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Article ; Online: Methoxyacetone revisited.

Sharma, Archna / Gupta, Vivek K / Reva, Igor

Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy

2023 Volume 308, Page(s) 123651

Abstract: Conformational space of methoxyacetone (MA) was studied at the MP2/6-311++G(d,p) and DFT(B3LYP)/6-311++G(d,p) levels of theory. Computations predict MA to adopt four conformations, resulting from internal rotations around the O=C-C-O (Trans, Cis) and C-C- ...

Abstract	Conformational space of methoxyacetone (MA) was studied at the MP2/6-311++G(d,p) and DFT(B3LYP)/6-311++G(d,p) levels of theory. Computations predict MA to adopt four conformations, resulting from internal rotations around the O=C-C-O (Trans, Cis) and C-C-O-C (trans, gauche) dihedral angles. The Tt (Trans-trans) conformer is the most stable. The computed energies of two gauche (Tg and Cg) conformers fall in the 3-8 kJ mol
Language	English
Publishing date	2023-11-17
Publishing country	England
Document type	Journal Article
ZDB-ID	210413-1
ISSN	1873-3557 ; 0370-8322 ; 0584-8539 ; 1386-1425
ISSN (online)	1873-3557
ISSN	0370-8322 ; 0584-8539 ; 1386-1425
DOI	10.1016/j.saa.2023.123651
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Article: Community-forming traits play role in effective colonization of plant-growth-promoting bacteria and improved plant growth.

Pathak, Devashish / Suman, Archna / Sharma, Pushpendra / Aswini, Krishnan / Govindasamy, Venkadasamy / Gond, Shrikant / Anshika, Rana

Frontiers in plant science

2024 Volume 15, Page(s) 1332745

Abstract: Community-forming traits (CFts) play an important role in the effective colonization of plant-growth-promoting bacterial communities that influence host plants positively by modulating their adaptive functions. In this study, by considering plant-growth- ... ...

Abstract	Community-forming traits (CFts) play an important role in the effective colonization of plant-growth-promoting bacterial communities that influence host plants positively by modulating their adaptive functions. In this study, by considering plant-growth-promoting traits (PGPts) and community-forming traits (CFts), three communities were constructed,
Language	English
Publishing date	2024-03-12
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2613694-6
ISSN	1664-462X
ISSN	1664-462X
DOI	10.3389/fpls.2024.1332745
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Article: Seed endophytic bacterial profiling from wheat varieties of contrasting heat sensitivity.

Aswini, Krishnan / Suman, Archna / Sharma, Pushpendra / Singh, Pradeep Kumar / Gond, Shrikant / Pathak, Devashish

Frontiers in plant science

2023 Volume 14, Page(s) 1101818

Abstract: Wheat yield can be limited by many biotic and abiotic factors. Heat stress at the grain filling stage is a factor that reduces wheat production tremendously. The potential role of endophytic microorganisms in mitigating plant stress through various ... ...

Abstract	Wheat yield can be limited by many biotic and abiotic factors. Heat stress at the grain filling stage is a factor that reduces wheat production tremendously. The potential role of endophytic microorganisms in mitigating plant stress through various biomolecules like enzymes and growth hormones and also by improving plant nutrition has led to a more in-depth exploration of the plant microbiome for such functions. Hence, we devised this study to investigate the abundance and diversity of wheat seed endophytic bacteria (WSEB) from heat
Language	English
Publishing date	2023-04-06
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2613694-6
ISSN	1664-462X
ISSN	1664-462X
DOI	10.3389/fpls.2023.1101818
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Article ; Online: Extracellular CIRP Induces Calpain Activation in Neurons via PLC-IP

Sharma, Archna / Sari, Ezgi / Lee, Yongchan / Patel, Shivani / Brenner, Max / Marambaud, Philippe / Wang, Ping

Molecular neurobiology

2023 Volume 60, Issue 6, Page(s) 3311–3328

Abstract: Abnormal calcium homeostasis, activation of protease calpain, generation of p25 and hyperactivation of cyclin-dependent kinase 5 (Cdk5) have all been implicated in the pathogenesis of neurogenerative diseases including Alzheimer's disease. We have ... ...

