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Article ; Online: P-type β-MoO

Guha, Puspendu / Ghosh, Arnab / Sarkar, Arijit / Mandal, Suman / Ray, Samit K / Goswami, Dipak K / Satyam, Parlapalli V

2018 Volume 30, Issue 3, Page(s) 35204

Abstract: We report on the synthesis and UV-vis photodetection application of p-type MoO ...

Abstract	We report on the synthesis and UV-vis photodetection application of p-type MoO
Language	English
Publishing date	2018-11-13
Publishing country	England
Document type	Journal Article
ZDB-ID	1362365-5
ISSN	1361-6528 ; 0957-4484
ISSN (online)	1361-6528
ISSN	0957-4484
DOI	10.1088/1361-6528/aaeadc
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Article ; Online: p-Cymene metallo-derivatives: An overview on anticancer activity.

Hassan, Shardar Mohammad Hafiz / Ray, Pranta / Hossain, Rajib / Islam, Muhammad Torequl / Salehi, Bahare / Martins, Natália / Sharifi-Rad, Javad / Amarowicz, Ryszard

Cellular and molecular biology (Noisy-le-Grand, France)

2020 Volume 66, Issue 4, Page(s) 28–32

Abstract: ... are being used against many tumors worldwide. Nonetheless, to p-cymene metallo-derivatives a promising ... an in-depth revision of p-cymene metallo-drugs possible mechanisms of anticancer action for upcoming ... pharmaceutical and biotechnological prospects. p-cymene metallo-derivatives have revealed very interesting ...

Abstract	Metallo-drugs have gained a huge attention among scientific community in the couple years. These drugs types have become important compounds in cancer therapy, where, for instance, platinum complexes are being used against many tumors worldwide. Nonetheless, to p-cymene metallo-derivatives a promising anticancer potential has also been increasingly proposed. In this sense, the present review aims to provide an in-depth revision of p-cymene metallo-drugs possible mechanisms of anticancer action for upcoming pharmaceutical and biotechnological prospects. p-cymene metallo-derivatives have revealed very interesting anticancer activities in various test systems, including cancer cells, being thus worth of note to deepen knowledge through clinical trials on their upcoming use for cancer chemotherapy combination.
MeSH term(s)	Animals ; Antineoplastic Agents/chemistry ; Antineoplastic Agents/pharmacology ; Antineoplastic Agents/therapeutic use ; Cymenes/chemistry ; Cymenes/pharmacology ; Cymenes/therapeutic use ; Humans ; Metals/pharmacology ; Metals/therapeutic use ; Neoplasms/drug therapy
Chemical Substances	Antineoplastic Agents ; Cymenes ; Metals ; 4-cymene (1G1C8T1N7Q)
Language	English
Publishing date	2020-06-25
Publishing country	France
Document type	Journal Article ; Review
ZDB-ID	1161779-2
ISSN	1165-158X ; 0145-5680
ISSN (online)	1165-158X
ISSN	0145-5680
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Article ; Online: Comment on: Langerhans cell histiocytosis with BRAF p.N486_P490del or MAP2K1 p.K57_G61del treated by the MEK inhibitor trametinib.

Vicenzi, Paige / Ray, Anish

Pediatric blood & cancer

2020 Volume 68, Issue 4, Page(s) e28776

MeSH term(s)	Histiocytosis, Langerhans-Cell/drug therapy ; Humans ; MAP Kinase Kinase 1/genetics ; Proto-Oncogene Proteins B-raf/genetics ; Pyridones ; Pyrimidinones
Chemical Substances	Pyridones ; Pyrimidinones ; trametinib (33E86K87QN) ; BRAF protein, human (EC 2.7.11.1) ; Proto-Oncogene Proteins B-raf (EC 2.7.11.1) ; MAP Kinase Kinase 1 (EC 2.7.12.2) ; MAP2K1 protein, human (EC 2.7.12.2)
Language	English
Publishing date	2020-10-21
Publishing country	United States
Document type	Letter ; Comment
ZDB-ID	2131448-2
ISSN	1545-5017 ; 1545-5009
ISSN (online)	1545-5017
ISSN	1545-5009
DOI	10.1002/pbc.28776
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Article: Plasma p-tau181, neurofilament light chain and association with cognition in Parkinson's disease.

