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  1. Article ; Online: A Paternal Methylation Error in the Congenital Hydrocephalic Texas (H-Tx) Rat Is Partially Rescued with Natural Folate Supplements.

    Naz, Naila / Moshkdanian, Ghazaleh / Miyan, Salma / Eljabri, Sereen / James, Charlotte / Miyan, Jaleel

    International journal of molecular sciences

    2023  Volume 24, Issue 2

    Abstract: Folate deficiencies, folate imbalance and associated abnormal methylation are associated with birth defects, developmental delays, neurological conditions and diseases. In the hydrocephalic Texas (H-Tx) rat, 10-formyl tetrahydrofolate dehydrogenase (FDH) ...

    Abstract Folate deficiencies, folate imbalance and associated abnormal methylation are associated with birth defects, developmental delays, neurological conditions and diseases. In the hydrocephalic Texas (H-Tx) rat, 10-formyl tetrahydrofolate dehydrogenase (FDH) is reduced or absent from the CSF and the nuclei of cells in the brain and liver and this is correlated with decreased DNA methylation. In the present study, we tested whether impaired folate metabolism or methylation exists in sexually mature, unaffected H-Tx rats, which may explain the propagation of hydrocephalus in their offspring. We compared normal Sprague Dawley (SD,
    MeSH term(s) Animals ; Male ; Rats ; DNA Methylation ; Folic Acid/metabolism ; Folic Acid/pharmacology ; Folic Acid/therapeutic use ; Rats, Sprague-Dawley ; Semen/metabolism ; Hydrocephalus/congenital ; Hydrocephalus/drug therapy ; Hydrocephalus/genetics ; Hydrocephalus/metabolism ; Disease Models, Animal ; Folate Receptor 1/genetics ; Folate Receptor 1/metabolism
    Chemical Substances Folic Acid (935E97BOY8) ; Folate Receptor 1
    Language English
    Publishing date 2023-01-13
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms24021638
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  2. Article ; Online: Effects of zinc supplementation from organic and inorganic sources on growth, blood biochemical indices, and intestinal microarchitecture in broilers.

    Khan, Muhammad Ishtiaq / Chand, Naila / Naz, Shabana / Alonaizan, Rasha / Hu, Hong / Shamsi, Shamsuddin / Khan, Rifat Ullah

    The veterinary quarterly

    2024  Volume 44, Issue 1, Page(s) 1–7

    Abstract: In poultry nutrition, zinc supplementation is typically achieved through the addition of zinc oxide or zinc sulfate to the feed. The alternative approach of organic sources utilizes an organic ligand to bind zinc (Zn), resulting in higher bioavailability. ...

    Abstract In poultry nutrition, zinc supplementation is typically achieved through the addition of zinc oxide or zinc sulfate to the feed. The alternative approach of organic sources utilizes an organic ligand to bind zinc (Zn), resulting in higher bioavailability. Thus, a study was conducted to assess and compare the impact of a methionine-complexed Zn versus an inorganic Zn on growth, blood biochemical profile, gut histomorphology, and fecal excretion of Zn in broilers. The experimental design included two treatments: the addition of a zinc amino acid complex or zinc oxide to the basal diet. The zinc amino acid complex was supplemented at a dose equivalent to the inorganic zinc (Zn-80), while the organic zinc was provided at levels of 20, 40, and 80 mg/kg to a total of 400 broilers. There were five treatments in total, and each treatment was replicated four times. Broilers supplemented with an organic form of Zn at the level of 80 mg/kg had significantly (
    MeSH term(s) Animals ; Zinc/pharmacology ; Zinc/chemistry ; Zinc/metabolism ; Chickens/metabolism ; Zinc Oxide/metabolism ; Dietary Supplements ; Diet/veterinary ; Methionine/metabolism ; Methionine/pharmacology ; Animal Feed/analysis
    Chemical Substances Zinc (J41CSQ7QDS) ; Zinc Oxide (SOI2LOH54Z) ; Methionine (AE28F7PNPL)
    Language English
    Publishing date 2024-01-31
    Publishing country England
    Document type Journal Article
    ZDB-ID 754161-2
    ISSN 1875-5941 ; 0165-2176
    ISSN (online) 1875-5941
    ISSN 0165-2176
    DOI 10.1080/01652176.2023.2298491
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Dietary tea tree (Melaleuca alternifolia) essential oil as alternative to antibiotics alleviates experimentally induced Eimeria tenella challenge in Japanese quails.