Abstract	Abnormal calcium homeostasis, activation of protease calpain, generation of p25 and hyperactivation of cyclin-dependent kinase 5 (Cdk5) have all been implicated in the pathogenesis of neurogenerative diseases including Alzheimer's disease. We have recently shown that extracellular cold-inducible RNA-binding protein (eCIRP) induces Cdk5 activation via p25. However, the precise molecular mechanism by which eCIRP regulates calcium signaling and calpain remains to be addressed. We hypothesized that eCIRP regulates p25 via Ca
MeSH term(s)	Calcium/metabolism ; Calpain/metabolism ; Neurons/metabolism ; Phosphorylation ; Proteolysis ; RNA-Binding Proteins/metabolism
Chemical Substances	Calcium (SY7Q814VUP) ; Calpain (EC 3.4.22.-) ; RNA-Binding Proteins
Language	English
Publishing date	2023-02-28
Publishing country	United States
Document type	Journal Article
ZDB-ID	645020-9
ISSN	1559-1182 ; 0893-7648
ISSN (online)	1559-1182
ISSN	0893-7648
DOI	10.1007/s12035-023-03273-3
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Article ; Online: Modified Atkins diet versus levetiracetam for non-surgical drug-resistant epilepsy in children: A randomized open-label study.

Archna / Garg, Divyani / Goel, Shaiphali / Mukherjee, Sharmila B / Pemde, Harish K / Jain, Puneet / Sharma, Suvasini

Seizure

2022 Volume 103, Page(s) 61–67

Abstract: Background: This study was undertaken to compare the efficacy of modified Atkins diet (MAD) among children with non-surgical drug-resistant epilepsy (DRE) to levetiracetam, when added to on-going anti-seizure medications.: Methods: An open-label, ... ...

Abstract	Background: This study was undertaken to compare the efficacy of modified Atkins diet (MAD) among children with non-surgical drug-resistant epilepsy (DRE) to levetiracetam, when added to on-going anti-seizure medications. Methods: An open-label, randomized controlled trial among children aged 2-12 years with non-surgical DRE was conducted. Eligible children were randomized in a 1:1 ratio to receive add-on MAD or levetiracetam. Baseline and post-intervention seizure frequency at 12 weeks was determined from seizure logs maintained by parents. The primary outcome was the proportion of responders, i.e., patients who achieved > 50% seizure reduction from baseline. Adverse events were compared. Analysis was intention-to-treat. (NCT04172311) RESULTS: One hundred and one children were enrolled (MAD-51, levetiracetam-50). The majority of the enrolled children had generalized seizures of mixed types secondary to structural brain lesions and Lennox-Gastaut syndrome was the most common electroclinical syndrome (46%). The proportion of children with >50% seizure reduction at 12 weeks was significantly higher in the MAD arm compared to the levetiracetam arm (27/51(52.9%) vs 11/50(22%); p < 0.001). At 12-weeks post-intervention, the change in mean seizure frequency compared to baseline was -47.33 ± 39.57% in the MAD arm and -31.15 ± 32.18% in the levetiracetam arm (p = 0.03). Constipation (41.1%) was the most frequent adverse effect with MAD. Sedation/lethargy (18%) and anxiety and irritability (14%) were the most frequent adverse effects in the levetiracetam group. Conclusion: Addition of MAD was found to be superior to levetiracetam among children with non-surgical DRE with predominant generalized seizures in achieving seizure reduction at 12 weeks. Both treatments were well tolerated. Adverse effects, although higher with MAD, were expected side effects.
MeSH term(s)	Child ; Humans ; Levetiracetam/adverse effects ; Diet, High-Protein Low-Carbohydrate ; Drug Resistant Epilepsy/drug therapy ; Diet, Ketogenic/adverse effects ; Drug-Related Side Effects and Adverse Reactions ; Seizures/drug therapy ; Treatment Outcome
Chemical Substances	Levetiracetam (44YRR34555)
Language	English
Publishing date	2022-10-14
Publishing country	England
Document type	Randomized Controlled Trial ; Journal Article
ZDB-ID	1137610-7
ISSN	1532-2688 ; 1059-1311
ISSN (online)	1532-2688
ISSN	1059-1311
DOI	10.1016/j.seizure.2022.10.015
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Article ; Online: Stakeholder participation in prioritizing sustainability issues at regional level using analytic hierarchy process (AHP) technique

Swati Kwatra / Archna Kumar / Sumit Sharma / Prateek Sharma

Environmental and Sustainability Indicators, Vol 11, Iss , Pp 100116- (2021)

A case study of Goa, India

2021

Abstract: This study involves stakeholders in prioritizing and ranking themes and sub-themes relevant to assess regional level sustainability. Three themes – social, economic and environment were identified as parent themes; to assess sustainability the key ... ...

