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Article ; Online: The International Association for the Study of Lung Cancer Thymic Epithelial Tumors Staging Project: Proposals for the N and the M Components for the Forthcoming (Ninth) Edition of the TNM Classification of Malignant Tumors.

Fang, Wentao / Girard, Nicolas / Cilento, Vanessa / Goren, Emily / Dibaba, Daniel / Ruffini, Enrico / Ahmad, Usman / Appel, Sarit / Bille, Andrea / Boubia, Souheil / Brambilla, Cecilia / Cangir, Ayten Kayi / Detterbeck, Frank / Falkson, Conrad / Filosso, Pier Luigi / Giaccone, Giuseppe / Guerrera, Francesco / Huang, James / Infante, Maurizio /

Kim, Dong Kwan / Lucchi, Marco / Marino, Mirella / Marom, Edith M / Nicholson, Andrew G / Okumura, Meinoshin / Rami-Porta, Ramon / Rimner, Andreas / Simone, Charles B / Asamura, Hisao

Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer

2023 Volume 19, Issue 1, Page(s) 52–70

Abstract: ... with cancer and rests on a combination of three components-T for tumor extent, N for nodal involvement, and M ... for distant metastases. This article details the revision of the N and the M components of thymic epithelial ... The N and M components of the eighth edition staging system were verified by a large international ...

Abstract	Introduction: Stage classification is an important underpinning of management in patients with cancer and rests on a combination of three components-T for tumor extent, N for nodal involvement, and M for distant metastases. This article details the revision of the N and the M components of thymic epithelial tumors for the ninth edition of the TNM classification of malignant tumors proposed by the Thymic Domain of the International Association for the Study of Lung Cancer Staging and Prognostic Factors Committee. Methods: The N and M components of the eighth edition staging system were verified by a large international collaborative data source through a data-driven analysis. A total of 9147 cases were included for analysis, including 7662 thymomas, 1345 thymic carcinomas, and 140 neuroendocrine thymic tumors. Results: Lymph node involvement rates were 1.5% in thymomas and 17.6% and 27.7% in thymic carcinomas and neuroendocrine thymic tumors, respectively. Rates of lymph node metastasis were increasingly higher in tumors with higher T stage and higher-grade histologic type. Survival analysis validated the differences in the N and M categories proposed in the eighth edition staging system. Good discrimination in overall survival was detected among pathologic (p)N and pM categories in patients with thymoma and thymic carcinoma. Conclusions: No changes are proposed from the eighth edition for the N and M components. The proposed stage classification will provide a useful tool for management of the disease among the global thymic community.
MeSH term(s)	Humans ; Neoplasm Staging ; Lung Neoplasms/pathology ; Thymoma/pathology ; Myeloma Proteins ; Thymus Neoplasms/pathology ; Prognosis ; Neoplasms, Glandular and Epithelial/pathology ; Neuroendocrine Tumors/pathology
Chemical Substances	Myeloma Proteins
Language	English
Publishing date	2023-09-27
Publishing country	United States
Document type	Journal Article
ZDB-ID	2432037-7
ISSN	1556-1380 ; 1556-0864
ISSN (online)	1556-1380
ISSN	1556-0864
DOI	10.1016/j.jtho.2023.09.1447
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Book ; Online: Evolving Concepts in Insulin Resistance

Infante, Marco

2022

Keywords	Endocrinology ; Clinical & internal medicine
Language	English
Size	1 electronic resource (190 pages)
Publisher	IntechOpen
Document type	Book ; Online
Note	English
HBZ-ID	HT030377626
ISBN	9781803555034 ; 1803555033
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Article ; Online: A novel activation-induced cytidine deaminase mutation in an adult with hyper-immunoglobulin M syndrome.

