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Article ; Online: A conspicuous reduced plasma creatinine: the first presenting sign of Waldenstrom macroglobulinemia.

Potze, Wilma / Vos, Michel J / Engel, Henk / Doornebal, Joan

Clinical chemistry and laboratory medicine

2021 Volume 60, Issue 1, Page(s) e21–e24

MeSH term(s)	Creatinine ; Humans ; Immunoglobulin M ; Kidney Function Tests ; Waldenstrom Macroglobulinemia/diagnosis
Chemical Substances	Immunoglobulin M ; Creatinine (AYI8EX34EU)
Language	English
Publishing date	2021-09-06
Publishing country	Germany
Document type	Letter
ZDB-ID	1418007-8
ISSN	1437-4331 ; 1434-6621 ; 1437-8523
ISSN (online)	1437-4331
ISSN	1434-6621 ; 1437-8523
DOI	10.1515/cclm-2021-0742
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Article ; Online: Issues with monitoring of unfractionated heparin in cirrhosis.

Potze, Wilma / Lisman, Ton

Therapeutic drug monitoring

2015 Volume 37, Issue 2, Page(s) 279–280

MeSH term(s)	Anticoagulants/administration & dosage ; Drug Monitoring/methods ; Factor Xa Inhibitors/pharmacology ; Female ; Heparin/administration & dosage ; Humans ; Liver Cirrhosis/blood ; Liver Cirrhosis/metabolism ; Male ; Partial Thromboplastin Time
Chemical Substances	Anticoagulants ; Factor Xa Inhibitors ; Heparin (9005-49-6)
Language	English
Publishing date	2015-04
Publishing country	United States
Document type	Comment ; Letter
ZDB-ID	424443-6
ISSN	1536-3694 ; 0163-4356
ISSN (online)	1536-3694
ISSN	0163-4356
DOI	10.1097/FTD.0000000000000132
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Zs.A 1503: Show issues

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Article ; Online: Reply to: "Procoagulant imbalance in patients with non-alcoholic fatty liver disease".

Potze, Wilma / Sanyal, Arun J / Lisman, Ton

Journal of hepatology

2016 Volume 66, Issue 1, Page(s) 250–251

MeSH term(s)	Humans ; Liver Cirrhosis ; Non-alcoholic Fatty Liver Disease
Language	English
Publishing date	2016-10-18
Publishing country	Netherlands
Document type	Letter ; Comment
ZDB-ID	605953-3
ISSN	1600-0641 ; 0168-8278
ISSN (online)	1600-0641
ISSN	0168-8278
DOI	10.1016/j.jhep.2016.10.011
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Article ; Online: Decreased in vitro anticoagulant potency of Rivaroxaban and Apixaban in plasma from patients with cirrhosis.

Potze, Wilma / Adelmeijer, Jelle / Lisman, Ton

Hepatology (Baltimore, Md.)

2015 Volume 61, Issue 4, Page(s) 1435–1436

MeSH term(s)	Anticoagulants/administration & dosage ; Humans ; Male ; Mesenteric Veins ; Morpholines/administration & dosage ; Portal Vein ; Thiophenes/administration & dosage ; Venous Thrombosis/drug therapy
Chemical Substances	Anticoagulants ; Morpholines ; Thiophenes
Language	English
Publishing date	2015-04
Publishing country	United States
Document type	Comment ; Letter
ZDB-ID	604603-4
ISSN	1527-3350 ; 0270-9139
ISSN (online)	1527-3350
ISSN	0270-9139
DOI	10.1002/hep.27350
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Zs.A 1660: Show issues

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Article ; Online: Management of coagulation abnormalities in liver disease.

Potze, Wilma / Porte, Robert J / Lisman, Ton

Expert review of gastroenterology & hepatology

2015 Volume 9, Issue 1, Page(s) 103–114

Abstract: Liver disease is characterized by changes in all phases of hemostasis. These hemostatic alterations were long considered to predispose patients with liver disease towards a bleeding tendency, as they are associated with prolonged conventional coagulation ...

