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  1. Article ; Online: The emerging importance of cross-ploidy hybridisation and introgression.

    Brown, Max R / Abbott, Richard J / Twyford, Alex D

    Molecular ecology

    2024  Volume 33, Issue 8, Page(s) e17315

    Abstract: Natural hybridisation is now recognised as pervasive in its occurrence across the Tree of Life. Resurgent interest in natural hybridisation fuelled by developments in genomics has led to an improved understanding of the genetic factors that promote or ... ...

    Abstract Natural hybridisation is now recognised as pervasive in its occurrence across the Tree of Life. Resurgent interest in natural hybridisation fuelled by developments in genomics has led to an improved understanding of the genetic factors that promote or prevent species cross-mating. Despite this body of work overturning many widely held assumptions about the genetic barriers to hybridisation, it is still widely thought that ploidy differences between species will be an absolute barrier to hybridisation and introgression. Here, we revisit this assumption, reviewing findings from surveys of polyploidy and hybridisation in the wild. In a case study in the British flora, 203 hybrids representing 35% of hybrids with suitable data have formed via cross-ploidy matings, while a wider literature search revealed 59 studies (56 in plants and 3 in animals) in which cross-ploidy hybridisation has been confirmed with genetic data. These results show cross-ploidy hybridisation is readily overlooked, and potentially common in some groups. General findings from these studies include strong directionality of hybridisation, with introgression usually towards the higher ploidy parent, and cross-ploidy hybridisation being more likely to involve allopolyploids than autopolyploids. Evidence for adaptive introgression across a ploidy barrier and cases of cross-ploidy hybrid speciation shows the potential for important evolutionary outcomes.
    MeSH term(s) Animals ; Hybridization, Genetic ; Biological Evolution ; Polyploidy ; Plants
    Language English
    Publishing date 2024-03-19
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1126687-9
    ISSN 1365-294X ; 0962-1083
    ISSN (online) 1365-294X
    ISSN 0962-1083
    DOI 10.1111/mec.17315
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Bonn / Germany

    Z 2005/723: Show issues

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  2. Article ; Conference proceedings: Utilization of Adipose-Derived Stem Cells in Cranial Nerve Regeneration: A Systematic Review

    Brown, Nolan J. / Aguirre, Alex / Chee, Keanu / Himstead, Alex / Kortz, Mike

    Journal of Neurological Surgery Part B: Skull Base

    2024  Volume 85, Issue S 01

    Event/congress 33rd Annual Meeting North American Skull Base Society, Atlanta Marriott Marquis Atlanta, Georgia, United States, 2024-02-16
    Language English
    Publishing date 2024-02-01
    Publisher Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article ; Conference proceedings
    ZDB-ID 2654269-9
    ISSN 2193-634X ; 2193-6331
    ISSN (online) 2193-634X
    ISSN 2193-6331
    DOI 10.1055/s-0044-1780040
    Database Thieme publisher's database

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3425: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  3. Article ; Online: Intermolecular Interactions of Pyrene and Its Oxides in Toluene Solution.

    King, Nathanael J / Brown, Alex

    The journal of physical chemistry. A

    2022  Volume 126, Issue 30, Page(s) 4931–4940

    Abstract: In this work, the conformer-rotamer ensemble sampling tool (CREST), with the underlying semiempirical GFN2-xtb method, was used for automated geometry exploration of the homodimers of pyrene, pyrene-4,5-dione, and pyrene-4,5,9,10-tetraone, along with the ...

    Abstract In this work, the conformer-rotamer ensemble sampling tool (CREST), with the underlying semiempirical GFN2-xtb method, was used for automated geometry exploration of the homodimers of pyrene, pyrene-4,5-dione, and pyrene-4,5,9,10-tetraone, along with the heterodimer of pyrene and pyrene-4,5,9,10-tetraone. Geometries and energies of the dimers were further refined at the ωB97X-D4/def2-TZVP level of theory, both in the gas phase and in toluene solution. Computations in solution were handled using the CPCM (conductor-like polarizible continuum model) and SMD (solvation model based on density) models. Two previously unidentified pyrene-homodimer conformations were identified, and the effects of oxidation on the geometries and energies of dimerization were explored; in general, oxidation leads to stronger intermolecular interactions and decreased solubility in toluene. For selected dimers, DLPNO-CCSD(T)/cc-pVTZ/SMD(Toluene) energies were determined at the DFT geometries and illustrated the accuracy of the ωB97X-D4 approach, with an MAD of 1.47 kJ/mol.
    MeSH term(s) Dimerization ; Oxides ; Pyrenes ; Quantum Theory ; Toluene
    Chemical Substances Oxides ; Pyrenes ; Toluene (3FPU23BG52)
    Language English
    Publishing date 2022-07-26
    Publishing country United States
    Document type Journal Article
    ISSN 1520-5215
    ISSN (online) 1520-5215
    DOI 10.1021/acs.jpca.2c02666
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Colour and melanopsin mediated responses in the murine retina.