Mendoza, Jun / Quinn, James / Infante, Anthony / Nath, Priya / Amornruk, Nutchaya

Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology

2020 Volume 126, Issue 2, Page(s) 199–200

MeSH term(s)	Adolescent ; Adult ; Asthma/blood ; Asthma/genetics ; Asthma/immunology ; Cytidine Deaminase/genetics ; Female ; Humans ; Hyper-IgM Immunodeficiency Syndrome/blood ; Hyper-IgM Immunodeficiency Syndrome/genetics ; Hyper-IgM Immunodeficiency Syndrome/immunology ; Immunoglobulins/blood ; Male ; Mutation ; Pulmonary Disease, Chronic Obstructive/blood ; Pulmonary Disease, Chronic Obstructive/genetics ; Pulmonary Disease, Chronic Obstructive/immunology
Chemical Substances	Immunoglobulins ; Cytidine Deaminase (EC 3.5.4.5)
Language	English
Publishing date	2020-10-28
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	1228189-x
ISSN	1534-4436 ; 0003-4738 ; 1081-1206
ISSN (online)	1534-4436
ISSN	0003-4738 ; 1081-1206
DOI	10.1016/j.anai.2020.10.016
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Article ; Online: Benchmark Assessment of Density Functional Methods on Group II-VI MX (M = Zn, Cd; X = S, Se, Te) Quantum Dots.

Azpiroz, Jon M / Ugalde, Jesus M / Infante, Ivan

Journal of chemical theory and computation

2014 Volume 10, Issue 1, Page(s) 76–89

Abstract: ... and low-lying excitation energies for MX quantum dots, with M = Cd, Zn, and X = S, Se, Te ...

Abstract	In this work, we build a benchmark data set of geometrical parameters, vibrational normal modes, and low-lying excitation energies for MX quantum dots, with M = Cd, Zn, and X = S, Se, Te. The reference database has been constructed by ab initio resolution-of-identity second-order approximate coupled cluster RI-CC2/def2-TZVPP calculations on (MX)6 model molecules in the wurtzite structure. We have tested 26 exchange-correlation density functionals, ranging from local generalized gradient approximation (GGA) and hybrid GGA to meta-GGA, meta-hybrid, and long-range corrected. The best overall functional is the hybrid PBE0 that outperforms all other functionals, especially for excited state energies, which are of particular relevance for the systems studied here. Among the DFT methodologies with no Hartree-Fock exchange, the M06-L is the best one. Local GGA functionals usually provide satisfactory results for geometrical structures and vibrational frequencies but perform rather poorly for excitation energies. Regarding the CdSe cluster, we also present a test of several basis sets that include relativistic effects via effective core potentials (ECPs) or via the ZORA approximation. The best basis sets in terms of computational efficiency and accuracy are the SBKJC and def2-SV(P). The LANL2DZ basis set, commonly employed nowadays on these types of nanoclusters, performs very disappointingly. Finally, we also provide some suggestions on how to perform calculations on larger systems keeping a balance between computational load and accuracy.
Language	English
Publishing date	2014-01-14
Publishing country	United States
Document type	Journal Article
ISSN	1549-9626
ISSN (online)	1549-9626
DOI	10.1021/ct400513s
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Article ; Online: M-H loop tracer based on digital signal processing for low frequency characterization of extremely thin magnetic wires.

Butta, M / Infante, G / Ripka, P / Badini-Confalonieri, G A / Vázquez, M

The Review of scientific instruments

2009 Volume 80, Issue 8, Page(s) 83906

Abstract: A high-sensitivity ac hysteresis loop tracer has been developed to measure the low frequency hysteresis loop of soft magnetic materials. It has been applied successfully to characterize straight pieces of amorphous glass-covered microwires with metallic ... ...

Abstract	A high-sensitivity ac hysteresis loop tracer has been developed to measure the low frequency hysteresis loop of soft magnetic materials. It has been applied successfully to characterize straight pieces of amorphous glass-covered microwires with metallic nucleus down to 1.5 microm thick. Based on the electromagnetic induction law, the proposed design is extremely simple and exploits the capabilities of commercially available data acquisition cards together with digital signal processing in order to achieve high-sensitivity without the need of expensive analog equipment.
Language	English
Publishing date	2009-08
Publishing country	United States
Document type	Journal Article
ZDB-ID	209865-9
ISSN	1089-7623 ; 0034-6748
ISSN (online)	1089-7623
ISSN	0034-6748
DOI	10.1063/1.3206264
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Article ; Online: Gadofluorine M-enhanced MRI shows involvement of circumventricular organs in neuroinflammation.

