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  1. Article ; Online: Metabolic regulation of the host-fungus interaction: from biological principles to therapeutic opportunities.

    Silva-Gomes, Rita / Caldeira, Inês / Fernandes, Raquel / Cunha, Cristina / Carvalho, Agostinho

    Journal of leukocyte biology

    2024  

    Abstract: Fungal infections present a significant global public health concern, impacting over one billion individuals worldwide and resulting in more than 3 million deaths annually. Despite considerable progress in recent years, the management of fungal ... ...

    Abstract Fungal infections present a significant global public health concern, impacting over one billion individuals worldwide and resulting in more than 3 million deaths annually. Despite considerable progress in recent years, the management of fungal infections remains challenging. The limited development of novel diagnostic and therapeutic approaches is largely attributed to our incomplete understanding of the pathogenetic mechanisms involved in these diseases. Recent research has highlighted the pivotal role of cellular metabolism in regulating the interaction between fungi and their hosts. In response to fungal infection, immune cells undergo complex metabolic adjustments to meet the energy demands necessary for an effective immune response. A comprehensive understanding of the metabolic circuits governing antifungal immunity, combined with the integration of individual host traits, holds the potential to inform novel medical interventions for fungal infections. This review explores recent insights into the immunometabolic regulation of host-fungal interactions and the infection outcome and discusses how the metabolic repurposing of immune cell function could be exploited in innovative and personalized therapeutic approaches.
    Language English
    Publishing date 2024-03-18
    Publishing country England
    Document type Journal Article
    ZDB-ID 605722-6
    ISSN 1938-3673 ; 0741-5400
    ISSN (online) 1938-3673
    ISSN 0741-5400
    DOI 10.1093/jleuko/qiae045
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 603: Show issues Location:
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  2. Article ; Online: Regulation of inflammation and protection against invasive pneumococcal infection by the long pentraxin PTX3.

    Porte, Rémi / Silva-Gomes, Rita / Theroude, Charlotte / Parente, Raffaella / Asgari, Fatemeh / Sironi, Marina / Pasqualini, Fabio / Valentino, Sonia / Asselta, Rosanna / Recordati, Camilla / Monari, Marta Noemi / Doni, Andrea / Inforzato, Antonio / Rodriguez-Gallego, Carlos / Obando, Ignacio / Colino, Elena / Bottazzi, Barbara / Mantovani, Alberto

    eLife

    2023  Volume 12

    Abstract: Streptococcus ... ...

    Abstract Streptococcus pneumoniae
    MeSH term(s) Animals ; Mice ; Inflammation/metabolism ; Neutrophils/metabolism ; Phagocytosis ; Pneumococcal Infections/genetics ; Pneumococcal Infections/metabolism ; Streptococcus pneumoniae
    Chemical Substances neuronal pentraxin
    Language English
    Publishing date 2023-05-24
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2687154-3
    ISSN 2050-084X ; 2050-084X
    ISSN (online) 2050-084X
    ISSN 2050-084X
    DOI 10.7554/eLife.78601
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  3. Article: An Incidental Myxoma Hidden in Chest Pain.

    Gomes Cochicho, Joana / Silva, José Miguel / Louro, Rita / Lavadinho, Isabel

    Cureus

    2023  Volume 15, Issue 9, Page(s) e45340

    Abstract: Chest pain is a very common symptom in an emergency context. Its differential diagnosis is extensive and includes some conditions that require immediate recognition and intervention. It can also be a symptom associated with rarer diagnostic possibilities. ...

    Abstract Chest pain is a very common symptom in an emergency context. Its differential diagnosis is extensive and includes some conditions that require immediate recognition and intervention. It can also be a symptom associated with rarer diagnostic possibilities. Here, we report the case of a 53-year-old woman admitted to the emergency department due to chest pain and initially diagnosed with non-ST elevation acute myocardial infarction. A transthoracic echocardiogram revealed a large hyperechogenic round mass, suggestive of a left atrial cardiac myxoma. Coronary angiography showed no significant lesions. The patient underwent cardiac surgery with excision of the mass, whose histological diagnosis was atrial myxoma. The immediate postoperative period was uneventful, and the patient was discharged asymptomatic and without echocardiographic changes. Cardiac tumors are a rare finding, of which myxomas are the most common. Symptoms can typically result from embolism, obstruction, or constitutional symptoms. A myxoma presenting as acute chest pain and mimicking an acute coronary syndrome is an uncommon finding. This case reminds us of an extremely rare differential diagnosis of chest pain and awakens us to the usefulness and importance of using echocardiography as a diagnostic tool.
    Language English
    Publishing date 2023-09-16
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.45340
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  4. Article ; Online: Diuretic-resistant heart failure and the role of ultrafiltration: A proposed protocol.

