LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 81

Search options

  1. Article ; Online: Three Decades of Interferon-β in Multiple Sclerosis: Can We Repurpose This Information for the Management of SARS-CoV2 Infection?

    Severa, Martina / Farina, Cinthia / Salvetti, Marco / Coccia, Eliana Marina

    Frontiers in immunology

    2020  Volume 11, Page(s) 1459

    MeSH term(s) Antiviral Agents/therapeutic use ; Betacoronavirus/drug effects ; Betacoronavirus/physiology ; Coronavirus Infections/drug therapy ; Coronavirus Infections/virology ; Drug Repositioning/methods ; Humans ; Immunologic Factors/therapeutic use ; Interferon-beta/therapeutic use ; Multiple Sclerosis/drug therapy ; Pandemics ; Pneumonia, Viral/drug therapy ; Pneumonia, Viral/virology ; Virus Replication/drug effects
    Chemical Substances Antiviral Agents ; Immunologic Factors ; Interferon-beta (77238-31-4)
    Keywords covid19
    Language English
    Publishing date 2020-06-18
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2020.01459
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  2. Article ; Online: Innate Immune Response to SARS-CoV-2 Infection: From Cells to Soluble Mediators.

    Ricci, Daniela / Etna, Marilena Paola / Rizzo, Fabiana / Sandini, Silvia / Severa, Martina / Coccia, Eliana Marina

    International journal of molecular sciences

    2021  Volume 22, Issue 13

    Abstract: The vulnerability of humankind to SARS-CoV-2 in the absence of a pre-existing immunity, the unpredictability of the infection outcome, and the high transmissibility, broad tissue tropism, and ability to exploit and subvert the immune response pose a ... ...

    Abstract The vulnerability of humankind to SARS-CoV-2 in the absence of a pre-existing immunity, the unpredictability of the infection outcome, and the high transmissibility, broad tissue tropism, and ability to exploit and subvert the immune response pose a major challenge and are likely perpetuating the COVID-19 pandemic. Nevertheless, this peculiar infectious scenario provides researchers with a unique opportunity for studying, with the latest immunological techniques and understandings, the immune response in SARS-CoV-2 naïve versus recovered subjects as well as in SARS-CoV-2 vaccinees. Interestingly, the current understanding of COVID-19 indicates that the combined action of innate immune cells, cytokines, and chemokines fine-tunes the outcome of SARS-CoV-2 infection and the related immunopathogenesis. Indeed, the emerging picture clearly shows that the excessive inflammatory response against this virus is among the main causes of disease severity in COVID-19 patients. In this review, the innate immune response to SARS-CoV-2 infection is described not only in light of its capacity to influence the adaptive immune response towards a protective phenotype but also with the intent to point out the multiple strategies exploited by SARS-CoV-2 to antagonize host antiviral response and, finally, to outline inborn errors predisposing individuals to COVID-19 disease severity.
    MeSH term(s) COVID-19/immunology ; COVID-19/pathology ; COVID-19/virology ; Chemokines/metabolism ; Cytokines/metabolism ; Host-Pathogen Interactions ; Humans ; Immunity, Innate ; Killer Cells, Natural/cytology ; Killer Cells, Natural/metabolism ; Monocytes/cytology ; Monocytes/metabolism ; SARS-CoV-2/isolation & purification ; Severity of Illness Index
    Chemical Substances Chemokines ; Cytokines
    Language English
    Publishing date 2021-06-29
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms22137017
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  3. Article ; Online: Three Decades of Interferon-β in Multiple Sclerosis

    Martina Severa / Cinthia Farina / Marco Salvetti / Eliana Marina Coccia

    Frontiers in Immunology, Vol

    Can We Repurpose This Information for the Management of SARS-CoV2 Infection?