    Khan, Mashal / Chand, Naila / Naz, Shabana / Khan, Rifat U

    Journal of animal physiology and animal nutrition

    2022  Volume 107, Issue 2, Page(s) 643–649

    Abstract: Coccidiosis is one of the most common infectious diseases seen in Japanese quails. The current study was conducted to evaluate the impact of tea tree essential oil (TTEO) on growth performance and intestinal health of quails in response to Eimeria ... ...

    Abstract Coccidiosis is one of the most common infectious diseases seen in Japanese quails. The current study was conducted to evaluate the impact of tea tree essential oil (TTEO) on growth performance and intestinal health of quails in response to Eimeria tenella challenge. A total of 250 Japanese quails were divided into five treatments: untreated uninfected (negative control); untreated infected (positive control); infected + Amprolium; infected and 1% TTEO; infected and 2% TTEO. Except negative control, all groups were orally dosed with 5 × 10
    MeSH term(s) Animals ; Eimeria tenella ; Coturnix ; Anti-Bacterial Agents/pharmacology ; Eimeria/physiology ; Melaleuca ; Trees ; Oils, Volatile/pharmacology ; Amprolium/pharmacology ; Coccidiosis/veterinary ; Quail ; Tea ; Poultry Diseases/pathology ; Chickens
    Chemical Substances Anti-Bacterial Agents ; Oils, Volatile ; Amprolium (H2T307KMZR) ; Tea
    Language English
    Publishing date 2022-04-25
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 232729-6
    ISSN 1439-0396 ; 0044-3565 ; 0931-2439
    ISSN (online) 1439-0396
    ISSN 0044-3565 ; 0931-2439
    DOI 10.1111/jpn.13719
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    In stock of ZB MED Bonn / Germany

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  4. Article ; Online: Conventional Ultrasonography

    Naila Jabeen / Ayesha Walid / Binish Rasheed / Nasreen Naz / Anila Rahim / Rabeeya Qutub uddin Siddiqui

    Pakistan Armed Forces Medical Journal, Vol 73, Iss

    A Remarkable Tool in Early Detection of Benign Ovarian Lesions in Comparison to Gold Standard MRI

    2023  Volume 2

    Abstract: Objective: This study aimed to assess the efficiency of ultrasonography in the accurate diagnosis of benign ovarian lesions as compared to the gold standard Magnetic Resonance Imaging (MRI). Study Design: Prospective analytical cross-sectional study. ... ...

    Abstract Objective: This study aimed to assess the efficiency of ultrasonography in the accurate diagnosis of benign ovarian lesions as compared to the gold standard Magnetic Resonance Imaging (MRI). Study Design: Prospective analytical cross-sectional study. Place and Duration of Study: Dow Institute of Radiology, Dow University of health sciences (DUHS), OJHA Campus, Karachi, Pakistan, from Jun 2018 to Nov 2019 Methodology: The consecutive sampling technique was used to recruit the patients. The frequency and percentage, and mean and standard deviation were calculated for qualitative and quantitative variables, respectively. The p-value <0.05 considered as significant. Results: Majority of the patients were aged ≥20 years (49.06%) and were obese (13.21%). Majority of the participants (88.68%) were married where 69.81% had normal menstrual status and 11.32% had menopause. On cross-tabulation, tumor status (Benign) was found to have a very high significant association with age and BMI at p-value <0.001 and menstrual status at pvalue 0.000. Benign lesions were most prevalent (60.47%) among 20-29 years old and the PPV is 92.86%; Diagnostic accuracy for this age group is 95.35%. PPV, NPV, sensitivity, specificity, and diagnostic accuracy were 100 % for Underweight, premenopause patients with 16 to 30 days symptoms. Benign tumor was more prevalent among patients with normal BMI (93.48%), post-menopause (63.64%), symptoms’ duration of 1 to 3years (66.67%), single (37.06%) and cystic mass (49.52%). Conclusion: Ultrasonography showed excellent diagnostic accuracy in the detection of benign ovarian tumors.
    Keywords Diagnostic accuracy ; Benign ; Ovarian mass ; Ultrasonography ; MRI ; Medicine ; R ; Medicine (General) ; R5-920
    Subject code 610
    Language English
    Publishing date 2023-05-01T00:00:00Z
    Publisher Army Medical College Rawalpindi
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Dietary tea tree (Melaleuca alternifolia) essential oil as alternative to antibiotics alleviates experimentally induced Eimeria tenella challenge in Japanese quails

    Khan, Mashal / Chand, Naila / Naz, Shabana / Khan, Rifat U.

    Journal of Animal Physiology and Animal Nutrition. 2023 Mar., v. 107, no. 2 p.643-649

    2023  

    Abstract: Coccidiosis is one of the most common infectious diseases seen in Japanese quails. The current study was conducted to evaluate the impact of tea tree essential oil (TTEO) on growth performance and intestinal health of quails in response to Eimeria ... ...

