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  1. Article ; Online: Single-nucleotide polymorphisms related to vitamin D metabolism and severity or mortality of COVID-19: A systematic review and meta-analysis.

    Regina da Silva Correa da Ronda, Carla / Berlofa Visacri, Marília / Tiemi Siguemoto, Júlia / Motta Neri, Carolini / Crispim Lopo de Abreu, Micaela / de Souza Nicoletti, Aline / Rotta, Inajara / Dagli-Hernandez, Carolina / Moriel Pincinato, Pedro / de Carvalho Pincinato, Eder / Moriel, Patricia

    Gene

    2024  Volume 906, Page(s) 148236

    Abstract: This systematic review and meta-analysis aimed to verify the association between single-nucleotide polymorphisms (SNPs) in vitamin D-related genes and the severity or mortality of coronavirus disease 19 (COVID-19). We systematically searched PubMed, BVS/ ... ...

    Abstract This systematic review and meta-analysis aimed to verify the association between single-nucleotide polymorphisms (SNPs) in vitamin D-related genes and the severity or mortality of coronavirus disease 19 (COVID-19). We systematically searched PubMed, BVS/Bireme, Scopus, Embase, and Web of Science for relevant studies published until November 24, 2023. Twelve studies were included. Thirty-one SNPs related to four genes were studied (VDR, 13 SNPs; GC, 6 SNPs; DHCR7/NADSYN1, 6 SNPs; CYP2R1, 6 SNPs). Eight SNPs were examined in two or more studies (VDR rs731236, rs2228570, rs1544410, rs7975232, rs739837, rs757343, rs11568820, and rs4516035). Meta-analysis showed a significant association between the VDR rs1544410 Bb + bb genotype and b allele and an increased odds of developing severe/critical COVID-19 (Bb + bb vs. BB = 2 studies, OR = 1.73, 95% confidence interval (CI): 1.16-2.57, P = 0.007, I
    MeSH term(s) Humans ; Polymorphism, Single Nucleotide ; Genetic Predisposition to Disease ; Receptors, Calcitriol/genetics ; COVID-19/genetics ; Genotype ; Vitamin D/genetics
    Chemical Substances Receptors, Calcitriol ; Vitamin D (1406-16-2)
    Language English
    Publishing date 2024-02-03
    Publishing country Netherlands
    Document type Meta-Analysis ; Systematic Review ; Journal Article ; Review
    ZDB-ID 391792-7
    ISSN 1879-0038 ; 0378-1119
    ISSN (online) 1879-0038
    ISSN 0378-1119
    DOI 10.1016/j.gene.2024.148236
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1357: Show issues Location:
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  2. Article ; Online: Guanosine, a guanine-based nucleoside relaxed isolated corpus cavernosum from mice through cGMP accumulation.

    de Souza Nicoletti, Aline / Passos, Gabriela Reolon / Bertollotto, Gabriela Maria / Lescano, Caroline Honaiser / de Oliveira, Mariana Gonçalves / Antunes, Edson / Mónica, Fabiola Zakia

    Purinergic signalling

    2020  Volume 16, Issue 2, Page(s) 241–249

    Abstract: In corpus cavernosum (CC), guanosine triphosphate (GTP) is converted into cyclic guanosine monophosphate (cGMP) to induce erection. The action of cGMP is terminated by phosphodiesterases and efflux transporters, which pump cGMP out of the cell. The ... ...

    Abstract In corpus cavernosum (CC), guanosine triphosphate (GTP) is converted into cyclic guanosine monophosphate (cGMP) to induce erection. The action of cGMP is terminated by phosphodiesterases and efflux transporters, which pump cGMP out of the cell. The nucleotides, GTP, and cGMP were detected in the extracellular space, and their hydrolysis lead to the formation of intermediate products, among them guanosine. Therefore, our study aims to pharmacologically characterize the effect of guanosine in isolated CC from mice. The penis was isolated and functional and biochemical analyses were carried out. The guanine-based nucleotides GTP, guanosine diphosphate, guanosine monophosphate, and cGMP relaxed mice corpus cavernosum, but the relaxation (90.7 ± 12.5%) induced by guanosine (0.000001-1 mM) was greater than that of the nucleotides (~ 45%, P < 0.05). Guanosine-induced relaxation was not altered in the presence of adenosine type 2A and 2B receptor antagonists. No augment was observed in the intracellular levels of cyclic adenosine monophosphate in tissues stimulated with guanosine. Inhibitors of nitric oxide synthase (L-NAME, 100 μM) and soluble guanylate cyclase (ODQ, 10 μM) produced a significant reduction in guanosine-induced relaxation in all concentrations studied, while in the presence of tadalafil (300 nM), a significant increase was observed. Pre-incubation of guanosine (100 μM) produced a 6.6-leftward shift in tadalafil-induced relaxation. The intracellular levels of cGMP were greater when CC was stimulated with guanosine. Inhibitors of ecto-nucleotidases and xanthine oxidase did not interfere in the response induced by guanosine. In conclusion, our study shows that guanosine relaxes mice CC and opens the possibility to test its role in models of erectile dysfunction.
    MeSH term(s) Animals ; Cyclic AMP/metabolism ; Cyclic GMP/metabolism ; Erectile Dysfunction/drug therapy ; Erectile Dysfunction/metabolism ; Guanosine/metabolism ; Guanosine/pharmacology ; Male ; Mice ; Mice, Inbred C57BL ; Nitric Oxide Synthase/drug effects ; Nitric Oxide Synthase/metabolism ; Nucleosides/drug effects ; Nucleosides/metabolism
    Chemical Substances Nucleosides ; Guanosine (12133JR80S) ; Cyclic AMP (E0399OZS9N) ; Nitric Oxide Synthase (EC 1.14.13.39) ; Cyclic GMP (H2D2X058MU)
    Language English
    Publishing date 2020-05-27
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2172143-9
    ISSN 1573-9546 ; 1573-9538
    ISSN (online) 1573-9546
    ISSN 1573-9538
    DOI 10.1007/s11302-020-09702-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Differentially expressed plasmatic microRNAs in Brazilian patients with Coronavirus disease 2019 (COVID-19): preliminary results.