    2020  Volume 11

    Keywords type I IFN ; antiviral-activity ; multiple scleorsis (MS) ; immunoregulation ; SARS-CoV-2 ; Immunologic diseases. Allergy ; RC581-607 ; covid19
    Language English
    Publishing date 2020-06-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  4. Article ; Online: Novel evidence of Thymosin α1 immunomodulatory properties in SARS-CoV-2 infection: Effect on innate inflammatory response in a peripheral blood mononuclear cell-based in vitro model.

    Ricci, Daniela / Etna, Marilena Paola / Severa, Martina / Fiore, Stefano / Rizzo, Fabiana / Iannetta, Marco / Andreoni, Massimo / Balducci, Stefano / Stefanelli, Paola / Palamara, Anna Teresa / Coccia, Eliana Marina

    International immunopharmacology

    2023  Volume 117, Page(s) 109996

    Abstract: The peculiar property of Thymosin alpha 1 (Tα1) to act as master regulator of immune homeostasis has been successfully defined in different physiological and pathological contexts ranging from cancer to infection. Interestingly, recent papers also ... ...

    Abstract The peculiar property of Thymosin alpha 1 (Tα1) to act as master regulator of immune homeostasis has been successfully defined in different physiological and pathological contexts ranging from cancer to infection. Interestingly, recent papers also demonstrated its mitigating effect on the "cytokine storm" as well as on the T-cell exhaustion/activation in SARS-CoV-2 infected individuals. Nevertheless, in spite of the increasing knowledge on Tα1-induced effects on T cell response confirming the distinctive features of this multifaceted peptide, little is known on its effects on innate immunity during SARS-CoV-2 infection. Here, we interrogated peripheral blood mononuclear cell (PBMC) cultures stimulated with SARS-CoV-2 to disclose Tα1 properties on the main cell players of early response to infection, namely monocytes and myeloid dendritic cells (mDC). Moving from ex vivo data showing an enhancement in the frequency of inflammatory monocytes and activated mDC in COVID-19 patients, a PBMC-based experimental setting reproduced in vitro a similar profile with an increased percentage of CD16
    MeSH term(s) Humans ; Thymalfasin/therapeutic use ; Leukocytes, Mononuclear/metabolism ; COVID-19 ; SARS-CoV-2/metabolism ; Cytokines/metabolism ; Inflammation/drug therapy ; Thymosin/pharmacology ; Thymosin/therapeutic use
    Chemical Substances Thymalfasin (W0B22ISQ1C) ; Cytokines ; Thymosin (61512-21-8)
    Language English
    Publishing date 2023-03-13
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2043785-7
    ISSN 1878-1705 ; 1567-5769
    ISSN (online) 1878-1705
    ISSN 1567-5769
    DOI 10.1016/j.intimp.2023.109996
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 5408: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  5. Article ; Online: Three Decades of Interferon-β in Multiple Sclerosis

    Severa, Martina / Farina, Cinthia / Salvetti, Marco / Coccia, Eliana Marina

    Frontiers in Immunology

    Can We Repurpose This Information for the Management of SARS-CoV2 Infection?

    2020  Volume 11

    Keywords covid19
    Publisher Frontiers Media SA
    Publishing country ch
    Document type Article ; Online
    ZDB-ID 2606827-8
    ISSN 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2020.01459
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  6. Article: Three Decades of Interferon-ß in Multiple Sclerosis: Can We Repurpose This Information for the Management of SARS-CoV2 Infection?

    Severa, Martina / Farina, Cinthia / Salvetti, Marco / Coccia, Eliana Marina

    Front Immunol

    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #644296
    Database COVID19

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  7. Article ; Online: Innate Immune Response to SARS-CoV-2 Infection

    Daniela Ricci / Marilena Paola Etna / Fabiana Rizzo / Silvia Sandini / Martina Severa / Eliana Marina Coccia

    International Journal of Molecular Sciences, Vol 22, Iss 7017, p

    From Cells to Soluble Mediators

    2021  Volume 7017

    Abstract: The vulnerability of humankind to SARS-CoV-2 in the absence of a pre-existing immunity, the unpredictability of the infection outcome, and the high transmissibility, broad tissue tropism, and ability to exploit and subvert the immune response pose a ... ...

