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  1. Article: Prof. Chun Chen: preoperative planning is essential in a segmental resection.

    Gao, Chen / Chapnick, Jeremy Dean

    Journal of thoracic disease

    2018  Volume 10, Issue 12, Page(s) E850–E852

    Language English
    Publishing date 2018-03-27
    Publishing country China
    Document type News
    ZDB-ID 2573571-8
    ISSN 2077-6624 ; 2072-1439
    ISSN (online) 2077-6624
    ISSN 2072-1439
    DOI 10.21037/jtd.2018.12.34
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: New inhibitors of α-glucosidase in Salacia hainanensis Chun et How.

    Guo, Zheng-hong / Huang, Jian / Wan, Guo-sheng / Huo, Xiao-ling / Gao, Hui-yuan

    Journal of natural medicines

    2013  Volume 67, Issue 4, Page(s) 844–849

    Abstract: The methanol extract from roots of Salacia hainanensis Chun et How afforded three new compounds, 24 ...

    Abstract The methanol extract from roots of Salacia hainanensis Chun et How afforded three new compounds, 24,26-dihydroxy-25-methoxy-tirucall-9-en-3-one (1), 2β,3β,22α-trihydroxy-lup-20(29)-ene (2) and 3β-hydroxy-2-carbonyl-lupan-29-oic acid (3), along with six known triterpenoids (4-9). Their structures were established on the basis of spectral analysis, in particular according to the data obtained by two-dimensional-NMR and high-resolution mass spectra experiments. Some of them showed much stronger inhibitory activity towards α-glucosidase than the positive control (acarbose, IC₅₀ 10.2 μM).
    MeSH term(s) Enzyme Inhibitors/chemistry ; Enzyme Inhibitors/pharmacology ; Glycoside Hydrolase Inhibitors ; Plant Roots/chemistry ; Salacia/chemistry ; Triterpenes/chemistry ; Triterpenes/pharmacology
    Chemical Substances Enzyme Inhibitors ; Glycoside Hydrolase Inhibitors ; Triterpenes
    Language English
    Publishing date 2013-01-30
    Publishing country Japan
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2227540-X
    ISSN 1861-0293 ; 1340-3443
    ISSN (online) 1861-0293
    ISSN 1340-3443
    DOI 10.1007/s11418-013-0744-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2692: Show issues Location:
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  3. Article: [A new trincallane derivative from Salacia hainanensis Chun et How].

    Guo, Zheng-Hong / Xi, Rong-Gang / Wang, Xiao-Bo / Wu, Li-Jun / Gao, Hui-Yuan

    Yao xue xue bao = Acta pharmaceutica Sinica

    2009  Volume 44, Issue 10, Page(s) 1123–1126

    Abstract: Chemical constituents of the roots and stem of Salacia hainanensis Chun et How were isolated and ...

    Abstract Chemical constituents of the roots and stem of Salacia hainanensis Chun et How were isolated and purified with column chromatography on silica gel, Sephadex LH-20 and preparative HPLC. Their structures were elucidated based on physicochemical and spectral spectroscopic analysis. Depending on the activities of anti-alpha-glucosidase and inhibiting AGEs (advanced glycation end products, AGEs) formation in vitro, nine compounds were identified as 26, 27-dihydroxy-7, 24-tirucalladien-3-one (1), abruslactone A (2), lupeol (3), 21alpha, 30-dihydroxy-D: A-friedooleanan-3-one (4), 15alpha-hydroxyfriedelan-3-one (5), friedelin (6), mangiferin (7), epicatechin (8) and beta-sitosterol (9), separately. Among them, compound 1 is a new compound, and compound 2 was isolated from the Salacia genus for the first time, while, compounds 3, 4, 5, 8 were obtained from this plant for the first time.
    MeSH term(s) Catechin/analogs & derivatives ; Catechin/chemistry ; Catechin/isolation & purification ; Molecular Structure ; Pentacyclic Triterpenes/chemistry ; Pentacyclic Triterpenes/isolation & purification ; Plant Roots/chemistry ; Plant Stems/chemistry ; Plants, Medicinal/chemistry ; Salacia/chemistry ; Steroids/chemistry ; Steroids/isolation & purification ; Triterpenes/chemistry ; Triterpenes/isolation & purification ; Xanthones/chemistry ; Xanthones/isolation & purification
    Chemical Substances 26,27-dihydroxy-7,24-tirucalladien-3-one ; Pentacyclic Triterpenes ; Steroids ; Triterpenes ; Xanthones ; abruslactone A ; mangiferin (1M84LD0UMD) ; Catechin (8R1V1STN48) ; friedelin (AK21264UAD) ; lupeol (O268W13H3O)
    Language Chinese
    Publishing date 2009-10
    Publishing country China
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 788758-9
    ISSN 0513-4870
    ISSN 0513-4870
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.B 3194: Show issues Location:
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  4. Article: New inhibitors of α-glucosidase in Salacia hainanensis Chun et How

