. Article ; Online: Emerging Trends in the Use of Topical Antifungal-Corticosteroid Combinations.

    Mijaljica, Dalibor / Spada, Fabrizio / Harrison, Ian P

    Journal of fungi (Basel, Switzerland)

    2022  Volume 8, Issue 8

    Abstract: A broad range of topical antifungal formulations containing miconazole or terbinafine as actives are commonly used as efficacious choices for combating fungal skin infections. Their many benefits, owing to their specific mechanism of action, include ... ...

    Abstract A broad range of topical antifungal formulations containing miconazole or terbinafine as actives are commonly used as efficacious choices for combating fungal skin infections. Their many benefits, owing to their specific mechanism of action, include their ability to target the site of infection, enhance treatment efficacy and reduce the risk of systemic side effects. Their proven efficacy, and positioning in the treatment of fungal skin infections, is enhanced by high patient compliance, especially when appropriate vehicles such as creams, ointments and gels are used. However, inflammation as a result of fungal infection can often impede treatment, especially when combined with pruritus (itch), an unpleasant sensation that elicits an urge to scratch. The scratching that occurs in response to pruritus frequently accelerates skin damage, ultimately aggravating and spreading the fungal infection. To help overcome this issue, a topical antifungal-corticosteroid combination consisting of miconazole or terbinafine and corticosteroids of varying potencies should be used. Due to their inherent benefits, these topical antifungal-corticosteroid combinations can concomitantly and competently attenuate inflammation, relieve pruritus and treat fungal infection.
    Language English
    Publishing date 2022-08-01
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2784229-0
    ISSN 2309-608X ; 2309-608X
    ISSN (online) 2309-608X
    ISSN 2309-608X
    DOI 10.3390/jof8080812
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Skin Cleansing without or with Compromise: Soaps and Syndets.

    Mijaljica, Dalibor / Spada, Fabrizio / Harrison, Ian P

    Molecules (Basel, Switzerland)

    2022  Volume 27, Issue 6

    Abstract: Products designed to cleanse the skin commonly do so through surfactant action, which leads to the lowering of the surface tension of the skin to facilitate the removal of dirt from its surface. Skin cleansers generally come in one of two types: soap- ... ...

    Abstract Products designed to cleanse the skin commonly do so through surfactant action, which leads to the lowering of the surface tension of the skin to facilitate the removal of dirt from its surface. Skin cleansers generally come in one of two types: soap-based and synthetic detergents, or syndets. While the latter can effectively maintain the native skin structure, function and integrity, the former tends to negatively affect the skin by causing barrier disruption, lipid dissolution and pH alteration. Despite this, soap is still often preferred, possibly due to the negative connotations around anything that is not perceived as 'natural'. It is, therefore, important that the science behind cleansers, especially those designed for the maintenance of healthy skin and the management of common skin conditions such as eczema, be understood by both formulators and end-users. Here, we carefully weigh the advantages and disadvantages of the different types of surfactant-the key ingredient(s) in skin cleansers-and provide insight into surfactants' physicochemical properties, biological activity and potential effects. Fine-tuning of the complex characteristics of surfactants can successfully lead to an 'optimal' skin cleanser that can simultaneously be milder in nature, highly effective and beneficial, and offer minimal skin interference and environmental impact.
    MeSH term(s) Detergents/chemistry ; Skin ; Skin Care ; Soaps/chemistry ; Surface-Active Agents/pharmacology
    Chemical Substances Detergents ; Soaps ; Surface-Active Agents
    Language English
    Publishing date 2022-03-21
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules27062010
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  7. Article ; Online: Autophagy/virophagy: a "disposal strategy" to combat COVID-19.

    Mijaljica, Dalibor / Klionsky, Daniel J

    Autophagy

    2020  Volume 16, Issue 12, Page(s) 2271–2272

    Abstract: Given the devastating consequences of the current COVID-19 pandemic and its impact on all of us, the question arises as to whether manipulating the cellular degradation (recycling, waste disposal) mechanism known as macroautophagy/autophagy (in ... ...

