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  1. Article: Providing care for the 99.9% during the COVID-19 pandemic: How ethics, equity, epidemiology, and cost per QALY inform healthcare policy.

    Archer, Stephen L

    Healthcare management forum

    2020  Volume 33, Issue 5, Page(s) 239–242

    Abstract: Managing healthcare in the Coronavirus Disease 2019 (COVID-19) era should be guided by ethics, epidemiology, equity, and economics, not emotion. Ethical healthcare policies ensure equitable access to care for patients regardless of whether they have ... ...

    Abstract Managing healthcare in the Coronavirus Disease 2019 (COVID-19) era should be guided by ethics, epidemiology, equity, and economics, not emotion. Ethical healthcare policies ensure equitable access to care for patients regardless of whether they have COVID-19 or another disease. Because healthcare resources are limited, a cost per Quality Life Year (QALY) approach to COVID-19 policy should also be considered. Policies that focus solely on mitigating COVID-19 are likely to be ethically or financially unsustainable. A cost/QALY approach could target resources to optimally improve QALYs. For example, most COVID-19 deaths occur in long-term care facilities, and this problem is likely better addressed by a focused long-term care reform than by a society-wide non-pharmacological intervention. Likewise, ramping up elective, non-COVID-19 care in low prevalence regions while expanding testing and case tracking in hot spots could reduce excess mortality from non-COVID-19 diseases and decrease adverse financial impacts while controlling the epidemic. Globally, only ∼0.1% of people have had a COVID-19 infection. Thus, ethical healthcare policy must address the needs of the 99.9%.
    MeSH term(s) Betacoronavirus ; COVID-19 ; Coronavirus Infections/epidemiology ; Coronavirus Infections/therapy ; Delivery of Health Care/economics ; Delivery of Health Care/ethics ; Health Equity/economics ; Health Equity/ethics ; Health Policy/economics ; Humans ; Pandemics ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/therapy ; Quality-Adjusted Life Years ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-07-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2140831-2
    ISSN 2352-3883 ; 0840-4704
    ISSN (online) 2352-3883
    ISSN 0840-4704
    DOI 10.1177/0840470420939854
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  2. Article ; Online: Corrigendum to: Scientist on the spot: Exploring the cause and cure for pulmonary arterial hypertension.

    Adão, Rui / Archer, Stephen L

    Cardiovascular research

    2021  Volume 117, Issue 9, Page(s) 2068

    Language English
    Publishing date 2021-07-05
    Publishing country England
    Document type Published Erratum
    ZDB-ID 80340-6
    ISSN 1755-3245 ; 0008-6363
    ISSN (online) 1755-3245
    ISSN 0008-6363
    DOI 10.1093/cvr/cvab191
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Complete Revascularization of the Pulmonary Circulation in Chronic Thromboembolic Pulmonary Hypertension: Value of Addressing Chronic Total Occlusions.

    Prins, Kurt W / Durbin, Josh / Archer, Stephen L

    The Canadian journal of cardiology

    2023  Volume 40, Issue 4, Page(s) 634–636

    MeSH term(s) Humans ; Hypertension, Pulmonary/diagnosis ; Hypertension, Pulmonary/etiology ; Pulmonary Circulation ; Pulmonary Embolism/complications ; Pulmonary Embolism/surgery ; Pulmonary Artery ; Vascular Diseases ; Chronic Disease
    Language English
    Publishing date 2023-11-27
    Publishing country England
    Document type Editorial
    ZDB-ID 632813-1
    ISSN 1916-7075 ; 0828-282X
    ISSN (online) 1916-7075
    ISSN 0828-282X
    DOI 10.1016/j.cjca.2023.11.028
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Publisher Correction: Pulmonary hypertension.

    Mocumbi, Ana / Humbert, Marc / Saxena, Anita / Jing, Zhi-Cheng / Sliwa, Karen / Thienemann, Friedrich / Archer, Stephen L / Stewart, Simon

    Nature reviews. Disease primers

    2024  Volume 10, Issue 1, Page(s) 5

    Language English
    Publishing date 2024-01-17
    Publishing country England
    Document type Published Erratum
    ISSN 2056-676X
    ISSN (online) 2056-676X
    DOI 10.1038/s41572-024-00493-2
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  5. Article ; Online: The Role of Mitochondrial Dynamics and Mitotic Fission in Regulating the Cell Cycle in Cancer and Pulmonary Arterial Hypertension:

    Colpman, Pierce / Dasgupta, Asish / Archer, Stephen L

    Cells

    2023  Volume 12, Issue 14

    Abstract: Mitochondria, which generate ATP through aerobic respiration, also have important noncanonical functions. Mitochondria are dynamic organelles, that engage in fission (division), fusion (joining) and translocation. They also regulate intracellular calcium ...