Batzu, Lucia / Rota, Silvia / Hye, Abdul / Heslegrave, Amanda / Trivedi, Dhaval / Gibson, Lucy L / Farrell, Chloe / Zinzalias, Pavlos / Rizos, Alexandra / Zetterberg, Henrik / Chaudhuri, K Ray / Aarsland, Dag

NPJ Parkinson's disease

2022 Volume 8, Issue 1, Page(s) 154

Abstract: ... at amino acid 181 (p-tau181) and plasma neurofilament light chain (NfL) as biomarkers of cognition in PD ... Baseline concentrations of plasma p-tau181 and NfL were measured in a cohort of 136 patients with PD and 63 ... linear regression and linear mixed effects models. At baseline, plasma p-tau181 concentration was significantly ...

Abstract	Early identification of cognitive impairment in Parkinson's disease (PD) has important clinical and research implications. The aim of our study was to investigate the role of plasma tau phosphorylated at amino acid 181 (p-tau181) and plasma neurofilament light chain (NfL) as biomarkers of cognition in PD. Baseline concentrations of plasma p-tau181 and NfL were measured in a cohort of 136 patients with PD and 63 healthy controls (HC). Forty-seven PD patients were followed up for up to 2 years. Cross-sectional and longitudinal associations between baseline plasma biomarkers and cognitive progression were investigated using linear regression and linear mixed effects models. At baseline, plasma p-tau181 concentration was significantly higher in PD subjects compared with HC (p = 0.026). In PD patients, higher plasma NfL was associated with lower MMSE score at baseline, after adjusting for age, sex and education (p = 0.027). Baseline plasma NfL also predicted MMSE decline over time in the PD group (p = 0.020). No significant association between plasma p-tau181 concentration and baseline or longitudinal cognitive performance was found. While the role of p-tau181 as a diagnostic biomarker for PD and its relationship with cognition need further elucidation, plasma NfL may serve as a feasible, non-invasive biomarker of cognitive progression in PD.
Language	English
Publishing date	2022-11-12
Publishing country	United States
Document type	Journal Article
ZDB-ID	2819218-7
ISSN	2373-8057
ISSN	2373-8057
DOI	10.1038/s41531-022-00384-x
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Article ; Online: Beam Energy Dependence of Triton Production and Yield Ratio (N_{t}×N_{p}/N_{d}^{2}) in Au+Au Collisions at RHIC.

Abdulhamid, M I / Aboona, B E / Adam, J / Adams, J R / Agakishiev, G / Aggarwal, I / Aggarwal, M M / Ahammed, Z / Aitbaev, A / Alekseev, I / Anderson, D M / Aparin, A / Aslam, S / Atchison, J / Averichev, G S / Bairathi, V / Baker, W / Ball Cap, J G / Barish, K /

