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Article ; Online: Prognostic significance of soluble CD25 in patients with sepsis: a prospective observational study.

Huang, Chun-Mei / Xu, Xin-Jie / Qi, Wen-Qi / Ge, Qin-Min

Clinical chemistry and laboratory medicine

2022 Volume 60, Issue 6, Page(s) 952–958

Abstract: Objectives: The diagnosis of sepsis is challenging, the need for sensitive and specific diagnostic and prognostic biomarkers has not been met. Soluble CD25 (sCD25) is a readily available biomarker reported to represent the severity of the disease. This ... ...

Abstract	Objectives: The diagnosis of sepsis is challenging, the need for sensitive and specific diagnostic and prognostic biomarkers has not been met. Soluble CD25 (sCD25) is a readily available biomarker reported to represent the severity of the disease. This study aimed to assess the association between sCD25 and mortality in patients with sepsis. Methods: In total, 329 adult patients with sepsis were screened through a prospective, observational study. We investigated the severity scores and sCD25 levels at admission to the intensive care unit (ICU), defined by sepsis (sepsis-3). The prognostic value of sCD25 was assessed using receiver operating characteristic (ROC) curves and binary logistic regression models in predicting unfavourable outcome. The correlations between variables and severity of disease were analysed by Spearman correlation tests. Results: After entering the ICU, the sCD25 level and sequential organ failure assessment (SOFA) score were significantly higher in nonsurvivors than in survivors. The prognostic values estimated by the ROC curves were 0.678 for sCD25 and 0.945 for SOFA score at ICU admission. sCD25 had a modest ability to predict poor outcome. Logistic regression showed that increased levels of sCD25 were independently associated with unfavourable outcome. Spearman correlation tests showed that sCD25 levels were positively correlated with disease severity. Conclusions: In sepsis patients, increased sCD25 levels were independently associated with poor clinical outcomes. Further research is needed to improve the understanding of the pathophysiology of this relationship.
MeSH term(s)	Adult ; Humans ; Intensive Care Units ; Organ Dysfunction Scores ; Prognosis ; Prospective Studies ; ROC Curve ; Retrospective Studies ; Sepsis/diagnosis
Language	English
Publishing date	2022-02-28
Publishing country	Germany
Document type	Journal Article ; Observational Study
ZDB-ID	1418007-8
ISSN	1437-4331 ; 1434-6621 ; 1437-8523
ISSN (online)	1437-4331
ISSN	1434-6621 ; 1437-8523
DOI	10.1515/cclm-2022-0068
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Zs.A 121: Show issues

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Article ; Online: Expression profiling and ontology analysis of circulating long non-coding RNAs in septic acute kidney injury patients.

Chun-Mei, Huang / Qin-Min, Ge / Shu-Ming, Pan / Xiang-Yang, Zhu

Clinical chemistry and laboratory medicine

2016 Volume 54, Issue 12, Page(s) e395–e399

MeSH term(s)	Acute Kidney Injury/blood ; Acute Kidney Injury/genetics ; Gene Expression Profiling ; Gene Ontology ; Humans ; Oligonucleotide Array Sequence Analysis ; RNA, Long Noncoding/blood ; RNA, Long Noncoding/genetics ; Sepsis/blood
Chemical Substances	RNA, Long Noncoding
Language	English
Publishing date	2016-12-01
Publishing country	Germany
Document type	Letter
ZDB-ID	1418007-8
ISSN	1437-4331 ; 1434-6621 ; 1437-8523
ISSN (online)	1437-4331
ISSN	1434-6621 ; 1437-8523
DOI	10.1515/cclm-2015-1281
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Zs.A 121: Show issues

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Article ; Online: Identification of important gene signatures in schizophrenia through feature fusion and genetic algorithm.