    Abstract Mitochondria, which generate ATP through aerobic respiration, also have important noncanonical functions. Mitochondria are dynamic organelles, that engage in fission (division), fusion (joining) and translocation. They also regulate intracellular calcium homeostasis, serve as oxygen-sensors, regulate inflammation, participate in cellular and organellar quality control and regulate the cell cycle. Mitochondrial fission is mediated by the large GTPase, dynamin-related protein 1 (Drp1) which, when activated, translocates to the outer mitochondrial membrane (OMM) where it interacts with binding proteins (Fis1, MFF, MiD49 and MiD51). At a site demarcated by the endoplasmic reticulum, fission proteins create a macromolecular ring that divides the organelle. The functional consequence of fission is contextual. Physiological fission in healthy, nonproliferating cells mediates organellar quality control, eliminating dysfunctional portions of the mitochondria via mitophagy. Pathological fission in somatic cells generates reactive oxygen species and triggers cell death. In dividing cells, Drp1-mediated mitotic fission is critical to cell cycle progression, ensuring that daughter cells receive equitable distribution of mitochondria. Mitochondrial fusion is regulated by the large GTPases mitofusin-1 (Mfn1) and mitofusin-2 (Mfn2), which fuse the OMM, and optic atrophy 1 (OPA-1), which fuses the inner mitochondrial membrane. Mitochondrial fusion mediates complementation, an important mitochondrial quality control mechanism. Fusion also favors oxidative metabolism, intracellular calcium homeostasis and inhibits cell proliferation. Mitochondrial lipids, cardiolipin and phosphatidic acid, also regulate fission and fusion, respectively. Here we review the role of mitochondrial dynamics in health and disease and discuss emerging concepts in the field, such as the role of central versus peripheral fission and the potential role of dynamin 2 (DNM2) as a fission mediator. In hyperproliferative diseases, such as pulmonary arterial hypertension and cancer, Drp1 and its binding partners are upregulated and activated, positing mitochondrial fission as an emerging therapeutic target.
    MeSH term(s) Humans ; Mitochondrial Dynamics/physiology ; Pulmonary Arterial Hypertension ; Calcium ; Dynamins/metabolism ; GTP Phosphohydrolases/metabolism ; Cell Cycle ; Neoplasms
    Chemical Substances Calcium (SY7Q814VUP) ; Dynamins (EC 3.6.5.5) ; GTP Phosphohydrolases (EC 3.6.1.-)
    Language English
    Publishing date 2023-07-20
    Publishing country Switzerland
    Document type Journal Article ; Review ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2661518-6
    ISSN 2073-4409 ; 2073-4409
    ISSN (online) 2073-4409
    ISSN 2073-4409
    DOI 10.3390/cells12141897
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  6. Article ; Online: Using omics to breathe new life into our understanding of the ductus arteriosus oxygen response.

    Bentley, Rachel E T / Hindmarch, Charles C T / Archer, Stephen L

    Seminars in perinatology

    2023  Volume 47, Issue 2, Page(s) 151715

    Abstract: The ductus arteriosus (DA) connects the aorta to the pulmonary artery (PA), directing placentally oxygenated blood away from the developing lungs. High pulmonary vascular resistance and low systemic vascular resistance facilitate shunting of blood in ... ...

    Abstract The ductus arteriosus (DA) connects the aorta to the pulmonary artery (PA), directing placentally oxygenated blood away from the developing lungs. High pulmonary vascular resistance and low systemic vascular resistance facilitate shunting of blood in utero from the pulmonary to the systemic circulation through the widely patent DA, thereby optimizing fetal oxygen (O
    MeSH term(s) Infant, Newborn ; Humans ; Ductus Arteriosus/physiology ; Oxygen ; Ductus Arteriosus, Patent ; Heart Defects, Congenital ; Infant, Premature
    Chemical Substances Oxygen (S88TT14065)
    Language English
    Publishing date 2023-03-02
    Publishing country United States
    Document type Review ; Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 752403-1
    ISSN 1558-075X ; 0146-0005
    ISSN (online) 1558-075X
    ISSN 0146-0005
    DOI 10.1016/j.semperi.2023.151715
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  7. Book: Potassium channels in cardiovascular biology

    Archer, Stephen L.

