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Article ; Online: Differential roles of RIG-I like receptors in SARS-CoV-2 infection.

Yang, Duo-Meng / Geng, Ting-Ting / Harrison, Andrew G / Wang, Peng-Hua

2021 Volume 8, Issue 1, Page(s) 49

Abstract: Retinoic acid-inducible gene I (RIG-I) and melanoma differentiation-associated protein 5 (MDA5) sense viral RNA and activate antiviral immune responses. Herein we investigate their functions in human epithelial cells, the primary and initial target of ... ...

Abstract	Retinoic acid-inducible gene I (RIG-I) and melanoma differentiation-associated protein 5 (MDA5) sense viral RNA and activate antiviral immune responses. Herein we investigate their functions in human epithelial cells, the primary and initial target of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). A deficiency in MDA5, RIG-I or mitochondrial antiviral signaling protein (MAVS) enhanced viral replication. The expression of the type I/III interferon (IFN) during infection was impaired in MDA5
MeSH term(s)	Adaptor Proteins, Signal Transducing/genetics ; Adaptor Proteins, Signal Transducing/metabolism ; Angiotensin-Converting Enzyme 2/metabolism ; COVID-19/immunology ; Cell Line ; DEAD Box Protein 58/genetics ; DEAD Box Protein 58/metabolism ; Humans ; Interferon Type I/metabolism ; Interferon-Induced Helicase, IFIH1/genetics ; Interferon-Induced Helicase, IFIH1/metabolism ; Interferons/metabolism ; Receptors, Immunologic/genetics ; Receptors, Immunologic/metabolism ; SARS-CoV-2/physiology ; Signal Transduction ; Virus Replication ; Interferon Lambda
Chemical Substances	Adaptor Proteins, Signal Transducing ; Interferon Type I ; MAVS protein, human ; Receptors, Immunologic ; Interferons (9008-11-1) ; ACE2 protein, human (EC 3.4.17.23) ; Angiotensin-Converting Enzyme 2 (EC 3.4.17.23) ; RIGI protein, human (EC 3.6.1.-) ; IFIH1 protein, human (EC 3.6.1.-) ; DEAD Box Protein 58 (EC 3.6.4.13) ; Interferon-Induced Helicase, IFIH1 (EC 3.6.4.13) ; Interferon Lambda
Language	English
Publishing date	2021-09-07
Publishing country	England
Document type	Letter ; Research Support, N.I.H., Extramural
ZDB-ID	2768940-2
ISSN	2054-9369 ; 2054-9369
ISSN (online)	2054-9369
ISSN	2054-9369
DOI	10.1186/s40779-021-00340-5
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Differential roles of RIG-I like receptors in SARS-CoV-2 infection

Duo-Meng Yang / Ting-Ting Geng / Andrew G. Harrison / Peng-Hua Wang

Military Medical Research, Vol 8, Iss 1, Pp 1-

2021 Volume 3

Abstract: Abstract Retinoic acid-inducible gene I (RIG-I) and melanoma differentiation-associated protein 5 (MDA5) sense viral RNA and activate antiviral immune responses. Herein we investigate their functions in human epithelial cells, the primary and initial ... ...

Abstract	Abstract Retinoic acid-inducible gene I (RIG-I) and melanoma differentiation-associated protein 5 (MDA5) sense viral RNA and activate antiviral immune responses. Herein we investigate their functions in human epithelial cells, the primary and initial target of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). A deficiency in MDA5, RIG-I or mitochondrial antiviral signaling protein (MAVS) enhanced viral replication. The expression of the type I/III interferon (IFN) during infection was impaired in MDA5 −/− and MAVS −/−, but not in RIG-I −/−, when compared to wild type (WT) cells. The mRNA level of full-length angiotensin-converting enzyme 2 (ACE2), the cellular entry receptor for SARS-CoV-2, was ~ 2.5-fold higher in RIG-I −/− than WT cells. These data demonstrate MDA5 as the predominant SARS-CoV-2 sensor, IFN-independent induction of ACE2 and anti-SARS-CoV-2 role of RIG-I in epithelial cells.
Keywords	SARS-CoV-2 ; Pathogen pattern recognition receptor ; Melanoma differentiation-associated protein 5 ; Retinoic acid-inducible gene I ; Medicine (General) ; R5-920 ; Military Science ; U
Subject code	570
Language	English
Publishing date	2021-09-01T00:00:00Z
Publisher	BMC
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Study on Rock-Electric Characteristics of Cracked Porous Rocks by the Novel Multifactor Conductivity Model.