Chen, Zhixiong / Ge, Ruiquan / Wang, Changmiao / Elazab, Ahmed / Fu, Xianjun / Min, Wenwen / Qin, Feiwei / Jia, Gangyong / Fan, Xiaopeng

Mammalian genome : official journal of the International Mammalian Genome Society

2024

Abstract: Schizophrenia is a debilitating psychiatric disorder that can significantly affect a patient's quality of life and lead to permanent brain damage. Although medical research has identified certain genetic risk factors, the specific pathogenesis of the ... ...

Abstract	Schizophrenia is a debilitating psychiatric disorder that can significantly affect a patient's quality of life and lead to permanent brain damage. Although medical research has identified certain genetic risk factors, the specific pathogenesis of the disorder remains unclear. Despite the prevalence of research employing magnetic resonance imaging, few studies have focused on the gene level and gene expression profile involving a large number of screened genes. However, the high dimensionality of genetic data presents a great challenge to accurately modeling the data. To tackle the current challenges, this study presents a novel feature selection strategy that utilizes heuristic feature fusion and a multi-objective optimization genetic algorithm. The goal is to improve classification performance and identify the key gene subset for schizophrenia diagnostics. Traditional gene screening techniques are inadequate for accurately determining the precise number of key genes associated with schizophrenia. Our innovative approach integrates a filter-based feature selection method to reduce data dimensionality and a multi-objective optimization genetic algorithm for improved classification tasks. By combining the filtering and wrapper methods, our strategy leverages their respective strengths in a deliberate manner, leading to superior classification accuracy and a more efficient selection of relevant genes. This approach has demonstrated significant improvements in classification results across 11 out of 14 relevant datasets. The performance on the remaining three datasets is comparable to the existing methods. Furthermore, visual and enrichment analyses have confirmed the practicality of our proposed method as a promising tool for the early detection of schizophrenia.
Language	English
Publishing date	2024-03-21
Publishing country	United States
Document type	Journal Article
ZDB-ID	1058547-3
ISSN	1432-1777 ; 0938-8990
ISSN (online)	1432-1777
ISSN	0938-8990
DOI	10.1007/s00335-024-10034-7
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Zs.A 3489: Show issues

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Article ; Online: Differentially expressed miRNAs in sepsis-induced acute kidney injury target oxidative stress and mitochondrial dysfunction pathways.

Qin-Min Ge / Chun-Mei Huang / Xiang-Yang Zhu / Fan Bian / Shu-Ming Pan

PLoS ONE, Vol 12, Iss 3, p e

2017 Volume 0173292

Abstract: OBJECTIVE:To identify specific miRNAs involved in sepsis-induced AKI and to explore their targeting pathways. METHODS:The expression profiles of miRNAs in serum from patients with sepsis-induced AKI (n = 6), sepsis-non AKI (n = 6), and healthy volunteers ...

Abstract	OBJECTIVE:To identify specific miRNAs involved in sepsis-induced AKI and to explore their targeting pathways. METHODS:The expression profiles of miRNAs in serum from patients with sepsis-induced AKI (n = 6), sepsis-non AKI (n = 6), and healthy volunteers (n = 3) were investigated by microarray assay and validated by quantitative PCR (qPCR). The targets of the differentially expressed miRNAs were predicted by Target Scan, mirbase and Miranda. Then the significant functions and involvement in signaling pathways of gene ontology (GO) and KEGG pathways were analyzed. Furthermore, eight miRNAs were randomly selected out of the differentially expressed miRNAs for further testing by qPCR. RESULTS:qPCR analysis confirmed that the expressions levels of hsa-miR-23a-3p, hsa-miR-4456, hsa-miR-142-5p, hsa-miR-22-3p and hsa-miR-191-5p were significantly lower in patients with sepsis compared with the healthy volunteers, while hsa-miR-4270, hsa-miR-4321, hsa-miR-3165 were higher in the sepsis patients. Statistically, miR-4321; miR-4270 were significantly upregulated in the sepsis-induced AKI compared with sepsis-non AKI, while only miR-4321 significantly overexpressed in the sepsis groups compared with control groups. GO analysis showed that biological processes regulated by the predicted target genes included diverse terms. They were related to kidney development, regulation of nitrogen compound metabolic process, regulation of cellular metabolic process, cellular response to oxidative stress, mitochondrial outer membrane permeabilization, etc. Pathway analysis showed that several significant pathways of the predicted target genes related to oxidative stress. miR-4321 was involved in regulating AKT1, mTOR and NOX5 expression while miR-4270 was involved in regulating PPARGC1A, AKT3, NOX5, PIK3C3, WNT1 expression. Function and pathway analysis highlighted the possible involvement of miRNA-deregulated mRNAs in oxidative stress and mitochondrial dysfunction. CONCLUSION:This study might help to improve understanding of the ...
Keywords	Medicine ; R ; Science ; Q
Subject code	500
Language	English
Publishing date	2017-01-01T00:00:00Z
Publisher	Public Library of Science (PLoS)
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Successful interventional treatment of arteriovenous fistula complicating percutaneous renal biopsy.