Bhagat, P / Bhasin, A / Bhatta, S / Bordyuzhin, I G / Brandenburg, J D / Brandin, A V / Cai, X Z / Caines, H / Calderón de la Barca Sánchez, M / Cebra, D / Ceska, J / Chakaberia, I / Chan, B K / Chang, Z / Chatterjee, A / Chen, D / Chen, J / Chen, J H / Chen, Z / Cheng, J / Cheng, Y / Choudhury, S / Christie, W / Chu, X / Crawford, H J / Dale-Gau, G / Das, A / Daugherity, M / Dedovich, T G / Deppner, I M / Derevschikov, A A / Dhamija, A / Di Carlo, L / Didenko, L / Dixit, P / Dong, X / Drachenberg, J L / Duckworth, E / Dunlop, J C / Engelage, J / Eppley, G / Esumi, S / Evdokimov, O / Ewigleben, A / Eyser, O / Fatemi, R / Fazio, S / Feng, C J / Feng, Y / Finch, E / Fisyak, Y / Flor, F A / Fu, C / Geurts, F / Ghimire, N / Gibson, A / Gopal, K / Gou, X / Grosnick, D / Gupta, A / Hamed, A / Han, Y / Harasty, M D / Harris, J W / Harrison-Smith, H / He, W / He, X H / He, Y / Hu, C / Hu, Q / Hu, Y / Huang, H / Huang, H Z / Huang, S L / Huang, T / Huang, X / Huang, Y / Humanic, T J / Isenhower, D / Isshiki, M / Jacobs, W W / Jalotra, A / Jena, C / Ji, Y / Jia, J / Jin, C / Ju, X / Judd, E G / Kabana, S / Kabir, M L / Kalinkin, D / Kang, K / Kapukchyan, D / Kauder, K / Ke, H W / Keane, D / Kechechyan, A / Kelsey, M / Kimelman, B / Kiselev, A / Knospe, A G / Ko, H S / Kochenda, L / Korobitsin, A A / Kravtsov, P / Kumar, L / Kumar, S / Kunnawalkam Elayavalli, R / Lacey, R / Landgraf, J M / Lebedev, A / Lednicky, R / Lee, J H / Leung, Y H / Lewis, N / Li, C / Li, W / Li, X / Li, Y / Li, Z / Liang, X / Liang, Y / Lin, T / Liu, C / Liu, F / Liu, H / Liu, L / Liu, T / Liu, X / Liu, Y / Liu, Z / Ljubicic, T / Llope, W J / Lomicky, O / Longacre, R S / Loyd, E M / Lu, T / Lukow, N S / Luo, X F / Luong, V B / Ma, L / Ma, R / Ma, Y G / Magdy, N / Mallick, D / Margetis, S / Matis, H S / Mazer, J A / McNamara, G / Mi, K / Minaev, N G / Mohanty, B / Mondal, M M / Mooney, I / Morozov, D A / Mudrokh, A / Nagy, M I / Nain, A S / Nam, J D / Nasim, Md / Neff, D / Nelson, J M / Nemes, D B / Nie, M / Nigmatkulov, G / Niida, T / Nishitani, R / Nogach, L V / Nonaka, T / Odyniec, G / Ogawa, A / Oh, S / Okorokov, V A / Okubo, K / Page, B S / Pak, R / Pan, J / Pandav, A / Pandey, A K / Panebratsev, Y / Pani, T / Parfenov, P / Paul, A / Perkins, C / Pokhrel, B R / Posik, M / Protzman, T / Pruthi, N K / Putschke, J / Qin, Z / Qiu, H / Quintero, A / Racz, C / Radhakrishnan, S K / Raha, N / Ray, R L / Ritter, H G / Robertson, C W / Rogachevsky, O V / Rosales Aguilar, M A / Roy, D / Ruan, L / Sahoo, A K / Sahoo, N R / Sako, H / Salur, S / Samigullin, E / Sato, S / Schmidke, W B / Schmitz, N / Seger, J / Seto, R / Seyboth, P / Shah, N / Shahaliev, E / Shanmuganathan, P V / Shao, T / Sharma, M / Sharma, N / Sharma, R / Sharma, S R / Sheikh, A I / Shen, D Y / Shen, K / Shi, S S / Shi, Y / Shou, Q Y / Si, F / Singh, J / Singha, S / Sinha, P / Skoby, M J / Söhngen, Y / Song, Y / Srivastava, B / Stanislaus, T D S / Stewart, D J / Strikhanov, M / Stringfellow, B / Su, Y / Sun, C / Sun, X / Sun, Y / Surrow, B / Svirida, D N / Sweger, Z W / Tamis, A / Tang, A H / Tang, Z / Taranenko, A / Tarnowsky, T / Thomas, J H / Tlusty, D / Todoroki, T / Tokarev, M V / Tomkiel, C A / Trentalange, S / Tribble, R E / Tribedy, P / Tsai, O D / Tsang, C Y / Tu, Z / Ullrich, T / Underwood, D G / Upsal, I / Van Buren, G / Vasiliev, A N / Verkest, V / Videbæk, F / Vokal, S / Voloshin, S A / Wang, F / Wang, G / Wang, J S / Wang, X / Wang, Y / Wang, Z / Webb, J C / Weidenkaff, P C / Westfall, G D / Wieman, H / Wilks, G / Wissink, S W / Wu, J / Wu, X / Wu, Y / Xi, B / Xiao, Z G / Xie, G / Xie, W / Xu, H / Xu, N / Xu, Q H / Xu, Y / Xu, Z / Yan, G / Yan, Z / Yang, C / Yang, Q / Yang, S / Yang, Y / Ye, Z / Yi, L / Yip, K / Yu, N / Yu, Y / Zha, W / Zhang, C / Zhang, D / Zhang, J / Zhang, S / Zhang, X / Zhang, Y / Zhang, Z J / Zhang, Z / Zhao, F / Zhao, J / Zhao, M / Zhou, C / Zhou, J / Zhou, S / Zhou, Y / Zhu, X / Zurek, M / Zyzak, M