Wuerfel, Eva / Infante-Duarte, Carmen / Glumm, Robert / Wuerfel, Jens T

Journal of neuroinflammation

2010 Volume 7, Page(s) 70

Abstract: ... we investigated in vivo alterations of CVO during neuroinflammation, applying Gadofluorine M- (Gf) enhanced ...

Abstract	Background: Circumventricular organs (CVO) are cerebral areas with incomplete endothelial blood-brain barrier (BBB) and therefore regarded as "gates to the brain". During inflammation, they may exert an active role in determining immune cell recruitment into the brain. Methods: In a longitudinal study we investigated in vivo alterations of CVO during neuroinflammation, applying Gadofluorine M- (Gf) enhanced magnetic resonance imaging (MRI) in experimental autoimmune encephalomyelitis, an animal model of multiple sclerosis. SJL/J mice were monitored by Gadopentate dimeglumine- (Gd-DTPA) and Gf-enhanced MRI after adoptive transfer of proteolipid-protein-specific T cells. Mean Gf intensity ratios were calculated individually for different CVO and correlated to the clinical disease course. Subsequently, the tissue distribution of fluorescence-labeled Gf as well as the extent of cellular inflammation was assessed in corresponding histological slices. Results: We could show that the Gf signal intensity of the choroid plexus, the subfornicular organ and the area postrema increased significantly during experimental autoimmune encephalomyelitis, correlating with (1) disease severity and (2) the delay of disease onset after immunization. For the choroid plexus, the extent of Gf enhancement served as a diagnostic criterion to distinguish between diseased and healthy control mice with a sensitivity of 89% and a specificity of 80%. Furthermore, Gf improved the detection of lesions, being particularly sensitive to optic neuritis. In correlated histological slices, Gf initially accumulated in the extracellular matrix surrounding inflammatory foci and was subsequently incorporated by macrophages/microglia. Conclusion: Gf-enhanced MRI provides a novel highly sensitive technique to study cerebral BBB alterations. We demonstrate for the first time in vivo the involvement of CVO during the development of neuroinflammation.
MeSH term(s)	Animals ; Blood-Brain Barrier/pathology ; Blood-Brain Barrier/physiology ; Blood-Brain Barrier/physiopathology ; Brain/anatomy & histology ; Brain/pathology ; Brain/physiopathology ; Contrast Media/metabolism ; Encephalomyelitis, Autoimmune, Experimental/pathology ; Encephalomyelitis, Autoimmune, Experimental/physiopathology ; Extracellular Matrix/metabolism ; Female ; Inflammation/pathology ; Inflammation/physiopathology ; Longitudinal Studies ; Magnetic Resonance Imaging/methods ; Mice ; Monocytes/immunology ; Organometallic Compounds/metabolism
Chemical Substances	Contrast Media ; Organometallic Compounds ; gadofluorine M
Language	English
Publishing date	2010-10-18
Publishing country	England
Document type	Journal Article
ISSN	1742-2094
ISSN (online)	1742-2094
DOI	10.1186/1742-2094-7-70
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Article: Usefulness of ventricular dyssynchrony measured using M-mode echocardiography to predict response to resynchronization therapy.

Díaz-Infante, Ernesto / Sitges, Marta / Vidal, Bàrbara / Mont, Luis / Delgado, Victoria / Marigliano, Alba / Macias, Alfonso / Tolosana, Jose María / Tamborero, David / Azqueta, Manel / Roig, Eulàlia / Paré, Carles / Brugada, Josep

The American journal of cardiology

2007 Volume 100, Issue 1, Page(s) 84–89

Abstract: ... assessed using M-mode echocardiography to predict an improvement with cardiac resynchronization therapy ... CRT). Baseline SPWMD was measured using M-mode in a parasternal short-axis view in a series of 67 ...