    Guo, Zheng-hong / Huang, Jian / Wan, Guo-sheng / Huo, Xiao-ling / Gao, Hui-Yuan

    Natural medicines. 2013 Oct., v. 67, no. 4

    2013  

    Abstract: The methanol extract from roots of Salacia hainanensis Chun et How afforded three new compounds, 24 ...

    Abstract The methanol extract from roots of Salacia hainanensis Chun et How afforded three new compounds, 24,26-dihydroxy-25-methoxy-tirucall-9-en-3-one (1), 2β,3β,22α-trihydroxy-lup-20(29)-ene (2) and 3β-hydroxy-2-carbonyl-lupan-29-oic acid (3), along with six known triterpenoids (4–9). Their structures were established on the basis of spectral analysis, in particular according to the data obtained by two-dimensional-NMR and high-resolution mass spectra experiments. Some of them showed much stronger inhibitory activity towards α-glucosidase than the positive control (acarbose, IC₅₀ 10.2� μM).
    Keywords acarbose ; alpha-glucosidase ; inhibitory concentration 50 ; methanol ; roots ; spectral analysis ; triterpenoids
    Language English
    Dates of publication 2013-10
    Size p. 844-849.
    Publishing place Springer-Verlag
    Document type Article
    ZDB-ID 1201350-x
    ISSN 1340-3443
    ISSN 1340-3443
    DOI 10.1007/s11418-013-0744-5
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2692: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: New triterpenes from Salacia hainanensis Chun et How with α-glucosidase inhibitory activity.

    Gao, Hui-Yuan / Guo, Zheng-Hong / Cheng, Peng / Xu, Xiao-Min / Wu, Li-Jun

    Journal of Asian natural products research

    2010  Volume 12, Issue 10, Page(s) 834–842

    Abstract: Fractionation of the methanol extract from the roots of Salacia hainanensis Chun et How showing ...

    Abstract Fractionation of the methanol extract from the roots of Salacia hainanensis Chun et How showing the potent inhibitory activity on α-glucosidase afforded two new lupane derivatives, 3α,28-dihydroxy-lup-20(29)-en-2-one (1) and 3α-hydroxy-lup-20(29)-en-2-one (2), a new friedelane derivative, D:A-friedo-oleanane-7α,30-dihydroxy-3-one (3), and a novel natural product, 2,3-seco-lup-20(29)-en-2,3-dioic acid (4), along with four known compounds (5-8). Their structures were established on the basis of spectral analysis, especially on the data afforded by 2D NMR and high-resolution mass spectra experiments. All of them showed a much stronger inhibiting activity on α-glucosidase than the positive control (acarbose, IC₅₀ = 5.83 μM). Constituents with α-glucosidase inhibitory activity from this plant are reported for the first time.
    MeSH term(s) Dose-Response Relationship, Drug ; Drugs, Chinese Herbal/chemistry ; Drugs, Chinese Herbal/isolation & purification ; Drugs, Chinese Herbal/pharmacology ; Glycoside Hydrolase Inhibitors ; Inhibitory Concentration 50 ; Molecular Structure ; Nuclear Magnetic Resonance, Biomolecular ; Plant Roots/chemistry ; Salacia/chemistry ; Stereoisomerism ; Triterpenes/chemistry ; Triterpenes/isolation & purification ; Triterpenes/pharmacology
    Chemical Substances Drugs, Chinese Herbal ; Glycoside Hydrolase Inhibitors ; Triterpenes ; lupane (464-99-3)
    Language English
    Publishing date 2010-10
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2077926-4
    ISSN 1477-2213 ; 1028-6020
    ISSN (online) 1477-2213
    ISSN 1028-6020
    DOI 10.1080/10286020.2010.503653
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Emerging Roles of RNA Methylation in Development.

