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Article ; Online: Ji-Chuan decoction ameliorates slow transit constipation

Wang, Xiu-Min / Lv, Li-Xia / Qin, Yue-Si / Zhang, Yu-Zhu / Yang, Ni / Wu, Shu / Xia, Xiu-Wen / Yang, Hong / Xu, Hong / Liu, Ying / Ding, Wei-Jun

World journal of gastroenterology

2022 Volume 28, Issue 34, Page(s) 5007–5022

Abstract: ... As a classical formula of traditional Chinese medicine, Ji-Chuan decoction (JCD) has been extensively and ...

Abstract	Background: Slow transit constipation (STC) is a common intestinal disease with increasing incidence. STC results from various factors, such as the enteric nervous system and metabolic changes. As a classical formula of traditional Chinese medicine, Ji-Chuan decoction (JCD) has been extensively and effectively used in STC treatment, yet its pharmacological mechanism remains unclear. Aim: To explore the integrated regulatory pattern of JCD against STC through hyphenated techniques from metabolism, network pharmacology and molecular methods. Methods: STC model mice were generated by intragastric administration of compound diphenoxylate (10 mg/kg/d) for 14 d. The STC mice in the low dose of JCD (3.04 g/kg), middle dose of JCD (6.08 g/kg) and high dose of JCD (12.16 g/kg) groups were orally administered JCD solution once a day for 2 wk. The acetylcholine (ACH) level was examined by enzyme-linked immunosorbent assay. The pathological features of colon tissue were observed by hematoxylin and eosin staining. The differentially expressed metabolites and metabolic pathways were tested by nontargeted metabolomics. The main targets and core ingredients of JCD were identified by network pharmacology, and the expression of AKT was confirmed by immunohistochemistry. Finally, the pathways involved in JCD treatment were predicted using a combination of differentially expressed metabolites and targets, and intestinal glial cell apoptosis was demonstrated by immunofluorescence. Results: JCD significantly promoted intestinal motility, increased the levels of the excitatory neurotransmitter ACH and reduced intestinal inflammation in STC mice. Untargeted metabolomics results showed that JCD significantly restored metabolic dysfunction and significantly affected taurine and hypotaurine metabolism. Network pharmacology and molecular experiments showed that JCD regulates AKT protein expression, and the core component is quercetin. Combined analysis demonstrated that apoptosis may be an important mechanism by which JCD relieves constipation. Further experiments showed that JCD reduced enteric glial cell (EGC) apoptosis. Conclusion: This work demonstrated that reducing EGC apoptosis may be the critical mechanism by which JCD treats STC. These findings call for further molecular research to facilitate the clinical application of JCD.
MeSH term(s)	Acetylcholine ; Animals ; Apoptosis ; Constipation ; Diphenoxylate ; Gastrointestinal Transit ; Mice ; Neuroglia/metabolism ; Proto-Oncogene Proteins c-akt ; Quercetin ; Taurine
Chemical Substances	Taurine (1EQV5MLY3D) ; Diphenoxylate (73312P173G) ; Quercetin (9IKM0I5T1E) ; Proto-Oncogene Proteins c-akt (EC 2.7.11.1) ; Acetylcholine (N9YNS0M02X)
Language	English
Publishing date	2022-09-19
Publishing country	United States
Document type	Journal Article
ZDB-ID	2185929-2
ISSN	2219-2840 ; 1007-9327
ISSN (online)	2219-2840
ISSN	1007-9327
DOI	10.3748/wjg.v28.i34.5007
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Article ; Online: Integrated network pharmacology and pharmacological investigations to explore the potential mechanism of Ding-Chuan-Tang against chronic obstructive pulmonary disease.

Xu, Lin-Tao / Wang, Tian / Han, Qing-Tong / Xu, Zhen-Peng / Wen, Xue-Sen / Wang, Xiao-Ning / Shen, Tao

Journal of ethnopharmacology

2024 Volume 327, Page(s) 117983

Abstract: Ethnopharmacological relevance: Ding-Chuan-Tang (Abbreviated as DCT) is frequently prescribed ...