    Gomes da Silva, Francisca / Calça, Rita / Rita Martins, Ana / Araújo, Inês / Aguiar, Carlos / Fonseca, Cândida / Branco, Patrícia

    Revista portuguesa de cardiologia : orgao oficial da Sociedade Portuguesa de Cardiologia = Portuguese journal of cardiology : an official journal of the Portuguese Society of Cardiology

    2023  Volume 42, Issue 9, Page(s) 797–803

    Abstract: Acute heart failure (HF) decompensation generally manifests with signs and symptoms of congestion that strongly predict poor poor patient outcome. Loop diuretics are the cornerstone of therapy to counteract fluid overload and are widely used for acute ... ...

    Abstract Acute heart failure (HF) decompensation generally manifests with signs and symptoms of congestion that strongly predict poor poor patient outcome. Loop diuretics are the cornerstone of therapy to counteract fluid overload and are widely used for acute management and chronic stabilization of HF. However, a diminished response to loop diuretics is a common problem, affecting the patient's clinical course and potentially prolonging hospitalization. Diuretic resistance is defined as failure to decongest despite appropriate and escalating loop diuretic therapy. We propose a protocol for the management of diuretic resistance. The initial approach should include an assessment of causes of pseudo-diuretic resistance. Adjustments to loop diuretic therapy, such as increasing doses and frequency of administration and sequential nephron blockade, may be successful. For hospitalized patients with progressive disease there are more invasive methods for fluid removal. Switching from oral to intravenous loop diuretics is essential to avoid variable absorption and for symptomatic relief. Extracorporeal ultrafiltration is also an option since this technique is highly effective at removing plasma fluid from blood. While extracorporeal ultrafiltration is an invasive solution, peritoneal dialysis is a home-based, intermittent therapeutic option that can enable efficient management of fluid overload, preventing HF-related hospital admission, and improving quality of life. As a last resort for fluid removal, a peritoneal dialysis regimen should fully exploit its decongestive properties and should be tailored to the patient's characteristics and clinical needs.
    MeSH term(s) Humans ; Diuretics/therapeutic use ; Sodium Potassium Chloride Symporter Inhibitors/therapeutic use ; Ultrafiltration/methods ; Quality of Life ; Heart Failure/drug therapy
    Chemical Substances Diuretics ; Sodium Potassium Chloride Symporter Inhibitors
    Language Portuguese
    Publishing date 2023-03-21
    Publishing country Portugal
    Document type Journal Article ; Review
    ZDB-ID 632718-7
    ISSN 2174-2030 ; 0870-2551 ; 0304-4750
    ISSN (online) 2174-2030
    ISSN 0870-2551 ; 0304-4750
    DOI 10.1016/j.repc.2022.05.012
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    In stock of ZB MED Cologne/Königswinter

    Zs.B 2865: Show issues Location:
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  5. Article ; Online: Vasospasmo Mamilar: Uma Causa Tratável de Mastalgia na Amamentação.

    Dias da Mota, Vanessa / D'Oliveira, Andreia / Marques Gomes, Luísa / Alberto Silva, Manuel / Oliveira, Ana Rita

    Acta medica portuguesa

    2024  Volume 37, Issue 4, Page(s) 303–304

    Title translation Nipple Vasospasm: A Treatable Cause of Lactational Mastalgia.
    MeSH term(s) Female ; Humans ; Mastodynia ; Nipples ; Breast Feeding ; Vascular Diseases
    Language Portuguese
    Publishing date 2024-04-01
    Publishing country Portugal
    Document type Letter
    ZDB-ID 603078-6
    ISSN 1646-0758 ; 0870-399X
    ISSN (online) 1646-0758
    ISSN 0870-399X
    DOI 10.20344/amp.20810
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    In stock of ZB MED Cologne/Königswinter

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  6. Article ; Online: Chilaiditi's syndrome: about a case of apparent pneumoperitoneum.