    Abstract Given the devastating consequences of the current COVID-19 pandemic and its impact on all of us, the question arises as to whether manipulating the cellular degradation (recycling, waste disposal) mechanism known as macroautophagy/autophagy (in particular, the selective degradation of virus particles, termed virophagy) might be a beneficial approach to fight the novel coronavirus, SARS-CoV-2. Knowing that "autophagy can reprocess everything", it seems almost inevitable that, sooner rather than later, a further hypothesis-driven work will detail the role of virophagy as a fundamental "disposal strategy" against COVID-19, yielding most needed therapeutic interventions.
    MeSH term(s) Autophagy/physiology ; COVID-19/epidemiology ; COVID-19/immunology ; COVID-19/pathology ; COVID-19/therapy ; Coronavirus Infections/epidemiology ; Coronavirus Infections/immunology ; Coronavirus Infections/therapy ; Disease Outbreaks ; Humans ; Immunity, Cellular/physiology ; Middle East Respiratory Syndrome Coronavirus/physiology ; Pandemics ; Phagocytosis/physiology ; SARS-CoV-2/immunology ; SARS-CoV-2/pathogenicity ; Virion/metabolism
    Keywords covid19
    Language English
    Publishing date 2020-06-24
    Publishing country United States
    Document type Editorial ; Research Support, N.I.H., Extramural
    ZDB-ID 2454135-7
    ISSN 1554-8635 ; 1554-8627
    ISSN (online) 1554-8635
    ISSN 1554-8627
    DOI 10.1080/15548627.2020.1782022
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6741: Show issues Location:
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  8. Article ; Online: Emerging Trends in the Use of Topical Antifungal-Corticosteroid Combinations

    Dalibor Mijaljica / Fabrizio Spada / Ian P. Harrison

    Journal of Fungi, Vol 8, Iss 8, p

    2022  Volume 812

    Abstract: A broad range of topical antifungal formulations containing miconazole or terbinafine as actives are commonly used as efficacious choices for combating fungal skin infections. Their many benefits, owing to their specific mechanism of action, include ... ...

    Abstract A broad range of topical antifungal formulations containing miconazole or terbinafine as actives are commonly used as efficacious choices for combating fungal skin infections. Their many benefits, owing to their specific mechanism of action, include their ability to target the site of infection, enhance treatment efficacy and reduce the risk of systemic side effects. Their proven efficacy, and positioning in the treatment of fungal skin infections, is enhanced by high patient compliance, especially when appropriate vehicles such as creams, ointments and gels are used. However, inflammation as a result of fungal infection can often impede treatment, especially when combined with pruritus (itch), an unpleasant sensation that elicits an urge to scratch. The scratching that occurs in response to pruritus frequently accelerates skin damage, ultimately aggravating and spreading the fungal infection. To help overcome this issue, a topical antifungal-corticosteroid combination consisting of miconazole or terbinafine and corticosteroids of varying potencies should be used. Due to their inherent benefits, these topical antifungal-corticosteroid combinations can concomitantly and competently attenuate inflammation, relieve pruritus and treat fungal infection.
    Keywords allylamines ; azoles ; ergosterol ; formulation ; fungi ; infection ; Biology (General) ; QH301-705.5
    Language English
    Publishing date 2022-08-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: Skin Cleansing without or with Compromise

    Dalibor Mijaljica / Fabrizio Spada / Ian P. Harrison

    Molecules, Vol 27, Iss 2010, p

    Soaps and Syndets

    2022  Volume 2010

    Abstract: Products designed to cleanse the skin commonly do so through surfactant action, which leads to the lowering of the surface tension of the skin to facilitate the removal of dirt from its surface. Skin cleansers generally come in one of two types: soap- ... ...

    Abstract Products designed to cleanse the skin commonly do so through surfactant action, which leads to the lowering of the surface tension of the skin to facilitate the removal of dirt from its surface. Skin cleansers generally come in one of two types: soap-based and synthetic detergents, or syndets. While the latter can effectively maintain the native skin structure, function and integrity, the former tends to negatively affect the skin by causing barrier disruption, lipid dissolution and pH alteration. Despite this, soap is still often preferred, possibly due to the negative connotations around anything that is not perceived as ‘natural’. It is, therefore, important that the science behind cleansers, especially those designed for the maintenance of healthy skin and the management of common skin conditions such as eczema, be understood by both formulators and end-users. Here, we carefully weigh the advantages and disadvantages of the different types of surfactant—the key ingredient(s) in skin cleansers—and provide insight into surfactants’ physicochemical properties, biological activity and potential effects. Fine-tuning of the complex characteristics of surfactants can successfully lead to an ‘optimal’ skin cleanser that can simultaneously be milder in nature, highly effective and beneficial, and offer minimal skin interference and environmental impact.
    Keywords capacity ; charge ; ingredient ; mildness ; pH ; cleanser ; Organic chemistry ; QD241-441
    Subject code 571
    Language English
    Publishing date 2022-03-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: Autophagy/virophagy

    Mijaljica, Dalibor / Klionsky, Daniel J.

    Autophagy

    a “disposal strategy” to combat COVID-19

    2020  , Page(s) 1–2

    Keywords Cell Biology ; Molecular Biology ; covid19
    Language English
    Publisher Informa UK Limited
    Publishing country uk
    Document type Article ; Online
    ZDB-ID 2146183-1
    ISSN 1551-4005 ; 1538-4101 ; 1554-8627
    ISSN (online) 1551-4005
    ISSN 1538-4101 ; 1554-8627
    DOI 10.1080/15548627.2020.1782022
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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