Xie, Yun / Ge, Qin-Min / Bian, Fan

VASA. Zeitschrift fur Gefasskrankheiten

2013 Volume 42, Issue 2, Page(s) 149–152

MeSH term(s)	Adult ; Arteriovenous Fistula/diagnosis ; Arteriovenous Fistula/etiology ; Arteriovenous Fistula/therapy ; Biopsy/adverse effects ; Embolization, Therapeutic ; Glomerulonephritis, IGA/pathology ; Hematuria/etiology ; Humans ; Kidney/blood supply ; Kidney/diagnostic imaging ; Kidney/pathology ; Male ; Renal Artery/diagnostic imaging ; Renal Veins/diagnostic imaging ; Tomography, X-Ray Computed ; Treatment Outcome ; Ultrasonography
Language	English
Publishing date	2013-03
Publishing country	Switzerland
Document type	Case Reports ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	120977-2
ISSN	1664-2872 ; 0301-1526
ISSN (online)	1664-2872
ISSN	0301-1526
DOI	10.1024/0301-1526/a000261
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Zs.A 808: Show issues

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Article ; Online: Yellow mealworm (Tenebrio Molitor) enhances intestinal immunity in largemouth bass (Micropterus salmoides) via the NFκB/survivin signaling pathway.

Ge, Chunyu / Liang, Xiaofang / Wu, Xiaoliang / Wang, Jie / Wang, Hao / Qin, Yuchang / Xue, Min

Fish & shellfish immunology

2023 Volume 136, Page(s) 108736

Abstract: This study aimed to elucidate the mechanisms of yellow mealworm (Tenebrio Molitor, YM) in intestinal immunity and health. Largemouth bass, as an enteritis modeling animal, were fed 3 diets containing YM at 0% (YM0), 24% (YM24) and 48% (YM48). The YM24 ... ...

Abstract	This study aimed to elucidate the mechanisms of yellow mealworm (Tenebrio Molitor, YM) in intestinal immunity and health. Largemouth bass, as an enteritis modeling animal, were fed 3 diets containing YM at 0% (YM0), 24% (YM24) and 48% (YM48). The YM24 group had reduced levels of proinflammatory cytokines, while the YM48 group experienced a negative impact on intestinal health. Next, the Edwardsiella tarda (E. tarda) challenge test consisted of 4 YM diets, 0% (EYM0), 12% (EYM12), 24% (EYM24), and 36% (EYM36). The EYM0 and EYM12 groups exhibited intestinal damage and immunosuppression by the pathogenic bacteria. However, the above adverse phenotypes were attenuated in the EYM24 and EYM36 groups. Mechanistically, the EYM24 and EYM36 groups enhanced intestinal immunity in largemouth bass via activating NFκBp65 and further upregulating survivin expression to inhibit apoptosis. The results identify a protective mechanism of YM as a novel food or feed source by improving intestinal health.
MeSH term(s)	Animals ; Bass/genetics ; Tenebrio ; Survivin ; Diet/veterinary ; Signal Transduction
Chemical Substances	Survivin
Language	English
Publishing date	2023-04-11
Publishing country	England
Document type	Journal Article
ZDB-ID	1067738-0
ISSN	1095-9947 ; 1050-4648
ISSN (online)	1095-9947
ISSN	1050-4648
DOI	10.1016/j.fsi.2023.108736
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Z 5917: Show issues

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Article ; Online: Comparison of methods for activating sesame stalk lignin biochar for removing benzo[a]pyrene from sesame oil.