Abstract	Ethnopharmacological relevance: Ding-Chuan-Tang (Abbreviated as DCT) is frequently prescribed for treatment of respiratory diseases, including chronic obstructive pulmonary disease (COPD), which is characterized by coughing, wheezing, and chest tightness in traditional Chinese medicine (TCM). However, the potential mechanism of DCT has not been investigated. Aim of study: The aim of the study is to explore the efficiency of DCT in the treatment of COPD in vivo and in vitro, and to illustrate the possible mechanism against COPD. Methods: COPD model was induced by exposure of mice to cigarette smoke (CS) for 16 weeks. Enzyme-linked immunosorbent assay (ELISA), immunofluorescence assay, Western blot, etc., were used to explore the efficiency and mechanisms of DCT. Network pharmacology analysis, including Gene Ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis, etc., was performed to explore the potential targets in the treatment of DCT on COPD. Results: DCT significantly alleviated pulmonary pathological changes in mouse COPD model, and inhibited inflammatory response induced by CS and LPS in vivo and in vitro. Network pharmacology analysis suggested that DCT alleviated COPD via inhibiting inflammation by regulating PI3K-AKT pathway. In cell-based models, DCT suppressed the phosphorylation of PI3K and AKT, which further regulated its downstream targets Nrf2 and NF-κB, and inhibited inflammatory response. Conclusions: DCT effectively attenuated COPD in the mouse model induced by CS. The therapeutic mechanism of DCT against COPD was closely associated with the regulation of PI3K-AKT pathway and its downstream transcription factors, Nrf2 and NF-κB.
MeSH term(s)	Mice ; Animals ; NF-kappa B/metabolism ; Proto-Oncogene Proteins c-akt/metabolism ; NF-E2-Related Factor 2/genetics ; NF-E2-Related Factor 2/metabolism ; Phosphatidylinositol 3-Kinases/metabolism ; Network Pharmacology ; Pulmonary Disease, Chronic Obstructive/drug therapy ; Pulmonary Disease, Chronic Obstructive/metabolism
Chemical Substances	NF-kappa B ; Proto-Oncogene Proteins c-akt (EC 2.7.11.1) ; NF-E2-Related Factor 2 ; Phosphatidylinositol 3-Kinases (EC 2.7.1.-)
Language	English
Publishing date	2024-03-02
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	134511-4
ISSN	1872-7573 ; 0378-8741
ISSN (online)	1872-7573
ISSN	0378-8741
DOI	10.1016/j.jep.2024.117983
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Article ; Online: Transcriptome sequencing and network pharmacology-based approach to reveal the effect and mechanism of Ji Chuan Jian against Parkinson's disease.

Wu, Yao / Bai, Yu / Lu, Yan / Zhang, Zhennian / Zhao, Yang / Huang, Sirui / Tang, Lili / Liang, Yan / Hu, Yue / Xu, Chengcheng

BMC complementary medicine and therapies

2023 Volume 23, Issue 1, Page(s) 182

Abstract: Background: Ji Chuan Jian (JCJ), a classic Traditional Chinese Medicine (TCM) formula, has been ...

Abstract	Background: Ji Chuan Jian (JCJ), a classic Traditional Chinese Medicine (TCM) formula, has been widely applied in treating Parkinson's disease (PD) in China, However, the interaction of bioactive compounds from JCJ with the targets involved in PD remains elusive. Methods: Based on the transcriptome sequencing and network pharmacology approaches, the chemical compounds of JCJ and gene targets for treating PD were identified. Then, the Protein-protein interaction (PPI) and "Compound-Disease-Target" (C-D-T) network were constructed by using of Cytoscape. Gene Ontology (GO) enrichment analysis and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis were applied to these target proteins. Finally, AutoDock Vina was used for applying molecular docking. Results: In the present study, a total number of 2669 differentially expressed genes (DEGs) were identified between PD and healthy controls using whole transcriptome RNA sequencing. Then, 260 targets of 38 bioactive compounds in JCJ were identified. Of these targets, 47 were considered PD-related targets. Based on the PPI degree, the top 10 targets were identified. In C-D-T network analysis, the most important anti-PD bioactive compounds in JCJ were determined. Molecular docking revealed that potential PD-related targets, matrix metalloproteinases-9 (MMP9) were more stably bound with naringenin, quercetin, baicalein, kaempferol and wogonin. Conclusion: Our study preliminarily investigated the bioactive compounds, key targets, and potential molecular mechanism of JCJ against PD. It also provided a promising approach for identifying the bioactive compounds in TCM as well as a scientific basis for further elucidating the mechanism of TCM formulae in treating diseases.
MeSH term(s)	Humans ; Molecular Docking Simulation ; Network Pharmacology ; Parkinson Disease/drug therapy ; Parkinson Disease/genetics ; Transcriptome ; China
Language	English
Publishing date	2023-06-03
Publishing country	England
Document type	Journal Article
ISSN	2662-7671
ISSN (online)	2662-7671
DOI	10.1186/s12906-023-03999-6
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Article ; Online: Tai Chi Chuan for Subjective Sleep Quality