    Abstract Coccidiosis is one of the most common infectious diseases seen in Japanese quails. The current study was conducted to evaluate the impact of tea tree essential oil (TTEO) on growth performance and intestinal health of quails in response to Eimeria tenella challenge. A total of 250 Japanese quails were divided into five treatments: untreated uninfected (negative control); untreated infected (positive control); infected + Amprolium; infected and 1% TTEO; infected and 2% TTEO. Except negative control, all groups were orally dosed with 5 × 10⁴ sporulated oocysts of E. tenella. The results revealed that supplementation of 1% TTEO and treatment of amprolium improved feed intake, weight gain and feed conversion ratio in infected quails compared to the positive control. Similarly, lesion score and mortality was significantly (p < 0.01) reduced in quails supplemented with 2% TTEO and amprolium treated birds. Moreover, oocysts counts and histological features of caecum in infected birds were reversed in 1% TTEO and amprolium treatment. The histological findings of amprolium and 1% TTEO supplemented quails showed intact intestinal villi with mild sloughed epithelium. In conclusion, 1% TTEO can be safely used to control coccidiosis in Japanese quails as natural effective compound.
    Keywords Eimeria tenella ; Melaleuca alternifolia ; amprolium ; animal physiology ; cecum ; coccidiosis ; epithelium ; essential oils ; feed conversion ; feed intake ; growth performance ; histology ; mortality ; oocysts ; tea ; tea tree oil ; trees ; weight gain
    Language English
    Dates of publication 2023-03
    Size p. 643-649.
    Publishing place John Wiley & Sons, Ltd
    Document type Article ; Online
    Note JOURNAL ARTICLE
    ZDB-ID 232729-6
    ISSN 0931-2439
    ISSN 0931-2439
    DOI 10.1111/jpn.13719
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Bonn / Germany

    Z 17: Show issues

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  6. Article: Immunoinformatic and reverse vaccinology-based designing of potent multi-epitope vaccine against Marburgvirus targeting the glycoprotein.

    Yousaf, Hassan / Naz, Anam / Zaman, Naila / Hassan, Mubashir / Obaid, Ayesha / Awan, Faryal Mehwish / Azam, Syed Sikander

    Heliyon

    2023  Volume 9, Issue 8, Page(s) e18059

    Abstract: Marburg virus (MARV) has been a major concern since its first outbreak in 1967. Although the deadly BSL-4 pathogen has been reported in few individuals with sporadic outbreaks following 1967, its rarity commensurate the degree of disease severity. The ... ...

    Abstract Marburg virus (MARV) has been a major concern since its first outbreak in 1967. Although the deadly BSL-4 pathogen has been reported in few individuals with sporadic outbreaks following 1967, its rarity commensurate the degree of disease severity. The virus has been known to cause extreme hemorrhagic fever presenting flu-like symptoms (as implicated in COVID-19) with a 90% case fatality rate (CFR). After a number of plausible evidences, it has been observed that the virus usually originates from African fruit bat,
    Language English
    Publishing date 2023-07-17
    Publishing country England
    Document type Journal Article
    ZDB-ID 2835763-2
    ISSN 2405-8440
    ISSN 2405-8440
    DOI 10.1016/j.heliyon.2023.e18059
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  7. Article: Folate Related Pathway Gene Analysis Reveals a Novel Metabolic Variant Associated with Alzheimer's Disease with a Change in Metabolic Profile.

    Miyan, Jaleel / Buttercase, Charlotte / Beswick, Emma / Miyan, Salma / Moshkdanian, Ghazaleh / Naz, Naila

    Metabolites

    2022  Volume 12, Issue 6

    Abstract: Metabolic disorders may be important potential causative pathways to Alzheimer's disease (AD). Cerebrospinal fluid (CSF) decreasing output, raised intracranial pressure, and ventricular enlargement have all been linked to AD. Cerebral folate metabolism ... ...

    Abstract Metabolic disorders may be important potential causative pathways to Alzheimer's disease (AD). Cerebrospinal fluid (CSF) decreasing output, raised intracranial pressure, and ventricular enlargement have all been linked to AD. Cerebral folate metabolism may be a key player since this is significantly affected by such changes in CSF, and genetic susceptibilities may exist in this pathway. In the current study, we aimed to identify whether any single nucleotide polymorphism (SNPs) affecting folate and the associated metabolic pathways were significantly associated with AD. We took a functional nutrigenomics approach to look for SNPs in genes for the linked folate, methylation, and biogenic amine neurotransmitter pathways. Changes in metabolism were found with the SNPs identified. An abnormal SNP in methylene tetrahydrofolate dehydrogenase 1 (
    Language English
    Publishing date 2022-05-24
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662251-8
    ISSN 2218-1989
    ISSN 2218-1989
    DOI 10.3390/metabo12060475
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: A hybrid deep learning-based intrusion detection system for IoT networks.