    Mouland, Joshua W / Watson, Alex J / Martial, Franck P / Lucas, Robert J / Brown, Timothy M

    Frontiers in cellular neuroscience

    2023  Volume 17, Page(s) 1114634

    Abstract: Introduction: ...

    Abstract Introduction:
    Language English
    Publishing date 2023-03-13
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2452963-1
    ISSN 1662-5102
    ISSN 1662-5102
    DOI 10.3389/fncel.2023.1114634
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  5. Article ; Online: tiny-count: a counting tool for hierarchical classification and quantification of small RNA-seq reads with single-nucleotide precision.

    Tate, Alex J / Brown, Kristen C / Montgomery, Taiowa A

    Bioinformatics advances

    2023  Volume 3, Issue 1, Page(s) vbad065

    Abstract: Summary: tiny-count is a highly flexible counting tool that allows for hierarchical classification and quantification of small RNA reads from high-throughput sequencing data. Selection rules can be used to filter reads by 5' nucleotide, length, position ...

    Abstract Summary: tiny-count is a highly flexible counting tool that allows for hierarchical classification and quantification of small RNA reads from high-throughput sequencing data. Selection rules can be used to filter reads by 5' nucleotide, length, position of alignments in relation to reference features, and by the number of mismatches to reference sequences. tiny-count can quantify reads aligned to a genome or directly to small RNA or transcript sequences. With tiny-count, users can quantify a single class of small RNAs or multiple classes in parallel. tiny-count can resolve distinct classes of small RNAs, for example, piRNAs and siRNAs, produced from the same locus. It can distinguish small RNA variants, such as miRNAs and isomiRs, with single-nucleotide precision. tRNA, rRNA, and other RNA fragments can also be quantified. tiny-count can be run alone or as part of tinyRNA, a workflow that provides a basic all-in-one command line-based solution for small RNA-seq data analysis, with documentation and statistics generated at each step for accurate and reproducible results.
    Availability and implementation: tiny-count and other tinyRNA tools are implemented in Python, C++, Cython, and R, and the workflow is coordinated with CWL. tiny-count and tinyRNA are free and open-source software distributed under the GPLv3 license. tiny-count can be installed via Bioconda (https://anaconda.org/bioconda/tiny-count) and both tiny-count and tinyRNA documentation and software downloads are available at https://github.com/MontgomeryLab/tinyRNA. Reference data, including genome and feature information, for certain species can be found at https://www.MontgomeryLab.org.
    Language English
    Publishing date 2023-05-18
    Publishing country England
    Document type Journal Article
    ISSN 2635-0041
    ISSN (online) 2635-0041
    DOI 10.1093/bioadv/vbad065
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Fishing for Trouble: A Novel Surgical Technique for Penetrating Fishhook Injuries of the Eyelid.

    Brown, Nathan J / Legocki, Alex T / Tam, Emily K / Baran, Francine M

    Cureus

    2023  Volume 15, Issue 3, Page(s) e36478

    Abstract: Fishhook injuries commonly occur and may present as ophthalmic surgical emergencies. Choosing the appropriate removal technique is critical and depends on the involved extra- and intra-ocular structures and hook characteristics. We describe the case of a ...

