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  1. Article: Chromatin Remodeling-Related PRDM1 Increases Stomach Cancer Proliferation and Is Counteracted by Bromodomain Inhibitor.

    Hung, Yu-Hsuan / Wang, Hui-Ching / Pan, Mei-Ren / Chen, Li-Tzong

    Journal of personalized medicine

    2024  Volume 14, Issue 3

    Abstract: Gastrointestinal (GI) cancers are some of the main public health threats to the world. Even though surgery, chemotherapy, and targeted therapy are available for their treatments, these approaches provide limited success in reducing mortality, making the ... ...

    Abstract Gastrointestinal (GI) cancers are some of the main public health threats to the world. Even though surgery, chemotherapy, and targeted therapy are available for their treatments, these approaches provide limited success in reducing mortality, making the identification of additional therapeutic targets mandatory. Chromatin remodeling in cancer has long been studied and related therapeutics are widely used, although less is known about factors with prognostic and therapeutic potential in such areas as gastrointestinal cancers. Through applying systematic bioinformatic analysis, we determined that out of 31 chromatin remodeling factors in six gastrointestinal cancers, only PR/SET domain 1 (PRDM1) showed both expression alteration and prognosis prediction. Analyses on pathways, therapies, and mediators showed that cell cycle, bromodomain inhibitor IBET151, and BET protein BRD4 were, respectively involved in PRDM1-high stomach cancer, while cell line experiments validated that PRDM1 knockdown in human stomach cancer cell line SNU-1 decreased its proliferation, BRD4 expression, and responsiveness to IBET151; accordingly, these results indicate the contribution by PRDM1 in stomach cancer formation and its association with BRD4 modulation as well as BET inhibitor treatment.
    Language English
    Publishing date 2024-02-20
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662248-8
    ISSN 2075-4426
    ISSN 2075-4426
    DOI 10.3390/jpm14030224
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Book: Chʻu chʻin huan ching wei sheng

    Li, Chʻi-chʻien / Wang, Chih-san

    1993  

    Institution Kuang-tung sheng chiao yü tʻing chiao tsʻai pien shen shih
    Author's details Kuang-tung sheng chiao yü tʻing chiao tsʻai pien shen shih pien ; Li Chʻi-chʻien, Wang Chih-san pien hsieh
    Keywords Veterinary hygiene
    Language Chinese
    Size 6, 254 p. :, ill. ;, 19 cm.
    Edition Ti 1 pan.
    Publisher Kuang-tung chiao yü chʻu pan she ; Kuang-tung sheng hsin hua shu tien fa hsing
    Publishing place Kuang-chou shih
    Document type Book
    Note "Kuang-tung sheng kao chung chih yeh chi shu chiao tsʻai."
    ISBN 7540621591 ; 9787540621599
    Database NAL-Catalogue (AGRICOLA)

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  3. Article: Neuron-derived neurotensin promotes pancreatic cancer invasiveness and gemcitabine resistance via the NTSR1/Akt pathway.

    Hung, Yu-Hsuan / Wang, Hui-Ching / Hsu, Shih-Han / Wang, Li-Yun / Tsai, Ya-Li / Su, Yung-Yeh / Hung, Wen-Chun / Chen, Li-Tzong

    American journal of cancer research

    2024  Volume 14, Issue 2, Page(s) 448–466

    Abstract: Perineural invasion and neurogenesis are frequently observed in pancreatic ductal adenocarcinoma (PDAC) and link to poor outcome. However, how neural factors affect PDAC prognosis and the underlying mechanism as well as counteracting therapeutic are ... ...

    Abstract Perineural invasion and neurogenesis are frequently observed in pancreatic ductal adenocarcinoma (PDAC) and link to poor outcome. However, how neural factors affect PDAC prognosis and the underlying mechanism as well as counteracting therapeutic are still unclear.
    Language English
    Publishing date 2024-02-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2589522-9
    ISSN 2156-6976
    ISSN 2156-6976
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Book: She hui chu i ching chi ho suan li lun

    Wang, Shao-fei

    1979  

    Author's details Wang Shao-fei ... [et al.] chu
    Keywords China
    Language Chinese
    Size 2, 144 p. ;, 19 cm.
    Edition Ti 1 pan.
    Publisher Chung-kuo she hui kʻo hsüeh chʻu pan she ; Hsin hua shu tien Pei-ching fa hsing so fa hsing
    Publishing place Pei-ching
    Document type Book
    Database NAL-Catalogue (AGRICOLA)

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  5. Article: Identification of Therapeutic Targets for the Selective Killing of HBV-Positive Hepatocytes.