    Nicoletti, Aline de Souza / Visacri, Marília Berlofa / da Ronda, Carla Regina da Silva Correa / Vasconcelos, Pedro Eduardo do Nascimento Silva / Quintanilha, Julia Coelho França / de Souza, Rafael Nogueira / Ventura, Deise de Souza / Eguti, Adriana / Silva, Lilian Ferreira de Souza / Perroud Junior, Mauricio Wesley / Catharino, Rodrigo Ramos / Reis, Leonardo Oliveira / Dos Santos, Luiz Augusto / Durán, Nelson / Fávaro, Wagner José / Lancellotti, Marcelo / da Costa, José Luiz / Moriel, Patricia / Pincinato, Eder de Carvalho

    Molecular biology reports

    2022  Volume 49, Issue 7, Page(s) 6931–6943

    Abstract: Background: Coronavirus disease 2019 (COVID-19) is caused by a novel coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). It is known that host microRNAs (miRNAs) can be modulated to favor viral infection or to protect the host. ... ...

    Abstract Background: Coronavirus disease 2019 (COVID-19) is caused by a novel coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). It is known that host microRNAs (miRNAs) can be modulated to favor viral infection or to protect the host. Herein, we report preliminary results of a study aiming at identifying differentially expressed plasmatic miRNAs in Brazilian patients with COVID-19.
    Methods and results: miRNAs were extracted from the plasma of eight patients with COVID-19 (four patients with mild COVID-19 and four patients with severe/critical COVID-19) and four healthy controls. Patients and controls were matched for sex and age. miRNA expression levels were detected using high-throughput sequencing. Differential miRNA expression and enrichment analyses were further evaluated. A total of 18 miRNAs were differentially expressed between patients with COVID-19 and controls. miR-4433b-5p, miR-6780b-3p, miR-6883-3p, miR-320b, miR-7111-3p, miR-4755-3p, miR-320c, and miR-6511a-3p were the most important miRNAs significantly involved in the PI3K/AKT, Wnt/β-catenin, and STAT3 signaling pathways. Moreover, 42 miRNAs were differentially expressed between severe/critical and mild patients with COVID-19. miR-451a, miR-101-3p, miR-185-5p, miR-30d-5p, miR-25-3p, miR-342-3p, miR-30e-5p, miR-150-5p, miR-15b-5p, and miR-29c-3p were the most important miRNAs significantly involved in the Wnt/β-catenin, NF-κβ, and STAT3 signaling pathways.
    Conclusions: If validated by quantitative real-time reverse transcriptase-polymerase chain reaction (RT-PCR) in a larger number of participants, the miRNAs identified in this study might be used as possible biomarkers for the diagnosis and severity of COVID-19.
    MeSH term(s) Brazil/epidemiology ; COVID-19/genetics ; Gene Expression Profiling/methods ; Humans ; MicroRNAs/metabolism ; Phosphatidylinositol 3-Kinases/genetics ; SARS-CoV-2 ; beta Catenin/genetics
    Chemical Substances MicroRNAs ; beta Catenin
    Language English
    Publishing date 2022-03-17
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 186544-4
    ISSN 1573-4978 ; 0301-4851
    ISSN (online) 1573-4978
    ISSN 0301-4851
    DOI 10.1007/s11033-022-07338-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1140: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article: Differentially expressed plasmatic microRNAs in Brazilian patients with Coronavirus disease 2019 (COVID-19): preliminary results