Meng, He / Ye, Yueming / Yang, Cun / Dong, Duo

ACS omega

2023 Volume 8, Issue 36, Page(s) 32615–32622

Abstract: Due to the influence of multiple factors on the conductive properties of rocks, the Archie's formula, considering only a single factor, makes it difficult to reasonably explain rock-electric characteristics of cracked porous rocks. In order to better ... ...

Abstract	Due to the influence of multiple factors on the conductive properties of rocks, the Archie's formula, considering only a single factor, makes it difficult to reasonably explain rock-electric characteristics of cracked porous rocks. In order to better describe the conductive mechanism of cracked porous rocks, a generalized multifactor conductivity model was proposed by considering and introducing multiple influencing factors such as the series-parallel structure, conductive matrix, cracks, and fluids, which is conducive to more accurate research on the conductive mechanism of rocks. It should be noted that the developed model is not only applicable to cracked porous rocks but also useful for porous rocks. Through the study and analysis of various influencing factors, it is demonstrated by the simulation results that both the conductive matrix and cracks improve the conductive ability, which are crucial factors resulting in the non-Archie behavior and low-resistivity pay zone, and rock conductivity is more sensitive to the conductive matrix and cracks in tight reservoirs with porosity below 10%. Furthermore, experimental data are available to validate the novel multifactor conductivity model, and the comparison results show its advantages in predicting and explaining the conductive properties of cracked porous rocks.
Language	English
Publishing date	2023-08-30
Publishing country	United States
Document type	Journal Article
ISSN	2470-1343
ISSN (online)	2470-1343
DOI	10.1021/acsomega.3c03193
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Genetic mechanism of body size variation in groupers: Insights from phylotranscriptomics.

Zhang, Wei-Wei / Weng, Zhuo-Ying / Wang, Xi / Yang, Yang / Li, Duo / Wang, Le / Liu, Xiao-Chun / Meng, Zi-Ning

Zoological research

2024 Volume 45, Issue 2, Page(s) 314–328

Abstract: Animal body size variation is of particular interest in evolutionary biology, but the genetic basis remains largely unknown. Previous studies have shown the presence of two parallel evolutionary genetic clusters within the fish ... ...

Abstract	Animal body size variation is of particular interest in evolutionary biology, but the genetic basis remains largely unknown. Previous studies have shown the presence of two parallel evolutionary genetic clusters within the fish genus
MeSH term(s)	Animals ; Bass/genetics ; Phylogeny ; Body Size/genetics ; China ; Genetic Variation
Language	English
Publishing date	2024-03-14
Publishing country	China
Document type	Journal Article
ISSN	2095-8137
ISSN	2095-8137
DOI	10.24272/j.issn.2095-8137.2023.222
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Article: Supplementation of Extender with Melatonin Improves the Motility, Mitochondrial Membrane Potential, and Fertilization Ability of Cryopreserved Brown-Marbled Grouper Sperm.

Ruan, Qingxin / Yang, Sen / Hua, Sijie / Zhang, Weiwei / Li, Duo / Yang, Yang / Wang, Xi / Wang, Qinghua / Meng, Zining

Animals : an open access journal from MDPI

2024 Volume 14, Issue 7

Abstract: Sperm cryopreservation is a valuable tool for breeding, conservation, and genetic improvement in aquatic resources, while oxidative damage will cause a decline in sperm quality during this progress. Melatonin (MT), a natural antioxidant hormone, is used ... ...