Yuhao Si / Cenyi Wang / Heng Yin / Jinghui Zheng / Yang Guo / Guihua Xu / Yong Ma

Evidence-Based Complementary and Alternative Medicine, Vol

A Systematic Review and Meta-Analysis of Randomized Controlled Trials

2020 Volume 2020

Abstract: Background. This review aims to investigate the efficacy of Tai Chi Chuan on subjective sleep ... results confirmed that Tai Chi Chuan elicited moderate improvements in subjective sleep quality (SMD = −0 ... 512, 95% CI [−0.767, −0.257], P<0.001). Notably, Tai Chi Chuan yielded more significant effects ...

Abstract	Background. This review aims to investigate the efficacy of Tai Chi Chuan on subjective sleep quality among adults. Methods. We systematically searched PubMed, Embase, Cochrane Library, Scopus, CNKI (China National Knowledge Infrastructure), and the Wanfang Database from their inception to August 2019 and identified 25 eligible studies that were published in both English and Chinese. Results. 24 out of 25 studies were identified to be high-quality studies according to the PEDro scale. The pooled results confirmed that Tai Chi Chuan elicited moderate improvements in subjective sleep quality (SMD = −0.512, 95% CI [−0.767, −0.257], P<0.001). Notably, Tai Chi Chuan yielded more significant effects on sleep quality among the healthy population (SMD = −0.684, 95% CI [−1.056, −0.311], P<0.001) than the clinical population (SMD = −0.395, 95% CI [−0.742, −0.047], P=0.026) and more benefits among the Asian population (SMD = −0.977, 95% CI [−1.446, −0.508], P<0.001) than the American population (SMD = −0.259, 95% CI [−0.624, 0.105], P=0.164). After controlling the methodological quality of studies, it has been noted that Asians could achieve the most significant sleep-promoting benefit when Tai Chi Chuan was practiced between 60 and 90 min per session. Conclusions. Available data implied that subjective sleep quality was improved via Tai Chi training, but more thorough studies must be executed to ascertain our findings and optimize Tai Chi practices accordingly toward various populations.
Keywords	Other systems of medicine ; RZ201-999
Subject code	610
Language	English
Publishing date	2020-01-01T00:00:00Z
Publisher	Hindawi Limited
Document type	Article ; Online
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Article: Altered Effective Connectivity of Resting-State Networks by Tai Chi Chuan in Chronic Fatigue Syndrome Patients: A Multivariate Granger Causality Study.

Li, Yuanyuan / Wu, Kang / Hu, Xiaojie / Xu, Tianjiao / Li, Zongheng / Zhang, Yong / Li, Kuangshi

Frontiers in neurology

2022 Volume 13, Page(s) 858833

Abstract: ... in resting brain functional connectivity, but there is no study on the brain network effect of Tai Chi Chuan ... intervention in CFS. To explore the influence of Tai Chi Chuan exercise on the causal relationship between ... Health Survey (SF-36) scale assessment before and after 1month-long training in Tai Chi Chuan. We extracted ...

Abstract	Numerous evidence has shown that patients with chronic fatigue syndrome (CFS) have changes in resting brain functional connectivity, but there is no study on the brain network effect of Tai Chi Chuan intervention in CFS. To explore the influence of Tai Chi Chuan exercise on the causal relationship between brain functional networks in patients with CFS, 21 patients with CFS and 19 healthy controls were recruited for resting-state functional magnetic resonance imaging (rs-fMRI) scanning and 36-item Short-Form Health Survey (SF-36) scale assessment before and after 1month-long training in Tai Chi Chuan. We extracted the resting brain networks using the independent component analysis (ICA) method, analyzed the changes of FC in these networks, conducted Granger causality analysis (GCA) on it, and analyzed the correlation between the difference causality value and the SF-36 scale. Compared to the healthy control group, the SF-36 scale scores of patients with CFS were lower at baseline. Meanwhile, the causal relationship between sensorimotor network (SMN) and default mode network (DMN) was weakened. The above abnormalities could be improved by Tai Chi Chuan training for 1 month. In addition, the correlation analyses showed that the causal relationship between SMN and DMN was positively correlated with the scores of Role Physical (RP) and Bodily Pain (BP) in CFS patients, and the change of causal relationship between SMN and DMN before and after training was positively correlated with the change of BP score. The findings suggest that Tai Chi Chuan is helpful to improve the quality of life for patients with CFS. The change of Granger causality between SMN and DMN may be a readout parameter of CFS. Tai Chi Chuan may promote the functional plasticity of brain networks in patients with CFS by regulating the information transmission between them.
Language	English
Publishing date	2022-06-03
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2564214-5
ISSN	1664-2295
ISSN	1664-2295
DOI	10.3389/fneur.2022.858833
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Article ; Online: Effects of Tai Chi Chuan on Cognitive Function in Adults 60 Years or Older With Type 2 Diabetes and Mild Cognitive Impairment in China: A Randomized Clinical Trial.