    Nicoletti, Aline de Souza / Visacri, Marília Berlofa / da Ronda, Carla Regina da Silva Correa / Vasconcelos, Pedro Eduardo do Nascimento Silva / Quintanilha, Julia Coelho França / de Souza, Rafael Nogueira / Ventura, Deise de Souza / Eguti, Adriana / Silva, Lilian Ferreira de Souza / Perroud Junior, Mauricio Wesley / Catharino, Rodrigo Ramos / Reis, Leonardo Oliveira / dos Santos, Luiz Augusto / Durán, Nelson / Fávaro, Wagner José / Lancellotti, Marcelo / da Costa, José Luiz / Moriel, Patricia / Pincinato, Eder de Carvalho

    Molecular biology reports. 2022 July, v. 49, no. 7

    2022  

    Abstract: BACKGROUND: Coronavirus disease 2019 (COVID-19) is caused by a novel coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). It is known that host microRNAs (miRNAs) can be modulated to favor viral infection or to protect the host. ... ...

    Abstract BACKGROUND: Coronavirus disease 2019 (COVID-19) is caused by a novel coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). It is known that host microRNAs (miRNAs) can be modulated to favor viral infection or to protect the host. Herein, we report preliminary results of a study aiming at identifying differentially expressed plasmatic miRNAs in Brazilian patients with COVID-19. METHODS AND RESULTS: miRNAs were extracted from the plasma of eight patients with COVID-19 (four patients with mild COVID-19 and four patients with severe/critical COVID-19) and four healthy controls. Patients and controls were matched for sex and age. miRNA expression levels were detected using high-throughput sequencing. Differential miRNA expression and enrichment analyses were further evaluated. A total of 18 miRNAs were differentially expressed between patients with COVID-19 and controls. miR-4433b-5p, miR-6780b-3p, miR-6883-3p, miR-320b, miR-7111-3p, miR-4755-3p, miR-320c, and miR-6511a-3p were the most important miRNAs significantly involved in the PI3K/AKT, Wnt/β-catenin, and STAT3 signaling pathways. Moreover, 42 miRNAs were differentially expressed between severe/critical and mild patients with COVID-19. miR-451a, miR-101-3p, miR-185-5p, miR-30d-5p, miR-25-3p, miR-342-3p, miR-30e-5p, miR-150-5p, miR-15b-5p, and miR-29c-3p were the most important miRNAs significantly involved in the Wnt/β-catenin, NF-κβ, and STAT3 signaling pathways. CONCLUSIONS: If validated by quantitative real-time reverse transcriptase-polymerase chain reaction (RT-PCR) in a larger number of participants, the miRNAs identified in this study might be used as possible biomarkers for the diagnosis and severity of COVID-19.
    Keywords COVID-19 infection ; Severe acute respiratory syndrome coronavirus 2 ; biomarkers ; microRNA ; molecular biology ; reverse transcriptase polymerase chain reaction
    Language English
    Dates of publication 2022-07
    Size p. 6931-6943.
    Publishing place Springer Netherlands
    Document type Article
    ZDB-ID 186544-4
    ISSN 1573-4978 ; 0301-4851
    ISSN (online) 1573-4978
    ISSN 0301-4851
    DOI 10.1007/s11033-022-07338-9
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Bonn / Germany

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  5. Article ; Online: Facing the hospitalization of the adult patient by the caregiver family member

    Caroline Passos Arruda / Giovana Calcagno Gomes / Manoela Cunha Nicoletti / Vanessa da Silva Tarouco / Cintia Camila Santos de Souza Costa / Aline Ney Grehs

    Revista de Enfermagem da Universidade Federal de Santa Maria, Vol 9, Iss 0, Pp e47-e

    2019  Volume 47

    Abstract: Objective: to know how the caregiver family member faces the hospitalization of the adult patient. Method: descriptive and exploratory qualitative research conducted in April 2018 at a University Hospital in southern Brazil. A total of 20 caregiver ... ...

    Abstract Objective: to know how the caregiver family member faces the hospitalization of the adult patient. Method: descriptive and exploratory qualitative research conducted in April 2018 at a University Hospital in southern Brazil. A total of 20 caregiver family members participated in the study. Data were collected through interviews and subjected to Thematic Analysis. Results: The feelings presented regarding hospitalization were worry, anxiety, fear of death and tranquility. The family elected one of the family members to be the primary caregiver or took turns. Sometimes the caregiver needed to take time off to care of the patient, other family members dedicated themselves to aspects of living outside the hospital, and the family expanded. Final Considerations: It is important to direct care to the caregiver family member, contemplating humanization, bonding and communication, as he/she is the greatest ally of the health team members in the hospital.
    Keywords hospital ; família ; cuidador ; sentimentos ; enfermagem ; Medicine ; R ; Nursing ; RT1-120
    Subject code 900
    Language Portuguese
    Publishing date 2019-10-01T00:00:00Z
    Publisher Universidade Federal de Santa Maria
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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