    Silva Vilela, Filipe / Pinto, Rita / Dias, Luís / Gomes, Vânia / Rodrigues, Céu

    Internal and emergency medicine

    2023  Volume 19, Issue 1, Page(s) 245–246

    MeSH term(s) Humans ; Chilaiditi Syndrome/complications ; Chilaiditi Syndrome/diagnostic imaging ; Pneumoperitoneum/diagnostic imaging ; Pneumoperitoneum/etiology ; Radiography ; Abdomen ; Diaphragm/diagnostic imaging ; Colon ; Liver
    Language English
    Publishing date 2023-09-21
    Publishing country Italy
    Document type Case Reports ; Journal Article
    ZDB-ID 2454173-4
    ISSN 1970-9366 ; 1828-0447
    ISSN (online) 1970-9366
    ISSN 1828-0447
    DOI 10.1007/s11739-023-03423-4
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    Zs.A 6673: Show issues Location:
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  7. Article ; Online: Regulation of inflammation and protection against invasive pneumococcal infection by the long pentraxin PTX3

    Rémi Porte / Rita Silva-Gomes / Charlotte Theroude / Raffaella Parente / Fatemeh Asgari / Marina Sironi / Fabio Pasqualini / Sonia Valentino / Rosanna Asselta / Camilla Recordati / Marta Noemi Monari / Andrea Doni / Antonio Inforzato / Carlos Rodriguez-Gallego / Ignacio Obando / Elena Colino / Barbara Bottazzi / Alberto Mantovani

    eLife, Vol

    2023  Volume 12

    Abstract: Streptococcus pneumoniae is a major pathogen in children, elderly subjects, and immunodeficient patients. Pentraxin 3 (PTX3) is a fluid-phase pattern recognition molecule (PRM) involved in resistance to selected microbial agents and in regulation of ... ...

    Abstract Streptococcus pneumoniae is a major pathogen in children, elderly subjects, and immunodeficient patients. Pentraxin 3 (PTX3) is a fluid-phase pattern recognition molecule (PRM) involved in resistance to selected microbial agents and in regulation of inflammation. The present study was designed to assess the role of PTX3 in invasive pneumococcal infection. In a murine model of invasive pneumococcal infection, PTX3 was strongly induced in non-hematopoietic (particularly, endothelial) cells. The IL-1β/MyD88 axis played a major role in regulation of the Ptx3 gene expression. Ptx3−/− mice presented more severe invasive pneumococcal infection. Although high concentrations of PTX3 had opsonic activity in vitro, no evidence of PTX3-enhanced phagocytosis was obtained in vivo. In contrast, Ptx3-deficient mice showed enhanced recruitment of neutrophils and inflammation. Using P-selectin-deficient mice, we found that protection against pneumococcus was dependent upon PTX3-mediated regulation of neutrophil inflammation. In humans, PTX3 gene polymorphisms were associated with invasive pneumococcal infections. Thus, this fluid-phase PRM plays an important role in tuning inflammation and resistance against invasive pneumococcal infection.
    Keywords Streptococcus pneumoniae ; Pentraxin 3 ; neutrophils ; inflammation ; P-selectin ; endothelial cells ; Medicine ; R ; Science ; Q ; Biology (General) ; QH301-705.5
    Subject code 570
    Language English
    Publishing date 2023-05-01T00:00:00Z
    Publisher eLife Sciences Publications Ltd
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: A cytokine/PTX3 prognostic index as a predictor of mortality in sepsis.

    Davoudian, Sadaf / Piovani, Daniele / Desai, Antonio / Mapelli, Sarah N / Leone, Roberto / Sironi, Marina / Valentino, Sonia / Silva-Gomes, Rita / Stravalaci, Matteo / Asgari, Fatemeh / Madera, Alessandra / Piccinini, Daniele / Fedeli, Carlo / Comina, Denise / Bonovas, Stefanos / Voza, Antonio / Mantovani, Alberto / Bottazzi, Barbara

    Frontiers in immunology

    2022  Volume 13, Page(s) 979232

    Abstract: Background: Early prognostic stratification of patients with sepsis is a difficult clinical challenge. Aim of this study was to evaluate novel molecules in association with clinical parameters as predictors of 90-days mortality in patients admitted with ...