Qin, Zhi / Yang, Qiao-Li / Fan, Wei / Wang, Ying-Ge / Fei, Jia-Lin / Yuan, Jing-Yang / Qin, Zhao / Liu, Hua-Min / Mei, Hong-Xian / Wang, Xue-De

International journal of biological macromolecules

2024 Volume 266, Issue Pt 1, Page(s) 131208

Abstract: In this study, three activators and two activation methods were employed to activate sesame lignin-based biochar. The biochar samples were comprehensively characterized, their abilities to adsorb benzo[a]pyrene (BaP) from sesame oil were assessed, and ... ...

Abstract	In this study, three activators and two activation methods were employed to activate sesame lignin-based biochar. The biochar samples were comprehensively characterized, their abilities to adsorb benzo[a]pyrene (BaP) from sesame oil were assessed, and the mechanism was analyzed. The results showed that the biochar obtained by one-step activation was more effective in removing BaP from sesame oil than the biochar produced by two-step activation. Among them, the biochar generated by one-step activation with ZnCl
MeSH term(s)	Charcoal/chemistry ; Lignin/chemistry ; Benzo(a)pyrene/chemistry ; Adsorption ; Sesame Oil/chemistry ; Sesamum/chemistry ; Zinc Compounds/chemistry ; Chlorides/chemistry
Chemical Substances	biochar ; Charcoal (16291-96-6) ; Lignin (9005-53-2) ; Benzo(a)pyrene (3417WMA06D) ; Sesame Oil (8008-74-0) ; zinc chloride (86Q357L16B) ; Zinc Compounds ; Chlorides
Language	English
Publishing date	2024-03-28
Publishing country	Netherlands
Document type	Journal Article ; Comparative Study
ZDB-ID	282732-3
ISSN	1879-0003 ; 0141-8130
ISSN (online)	1879-0003
ISSN	0141-8130
DOI	10.1016/j.ijbiomac.2024.131208
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Zs.B 2374: Show issues

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Article ; Online: Differentially expressed miRNAs in sepsis-induced acute kidney injury target oxidative stress and mitochondrial dysfunction pathways.

Ge, Qin-Min / Huang, Chun-Mei / Zhu, Xiang-Yang / Bian, Fan / Pan, Shu-Ming

PloS one

2017 Volume 12, Issue 3, Page(s) e0173292

Abstract: Objective: To identify specific miRNAs involved in sepsis-induced AKI and to explore their targeting pathways.: Methods: The expression profiles of miRNAs in serum from patients with sepsis-induced AKI (n = 6), sepsis-non AKI (n = 6), and healthy ... ...