Abstract	Sperm cryopreservation is a valuable tool for breeding, conservation, and genetic improvement in aquatic resources, while oxidative damage will cause a decline in sperm quality during this progress. Melatonin (MT), a natural antioxidant hormone, is used as an additive in sperm cryopreservation to reduce cellular damage from oxidative stress. Here, we aimed to investigate the effect of adding MT to the freezing medium in sperm cryopreservation of brown-marbled grouper (
Language	English
Publishing date	2024-03-24
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2606558-7
ISSN	2076-2615
ISSN	2076-2615
DOI	10.3390/ani14070995
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Article ; Online: Efficacy of mouthwash on reducing salivary SARS-CoV-2 viral load and clinical symptoms: a systematic review and meta-analysis.

Zhang, Mingrui / Meng, Nan / Duo, Hong / Yang, Yuanbo / Dong, Qing / Gu, Jianqi

BMC infectious diseases

2023 Volume 23, Issue 1, Page(s) 678

Abstract: Background: COVID-19 has been a public health emergency of international concern (PHEIC) for a lengthy period of time. The novel coronavirus is primarily spread via aerosols at a short distance, with infected individuals releasing large amounts of ... ...

Abstract	Background: COVID-19 has been a public health emergency of international concern (PHEIC) for a lengthy period of time. The novel coronavirus is primarily spread via aerosols at a short distance, with infected individuals releasing large amounts of aerosols when speaking and coughing. However, there is an open question regarding whether mouthwash could effectively reduce virus transmission during the COVID-19 pandemic and support the prevention of infection among medical workers. Methods: Cochrane Library, PubMed, Web of Science, and Embase databases were systematically searched from the inception of each database to January 12, 2023 for currently available randomized clinical trials (RCTs) on the effect of mouthwash on novel coronavirus load in the oral cavity in COVID-19 patients. The treatment group received mouthwash for rinsing the mouth, while the control group received a placebo or distilled water for COVID-19 patients. The primary outcomes were CT value and viral load. Odds ratios (ORs) were estimated using a random-effects model. Subgroup and sensitivity analyses were performed to minimize the bias and the impact of heterogeneity. Results: Thirteen RCTs were included. Seven studies reported the intervention effect of mouthwash on the CT value of novel coronavirus. The analysis results showed that the mouthwash group had a positive impact on the CT value of novel coronavirus [ SMD = 0.35, 95% CI (0.21, 0.50)] compared with the control group. In addition, subgroup analysis showed a significant positive effect of mouthwash on CT values in the treatment group compared with the control group, with chlorhexidine (CHX) [SMD = 0.33, 95% CI (0.10, 0.56)], povidone-iodine (PVP-I) [SMD = 0.61, 95% CI (0.23, 0.99)], or hydrogen peroxide (HP) [SMD = 1.04, 95% CI (0.30, 1.78)] as an ingredient of the mouthwash. Six studies reported the intervention effect of mouthwash on the viral load, 263 cases in the treatment group and 164 cases in the control group. The analysis results showed that there was no statistical difference between the mouthwash group and the control group in the viral load of novel coronavirus [SMD = -0.06, 95% CI (-0.18, 0.05)]. In the subgroup analysis by measurement time, there were statistically significant differences between the mouthwash and control groups for CT values [SMD = 0.52, 95% CI (0.31, 0.72)] and viral load [SMD = - 0.32, 95% CI (- 0.56, - 0.07)] within 30 min of gargling. Conclusions: In summary, mouthwash has some efficacy in reducing the viral load of novel coronavirus, especially within 30 min after rinsing the mouth. Mouthwash containing CHX, PVP-I and HP all had significant positive effects on CT values, and PVP-I-containing mouthwash may be a promising option to control novel coronavirus infections and relieve virus-related symptoms. However, studies on the dose and frequency of use of mouthwash for infection control are still lacking, which may limit the clinical application of mouthwash. Trial registration: Protocol registration: The protocol was registered at PROSPERO (CRD42023401961).
MeSH term(s)	Humans ; Mouthwashes/therapeutic use ; Mouthwashes/adverse effects ; SARS-CoV-2 ; COVID-19 ; Povidone-Iodine ; Viral Load ; Respiratory Aerosols and Droplets ; Chlorhexidine/therapeutic use ; Hydrogen Peroxide
Chemical Substances	Mouthwashes ; Povidone-Iodine (85H0HZU99M) ; Chlorhexidine (R4KO0DY52L) ; Hydrogen Peroxide (BBX060AN9V)
Language	English
Publishing date	2023-10-11
Publishing country	England
Document type	Meta-Analysis ; Systematic Review ; Journal Article
ZDB-ID	2041550-3
ISSN	1471-2334 ; 1471-2334
ISSN (online)	1471-2334
ISSN	1471-2334
DOI	10.1186/s12879-023-08669-z
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Article: The cellular and molecular basis of the spur development in