Abstract	Liver disease is characterized by changes in all phases of hemostasis. These hemostatic alterations were long considered to predispose patients with liver disease towards a bleeding tendency, as they are associated with prolonged conventional coagulation tests. However, these patients may also suffer from thrombotic complications, and we now know that the hemostatic system in patient with liver disease is, in fact, in a rebalanced state. In this review we discuss the concept of rebalanced hemostasis and its implications for clinical management of patients with liver disease. For instance, there is no evidence that the use of prophylactic blood product transfusion prior to invasive procedures reduces bleeding risk. Clinicians should also be aware of the possibility of thrombosis occurring in patients with a liver disease, and regular thrombosis prophylaxis should not be withheld in these patients.
MeSH term(s)	Animals ; Blood Coagulation/drug effects ; Blood Coagulation Tests ; Blood Transfusion ; Coagulants/adverse effects ; Coagulants/therapeutic use ; Fibrinolysis/drug effects ; Fibrinolytic Agents/adverse effects ; Fibrinolytic Agents/therapeutic use ; Hemorrhage/diagnosis ; Hemorrhage/etiology ; Hemorrhage/prevention & control ; Humans ; Liver Diseases/blood ; Liver Diseases/complications ; Liver Diseases/diagnosis ; Liver Diseases/drug therapy ; Predictive Value of Tests ; Risk Factors ; Thrombosis/diagnosis ; Thrombosis/etiology ; Thrombosis/prevention & control ; Treatment Outcome
Chemical Substances	Coagulants ; Fibrinolytic Agents
Language	English
Publishing date	2015-01
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2481021-6
ISSN	1747-4132 ; 1747-4124
ISSN (online)	1747-4132
ISSN	1747-4124
DOI	10.1586/17474124.2014.934673
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Zs.A 6978: Show issues

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Article ; Online: Vascular Disease in Patients with Nonalcoholic Fatty Liver Disease.

Potze, Wilma / Siddiqui, M Shadab / Sanyal, Arun J

Seminars in thrombosis and hemostasis

2015 Volume 41, Issue 5, Page(s) 488–493

Abstract: Nonalcoholic fatty liver disease (NAFLD) is increasingly being diagnosed and is considered to be the most frequent chronic liver disorder in Western countries. It represents a histopathological spectrum ranging from simple hepatic steatosis to ... ...

Abstract	Nonalcoholic fatty liver disease (NAFLD) is increasingly being diagnosed and is considered to be the most frequent chronic liver disorder in Western countries. It represents a histopathological spectrum ranging from simple hepatic steatosis to steatohepatitis and finally cirrhosis. NAFLD is considered as the hepatic manifestation of the metabolic syndrome and is associated with increased mortality. Increasing evidence now suggests that NAFLD is also associated with higher cardiovascular disease (CVD) morbidity and mortality independent of conventional cardiometabolic risk factors (such as obesity, insulin resistance, and diabetes mellitus). The exact mechanisms linking NAFLD to increased CVD risk are still incompletely understood and likely reflect multiple coexisting pathways. Recent evidence suggests a contributive effect of an altered hemostasis in patients with NAFLD. For example, patients with NAFLD have higher levels of prothrombotic factors (e.g., von Willebrand factor, fibrinogen, factor VII activity, and plasminogen activator inhibitor-1), which correlate with underlying histological severity of the disease. The current review focuses on these hemostatic abnormalities in NAFLD and the link with increased CVD risk.
MeSH term(s)	Cardiovascular Diseases/etiology ; Cardiovascular Diseases/pathology ; Hemostasis/physiology ; Humans ; Metabolic Syndrome/complications ; Non-alcoholic Fatty Liver Disease/complications ; Obesity/complications ; Risk Factors ; Thrombosis/complications ; Vascular Diseases/etiology
Language	English
Publishing date	2015-07
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	196901-8
ISSN	1098-9064 ; 0094-6176
ISSN (online)	1098-9064
ISSN	0094-6176
DOI	10.1055/s-0035-1550433
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Zs.A 1259: Show issues

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Article ; Online: Preserved clot formation detected by the Thrombodynamics analyzer in patients with cirrhosis.

Potze, Wilma / Adelmeijer, Jelle / Porte, Robert J / Lisman, Ton

Thrombosis research

2015 Volume 135, Issue 5, Page(s) 1012–1016

Abstract: Introduction: Patients with cirrhosis have substantial alterations in their hemostatic system, which are paradoxically associated with the risk of both bleeding and thrombotic complications. However, it still remains difficult to predict those risks, ... ...