    Wang, Meng-Ke / Gao, Chun-Chun / Yang, Yun-Gui

    Accounts of chemical research

    2023  Volume 56, Issue 23, Page(s) 3417–3427

    Abstract: More than 170 different types of chemical modifications have been identified on diverse types of RNA, collectively known as the epitranscriptome. Among them, ...

    Abstract More than 170 different types of chemical modifications have been identified on diverse types of RNA, collectively known as the epitranscriptome. Among them,
    MeSH term(s) Animals ; Methylation ; RNA/genetics ; RNA/metabolism ; RNA, Messenger/metabolism ; Methyltransferases/genetics ; Methyltransferases/metabolism ; Cell Differentiation ; RNA Processing, Post-Transcriptional ; Mammals/genetics ; Mammals/metabolism
    Chemical Substances RNA (63231-63-0) ; RNA, Messenger ; Methyltransferases (EC 2.1.1.-)
    Language English
    Publishing date 2023-11-15
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1483291-4
    ISSN 1520-4898 ; 0001-4842
    ISSN (online) 1520-4898
    ISSN 0001-4842
    DOI 10.1021/acs.accounts.3c00448
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: The "Hand as Foot" teaching method in larynx.

    Yang, Chun / Gao, Yan

    Asian journal of surgery

    2023  Volume 46, Issue 7, Page(s) 2952–2953

    MeSH term(s) Humans ; Larynx ; Hand ; Upper Extremity ; Foot ; Lower Extremity
    Language English
    Publishing date 2023-02-24
    Publishing country Netherlands
    Document type Letter
    ZDB-ID 1068461-x
    ISSN 0219-3108 ; 1015-9584
    ISSN (online) 0219-3108
    ISSN 1015-9584
    DOI 10.1016/j.asjsur.2023.02.029
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 2831: Show issues Location:
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  8. Article: Gallium-Based Liquid Metal Materials for Antimicrobial Applications.

    Qu, Chun-Chun / Liang, Yu-Tong / Wang, Xi-Qing / Gao, Shang / He, Zhi-Zhu / Sun, Xu-Yang

    Bioengineering (Basel, Switzerland)

    2022  Volume 9, Issue 9

    Abstract: The hazards caused by drug-resistant bacteria are rocketing along with the indiscriminate use of antibiotics. The development of new non-antibiotic antibacterial drugs is urgent. The excellent biocompatibility and diverse multifunctionalities of liquid ... ...

    Abstract The hazards caused by drug-resistant bacteria are rocketing along with the indiscriminate use of antibiotics. The development of new non-antibiotic antibacterial drugs is urgent. The excellent biocompatibility and diverse multifunctionalities of liquid metal have stimulated the studies of antibacterial application. Several gallium-based antimicrobial agents have been developed based on the mechanism that gallium (a type of liquid metal) ions disorder the normal metabolism of iron ions. Other emerging strategies, such as physical sterilization by directly using LM microparticles to destroy the biofilm of bacteria or thermal destruction via infrared laser irradiation, are gaining increasing attention. Different from traditional antibacterial agents of gallium compounds, the pronounced property of gallium-based liquid metal materials would bring innovation to the antibacterial field. Here, LM-based antimicrobial mechanisms, including iron metabolism disorder, production of reactive oxygen species, thermal injury, and mechanical destruction, are highlighted. Antimicrobial applications of LM-based materials are summarized and divided into five categories, including liquid metal motors, antibacterial fabrics, magnetic field-responsive microparticles, liquid metal films, and liquid metal polymer composites. In addition, future opportunities and challenges towards the development and application of LM-based antimicrobial materials are presented.
    Language English
    Publishing date 2022-08-25
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2746191-9
    ISSN 2306-5354
    ISSN 2306-5354
    DOI 10.3390/bioengineering9090416
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: scm

    Yao, Huan / Gao, Chun-Chun / Zhang, Danru / Xu, Jiawei / Song, Gege / Fan, Xiu / Liang, Dao-Bo / Chen, Yu-Sheng / Li, Qian / Guo, Yanjie / Cai, Yu-Ting / Hu, Lulu / Zhao, Yong-Liang / Sun, Ying-Pu / Yang, Ying / Han, Jianyong / Yang, Yun-Gui

    Nature communications

    2023  Volume 14, Issue 1, Page(s) 315

    Abstract: ... ...