Abstract	This study involves stakeholders in prioritizing and ranking themes and sub-themes relevant to assess regional level sustainability. Three themes – social, economic and environment were identified as parent themes; to assess sustainability the key stakeholders identified 18 sub-themes to assess these three themes in detail. The key stakeholder groups of elected representatives (panchayats), government, industry and non-governmental organizations (NGOs)/academia, have been involved to assign weights to the themes and the sub-themes of the SDI, keeping the regional priorities in mind. Analytical Hierarchy Process (AHP), a decision-making technique has been used to prioritize and rank the various themes and sub-themes. Goa, one of the states of India, which has performed well on national level SDI developed as part of the earlier study (Kwatra et al., 2016), was taken as the case study to assess sustainability issues at regional level. It was found that all the stakeholder groups gave nearly equal importance to the three themes of sustainability – environment (38%), social (32%) and economic (30%), environmental theme was apparently given slightly higher weights. Among the sub-themes, livelihood received highest weight (11%), followed by waste management (8%), and environmental budget (8%). Issues like waste management, unemployment, forests and biodiversity, governance which are of local importance were given higher weights by the local stakeholders over the national level priority issues like climate change, air pollution, health and literacy etc. The study proposes and tests a methodology which can be applied at a regional scale to assess and prioritize key sustainability issues so that policy makers can take informed decisions.
Keywords	Sustainable development ; Regional sustainable development index ; Analytic hierarchy process ; India ; Stakeholder participation ; Weighing indicators ; Environmental sciences ; GE1-350
Subject code	910
Language	English
Publishing date	2021-09-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Endophytic bacterial taxonomic and functional diversity in the seeds of wheat genotypes from different agroecologies

Pushpendra Sharma / Archna Suman / Krishnan Aswini / Jogdande SaiPrasad / Shrikant Gond

Journal of Plant Interactions, Vol 18, Iss

2023 Volume 1

Abstract: ABSTRACTPlant genotype and agroecology influence the composition and functionality of seed endophytic bacterial communities. Taxonomic analysis of 123 wheat seeds endophytic bacteria classified these into 23 genera predominantly under Firmicutes followed ...

Abstract	ABSTRACTPlant genotype and agroecology influence the composition and functionality of seed endophytic bacterial communities. Taxonomic analysis of 123 wheat seeds endophytic bacteria classified these into 23 genera predominantly under Firmicutes followed by Actinobacteria and Proteobacteria. Genus Bacillus was most abundant (30.7%) followed by Streptomyces (18.4%) with other representative genera such as Stenotrophomonas, Paenibacillus, Mixta, Enterobacter, Micrococcus, Pantoea, Alkalihalobacillus, Cortiobacterium, and more. Across agroecologies, the core microbiota of seeds consists of Bacillus, Streptomyces, Paenibacillus, and Stenotrophomonas, with maximum diversity and abundance observed in seeds of the North Western Plain Zone of India. Seed endophytic bacteria had PGP traits; nitrogen fixation (n = 101), production of IAA (n = 65), siderophores (n = 43), ammonia (n = 82) and solubilization of phosphate (n = 47), potassium (n = 37), and zinc (n = 8). The isolates produced HCN and hydrolytic enzymes and displayed antagonism against fungal pathogens. Overall, the information generated on wheat seeds’ endophytic bacterial taxonomy and beneficial traits may pave the path for the development of novel bioinoculants.Key message Wheat seeds from various agro-ecologies of India harbor diverse endophytic bacteria.Firmicutes were dominant followed by Actinobacteria and Proteobacteria.Genus Bacillus, Stenotrophomonas, Streptomyces, and Paenibacillus were core endophytic bacteria in different agro-ecologies.The endophytic bacterial strains were displaying diverse functional traits.
Keywords	Agroecological zones ; bacterial endophytes ; wheat ; diversity ; functional traits ; Plant culture ; SB1-1110 ; Plant ecology ; QK900-989
Language	English
Publishing date	2023-12-01T00:00:00Z
Publisher	Taylor & Francis Group
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Late presentation of lane-hamilton syndrome in a 33 year old female: A case report.

Mishra, Sarvesh Chandra / Gupta, Aviral / Sharma, Srishti / Gupta, Archna

International journal of applied & basic medical research

2022 Volume 12, Issue 2, Page(s) 137–139

Abstract: Lane-Hamilton syndrome (LHS) is a rare syndromic association between idiopathic pulmonary hemosiderosis and celiac disease (CD). It is usually seen in children below 15 years of age. It can occasionally be seen in adults. We present the case of a 33-year- ...

Abstract	Lane-Hamilton syndrome (LHS) is a rare syndromic association between idiopathic pulmonary hemosiderosis and celiac disease (CD). It is usually seen in children below 15 years of age. It can occasionally be seen in adults. We present the case of a 33-year-old female patient who presented with recurrent episodes of hemoptysis to the pulmonary outpatient department. She also gave a history of having frequent loose stools. She was admitted and investigated thoroughly and was found to be suffering from LHS which is a rare disease. High-resolution computed tomography (HRCT) of the chest and duodenal biopsy helped in concluding the diagnosis. She was started on gluten-free diet (GFD) and has responded well with no episodes of hemoptysis on 9-month follow-up and is in good general condition. This case highlights the importance of keeping a high index of suspicion of LHS in a young patient presenting with unexplained hemoptysis and diarrhea. In a known case of CD presenting with hemoptysis, a HRCT chest aids in the diagnosis of LHS. A GFD is the mainstay of long-term treatment, and adherence to this diet shows remarkable improvement in the symptoms of the patient and their overall general condition.
Language	English
Publishing date	2022-05-10
Publishing country	India
Document type	Case Reports
ZDB-ID	2645750-7
ISSN	2248-9606 ; 2229-516X
ISSN (online)	2248-9606
ISSN	2229-516X
DOI	10.4103/ijabmr.ijabmr_620_21
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Article ; Online: Silver-Nanoparticle-Embedded Short Amphiphilic Peptide Nanostructures and Their Plausible Application to Reduce Bacterial Infections.