Abstract	Introduction: Patients with cirrhosis have substantial alterations in their hemostatic system, which are paradoxically associated with the risk of both bleeding and thrombotic complications. However, it still remains difficult to predict those risks, because results from conventional coagulation tests, such as the prothrombin time (PT) and activated partial thromboplastin time (APTT), do not reflect the complex hemostatic changes in these patients. More sophisticated global hemostasis tests, such as thrombin generation assays, are not standardized for routine use yet. Here we examined the spatial clot growth in plasma from patients with cirrhosis using the novel Thrombodynamics assay, which uses a fundamentally new approach to test plasma hemostatic capacity. Materials and methods: Thrombodynamics assays were performed in plasma from thirty-one patients with cirrhosis and twenty-five healthy controls. Results were compared to results with thrombin generation testing and PT/APTT test results. Results: Rates of clot growth, clot size, and clot density from the Thrombodynamics assay were comparable between patients and controls. Thrombin generation in the presence of thrombomodulin was increased in the patients, despite prolonged PT and APTT test results. There was little correlation between parameters derived from the Thrombodynamics assay and the PT, APTT, or thrombin generation data. Conclusions: The Thrombodynamics assay showed preserved clot formation in plasma from patients with cirrhosis, which is in line with the results of the thrombin generation assay in this study and previously reported by others.
MeSH term(s)	Adult ; Aged ; Blood Coagulation ; Blood Coagulation Tests/methods ; Case-Control Studies ; Female ; Hemorrhage/blood ; Hemorrhage/etiology ; Hemostasis ; Humans ; Liver Cirrhosis/blood ; Liver Cirrhosis/complications ; Male ; Middle Aged ; Partial Thromboplastin Time ; Prothrombin Time ; Risk Factors ; Thrombin/biosynthesis ; Thrombosis/blood ; Thrombosis/etiology ; Young Adult
Chemical Substances	Thrombin (EC 3.4.21.5)
Language	English
Publishing date	2015-05
Publishing country	United States
Document type	Journal Article
ZDB-ID	121852-9
ISSN	1879-2472 ; 0049-3848
ISSN (online)	1879-2472
ISSN	0049-3848
DOI	10.1016/j.thromres.2015.02.025
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Zs.A 863: Show issues

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Article ; Online: Changes of in vitro potency of anticoagulant drugs are similar between patients with cirrhosis due to alcohol or non-alcoholic fatty liver disease.

Bos, Sarah / Potze, Wilma / Siddiqui, Mohammad S / Boyett, Sherry L / Adelmeijer, Jelle / Daita, Kalyani / Lisman, Ton / Sanyal, Arun J

Thrombosis research

2017 Volume 150, Page(s) 41–43

MeSH term(s)	Adult ; Alcoholism/blood ; Alcoholism/complications ; Anticoagulants/pharmacology ; Anticoagulants/therapeutic use ; Dabigatran/pharmacology ; Dabigatran/therapeutic use ; Enoxaparin/pharmacology ; Enoxaparin/therapeutic use ; Female ; Hemostasis/drug effects ; Humans ; Liver Cirrhosis/blood ; Liver Cirrhosis/complications ; Liver Cirrhosis/etiology ; Male ; Middle Aged ; Non-alcoholic Fatty Liver Disease/blood ; Non-alcoholic Fatty Liver Disease/complications ; Pyrazoles/pharmacology ; Pyrazoles/therapeutic use ; Pyridones/pharmacology ; Pyridones/therapeutic use ; Thrombosis/etiology ; Thrombosis/prevention & control
Chemical Substances	Anticoagulants ; Enoxaparin ; Pyrazoles ; Pyridones ; apixaban (3Z9Y7UWC1J) ; Dabigatran (I0VM4M70GC)
Language	English
Publishing date	2017-02
Publishing country	United States
Document type	Letter
ZDB-ID	121852-9
ISSN	1879-2472 ; 0049-3848
ISSN (online)	1879-2472
ISSN	0049-3848
DOI	10.1016/j.thromres.2016.12.008
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Article: Vascular Disease in Patients with Nonalcoholic Fatty Liver Disease

Potze, Wilma / Siddiqui, M. Shadab / Sanyal, Arun J.

