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  1. Article ; Online: Living on the edge

    Luke Boulter

    Disease Models & Mechanisms, Vol 16, Iss

    how stromal cells restrict liver cancer invasion

    2023  Volume 3

    Keywords Medicine ; R ; Pathology ; RB1-214
    Language English
    Publishing date 2023-03-01T00:00:00Z
    Publisher The Company of Biologists
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: NOTCH signalling - a core regulator of bile duct disease?

    Martinez Lyons, Anabel / Boulter, Luke

    Disease models & mechanisms

    2023  Volume 16, Issue 9

    Abstract: The Notch signalling pathway is an evolutionarily conserved mechanism of cell-cell communication that mediates cellular proliferation, fate determination and maintenance of stem/progenitor cell populations across tissues. Although it was originally ... ...

    Abstract The Notch signalling pathway is an evolutionarily conserved mechanism of cell-cell communication that mediates cellular proliferation, fate determination and maintenance of stem/progenitor cell populations across tissues. Although it was originally identified as a critical regulator of embryonic liver development, NOTCH signalling activation has been associated with the pathogenesis of a number of paediatric and adult liver diseases. It remains unclear, however, what role NOTCH actually plays in these pathophysiological processes and whether NOTCH activity represents the reactivation of a conserved developmental programme that is essential for adult tissue repair. In this Review, we explore the concepts that NOTCH signalling reactivation in the biliary epithelium is a reiterative and essential response to bile duct damage and that, in disease contexts in which biliary epithelial cells need to be regenerated, NOTCH signalling supports ductular regrowth. Furthermore, we evaluate the recent literature on NOTCH signalling as a critical factor in progenitor-mediated hepatocyte regeneration, which indicates that the mitogenic role for NOTCH signalling in biliary epithelial cell proliferation has also been co-opted to support other forms of epithelial regeneration in the adult liver.
    MeSH term(s) Adult ; Humans ; Child ; Bile Duct Diseases ; Signal Transduction ; Cell Communication ; Bile Ducts ; Liver
    Language English
    Publishing date 2023-08-22
    Publishing country England
    Document type Review ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2451104-3
    ISSN 1754-8411 ; 1754-8403
    ISSN (online) 1754-8411
    ISSN 1754-8403
    DOI 10.1242/dmm.050231
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: NOTCH signalling – a core regulator of bile duct disease?

    Anabel Martinez Lyons / Luke Boulter

    Disease Models & Mechanisms, Vol 16, Iss

    2023  Volume 9

    Keywords bile duct ; cancer ; liver ; notch ; Medicine ; R ; Pathology ; RB1-214
    Language English
    Publishing date 2023-09-01T00:00:00Z
    Publisher The Company of Biologists
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Joining the dots - NEDDylation in cancer cells regulates the tumour environment in cholangiocarcinoma.

    Lüdde, Tom / Boulter, Luke

    Journal of hepatology

    2022  Volume 77, Issue 1, Page(s) 12–14

    MeSH term(s) Bile Duct Neoplasms/pathology ; Bile Ducts, Intrahepatic/pathology ; Cholangiocarcinoma/pathology ; Humans ; Ubiquitin-Protein Ligases
    Chemical Substances Ubiquitin-Protein Ligases (EC 2.3.2.27)
    Language English
    Publishing date 2022-04-28
    Publishing country Netherlands
    Document type Editorial ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 605953-3
    ISSN 1600-0641 ; 0168-8278
    ISSN (online) 1600-0641
    ISSN 0168-8278
    DOI 10.1016/j.jhep.2022.04.018
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2027: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
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  5. Article ; Online: Developing models of cholangiocarcinoma to close the translational gap in cancer research.

    Waddell, Scott H / Boulter, Luke

    Expert opinion on investigational drugs

    2021  Volume 30, Issue 4, Page(s) 439–450

    Abstract: Introduction: ...

    Abstract Introduction:
    MeSH term(s) Animals ; Antineoplastic Agents/pharmacology ; Bile Duct Neoplasms/drug therapy ; Bile Duct Neoplasms/pathology ; Cholangiocarcinoma/drug therapy ; Cholangiocarcinoma/pathology ; Disease Models, Animal ; Drug Development/methods ; Drug Evaluation, Preclinical/methods ; Humans ; Prognosis ; Translational Medical Research
    Chemical Substances Antineoplastic Agents
    Language English
    Publishing date 2021-02-14
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1182884-5
    ISSN 1744-7658 ; 0967-8298 ; 1354-3784
    ISSN (online) 1744-7658
    ISSN 0967-8298 ; 1354-3784
    DOI 10.1080/13543784.2021.1882993
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3739: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: Build to understand biliary oncogenesis via organoids and FGFR2 fusion proteins.