Li, Yang / Huang, Wu-Lue / Li, Xin-Yi / Zhang, Ying-Duo / Meng, Dan-Chen / Wei, Chun-Mei / Huang, Mei-Juan / Huang, Hai-Quan

Horticulture research

2024 Volume 11, Issue 3, Page(s) uhae015

Abstract: The nectar spur is an important feature of pollination and ecological adaptation in flowering plants, and it is a key innovation to promote species diversity in certain plant lineages. The development mechanism of spurs varies among different plant taxa. ...

Abstract	The nectar spur is an important feature of pollination and ecological adaptation in flowering plants, and it is a key innovation to promote species diversity in certain plant lineages. The development mechanism of spurs varies among different plant taxa. As one of the largest angiosperm genera, we have little understanding of the mechanism of spur development in
Language	English
Publishing date	2024-01-12
Publishing country	England
Document type	Journal Article
ISSN	2662-6810
ISSN	2662-6810
DOI	10.1093/hr/uhae015
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Article ; Online: Prevention of high-fat-diet-induced obesity in mice by soluble dietary fiber from fermented and unfermented millet bran.

Yang, Duo / Shen, Juan / Tang, Chao / Lu, Zhaoxin / Lu, Fengxia / Bie, Xiaomei / Meng, Fanqiang / Zhao, Haizhen

Food research international (Ottawa, Ont.)

2024 Volume 179, Page(s) 113974

Abstract: Obesity-related diabetes, cardiovascular disease, and hypertension pose many risks to human health. Thus, mice on a high-fat diet were gavaged with millet bran (unfermented/fermented) soluble dietary fiber (RSDF/FSDF, 500 mg· ... ...

Abstract	Obesity-related diabetes, cardiovascular disease, and hypertension pose many risks to human health. Thus, mice on a high-fat diet were gavaged with millet bran (unfermented/fermented) soluble dietary fiber (RSDF/FSDF, 500 mg·kg
MeSH term(s)	Mice ; Humans ; Animals ; Diet, High-Fat/adverse effects ; Millets ; Obesity ; Cholesterol ; Dietary Fiber
Chemical Substances	Cholesterol (97C5T2UQ7J) ; Dietary Fiber
Language	English
Publishing date	2024-01-10
Publishing country	Canada
Document type	Journal Article
ZDB-ID	1111695-x
ISSN	1873-7145 ; 0963-9969
ISSN (online)	1873-7145
ISSN	0963-9969
DOI	10.1016/j.foodres.2024.113974
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Article: Anti-tumor effect of coix seed based on the theory of medicinal and food homology.

Meng, Fan-Di / Yuan, Ling / Lu, Dou-Dou / Yang, Ya-Ting / Xu, Duo-Jie / Che, Meng-Ying / Nan, Yi

World journal of clinical oncology

2023 Volume 14, Issue 12, Page(s) 593–605

Abstract: Coix seed is a dry and mature seed ... ...