    Abstract Background: Early prognostic stratification of patients with sepsis is a difficult clinical challenge. Aim of this study was to evaluate novel molecules in association with clinical parameters as predictors of 90-days mortality in patients admitted with sepsis at Humanitas Research Hospital.
    Methods: Plasma samples were collected from 178 patients, diagnosed based on Sepsis-3 criteria, at admission to the Emergency Department and after 5 days of hospitalization. Levels of pentraxin 3 (PTX3), soluble IL-1 type 2 receptor (sIL-1R2), and of a panel of pro- and anti-inflammatory cytokines were measured by ELISA. Cox proportional-hazard models were used to evaluate predictors of 90-days mortality.
    Results: Circulating levels of PTX3, sIL-1R2, IL-1β, IL-6, IL-8, IL-10, IL-18, IL-1ra, TNF-α increased significantly in sepsis patients on admission, with the highest levels measured in shock patients, and correlated with SOFA score (PTX3: r=0.44, p<0.0001; sIL-1R2: r=0.35, p<0.0001), as well as with 90-days mortality. After 5 days of hospitalization, PTX3 and cytokines, but not sIL-1R2 levels, decreased significantly, in parallel with a general improvement of clinical parameters. The combination of age, blood urea nitrogen, PTX3, IL-6 and IL-18, defined a prognostic index predicting 90-days mortality in Sepsis-3 patients and showing better apparent discrimination capacity than the SOFA score (AUC=0.863, 95% CI: 0.780-0.945
    Conclusion: These data suggest that a prognostic index based on selected cytokines, PTX3 and clinical parameters, and hence easily adoptable in clinical practice, performs in predicting 90-days mortality better than SOFA. An independent validation is required.
    MeSH term(s) Biomarkers ; C-Reactive Protein ; Cytokines ; Humans ; Infant, Newborn ; Interleukin 1 Receptor Antagonist Protein ; Interleukin-1 ; Interleukin-10 ; Interleukin-18 ; Interleukin-6 ; Interleukin-8 ; Prognosis ; ROC Curve ; Sepsis ; Serum Amyloid P-Component ; Tumor Necrosis Factor-alpha
    Chemical Substances Biomarkers ; Cytokines ; Interleukin 1 Receptor Antagonist Protein ; Interleukin-1 ; Interleukin-18 ; Interleukin-6 ; Interleukin-8 ; Serum Amyloid P-Component ; Tumor Necrosis Factor-alpha ; Interleukin-10 (130068-27-8) ; PTX3 protein (148591-49-5) ; C-Reactive Protein (9007-41-4)
    Language English
    Publishing date 2022-09-15
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2022.979232
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  9. Article: Knocking Down TcNTPDase-1 Gene Reduces

    Silva-Gomes, Natália Lins / Rampazzo, Rita de Cássia Pontello / Moreira, Claudia Maria do Nascimento / Porcino, Gabriane Nascimento / Dos Santos, Cyndia Mara Bezerra / Krieger, Marco Aurélio / Vasconcelos, Eveline Gomes / Fragoso, Stenio Perdigão / Moreira, Otacilio C

    Frontiers in microbiology

    2020  Volume 11, Page(s) 434

    Abstract: Ecto-Nucleoside Triphosphate Diphosphohydrolases are enzymes that hydrolyze tri- and/or diphosphate nucleosides. Evidences pointed out to their participation ... ...

    Abstract Ecto-Nucleoside Triphosphate Diphosphohydrolases are enzymes that hydrolyze tri- and/or diphosphate nucleosides. Evidences pointed out to their participation in
    Language English
    Publishing date 2020-03-18
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587354-4
    ISSN 1664-302X
    ISSN 1664-302X
    DOI 10.3389/fmicb.2020.00434
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  10. Article: The Genus

    Ribeiro, Adriana / Serrano, Rita / da Silva, Isabel B Moreira / Gomes, Elsa T / Pinto, João F / Silva, Olga

    Plants (Basel, Switzerland)

    2023  Volume 12, Issue 15

    Abstract: Species of ... ...

    Abstract Species of the
    Language English
    Publishing date 2023-07-31
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2704341-1
    ISSN 2223-7747
    ISSN 2223-7747
    DOI 10.3390/plants12152833
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