    Abstract The vulnerability of humankind to SARS-CoV-2 in the absence of a pre-existing immunity, the unpredictability of the infection outcome, and the high transmissibility, broad tissue tropism, and ability to exploit and subvert the immune response pose a major challenge and are likely perpetuating the COVID-19 pandemic. Nevertheless, this peculiar infectious scenario provides researchers with a unique opportunity for studying, with the latest immunological techniques and understandings, the immune response in SARS-CoV-2 naïve versus recovered subjects as well as in SARS-CoV-2 vaccinees. Interestingly, the current understanding of COVID-19 indicates that the combined action of innate immune cells, cytokines, and chemokines fine-tunes the outcome of SARS-CoV-2 infection and the related immunopathogenesis. Indeed, the emerging picture clearly shows that the excessive inflammatory response against this virus is among the main causes of disease severity in COVID-19 patients. In this review, the innate immune response to SARS-CoV-2 infection is described not only in light of its capacity to influence the adaptive immune response towards a protective phenotype but also with the intent to point out the multiple strategies exploited by SARS-CoV-2 to antagonize host antiviral response and, finally, to outline inborn errors predisposing individuals to COVID-19 disease severity.
    Keywords SARS-CoV-2 ; innate immunity ; soluble and cellular mediators ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
    Subject code 570
    Language English
    Publishing date 2021-06-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  8. Article ; Online: Affordable Motion Tracking System for Intuitive Programming of Industrial Robots.

    Švejda, Martin / Goubej, Martin / Jáger, Arnold / Reitinger, Jan / Severa, Ondřej

    Sensors (Basel, Switzerland)

    2022  Volume 22, Issue 13

    Abstract: The paper deals with a lead-through method of programming for industrial robots. The goal is to automatically reproduce 6DoF trajectories of a tool wielded by a human operator demonstrating a motion task. We present a novel motion-tracking system built ... ...

    Abstract The paper deals with a lead-through method of programming for industrial robots. The goal is to automatically reproduce 6DoF trajectories of a tool wielded by a human operator demonstrating a motion task. We present a novel motion-tracking system built around the HTC Vive pose estimation system. Our solution allows complete automation of the robot teaching process. Specific algorithmic issues of system calibration and motion data post-processing are also discussed, constituting the paper's theoretical contribution. The motion tracking system is successfully deployed in a pilot application of robot-assisted spray painting.
    MeSH term(s) Calibration ; Humans ; Motion ; Robotics
    Language English
    Publishing date 2022-06-30
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2052857-7
    ISSN 1424-8220 ; 1424-8220
    ISSN (online) 1424-8220
    ISSN 1424-8220
    DOI 10.3390/s22134962
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  9. Article: A specific anti-COVID-19 BNT162b2 vaccine-induced early innate immune signature positively correlates with the humoral protective response in healthy and multiple sclerosis vaccine recipients.

    Severa, Martina / Rizzo, Fabiana / Sinigaglia, Alessandro / Ricci, Daniela / Etna, Marilena Paola / Cola, Gaia / Landi, Doriana / Buscarinu, Maria Chiara / Valdarchi, Catia / Ristori, Giovanni / Riccetti, Silvia / Piubelli, Chiara / Palmerini, Pierangela / Rosato, Antonio / Gobbi, Federico / Balducci, Stefano / Marfia, Girolama Alessandra / Salvetti, Marco / Barzon, Luisa /
    Coccia, Eliana Marina

    Clinical & translational immunology

    2023  Volume 12, Issue 3, Page(s) e1434

    Abstract: Objectives: The very rapidly approved mRNA-based vaccines against SARS-CoV-2 spike glycoprotein, including Pfizer-BioNTech BNT162b2, are effective in protecting from severe coronavirus disease 2019 (COVID-19) in immunocompetent population. However, ... ...