Physical review letters

2023 Volume 130, Issue 20, Page(s) 202301

Abstract: ... at the Relativistic Heavy Ion Collider. The nuclear compound yield ratio (N_{t}×N_{p}/N_{d}^{2}), which is predicted ... without critical fluctuation, and decreases with a smaller p_{T} acceptance. The physics implications ...

Abstract	We report the triton (t) production in midrapidity (\|y\|<0.5) Au+Au collisions at sqrt[s_{NN}]=7.7-200 GeV measured by the STAR experiment from the first phase of the beam energy scan at the Relativistic Heavy Ion Collider. The nuclear compound yield ratio (N_{t}×N_{p}/N_{d}^{2}), which is predicted to be sensitive to the fluctuation of local neutron density, is observed to decrease monotonically with increasing charged-particle multiplicity (dN_{ch}/dη) and follows a scaling behavior. The dN_{ch}/dη dependence of the yield ratio is compared to calculations from coalescence and thermal models. Enhancements in the yield ratios relative to the coalescence baseline are observed in the 0%-10% most central collisions at 19.6 and 27 GeV, with a significance of 2.3σ and 3.4σ, respectively, giving a combined significance of 4.1σ. The enhancements are not observed in peripheral collisions or model calculations without critical fluctuation, and decreases with a smaller p_{T} acceptance. The physics implications of these results on the QCD phase structure and the production mechanism of light nuclei in heavy-ion collisions are discussed.
Language	English
Publishing date	2023-06-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	208853-8
ISSN	1079-7114 ; 0031-9007
ISSN (online)	1079-7114
ISSN	0031-9007
DOI	10.1103/PhysRevLett.130.202301
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Article ; Online: Autophagy Underlies the Proteostasis Mechanisms of Artemisinin Resistance in P. falciparum Malaria.

Ray, Ananya / Mathur, Miti / Choubey, Deepak / Karmodiya, Krishanpal / Surolia, Namita

mBio

2022 Volume 13, Issue 3, Page(s) e0063022

Abstract: Emerging resistance to artemisinin (ART) has become a challenge for reducing worldwide malaria mortality and morbidity. The C580Y mutation in Plasmodium falciparum Kelch13 has been identified as the major determinant for ART resistance in the background ... ...

Abstract	Emerging resistance to artemisinin (ART) has become a challenge for reducing worldwide malaria mortality and morbidity. The C580Y mutation in Plasmodium falciparum Kelch13 has been identified as the major determinant for ART resistance in the background of other mutations, which include the T38I mutation in autophagy-related protein
MeSH term(s)	Antimalarials/pharmacology ; Artemisinins/pharmacology ; Artemisinins/therapeutic use ; Autophagy ; Drug Resistance/genetics ; Hemoglobins/genetics ; Humans ; Malaria ; Malaria, Falciparum/parasitology ; Mutation ; Plasmodium falciparum/metabolism ; Proteostasis ; Protozoan Proteins/genetics ; Protozoan Proteins/metabolism
Chemical Substances	Antimalarials ; Artemisinins ; Hemoglobins ; Protozoan Proteins
Language	English
Publishing date	2022-04-14
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2557172-2
ISSN	2150-7511 ; 2161-2129
ISSN (online)	2150-7511
ISSN	2161-2129
DOI	10.1128/mbio.00630-22
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Article ; Online: The Chlamydia trachomatis p-aminobenzoate synthase CADD is a manganese-dependent oxygenase that uses its own amino acid residues as substrates.

Wooldridge, Rowan / Stone, Spenser / Pedraza, Andrew / Ray, W Keith / Helm, Richard F / Allen, Kylie D

FEBS letters

2023 Volume 597, Issue 4, Page(s) 557–572

Abstract: CADD (chlamydia protein associating with death domains) is a p-aminobenzoate (pAB) synthase ...