Seminars in Thrombosis and Hemostasis

(Hemostatic Dysfunction in Liver Diseases)

2015 Volume 41, Issue 05, Page(s) 488–493

Series title	Hemostatic Dysfunction in Liver Diseases
Abstract	Nonalcoholic fatty liver disease (NAFLD) is increasingly being diagnosed and is considered to be the most frequent chronic liver disorder in Western countries. It represents a histopathological spectrum ranging from simple hepatic steatosis to steatohepatitis and finally cirrhosis. NAFLD is considered as the hepatic manifestation of the metabolic syndrome and is associated with increased mortality. Increasing evidence now suggests that NAFLD is also associated with higher cardiovascular disease (CVD) morbidity and mortality independent of conventional cardiometabolic risk factors (such as obesity, insulin resistance, and diabetes mellitus). The exact mechanisms linking NAFLD to increased CVD risk are still incompletely understood and likely reflect multiple coexisting pathways. Recent evidence suggests a contributive effect of an altered hemostasis in patients with NAFLD. For example, patients with NAFLD have higher levels of prothrombotic factors (e.g., von Willebrand factor, fibrinogen, factor VII activity, and plasminogen activator inhibitor-1), which correlate with underlying histological severity of the disease. The current review focuses on these hemostatic abnormalities in NAFLD and the link with increased CVD risk.
Keywords	nonalcoholic fatty liver disease ; cardiovascular disease ; hemostasis ; coagulation disorders ; thrombosis
Language	English
Publishing date	2015-06-06
Publisher	Thieme Medical Publishers
Publishing place	Stuttgart ; New York
Document type	Article
ZDB-ID	196901-8
ISSN	1098-9064 ; 0094-6176
ISSN (online)	1098-9064
ISSN	0094-6176
DOI	10.1055/s-0035-1550433
Database	Thieme publisher's database

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Article ; Online: Preserved hemostatic status in patients with non-alcoholic fatty liver disease.

Potze, Wilma / Siddiqui, Mohammad S / Boyett, Sherry L / Adelmeijer, Jelle / Daita, Kalyani / Sanyal, Arun J / Lisman, Ton

Journal of hepatology

2016 Volume 65, Issue 5, Page(s) 980–987

Abstract: Background & aims: Non-alcoholic fatty liver disease (NAFLD) is associated with an increased risk of thrombosis. However, it remains unclear if hypercoagulability contributes to this risk. We, therefore, determined an in-depth hemostatic profile in a ... ...

Abstract	Background & aims: Non-alcoholic fatty liver disease (NAFLD) is associated with an increased risk of thrombosis. However, it remains unclear if hypercoagulability contributes to this risk. We, therefore, determined an in-depth hemostatic profile in a cohort of well-defined patients with NAFLD. Methods: We drew blood samples from 68 patients with biopsy-proven NAFLD (simple steatosis n=24, NASH n=22, and NASH cirrhosis n=22), 30 lean controls, 30 overweight controls (body mass index (BMI) >25kg/m Results: Basal and agonist-induced platelet activation, plasma levels of markers of platelet activation, and plasma levels of the platelet adhesion regulators von Willebrand factor and ADAMTS13 were comparable between patients with non-cirrhotic NAFLD and controls. Agonist-induced platelet activation was decreased in patients with cirrhosis. Thrombomodulin-modified thrombin generation was comparable between all patients and controls, although patients with cirrhosis had a reduced anticoagulant response to thrombomodulin. Thromboelastography test results were comparable between controls and non-cirrhotic NAFLD patients, but revealed moderate hypocoagulability in cirrhosis. Plasma fibrinolytic potential was decreased in overweight controls and non-cirrhotic NAFLD, but accelerated fibrinolysis was observed in ASH cirrhosis. Clot permeability was decreased in overweight controls and patients with NAFLD. Conclusions: The overall hemostatic profile is comparable between patients with non-cirrhotic NAFLD and controls. Additionally, pro-thrombotic features (hypofibrinolysis and a pro-thrombotic structure of fibrin clot) in patients with NAFLD are likely driven by obesity. Our study suggests a limited role for hyperactive hemostasis in the increased thrombotic risk in NAFLD. Lay summary: The combined results of this study show that the overall hemostatic status is comparable between healthy individuals and patients with a fatty liver disease.
MeSH term(s)	Hemostasis ; Hemostatics ; Humans ; Liver Cirrhosis ; Non-alcoholic Fatty Liver Disease ; Overweight
Chemical Substances	Hemostatics
Language	English
Publishing date	2016-06-11
Publishing country	Netherlands
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	605953-3
ISSN	1600-0641 ; 0168-8278
ISSN (online)	1600-0641
ISSN	0168-8278
DOI	10.1016/j.jhep.2016.06.001
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