Abstract	Coix seed is a dry and mature seed of
Language	English
Publishing date	2023-12-05
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2587357-X
ISSN	2218-4333
ISSN	2218-4333
DOI	10.5306/wjco.v14.i12.593
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Article ; Online: Phenylephrine Attenuated Sepsis-Induced Cardiac Inflammation and Mitochondrial Injury Through an Effect on the PI3K/Akt Signaling Pathway.

Li, Hong-Mei / Li, Kai-Ying / Xing, Yun / Tang, Xiang-Xu / Yang, Duo-Meng / Dai, Xiao-Meng / Lu, Da-Xiang / Wang, Hua-Dong

Journal of cardiovascular pharmacology

2019 Volume 73, Issue 3, Page(s) 186–194

Abstract: Objective: To investigate whether phenylephrine (PE) inhibits sepsis-induced cardiac dysfunction, cardiac inflammation, and mitochondrial injury through the PI3K/Akt signaling pathway.: Methods: A rat model of sepsis was established by cecal ligation ...

Abstract	Objective: To investigate whether phenylephrine (PE) inhibits sepsis-induced cardiac dysfunction, cardiac inflammation, and mitochondrial injury through the PI3K/Akt signaling pathway. Methods: A rat model of sepsis was established by cecal ligation and puncture. PE and/or wortmannin (a PI3K inhibitor) were administered to investigate the role of PI3K/Akt signaling in mediating the effects of PE on inhibiting sepsis-induced cardiac dysfunction, cardiac inflammation, and mitochondrial injury. Hematoxylin-eosin staining, echocardiography, and Langendorff system were used to examine the myocardial injury and function. The concentrations of TNF-α and IL-6 were analyzed by enzyme-linked immunosorbent assay. Intercellular cell adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1), myeloperoxidase, mitochondria-related fusion/fission proteins, and PI3K/Akt signaling pathway-associated proteins were analyzed by Western blotting. Results: PE improved the cardiac function and survival in septic rats. PE decreased TNF-α, IL-6, ICAM-1, VCAM-1, and myeloperoxidase contents in the myocardium of septic rats. Meanwhile, PE increased the fusion-related proteins and decreased the fission-related proteins in the myocardial mitochondria of septic rats. On the other hand, PE activated the PI3K/Akt signaling pathway in the cecal ligation and puncture-treated rats, and all the protective effects of PE were abolished by wortmannin. Conclusions: PE attenuated sepsis-induced cardiac dysfunction, cardiac inflammation, and mitochondrial injury through the PI3K/Akt signaling pathway.
MeSH term(s)	Animals ; Disease Models, Animal ; Inflammation Mediators/metabolism ; Isolated Heart Preparation ; Male ; Mitochondria, Heart/drug effects ; Mitochondria, Heart/enzymology ; Mitochondria, Heart/pathology ; Mitochondrial Dynamics/drug effects ; Mitochondrial Proteins/metabolism ; Myocarditis/enzymology ; Myocarditis/etiology ; Myocarditis/pathology ; Myocarditis/prevention & control ; Myocytes, Cardiac/drug effects ; Myocytes, Cardiac/enzymology ; Myocytes, Cardiac/pathology ; Peroxidase/metabolism ; Phenylephrine/pharmacology ; Phosphatidylinositol 3-Kinase/metabolism ; Proto-Oncogene Proteins c-akt/metabolism ; Rats, Sprague-Dawley ; Sepsis/complications ; Sepsis/drug therapy ; Signal Transduction ; Stroke Volume/drug effects ; Ventricular Function, Left
Chemical Substances	Inflammation Mediators ; Mitochondrial Proteins ; Phenylephrine (1WS297W6MV) ; Peroxidase (EC 1.11.1.7) ; Phosphatidylinositol 3-Kinase (EC 2.7.1.137) ; Proto-Oncogene Proteins c-akt (EC 2.7.11.1)
Language	English
Publishing date	2019-03-20
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	391970-5
ISSN	1533-4023 ; 0160-2446
ISSN (online)	1533-4023
ISSN	0160-2446
DOI	10.1097/FJC.0000000000000651
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