    Abstract Fishhook injuries commonly occur and may present as ophthalmic surgical emergencies. Choosing the appropriate removal technique is critical and depends on the involved extra- and intra-ocular structures and hook characteristics. We describe the case of a challenging fishhook removal where a novel surgical technique was developed. An eight-year-old boy presented with a full-thickness fishhook injury to the eyelid. During removal surgery, the thickness and density of the fishhook prevented surgical tools from transecting the shank. A novel approach was deemed necessary for safe removal, termed the clamp and retract technique. To our knowledge, this is its first documented use in the literature.
    Language English
    Publishing date 2023-03-21
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.36478
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  7. Article ; Online: Competing Magnetic Interactions and the Role of Unpaired 4

    Brown, Alex J / Avdeev, Maxim / Manjón-Sanz, Alicia / Brand, Helen E A / Ling, Chris D

    Inorganic chemistry

    2023  Volume 62, Issue 17, Page(s) 6786–6793

    Abstract: Oxygen-deficient perovskite compounds with the general formula ... ...

    Abstract Oxygen-deficient perovskite compounds with the general formula Ba
    Language English
    Publishing date 2023-04-20
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1484438-2
    ISSN 1520-510X ; 0020-1669
    ISSN (online) 1520-510X
    ISSN 0020-1669
    DOI 10.1021/acs.inorgchem.3c00524
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  8. Article ; Online: Krein support vector machine classification of antimicrobial peptides.

    Redshaw, Joseph / Ting, Darren S J / Brown, Alex / Hirst, Jonathan D / Gärtner, Thomas

    Digital discovery

    2023  Volume 2, Issue 2, Page(s) 502–511

    Abstract: Antimicrobial peptides (AMPs) represent a potential solution to the growing problem of antimicrobial resistance, yet their identification through wet-lab experiments is a costly and time-consuming process. Accurate computational predictions would allow ... ...

    Abstract Antimicrobial peptides (AMPs) represent a potential solution to the growing problem of antimicrobial resistance, yet their identification through wet-lab experiments is a costly and time-consuming process. Accurate computational predictions would allow rapid
    Language English
    Publishing date 2023-02-27
    Publishing country England
    Document type Journal Article
    ISSN 2635-098X
    ISSN (online) 2635-098X
    DOI 10.1039/d3dd00004d
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Multispectral multibeam backscatter response of heterogeneous rhodolith beds.

    Menandro, Pedro S / Misiuk, Benjamin / Brown, Craig J / Bastos, Alex C

    Scientific reports

    2023  Volume 13, Issue 1, Page(s) 20220

    Abstract: Acoustic backscatter has been used as a tool to map the seafloor in greater detail and plays an increasingly important role in seafloor mapping to meet multiple ocean management needs. An outstanding challenge to the use of backscatter for seafloor ... ...

    Abstract Acoustic backscatter has been used as a tool to map the seafloor in greater detail and plays an increasingly important role in seafloor mapping to meet multiple ocean management needs. An outstanding challenge to the use of backscatter for seafloor mapping is the distinction between acoustically similar substrates, such as mixed sediments from rhodoliths. Rhodolith beds are a biogenic substrate that provides important ecological services, and are typically classified as a single categorical substrate type-though nodules coverage may be spatially variable. Recently, multispectral acoustic backscatter has demonstrated great potential to improve thematic seafloor mapping compared to single-frequency systems. This work employs multispectral multibeam backscatter and underwater imagery to characterize and map rhodolith beds in the Costa das Algas Marine Protected Area (Brazil). A support vector machine classifier was used to classify multifrequency backscatter mosaics according to rhodolith classes identified from underwater imagery. Results suggest that multispectral backscatter is effective both in providing information for mapping different proportions of rhodolith coverage and in predicting the presence or absence of these nodules. The backscatter of the lowest frequency was the most useful for distinguishing variable proportions of rhodolith coverage, and the two higher frequencies were better predictors of presence and absence.
    Language English
    Publishing date 2023-11-18
    Publishing country England
    Document type Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-023-46240-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: A fast ceramic mixed OH

    Zou, Peimiao / Iuga, Dinu / Ling, Sanliang / Brown, Alex J / Chen, Shigang / Zhang, Mengfei / Han, Yisong / Fortes, A Dominic / Howard, Christopher M / Tao, Shanwen

    Nature communications

    2024  Volume 15, Issue 1, Page(s) 909

    Abstract: Low temperature ionic conducting materials such as ... ...

    Abstract Low temperature ionic conducting materials such as OH
    Language English
    Publishing date 2024-01-30
    Publishing country England
    Document type Journal Article
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-024-45060-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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