Chen, Yannan / Qin, Jiawei / Tao, Liyuan / Liu, Zhizhen / Huang, Jia / Liu, Weilin / Xu, Ying / Tang, Qiang / Liu, Yongguo / Chen, Zhuhong / Chen, Shangjie / Liang, Shengxiang / Chen, Cong / Xie, Jinjin / Liu, Jue / Chen, Lidian / Tao, Jing

JAMA network open

2023 Volume 6, Issue 4, Page(s) e237004

Abstract: ... whether tai chi chuan has better long-term benefits than fitness walking in cognitive function for patients with T2D and ... mild cognitive impairment (MCI).: Objective: To compare the effectiveness of tai chi chuan, a mind-body exercise ... MCI.: Interventions: Participants were randomized in a 1:1:1 ratio to a tai chi chuan group ...

Abstract	Importance: Type 2 diabetes (T2D) is associated with the progression of cognitive dysfunction. Physical activity benefits cognition, but no evidence from randomized clinical trials has shown whether tai chi chuan has better long-term benefits than fitness walking in cognitive function for patients with T2D and mild cognitive impairment (MCI). Objective: To compare the effectiveness of tai chi chuan, a mind-body exercise, for improving cognitive function in older adults with T2D and MCI, with fitness walking. Design, setting, and participants: This randomized clinical trial was conducted between June 1, 2020, and February 28, 2022, at 4 sites in China. Participants included 328 adults (aged ≥60 years) with a clinical diagnosis of T2D and MCI. Interventions: Participants were randomized in a 1:1:1 ratio to a tai chi chuan group, a fitness walking group, or a control group. The tai chi chuan group received 24-form simplified tai chi chuan. The fitness walking group received fitness walking training. Both exercise groups took the training for 60 min/session, 3 times/wk, for 24 weeks in a supervised setting. All 3 groups were provided with a 30-minute diabetes self-management education session, once every 4 weeks for 24 weeks. The participants were followed up for 36 weeks. Main outcomes and measures: The primary outcome was the global cognitive function measured at 36 weeks by the Montreal Cognitive Assessment (MoCA). Secondary outcomes included MoCA at 24 weeks and other cognitive subdomain measures and blood metabolic indices at 24 and 36 weeks. Results: A total of 328 participants (mean [SD] age, 67.55 [5.02] years; mean [SD] T2D duration, 10.48 [6.81] years; 167 [50.9%] women) were randomized to the tai chi chuan group (n = 107), fitness walking group (n = 110), or control group (n = 111) and included in the intention-to-treat analysis. At 36 weeks, the tai chi chuan group showed improved MoCA scores compared with the fitness walking group (mean [SD], 24.67 [2.72] vs 23.84 [3.17]; between-group mean difference, 0.84 [95% CI, 0.02-1.66]; P = .046) in the intention-to-treat analysis. The per-protocol analysis data set and subgroup analysis at 36 weeks showed similar results. Based on the generalized linear models, the treatment effects were similar in each group after adjusting for self-reported dietary calories and physical activity. There were 37 nonserious adverse events (tai chi chuan group, 8; fitness walking group, 13; control group, 16) unrelated to the study with no statistically significant difference among the 3 groups (P = .26). Conclusions and relevance: In this randomized clinical trial including older adults with T2D and MCI, tai chi chuan was more effective than fitness walking in improving global cognitive function. The findings support a long-term benefit, suggesting the potential clinical use of tai chi chuan as an exercise intervention to improve cognitive function for older adults with T2D and MCI. Trial registration: ClinicalTrials.gov Identifier: NCT04416841.
MeSH term(s)	Humans ; Female ; Aged ; Male ; Tai Ji ; Diabetes Mellitus, Type 2/complications ; Diabetes Mellitus, Type 2/therapy ; Cognition ; Cognitive Dysfunction/therapy ; Exercise Therapy
Language	English
Publishing date	2023-04-03
Publishing country	United States
Document type	Randomized Controlled Trial ; Journal Article ; Research Support, Non-U.S. Gov't
ISSN	2574-3805
ISSN (online)	2574-3805
DOI	10.1001/jamanetworkopen.2023.7004
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Article ; Online: Effects of Tai Chi Chuan on the Physical and Mental Health of the Elderly