    Huang, Chien-Jung / Wang, Lily Hui-Ching / Wang, Yu-Chao

    Journal of personalized medicine

    2021  Volume 11, Issue 7

    Abstract: The hepatitis B virus (HBV) infection is a major risk factor for cirrhosis and hepatocellular carcinoma. Most infected individuals become lifelong carriers of HBV as the drugs currently used to treat the patients can only control the disease, thereby ... ...

    Abstract The hepatitis B virus (HBV) infection is a major risk factor for cirrhosis and hepatocellular carcinoma. Most infected individuals become lifelong carriers of HBV as the drugs currently used to treat the patients can only control the disease, thereby achieving functional cure (loss of the hepatitis B surface antigen) but not complete cure (elimination of infected hepatocytes). Therefore, we aimed to identify the target genes for the selective killing of HBV-positive hepatocytes to develop a novel therapy for the treatment of HBV infection. Our strategy was to recognize the conditionally essential genes that are essential for the survival of HBV-positive hepatocytes, but non-essential for the HBV-negative hepatocytes. Using microarray gene expression data curated from the Gene Expression Omnibus database and the known essential genes from the Online GEne Essentiality database, we used two approaches, comprising the random walk with restart algorithm and the support vector machine approach, to determine the potential targets for the selective killing of HBV-positive hepatocytes. The final candidate genes list obtained using these two approaches consisted of 36 target genes, which may be conditionally essential for the cell survival of HBV-positive hepatocytes; however, this requires further experimental validation. Therefore, the genes identified in this study can be used as potential drug targets to develop novel therapeutic strategies for the treatment of HBV, and may ultimately help in achieving the elusive goal of a complete cure for hepatitis B.
    Language English
    Publishing date 2021-07-10
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662248-8
    ISSN 2075-4426
    ISSN 2075-4426
    DOI 10.3390/jpm11070649
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Prognostic mutation signature would serve as a potential prognostic predictor in patients with diffuse large B-cell lymphoma.

    Cho, Shih-Feng / Yeh, Tsung-Jang / Wang, Hui-Ching / Du, Jeng-Shiun / Gau, Yuh-Ching / Lin, Yu-Yin / Chuang, Tzer-Ming / Liu, Yi-Chang / Hsiao, Hui-Hua / Moi, Sin-Hua

    Scientific reports

    2024  Volume 14, Issue 1, Page(s) 6161

    Abstract: The present study aimed to elucidate the prognostic mutation signature (PMS) associated with long-term survival in a diffuse large B-cell lymphoma (DLBCL) cohort. All data including derivation and validation cohorts were retrospectively retrieved from ... ...

    Abstract The present study aimed to elucidate the prognostic mutation signature (PMS) associated with long-term survival in a diffuse large B-cell lymphoma (DLBCL) cohort. All data including derivation and validation cohorts were retrospectively retrieved from The Cancer Genome Atlas (TCGA) database and whole-exome sequencing (WES) data. The Lasso Cox regression analysis was used to construct the PMS based on WES data, and the PMS was determined using the area under the receiver operating curve (AUC). The predictive performance of eligible PMS was analyzed by time-dependent receiver operating curve (ROC) analyses. After the initial evaluation, a PMS composed of 94 PFS-related genes was constructed. Notably, this constructed PMS accurately predicted the 12-, 36-, and 60-month PFS, with AUC values of 0.982, 0.983, and 0.987, respectively. A higher level of PMS was closely linked to a significantly worse PFS, regardless of the molecular subtype. Further evaluation by forest plot revealed incorporation of international prognostic index or tumor mutational burden into PMS increased the prediction capability for PFS. The drug-gene interaction and pathway exploration revealed the PFS-related genes were associated with DNA damage, TP53, apoptosis, and immune cell functions. In conclusion, this study utilizing a high throughput genetic approach demonstrated that the PMS could serve as a prognostic predictor in DLBCL patients. Furthermore, the identification of the key signaling pathways for disease progression also provides information for further investigation to gain more insight into novel drug-resistant mechanisms.
    MeSH term(s) Humans ; Prognosis ; Retrospective Studies ; Mutation ; Lymphoma, Large B-Cell, Diffuse/diagnosis ; Lymphoma, Large B-Cell, Diffuse/genetics ; DNA Damage
    Language English
    Publishing date 2024-03-14
    Publishing country England
    Document type Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-024-56583-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Growth Regulated Oncogene-α Upregulates TNF-α and COX-2 and Activates NOD1/RIPK2 mediated-MAPK Pathway in Head and Neck Squamous Cell Carcinoma.