Abstract	Objective: To identify specific miRNAs involved in sepsis-induced AKI and to explore their targeting pathways. Methods: The expression profiles of miRNAs in serum from patients with sepsis-induced AKI (n = 6), sepsis-non AKI (n = 6), and healthy volunteers (n = 3) were investigated by microarray assay and validated by quantitative PCR (qPCR). The targets of the differentially expressed miRNAs were predicted by Target Scan, mirbase and Miranda. Then the significant functions and involvement in signaling pathways of gene ontology (GO) and KEGG pathways were analyzed. Furthermore, eight miRNAs were randomly selected out of the differentially expressed miRNAs for further testing by qPCR. Results: qPCR analysis confirmed that the expressions levels of hsa-miR-23a-3p, hsa-miR-4456, hsa-miR-142-5p, hsa-miR-22-3p and hsa-miR-191-5p were significantly lower in patients with sepsis compared with the healthy volunteers, while hsa-miR-4270, hsa-miR-4321, hsa-miR-3165 were higher in the sepsis patients. Statistically, miR-4321; miR-4270 were significantly upregulated in the sepsis-induced AKI compared with sepsis-non AKI, while only miR-4321 significantly overexpressed in the sepsis groups compared with control groups. GO analysis showed that biological processes regulated by the predicted target genes included diverse terms. They were related to kidney development, regulation of nitrogen compound metabolic process, regulation of cellular metabolic process, cellular response to oxidative stress, mitochondrial outer membrane permeabilization, etc. Pathway analysis showed that several significant pathways of the predicted target genes related to oxidative stress. miR-4321 was involved in regulating AKT1, mTOR and NOX5 expression while miR-4270 was involved in regulating PPARGC1A, AKT3, NOX5, PIK3C3, WNT1 expression. Function and pathway analysis highlighted the possible involvement of miRNA-deregulated mRNAs in oxidative stress and mitochondrial dysfunction. Conclusion: This study might help to improve understanding of the relationship between serum miRNAs and sepsis-induced AKI, and laid an important foundation for further identification of the potential mechanisms of sepsis-induced AKI and oxidative stress and mitochondrial dysfunction.
MeSH term(s)	Acute Kidney Injury/etiology ; Acute Kidney Injury/genetics ; Aged ; Cytokines/blood ; Female ; Humans ; Male ; MicroRNAs/blood ; MicroRNAs/genetics ; Middle Aged ; Mitochondria/metabolism ; Oligonucleotide Array Sequence Analysis ; Oxidative Stress ; Real-Time Polymerase Chain Reaction ; Sepsis/complications ; Sepsis/genetics
Chemical Substances	Cytokines ; MicroRNAs
Language	English
Publishing date	2017-03-15
Publishing country	United States
Document type	Journal Article
ISSN	1932-6203
ISSN (online)	1932-6203
DOI	10.1371/journal.pone.0173292
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Design of a single-center, phase II trial to explore the efficacy and safety of 'R-ISV-RO' treatment in advanced tumors.

Min, Limei / Wang, Xiaolu / Chen, Anni / Zhou, Yingling / Ge, Yuchen / Dai, Juanjuan / Chang, Xiaofeng / Sun, Wu / Liu, Qin / Zhou, Xia / Tian, Manman / Kong, Wentao / Zhu, Junmeng / Shen, Jie / Liu, Baorui / Li, Rutian

Future oncology (London, England)

2024

Abstract: Background: ...

Abstract	Background:
Language	English
Publishing date	2024-03-06
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2274956-1
ISSN	1744-8301 ; 1479-6694
ISSN (online)	1744-8301
ISSN	1479-6694
DOI	10.2217/fon-2023-0962
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Zs.A 6478: Show issues

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Article: Macroscopic handedness inversion of terbium coordination polymers achieved by doping homochiral ligand analogues.

Wang, Chang-Yu / Jia, Jia-Ge / Weng, Guo-Guo / Qin, Ming-Feng / Xu, Kui / Zheng, Li-Min

Chemical science

2023 Volume 14, Issue 39, Page(s) 10892–10901

Abstract: Inspired by natural biological systems, chiral or handedness inversion by altering external and internal conditions to influence intermolecular interactions is an attractive topic for regulating chiral self-assembled materials. For coordination polymers, ...

Abstract	Inspired by natural biological systems, chiral or handedness inversion by altering external and internal conditions to influence intermolecular interactions is an attractive topic for regulating chiral self-assembled materials. For coordination polymers, the regulation of their helical handedness remains little reported compared to polymers and supramolecules. In this work, we choose the chiral ligands
Language	English
Publishing date	2023-09-15
Publishing country	England
Document type	Journal Article
ZDB-ID	2559110-1
ISSN	2041-6539 ; 2041-6520
ISSN (online)	2041-6539
ISSN	2041-6520
DOI	10.1039/d3sc03230b
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