Abstract	CADD (chlamydia protein associating with death domains) is a p-aminobenzoate (pAB) synthase involved in a noncanonical route for tetrahydrofolate biosynthesis in Chlamydia trachomatis. Although previously implicated to employ a diiron cofactor, here, we show that pAB synthesis by CADD requires manganese and the physiological cofactor is most likely a heterodinuclear Mn/Fe cluster. Isotope-labeling experiments revealed that the two oxygen atoms in the carboxylic acid portion of pAB are derived from molecular oxygen. Further, mass spectrometry-based proteomic analyses of CADD-derived peptides demonstrated a glycine substitution at Tyr27, providing strong evidence that this residue is sacrificed for pAB synthesis. Additionally, Lys152 was deaminated and oxidized to aminoadipic acid, supporting its proposed role as a sacrificial amino group donor.
MeSH term(s)	Chlamydia trachomatis/genetics ; Oxygenases ; Iron/metabolism ; Manganese/metabolism ; Amino Acids ; Proteomics ; Ribonucleotide Reductases/chemistry ; Ribonucleotide Reductases/metabolism ; Oxygen/metabolism
Chemical Substances	Oxygenases (EC 1.13.-) ; Iron (E1UOL152H7) ; Manganese (42Z2K6ZL8P) ; Amino Acids ; PABA synthase (EC 2.6.1.-) ; Ribonucleotide Reductases (EC 1.17.4.-) ; Oxygen (S88TT14065)
Language	English
Publishing date	2023-01-20
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	212746-5
ISSN	1873-3468 ; 0014-5793
ISSN (online)	1873-3468
ISSN	0014-5793
DOI	10.1002/1873-3468.14573
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Article ; Online: Tid1-S attenuates LPS-induced cardiac hypertrophy and apoptosis through ER-a mediated modulation of p-PI3K/p-Akt signaling cascade.

Chao, Chun-Nun / Lo, Jeng-Fan / Khan, Farheen B / Day, Cecilia H / Lai, Chao-Hung / Chen, Chia-Hua / Chen, Ray-Jade / Viswanadha, Vijaya P / Kuo, Chia-Hua / Huang, Chih-Yang

Journal of cellular biochemistry

2019 Volume 120, Issue 10, Page(s) 16703–16710

Abstract: ... activated survival proteins p-PI3K and p ...

Abstract	Myocardial dysfunction is clinically relevant? repercussion that follows sepsis. Tid 1 protein has been implicated in many biological process. However, the role of Tid 1 in lipopolysaccharide (LPS)-induced cardiomyocyte hypertrophy and apoptosis remains elusive. In the current research endeavor, we have elucidated the role of Tid1-S on LPS-induced cardiac hypertrophy and apoptosis. Interestingly, we found that overexpression of Tid1-S suppressed TLR-4, NFATc3, and BNP protein expression which eventually led to inhibition of LPS-induced cardiac hypertrophy. Moreover, Tid1-S overexpression attenuated cellular apoptosis and activated survival proteins p-PI3K and p
MeSH term(s)	Adult ; Aged ; Aged, 80 and over ; Animals ; Apoptosis/drug effects ; Cardiomegaly/chemically induced ; Cardiomegaly/metabolism ; Cardiomegaly/pathology ; Estrogen Receptor alpha/metabolism ; Female ; Gene Expression Regulation/drug effects ; HSP40 Heat-Shock Proteins/metabolism ; Humans ; Lipopolysaccharides/toxicity ; Male ; Middle Aged ; Myocytes, Cardiac/metabolism ; Myocytes, Cardiac/pathology ; Phosphatidylinositol 3-Kinases/metabolism ; Proto-Oncogene Proteins c-akt/metabolism ; Rats ; Signal Transduction/drug effects
Chemical Substances	DNAJA3 protein, human ; ESR1 protein, human ; Estrogen Receptor alpha ; HSP40 Heat-Shock Proteins ; Lipopolysaccharides ; Proto-Oncogene Proteins c-akt (EC 2.7.11.1)
Language	English
Publishing date	2019-05-13
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	392402-6
ISSN	1097-4644 ; 0730-2312
ISSN (online)	1097-4644
ISSN	0730-2312
DOI	10.1002/jcb.28928
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Article ; Online: p-Synephrine, ephedrine, p-octopamine and m-synephrine: Comparative mechanistic, physiological and pharmacological properties.