Abstract	There are discordant data about the utility of septal-to-posterior wall motion delay (SPWMD) assessed using M-mode echocardiography to predict an improvement with cardiac resynchronization therapy (CRT). Baseline SPWMD was measured using M-mode in a parasternal short-axis view in a series of 67 patients undergoing CRT and followed up after 6 months. Heart failure was caused by coronary artery disease in 27 patients. Clinical responders were patients who were alive, had not undergone heart transplantation, and also increased the distance walked in 6 minutes by >10%. Baseline SPWMDs were mean 155 +/- 113 ms and median 135. Thirty-four patients (51%) had an SPWMD >130 ms. At 6-month follow-up, there were 17 nonresponders. At baseline, there were no significant differences between patients with SPWMD >130 or <130 ms in age, drug therapy, permanent atrial fibrillation, New York Heart Association functional class, underlying cause of cardiomyopathy, QRS duration, left ventricular (LV) ejection fraction, LV dimensions, or neurohormonal activation (norepinephrine and atrial and brain natriuretic peptide). At 6-month follow-up, baseline SPWMD was not associated with clinical response, New York Heart Association functional class, distance walked in 6 minutes, LV reverse remodeling, or neurohormonal activation. SPWMD >130 ms was also not a predictor. In conclusion, SPWMD is not a good predictor of response to CRT.
MeSH term(s)	Aged ; Cardiac Pacing, Artificial ; Coronary Artery Disease/complications ; Echocardiography/methods ; Female ; Follow-Up Studies ; Heart Failure/etiology ; Heart Failure/therapy ; Humans ; Male ; Middle Aged ; Predictive Value of Tests ; Systole ; Ventricular Dysfunction, Left/diagnostic imaging ; Ventricular Dysfunction, Left/etiology ; Ventricular Dysfunction, Left/therapy
Language	English
Publishing date	2007-07-01
Publishing country	United States
Document type	Clinical Trial ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	80014-4
ISSN	1879-1913 ; 0002-9149
ISSN (online)	1879-1913
ISSN	0002-9149
DOI	10.1016/j.amjcard.2007.02.054
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Article ; Online: Gadofluorine M-enhanced MRI shows involvement of circumventricular organs in neuroinflammation

Glumm Robert / Infante-Duarte Carmen / Wuerfel Eva / Wuerfel Jens T

Journal of Neuroinflammation, Vol 7, Iss 1, p

2010 Volume 70

Abstract: ... we investigated in vivo alterations of CVO during neuroinflammation, applying Gadofluorine M- (Gf) enhanced ...

Abstract	Abstract Background Circumventricular organs (CVO) are cerebral areas with incomplete endothelial blood-brain barrier (BBB) and therefore regarded as "gates to the brain". During inflammation, they may exert an active role in determining immune cell recruitment into the brain. Methods In a longitudinal study we investigated in vivo alterations of CVO during neuroinflammation, applying Gadofluorine M- (Gf) enhanced magnetic resonance imaging (MRI) in experimental autoimmune encephalomyelitis, an animal model of multiple sclerosis. SJL/J mice were monitored by Gadopentate dimeglumine- (Gd-DTPA) and Gf-enhanced MRI after adoptive transfer of proteolipid-protein-specific T cells. Mean Gf intensity ratios were calculated individually for different CVO and correlated to the clinical disease course. Subsequently, the tissue distribution of fluorescence-labeled Gf as well as the extent of cellular inflammation was assessed in corresponding histological slices. Results We could show that the Gf signal intensity of the choroid plexus, the subfornicular organ and the area postrema increased significantly during experimental autoimmune encephalomyelitis, correlating with (1) disease severity and (2) the delay of disease onset after immunization. For the choroid plexus, the extent of Gf enhancement served as a diagnostic criterion to distinguish between diseased and healthy control mice with a sensitivity of 89% and a specificity of 80%. Furthermore, Gf improved the detection of lesions, being particularly sensitive to optic neuritis. In correlated histological slices, Gf initially accumulated in the extracellular matrix surrounding inflammatory foci and was subsequently incorporated by macrophages/microglia. Conclusion Gf-enhanced MRI provides a novel highly sensitive technique to study cerebral BBB alterations. We demonstrate for the first time in vivo the involvement of CVO during the development of neuroinflammation.
Keywords	Medicine (General) ; R5-920 ; Medicine ; R ; DOAJ:Medicine (General) ; DOAJ:Health Sciences ; Neurology. Diseases of the nervous system ; RC346-429 ; Neurosciences. Biological psychiatry. Neuropsychiatry ; RC321-571 ; Internal medicine ; RC31-1245 ; DOAJ:Neurology
Subject code	610
Language	English
Publishing date	2010-10-01T00:00:00Z
Publisher	BioMed Central
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Binding motifs for lanthanide hydrides: a combined experimental and theoretical study of the MH(x)(H2)(y) species (M = La-Gd; x = 1-4; y = 0-6).