    Abstract Objectives: The very rapidly approved mRNA-based vaccines against SARS-CoV-2 spike glycoprotein, including Pfizer-BioNTech BNT162b2, are effective in protecting from severe coronavirus disease 2019 (COVID-19) in immunocompetent population. However, establishing the duration and identifying correlates of vaccine-induced protection will be crucial to optimise future immunisation strategies. Here, we studied in healthy vaccine recipients and people with multiple sclerosis (pwMS), undergoing different therapies, the regulation of innate immune response by mRNA vaccination in order to correlate it with the magnitude of vaccine-induced protective humoral responses.
    Methods: Healthy subjects (
    Results: We identified an early immune module composed of the IFN-inducible genes Mx1, OAS1 and IRF1, the serum cytokines IL-15, IL-6, TNF-α and IFN-γ and the chemokines IP-10, MCP-1 and MIG, induced 1 day post second and third BNT162b2 vaccine doses, strongly correlating with magnitude of humoral response to vaccination in healthy and MS vaccinees. Moreover, induction of the early immune module was dramatically affected in pwMS treated with fingolimod and ocrelizumab, both groups unable to induce a protective humoral response to COVID-19 vaccine.
    Conclusion: Overall, this study suggests that the vaccine-induced early regulation of innate immunity is mediated by IFN signalling, impacts on the magnitude of adaptive responses and it might be indicative of vaccine-induced humoral protection.
    Language English
    Publishing date 2023-03-23
    Publishing country Australia
    Document type Journal Article
    ZDB-ID 2694482-0
    ISSN 2050-0068
    ISSN 2050-0068
    DOI 10.1002/cti2.1434
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  10. Article ; Online: Genome-Wide Gene Expression Analysis of Mtb-Infected DC Highlights the Rapamycin-Driven Modulation of Regulatory Cytokines

    Etna, Marilena P / Severa, Martina / Licursi, Valerio / Pardini, Manuela / Cruciani, Melania / Rizzo, Fabiana / Giacomini, Elena / Macchia, Gianfranco / Palumbo, Orazio / Stallone, Raffaella / Carella, Massimo / Livingstone, Mark / Negri, Rodolfo / Pellegrini, Sandra / Coccia, Eliana M

    Frontiers in immunology

    2021  Volume 12, Page(s) 649475

    Abstract: In human primary dendritic cells (DC) rapamycin-an autophagy inducer and protein synthesis inhibitor-overcomes the autophagy block induced ... ...

    Abstract In human primary dendritic cells (DC) rapamycin-an autophagy inducer and protein synthesis inhibitor-overcomes the autophagy block induced by
    MeSH term(s) Autophagy/drug effects ; Autophagy/genetics ; Cells, Cultured ; Cytokines/metabolism ; Dendritic Cells/drug effects ; Dendritic Cells/immunology ; Gene Expression Profiling ; Glycogen Synthase Kinase 3 beta/metabolism ; Humans ; Mycobacterium tuberculosis/immunology ; Primary Cell Culture ; Signal Transduction/drug effects ; Signal Transduction/genetics ; Signal Transduction/immunology ; Sirolimus/pharmacology ; Sirolimus/therapeutic use ; TOR Serine-Threonine Kinases/metabolism ; Tuberculosis/drug therapy ; Tuberculosis/immunology ; Tuberculosis/microbiology
    Chemical Substances Cytokines ; MTOR protein, human (EC 2.7.1.1) ; TOR Serine-Threonine Kinases (EC 2.7.1.1) ; GSK3B protein, human (EC 2.7.11.1) ; Glycogen Synthase Kinase 3 beta (EC 2.7.11.1) ; Sirolimus (W36ZG6FT64)
    Language English
    Publishing date 2021-04-16
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2021.649475
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

To top