Kumar Tripathi, Satyendra / Kesharwani, Khushboo / Saxena, Deepanshi / Singh, Ramesh / Kautu, Aanand / Sharma, Shruti / Pandey, Archna / Chopra, Sidharth / Ballabh Joshi, Khashti

ChemMedChem

2023 Volume 18, Issue 5, Page(s) e202200654

Abstract: The microbiota-gut-brain axis (GBA) plays a critical role in the development of neurodegenerative diseases. Dysbiosis of the intestinal microbiome causes a significant alteration in the gut microbiota of Alzheimer's disease (AD) patients, followed by ... ...

Abstract	The microbiota-gut-brain axis (GBA) plays a critical role in the development of neurodegenerative diseases. Dysbiosis of the intestinal microbiome causes a significant alteration in the gut microbiota of Alzheimer's disease (AD) patients, followed by neuroinflammatory processes. Thus, AD beginning in the gut is closely related to an imbalance in gut microbiota, and hence a multidomain approach to reduce this imbalance by exerting positive effects on the gut microbiota is needed. In one example, a tyrosine-based short peptide amphiphile (sPA) was used to synthesize antibacterial AgNPs-sPA nanostructures. Such nanostructures showed high biocompatibility and low cytotoxicity, and therefore work as model drug delivery agents for addressing local bacterial infections. These may have therapeutic value for the treatment of microbiota-triggered progression of neurodegenerative diseases.
MeSH term(s)	Humans ; Silver ; Alzheimer Disease ; Bacterial Infections ; Neurodegenerative Diseases ; Peptides ; Nanostructures ; Nanoparticles ; Brain
Chemical Substances	colloidal silver ; Silver (3M4G523W1G) ; Peptides
Language	English
Publishing date	2023-01-19
Publishing country	Germany
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2218496-X
ISSN	1860-7187 ; 1860-7179
ISSN (online)	1860-7187
ISSN	1860-7179
DOI	10.1002/cmdc.202200654
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Article: Stakeholder participation in prioritizing sustainability issues at regional level using analytic hierarchy process (AHP) technique: A case study of Goa, India

Kwatra, Swati / Kumar, Archna / Sharma, Sumit / Sharma, Prateek

Environmental and sustainability indicators. 2021 Sept., v. 11

2021

Abstract	This study involves stakeholders in prioritizing and ranking themes and sub-themes relevant to assess regional level sustainability. Three themes – social, economic and environment were identified as parent themes; to assess sustainability the key stakeholders identified 18 sub-themes to assess these three themes in detail. The key stakeholder groups of elected representatives (panchayats), government, industry and non-governmental organizations (NGOs)/academia, have been involved to assign weights to the themes and the sub-themes of the SDI, keeping the regional priorities in mind. Analytical Hierarchy Process (AHP), a decision-making technique has been used to prioritize and rank the various themes and sub-themes. Goa, one of the states of India, which has performed well on national level SDI developed as part of the earlier study (Kwatra et al., 2016), was taken as the case study to assess sustainability issues at regional level. It was found that all the stakeholder groups gave nearly equal importance to the three themes of sustainability – environment (38%), social (32%) and economic (30%), environmental theme was apparently given slightly higher weights. Among the sub-themes, livelihood received highest weight (11%), followed by waste management (8%), and environmental budget (8%). Issues like waste management, unemployment, forests and biodiversity, governance which are of local importance were given higher weights by the local stakeholders over the national level priority issues like climate change, air pollution, health and literacy etc. The study proposes and tests a methodology which can be applied at a regional scale to assess and prioritize key sustainability issues so that policy makers can take informed decisions.
Keywords	air pollution ; biodiversity ; case studies ; climate change ; decision making ; governance ; industry ; issues and policy ; literacy ; livelihood ; stakeholders ; unemployment ; waste management ; India
Language	English
Dates of publication	2021-09
Publishing place	Elsevier Inc.
Document type	Article
Note	NAL-AP-2-clean
ISSN	2665-9727
DOI	10.1016/j.indic.2021.100116
Database	NAL-Catalogue (AGRICOLA)

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