    Khan, Noor Wali / Alshehri, Mohammed S / Khan, Muazzam A / Almakdi, Sultan / Moradpoor, Naghmeh / Alazeb, Abdulwahab / Ullah, Safi / Naz, Naila / Ahmad, Jawad

    Mathematical biosciences and engineering : MBE

    2023  Volume 20, Issue 8, Page(s) 13491–13520

    Abstract: The Internet of Things (IoT) is a rapidly evolving technology with a wide range of potential applications, but the security of IoT networks remains a major concern. The existing system needs improvement in detecting intrusions in IoT networks. Several ... ...

    Abstract The Internet of Things (IoT) is a rapidly evolving technology with a wide range of potential applications, but the security of IoT networks remains a major concern. The existing system needs improvement in detecting intrusions in IoT networks. Several researchers have focused on intrusion detection systems (IDS) that address only one layer of the three-layered IoT architecture, which limits their effectiveness in detecting attacks across the entire network. To address these limitations, this paper proposes an intelligent IDS for IoT networks based on deep learning algorithms. The proposed model consists of a recurrent neural network and gated recurrent units (RNN-GRU), which can classify attacks across the physical, network, and application layers. The proposed model is trained and tested using the ToN-IoT dataset, specifically collected for a three-layered IoT system, and includes new types of attacks compared to other publicly available datasets. The performance analysis of the proposed model was carried out by a number of evaluation metrics such as accuracy, precision, recall, and F1-measure. Two optimization techniques, Adam and Adamax, were applied in the evaluation process of the model, and the Adam performance was found to be optimal. Moreover, the proposed model was compared with various advanced deep learning (DL) and traditional machine learning (ML) techniques. The results show that the proposed system achieves an accuracy of 99% for network flow datasets and 98% for application layer datasets, demonstrating its superiority over previous IDS models.
    Language English
    Publishing date 2023-09-07
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2265126-3
    ISSN 1551-0018 ; 1551-0018
    ISSN (online) 1551-0018
    ISSN 1551-0018
    DOI 10.3934/mbe.2023602
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Role of socioeconomic and parental involvement factors on children foundational learning skills based on MICS (2017–2018) data Punjab, Pakistan

    Asifa Kamal / Naila Amjad / Uzma Yaqoob / Naz Saud / Muhammad Ijaz / Ilyas Khan / Mulugeta Andualem

    Scientific Reports, Vol 12, Iss 1, Pp 1-

    2022  Volume 13

    Abstract: Abstract Developing countries lack studies investigated the socioeconomic and parental role on students’ learning skills. This study is helpful to detect bottlenecks in the foundational learning skills (reading skills and numeracy skills) in the ... ...

    Abstract Abstract Developing countries lack studies investigated the socioeconomic and parental role on students’ learning skills. This study is helpful to detect bottlenecks in the foundational learning skills (reading skills and numeracy skills) in the education system of Pakistan. Reading skills of children are found better who had no functional disabilities. Mothers with higher education had a significant positive contribution toward children learning skills. Children deprived of books for reading in appropriate language had a negative impact on their reading skills. Rich children had predominantly higher possibilities of good learning skills than poor children. Parents who had not attended children’s school to discuss child progress had a significantly negative effect on children’s numeracy skills. Overall parental involvement in some forms had insignificantly improved children reading and numeracy skills in Punjab, Pakistan.
    Keywords Medicine ; R ; Science ; Q
    Language English
    Publishing date 2022-06-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article: Dietary Oyster Mushroom (

    Nasir, Jamal Abdul / Chand, Naila / Naz, Shabana / Alhidary, Ibrahim A / Khan, Rifat U / Batool, Sajida / Zelai, Noha T / Pugliese, Gianluca / Tufarelli, Vincenzo / Losacco, Caterina

    Animals : an open access journal from MDPI

    2023  Volume 13, Issue 21

    Abstract: The aim of this study was to investigate the potential of dietary 3% oyster mushroom ( ...

    Abstract The aim of this study was to investigate the potential of dietary 3% oyster mushroom (
    Language English
    Publishing date 2023-11-04
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2606558-7
    ISSN 2076-2615
    ISSN 2076-2615
    DOI 10.3390/ani13213421
    Database MEDical Literature Analysis and Retrieval System OnLINE

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