    2001  

    Author's details ed. by Stephen L. Archer
    Keywords Kardiovaskuläres System ; Kaliumkanal
    Subject Herz-Kreislauf-System ; Cardiovasculäres System
    Language English
    Size XLV, 899 S. : graph. Darst.
    Publisher Kluwer/Plenum
    Publishing place New York u.a.
    Publishing country United States
    Document type Book
    HBZ-ID HT013078320
    ISBN 0-306-46402-0 ; 978-0-306-46402-7
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    2001 A 3599 order for loan Magazin

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  8. Article ; Online: Anomalous Right Coronary Artery Arising From Distal Left Circumflex Artery.

    Hanson, Matthew G / Abuzeid, Wael / Archer, Stephen L

    CJC open

    2021  Volume 4, Issue 1, Page(s) 112–113

    Language English
    Publishing date 2021-10-01
    Publishing country United States
    Document type Journal Article
    ISSN 2589-790X
    ISSN (online) 2589-790X
    DOI 10.1016/j.cjco.2021.09.025
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  9. Article: Providing care for the 99.9% during the COVID-19 pandemic: How ethics, equity, epidemiology, and cost per QALY inform healthcare policy

    Archer, Stephen L

    Healthc Manage Forum

    Abstract: Managing healthcare in the Coronavirus Disease 2019 (COVID-19) era should be guided by ethics, epidemiology, equity, and economics, not emotion. Ethical healthcare policies ensure equitable access to care for patients regardless of whether they have ... ...

    Abstract Managing healthcare in the Coronavirus Disease 2019 (COVID-19) era should be guided by ethics, epidemiology, equity, and economics, not emotion. Ethical healthcare policies ensure equitable access to care for patients regardless of whether they have COVID-19 or another disease. Because healthcare resources are limited, a cost per Quality Life Year (QALY) approach to COVID-19 policy should also be considered. Policies that focus solely on mitigating COVID-19 are likely to be ethically or financially unsustainable. A cost/QALY approach could target resources to optimally improve QALYs. For example, most COVID-19 deaths occur in long-term care facilities, and this problem is likely better addressed by a focused long-term care reform than by a society-wide non-pharmacological intervention. Likewise, ramping up elective, non-COVID-19 care in low prevalence regions while expanding testing and case tracking in hot spots could reduce excess mortality from non-COVID-19 diseases and decrease adverse financial impacts while controlling the epidemic. Globally, only ∼0.1% of people have had a COVID-19 infection. Thus, ethical healthcare policy must address the needs of the 99.9%.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #637631
    Database COVID19

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  10. Article ; Online: Providing care for the 99.9% during the COVID-19 pandemic

    Archer, Stephen L.

    Healthcare Management Forum

    How ethics, equity, epidemiology, and cost per QALY inform healthcare policy

    2020  Volume 33, Issue 5, Page(s) 239–242

    Abstract: Managing healthcare in the Coronavirus Disease 2019 (COVID-19) era should be guided by ethics, epidemiology, equity, and economics, not emotion. Ethical healthcare policies ensure equitable access to care for patients regardless of whether they have ... ...

    Abstract Managing healthcare in the Coronavirus Disease 2019 (COVID-19) era should be guided by ethics, epidemiology, equity, and economics, not emotion. Ethical healthcare policies ensure equitable access to care for patients regardless of whether they have COVID-19 or another disease. Because healthcare resources are limited, a cost per Quality Life Year (QALY) approach to COVID-19 policy should also be considered. Policies that focus solely on mitigating COVID-19 are likely to be ethically or financially unsustainable. A cost/QALY approach could target resources to optimally improve QALYs. For example, most COVID-19 deaths occur in long-term care facilities, and this problem is likely better addressed by a focused long-term care reform than by a society-wide non-pharmacological intervention. Likewise, ramping up elective, non-COVID-19 care in low prevalence regions while expanding testing and case tracking in hot spots could reduce excess mortality from non-COVID-19 diseases and decrease adverse financial impacts while controlling the epidemic. Globally, only ∼0.1% of people have had a COVID-19 infection. Thus, ethical healthcare policy must address the needs of the 99.9%.
    Keywords Health Policy ; covid19
    Language English
    Publisher SAGE Publications
    Publishing country us
    Document type Article ; Online
    ZDB-ID 2140831-2
    ISSN 2352-3883 ; 0840-4704
    ISSN (online) 2352-3883
    ISSN 0840-4704
    DOI 10.1177/0840470420939854
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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