Chen Xianjian / Xu Datao

Physical Activity and Health, Vol 5, Iss

A Systematic Review

2021 Volume 1

Abstract: ... caused serious psychological and physical damage to the elderly. Tai Chi chuan is both rigid and flexible ... analyzes the effects of Tai Chi chuan on the Psychological and Physiological Health of the elderly and ... its mechanism, and provides corresponding methods of Tai Chi chuan practice for reference when practicing ...

Abstract	Background:Many studies revealed that the elderly people are more susceptible to respiratory infections including the Novel Coronavirus (COVID-19) Pneumonia. The outbreak of the Novel Coronavirus has caused serious psychological and physical damage to the elderly. Tai Chi chuan is both rigid and flexible, with unique breathing and movement rhythms, and has a positive effect on the mental and physical health of the elderly. Related research is scattered in the literature. Research purposes:This article summarizes and analyzes the effects of Tai Chi chuan on the Psychological and Physiological Health of the elderly and its mechanism, and provides corresponding methods of Tai Chi chuan practice for reference when practicing. Provide a reference for the health promotion of the senior citizens under the normalized prevention and control of the epidemic. Methods:literature systematic evaluation, through Google Scholar, Web of Science, PubMed and other databases to search the literature on the effects of Tai Chi chuan on the health of the elderly, sort out the research progress at home and abroad, and determine the relevant literature for analysis according to the inclusion and exclusion criteria of this study. Results:Through the preliminary screening of literature titles and abstracts, 84 articles were obtained, 64 articles were excluded according to the elimination criteria, and 20 articles were obtained; 15 articles were excluded according to the final criteria, 1 article included based on reference searching, and finally 6 articles were included in the study. Conclusion:Tai Chi chuan has a potential effect on the prevention, treatment and rehabilitation of COVID-19. Its potential mechanisms include reducing anxiety, relieving depression and stress, enhancing pulmonary and cardiovascular function, enhancing immunity and improving quality of life.
Keywords	covid-19 ; systematic evaluation ; health promotion ; Medicine (General) ; R5-920
Subject code	306
Language	English
Publishing date	2021-01-01T00:00:00Z
Publisher	Ubiquity Press
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Transcriptome sequencing and network pharmacology-based approach to reveal the effect and mechanism of Ji Chuan Jian against Parkinson’s disease

Yao Wu / Yu Bai / Yan Lu / Zhennian Zhang / Yang Zhao / Sirui Huang / Lili Tang / Yan Liang / Yue Hu / Chengcheng Xu

BMC Complementary Medicine and Therapies, Vol 23, Iss 1, Pp 1-

2023 Volume 13

Abstract: Abstract Background Ji Chuan Jian (JCJ), a classic Traditional Chinese Medicine (TCM) formula, has ...