Stohs, Sidney J / Shara, Mohd / Ray, Sidhartha D

Phytotherapy research : PTR

2020 Volume 34, Issue 8, Page(s) 1838–1846

Abstract: ... other adverse health effects of p-synephrine and p-octopamine relative to ephedrine and m-synephrine (phenylephrine) which are ... similarities. However, the structural and stereochemical differences of p-synephrine and p-octopamine ... characteristics as well as other mechanistic differences which are reviewed. p-Synephrine and p-octopamine exhibit ...

Abstract	Confusion and misunderstanding exist regarding the lack of cardiovascular and other adverse health effects of p-synephrine and p-octopamine relative to ephedrine and m-synephrine (phenylephrine) which are known for their effects on the cardiovascular system. These four molecules have some structural similarities. However, the structural and stereochemical differences of p-synephrine and p-octopamine as related to ephedrine and m-synephrine result in markedly different adrenergic receptor binding characteristics as well as other mechanistic differences which are reviewed. p-Synephrine and p-octopamine exhibit little binding to α-1, α-2, β-1 and β-2 adrenergic receptors, nor are they known to exhibit indirect actions leading to an increase in available levels of endogenous norepinephrine and epinephrine at commonly used doses. The relative absence of these mechanistic actions provides an explanation for their lack of production of cardiovascular effects at commonly used oral doses as compared to ephedrine and m-synephrine. As a consequence, the effects of ephedrine and m-synephrine cannot be directly extrapolated to p-synephrine and p-octopamine which exhibit significantly different pharmacokinetic, and physiological/pharmacological properties. These conclusions are supported by human, animal and in vitro studies that are discussed.
MeSH term(s)	Animals ; Ephedrine/pharmacology ; Ephedrine/therapeutic use ; Humans ; Octopamine/pharmacology ; Octopamine/therapeutic use ; Rats ; Synephrine/pharmacology ; Synephrine/therapeutic use
Chemical Substances	Octopamine (14O50WS8JD) ; Ephedrine (GN83C131XS) ; Synephrine (PEG5DP7434)
Language	English
Publishing date	2020-02-26
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	639136-9
ISSN	1099-1573 ; 0951-418X
ISSN (online)	1099-1573
ISSN	0951-418X
DOI	10.1002/ptr.6649
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Article ; Online: Temporal progression of P wave abnormality in a patient with classical or atriopulmonary Fontan.

Kohli, Utkarsh / Chaudhuri, Nita Ray / Sriram, Chenni S / Rhodes, Larry

Journal of electrocardiology

2021 Volume 68, Page(s) 109–113

Abstract: ... P wave deflection and terminal negative P deflection in all leads with progressive increase in P ...

Abstract	We present the electrocardiographic findings in a 36-year-old female with tricuspid atresia with double-outlet right ventricle and malposition of great arteries who underwent classical or "atriopulmonary" Fontan procedure in childhood. Her electrocardiograms have consistently shown marked intra-atrial delay with an initial positive P wave deflection and terminal negative P deflection in all leads with progressive increase in P wave duration with time. She has had frequent episodes of intra-atrial tachycardia, atrial fibrillation and sinus and post ectopic pauses over the past few years. The findings in our patient, which have not been reported before, illustrate the atrial pathology, which is unique to Fontan physiology, particularly those with classical or atriopulmonary Fontan. We hope that the specific electrocardiographic findings presented will allow for their recognition.
MeSH term(s)	Adult ; Arrhythmias, Cardiac ; Electrocardiography ; Female ; Fontan Procedure ; Heart Atria/surgery ; Humans ; Tricuspid Atresia/surgery
Language	English
Publishing date	2021-08-13
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	410286-1
ISSN	1532-8430 ; 0022-0736
ISSN (online)	1532-8430
ISSN	0022-0736
DOI	10.1016/j.jelectrocard.2021.08.008
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