    Abstract N
    MeSH term(s) Animals ; Oogenesis ; Oocytes/metabolism ; Embryonic Development/genetics ; Transcriptome/genetics ; RNA/metabolism ; Mammals/genetics
    Chemical Substances RNA (63231-63-0)
    Language English
    Publishing date 2023-01-19
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-023-35958-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: In vivo

    Zhou, Peng / Gao, Ge / Zhao, Chun-Chun / Li, Jing-Ya / Peng, Jian-Fei / Wang, Shu-Shu / Song, Rui / Shi, Hui / Wang, Liang

    Pharmaceutical biology

    2022  Volume 60, Issue 1, Page(s) 638–651

    Abstract: Context: Shengmai injection (SMI) has been used to treat heart failure.: Objective: This study determines the molecular mechanisms of SMI against cardiotoxicity caused by doxorubicin (DOX).: Materials and methods: In vivo: Results: SMI markedly ...

    Abstract Context: Shengmai injection (SMI) has been used to treat heart failure.
    Objective: This study determines the molecular mechanisms of SMI against cardiotoxicity caused by doxorubicin (DOX).
    Materials and methods: In vivo
    Results: SMI markedly improved cardiac pathology, decreased cardiomyocyte apoptosis, increased creatine kinase (CK), lactate dehydrogenase (LDH), malondialdehyde (MDA), decreased superoxide dismutase (SOD). Compared with the model group, the protein expression of nuclear factor erythroid2-related factor 2 (Nrf2) (SMI-L: 2.42-fold, SMI-M: 2.67-fold, SMI-H: 3.07-fold) and haem oxygenase-1(HO-1) (SMI-L: 1.64-fold, SMI-M: 2.01-fold, SMI-H: 2.19-fold) was increased and the protein expression of kelch-like ECH-associated protein 1 (Keap1) (SMI-L: 0.90-fold, SMI-M: 0.77-fold, SMI-H: 0.66-fold) was decreased in SMI groups and Dex group
    Conclusions: This study revealed a new mechanism by which SMI alleviates DOX-induced 45 cardiomyopathy by modulating the Nrf2/Keap1 signal pathway.
    MeSH term(s) Animals ; Apoptosis/drug effects ; Cardiotoxicity/prevention & control ; Cells, Cultured ; Doxorubicin/toxicity ; Drug Combinations ; Drugs, Chinese Herbal/chemistry ; Drugs, Chinese Herbal/pharmacology ; Kelch-Like ECH-Associated Protein 1/chemistry ; Kelch-Like ECH-Associated Protein 1/physiology ; Molecular Docking Simulation ; Myocardium/pathology ; NF-E2-Related Factor 2/antagonists & inhibitors ; NF-E2-Related Factor 2/physiology ; Rats ; Rats, Sprague-Dawley ; Signal Transduction/drug effects
    Chemical Substances Drug Combinations ; Drugs, Chinese Herbal ; KEAP1 protein, rat ; Kelch-Like ECH-Associated Protein 1 ; NF-E2-Related Factor 2 ; Nfe2l2 protein, rat ; fructus schizandrae, radix ginseng, radix ophiopogonis drug combination ; Doxorubicin (80168379AG)
    Language English
    Publishing date 2022-03-17
    Publishing country England
    Document type Journal Article
    ZDB-ID 1440131-9
    ISSN 1744-5116 ; 1388-0209
    ISSN (online) 1744-5116
    ISSN 1388-0209
    DOI 10.1080/13880209.2022.2046801
    Database MEDical Literature Analysis and Retrieval System OnLINE

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