Infante, Ivan / Gagliardi, Laura / Wang, Xuefeng / Andrews, Lester

The journal of physical chemistry. A

2009 Volume 113, Issue 11, Page(s) 2446–2455

Abstract: ... with the general formula MH(x)(H(2))(y), where M = La, Ce, Pr, Nd, Sm, Eu, and Gd, x = 1-4, and y = 0-6 are ...

Abstract	The results of a combined spectroscopic and computational study of lanthanide hydrides with the general formula MH(x)(H(2))(y), where M = La, Ce, Pr, Nd, Sm, Eu, and Gd, x = 1-4, and y = 0-6 are reported. To understand the nature of the dihydrogen complexes formed with lanthanide metal hydride molecules, we have first identified the binary MH(x) species formed in the ablation/deposition process and then analyzed the dihydrogen supercomplexes, MH(x)(H(2))(y). Our investigation shows that the trihydrides bind dihydrogen more weakly than the dihydrides and that the interaction between the central lanthanide and the H(2) molecules occurs via a 6s electron transfer from the lanthanide to the H(2) molecules. Evidence is also presented for the SmH and EuH diatomic molecules and the tetrahydride anions in solid hydrogen.
Language	English
Publishing date	2009-03-19
Publishing country	United States
Document type	Journal Article
ISSN	1520-5215
ISSN (online)	1520-5215
DOI	10.1021/jp8099658
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Article ; Online: Matrix infrared spectroscopic and computational investigation of late lanthanide metal hydride species MH(x)(H(2))(y) (M = Tb-Lu, x = 1-4, y = 0-3).

Wang, Xuefeng / Andrews, Lester / Infante, Ivan / Gagliardi, Laura

The journal of physical chemistry. A

2009 Volume 113, Issue 45, Page(s) 12566–12572

Abstract: Laser-ablated late lanthanide metal atoms were condensed with pure hydrogen at 4 K, and new infrared absorptions are assigned to binary metal hydrides on the basis of deuterium substitution and density functional theory frequency calculations. The ... ...

Abstract	Laser-ablated late lanthanide metal atoms were condensed with pure hydrogen at 4 K, and new infrared absorptions are assigned to binary metal hydrides on the basis of deuterium substitution and density functional theory frequency calculations. The dominant absorptions in the 1330-1400 cm(-1) region are identified as LnH(3) complexes with very weak ligand bands near 3900 cm(-1). With ytterbium, YbH and YbH(2) were the major initial products, but YbH(3) increased at their expense upon sample irradiation. Evidence is also presented for the LuH and ErH molecules and the tetrahydride anions in solid hydrogen.
Language	English
Publishing date	2009-11-12
Publishing country	United States
Document type	Journal Article
ISSN	1520-5215
ISSN (online)	1520-5215
DOI	10.1021/jp9043754
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