    Chan, Leong-Perng / Tseng, Ya-Ping / Wang, Hui-Ching / Chien, Chen-Yu / Wu, Che-Wei / Wang, Ling-Feng / Liang, Chia-Hua

    Journal of Cancer

    2023  Volume 14, Issue 6, Page(s) 989–1000

    Abstract: Purpose: ...

    Abstract Purpose:
    Language English
    Publishing date 2023-04-09
    Publishing country Australia
    Document type Journal Article
    ZDB-ID 2573318-7
    ISSN 1837-9664
    ISSN 1837-9664
    DOI 10.7150/jca.82300
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Reversible dasatinib-related pulmonary arterial hypertension diagnosed by noninvasive echocardiography

    Hui-Ching Wang

    Kaohsiung Journal of Medical Sciences, Vol 31, Iss 3, Pp 165-

    2015  Volume 166

    Keywords Medicine (General) ; R5-920
    Language English
    Publishing date 2015-03-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: Identification of Therapeutic Targets for the Selective Killing of HBV-Positive Hepatocytes

    Chien-Jung Huang / Lily Hui-Ching Wang / Yu-Chao Wang

    Journal of Personalized Medicine, Vol 11, Iss 649, p

    2021  Volume 649

    Abstract: The hepatitis B virus (HBV) infection is a major risk factor for cirrhosis and hepatocellular carcinoma. Most infected individuals become lifelong carriers of HBV as the drugs currently used to treat the patients can only control the disease, thereby ... ...

    Abstract The hepatitis B virus (HBV) infection is a major risk factor for cirrhosis and hepatocellular carcinoma. Most infected individuals become lifelong carriers of HBV as the drugs currently used to treat the patients can only control the disease, thereby achieving functional cure (loss of the hepatitis B surface antigen) but not complete cure (elimination of infected hepatocytes). Therefore, we aimed to identify the target genes for the selective killing of HBV-positive hepatocytes to develop a novel therapy for the treatment of HBV infection. Our strategy was to recognize the conditionally essential genes that are essential for the survival of HBV-positive hepatocytes, but non-essential for the HBV-negative hepatocytes. Using microarray gene expression data curated from the Gene Expression Omnibus database and the known essential genes from the Online GEne Essentiality database, we used two approaches, comprising the random walk with restart algorithm and the support vector machine approach, to determine the potential targets for the selective killing of HBV-positive hepatocytes. The final candidate genes list obtained using these two approaches consisted of 36 target genes, which may be conditionally essential for the cell survival of HBV-positive hepatocytes; however, this requires further experimental validation. Therefore, the genes identified in this study can be used as potential drug targets to develop novel therapeutic strategies for the treatment of HBV, and may ultimately help in achieving the elusive goal of a complete cure for hepatitis B.
    Keywords hepatitis B virus ; hepatocytes ; conditionally essential genes ; weighted co-expression network ; random walk with restart ; support vector machine ; Medicine ; R
    Subject code 570
    Language English
    Publishing date 2021-07-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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  10. Book: Chia ch'u huan ching wei sheng hsüeh

    Wang, Ch'ing-kao

    hsü mu, shou i chuan yeh yung

    1981  

    Title translation Study of domestics animals and their living environments.
    Institution Tung-pei nung hsüeh yüan
    Author's details Tung-pei nung hsüeh yüan chu pien ; [chu pien Wang ch'ing-kao]
    Keywords Animal housing. ; Domestic animals/Heating and ventilation. ; Domestic animals/Health and hygiene.
    Language Chinese
    Size 2, 231 p. :, ill. ;, 26 cm.
    Edition Ti 1 pan.
    Publisher Nung yeh ch'u pan she ; Hsin hua shu tien Pei-ching fa hsing so fa hsing
    Publishing place Pei-ching
    Document type Book
    Database NAL-Catalogue (AGRICOLA)

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