Abstract	Abstract Background Ji Chuan Jian (JCJ), a classic Traditional Chinese Medicine (TCM) formula, has been widely applied in treating Parkinson’s disease (PD) in China, However, the interaction of bioactive compounds from JCJ with the targets involved in PD remains elusive. Methods Based on the transcriptome sequencing and network pharmacology approaches, the chemical compounds of JCJ and gene targets for treating PD were identified. Then, the Protein-protein interaction (PPI) and “Compound-Disease-Target” (C-D-T) network were constructed by using of Cytoscape. Gene Ontology (GO) enrichment analysis and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis were applied to these target proteins. Finally, AutoDock Vina was used for applying molecular docking. Results In the present study, a total number of 2669 differentially expressed genes (DEGs) were identified between PD and healthy controls using whole transcriptome RNA sequencing. Then, 260 targets of 38 bioactive compounds in JCJ were identified. Of these targets, 47 were considered PD-related targets. Based on the PPI degree, the top 10 targets were identified. In C-D-T network analysis, the most important anti-PD bioactive compounds in JCJ were determined. Molecular docking revealed that potential PD-related targets, matrix metalloproteinases-9 (MMP9) were more stably bound with naringenin, quercetin, baicalein, kaempferol and wogonin. Conclusion Our study preliminarily investigated the bioactive compounds, key targets, and potential molecular mechanism of JCJ against PD. It also provided a promising approach for identifying the bioactive compounds in TCM as well as a scientific basis for further elucidating the mechanism of TCM formulae in treating diseases.
Keywords	Transcriptome sequencing ; Ji Chuan Jian ; Network pharmacology ; Parkinson’s disease ; Mechanism ; Other systems of medicine ; RZ201-999
Subject code	540
Language	English
Publishing date	2023-06-01T00:00:00Z
Publisher	BMC
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Tai Chi Chuan for Subjective Sleep Quality: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

Si, Yuhao / Wang, Cenyi / Yin, Heng / Zheng, Jinghui / Guo, Yang / Xu, Guihua / Ma, Yong

Evidence-based complementary and alternative medicine : eCAM

2020 Volume 2020, Page(s) 4710527

Abstract: Background: This review aims to investigate the efficacy of Tai Chi Chuan on subjective sleep ... The pooled results confirmed that Tai Chi Chuan elicited moderate improvements in subjective sleep quality ...

Abstract	Background: This review aims to investigate the efficacy of Tai Chi Chuan on subjective sleep quality among adults. Methods: We systematically searched PubMed, Embase, Cochrane Library, Scopus, CNKI (China National Knowledge Infrastructure), and the Wanfang Database from their inception to August 2019 and identified 25 eligible studies that were published in both English and Chinese. Results: 24 out of 25 studies were identified to be high-quality studies according to the PEDro scale. The pooled results confirmed that Tai Chi Chuan elicited moderate improvements in subjective sleep quality (SMD = -0.512, 95% CI [-0.767, -0.257], Conclusions: Available data implied that subjective sleep quality was improved via Tai Chi training, but more thorough studies must be executed to ascertain our findings and optimize Tai Chi practices accordingly toward various populations.
Language	English
Publishing date	2020-08-11
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2171158-6
ISSN	1741-4288 ; 1741-427X
ISSN (online)	1741-4288
ISSN	1741-427X
DOI	10.1155/2020/4710527
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Article: Chuan Huang Fang combining reduced glutathione in treating acute kidney injury (grades 1-2) on chronic kidney disease (stages 2-4): A multicenter randomized controlled clinical trial.

Chen, Ling / Ye, Zi / Wang, Danjun / Liu, Jianlian / Wang, Qian / Wang, Chen / Xu, Bing / Gong, Xuezhong

Frontiers in pharmacology

2022 Volume 13, Page(s) 969107

Abstract: ... Our previously single-center clinical studies indicated Chuan Huang Fang (CHF) might have nephroprotection in AKI ...

Abstract	Lack of effective drugs for acute kidney injury (AKI) grades 1-2 is a crucial challenge in clinic. Our previously single-center clinical studies indicated Chuan Huang Fang (CHF) might have nephroprotection in AKI on chronic kidney disease (CKD) (A on C) patients by preventing oxidant damage and inhibiting inflammation. Reduced glutathione (RG) has recently been shown to increase the clinical effectiveness of high-flux hemodialysis among patients with severe AKI. In this multicenter randomized controlled clinical study, we designed a new protocol to assess the efficacy and safety of CHF combining RG in patients with A on C. We also explored therapeutic mechanisms from renal fibrosis biomarkers. 98 participants were randomly and equally divided into the RG and RG + CHF subgroups. The RG and RG + CHF groups received general treatments with RG and a combination of RG and CHF, respectively. The therapy lasted for 2 weeks. In this study, the primary assessment result was a difference in the slope of serum creatinine (Scr) over the course of 2 weeks. The secondary evaluation outcomes were alterations in blood urea nitrogen (BUN), uric acid (UA), estimated glomerular filtration rate (eGFR), urinary AKI biomarkers, renal fibrosis biomarkers (transforming growth factor-
Language	English
Publishing date	2022-10-03
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2587355-6
ISSN	1663-9812
ISSN	1663-9812
DOI	10.3389/fphar.2022.969107
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