    Boulter, Luke / Ebrahimkhani, Mo R

    Journal of hepatology

    2021  Volume 75, Issue 2, Page(s) 262–264

    MeSH term(s) Biliary Tract ; Carcinogenesis/genetics ; Cell Transformation, Neoplastic ; Humans ; Organoids ; Receptor, Fibroblast Growth Factor, Type 2/genetics
    Chemical Substances FGFR2 protein, human (EC 2.7.10.1) ; Receptor, Fibroblast Growth Factor, Type 2 (EC 2.7.10.1)
    Language English
    Publishing date 2021-05-21
    Publishing country Netherlands
    Document type Editorial ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 605953-3
    ISSN 1600-0641 ; 0168-8278
    ISSN (online) 1600-0641
    ISSN 0168-8278
    DOI 10.1016/j.jhep.2021.05.006
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2027: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: The developmental origins of Notch-driven intrahepatic bile duct disorders.

    Martinez Lyons, Anabel / Boulter, Luke

    Disease models & mechanisms

    2021  Volume 14, Issue 9

    Abstract: The Notch signaling pathway is an evolutionarily conserved mechanism of cell-cell communication that mediates cellular proliferation, cell fate specification, and maintenance of stem and progenitor cell populations. In the vertebrate liver, an absence of ...

    Abstract The Notch signaling pathway is an evolutionarily conserved mechanism of cell-cell communication that mediates cellular proliferation, cell fate specification, and maintenance of stem and progenitor cell populations. In the vertebrate liver, an absence of Notch signaling results in failure to form bile ducts, a complex tubular network that radiates throughout the liver, which, in healthy individuals, transports bile from the liver into the bowel. Loss of a functional biliary network through congenital malformations during development results in cholestasis and necessitates liver transplantation. Here, we examine to what extent Notch signaling is necessary throughout embryonic life to initiate the proliferation and specification of biliary cells and concentrate on the animal and human models that have been used to define how perturbations in this signaling pathway result in developmental liver disorders.
    MeSH term(s) Animals ; Bile Ducts ; Bile Ducts, Intrahepatic/metabolism ; Cholestasis ; Liver/metabolism ; Receptors, Notch/metabolism
    Chemical Substances Receptors, Notch
    Language English
    Publishing date 2021-09-22
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2451104-3
    ISSN 1754-8411 ; 1754-8403
    ISSN (online) 1754-8411
    ISSN 1754-8403
    DOI 10.1242/dmm.048413
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Targeting the Wnt signaling pathway: the challenge of reducing scarring without affecting repair.

    Jarman, Edward J / Boulter, Luke

    Expert opinion on investigational drugs

    2020  Volume 29, Issue 2, Page(s) 179–190

    Abstract: ... ...

    Abstract Introduction
    MeSH term(s) Animals ; Cicatrix/prevention & control ; Disease Progression ; Drug Development ; Humans ; Liver Cirrhosis/drug therapy ; Liver Cirrhosis/physiopathology ; Liver Diseases/drug therapy ; Liver Diseases/physiopathology ; Liver Regeneration/drug effects ; Wnt Signaling Pathway/drug effects
    Language English
    Publishing date 2020-01-23
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1182884-5
    ISSN 1744-7658 ; 0967-8298 ; 1354-3784
    ISSN (online) 1744-7658
    ISSN 0967-8298 ; 1354-3784
    DOI 10.1080/13543784.2020.1718105
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3739: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  9. Article ; Online: The developmental origins of Notch-driven intrahepatic bile duct disorders

    Anabel Martinez Lyons / Luke Boulter

    Disease Models & Mechanisms, Vol 14, Iss

    2021  Volume 9

    Abstract: The Notch signaling pathway is an evolutionarily conserved mechanism of cell–cell communication that mediates cellular proliferation, cell fate specification, and maintenance of stem and progenitor cell populations. In the vertebrate liver, an absence of ...

    Abstract The Notch signaling pathway is an evolutionarily conserved mechanism of cell–cell communication that mediates cellular proliferation, cell fate specification, and maintenance of stem and progenitor cell populations. In the vertebrate liver, an absence of Notch signaling results in failure to form bile ducts, a complex tubular network that radiates throughout the liver, which, in healthy individuals, transports bile from the liver into the bowel. Loss of a functional biliary network through congenital malformations during development results in cholestasis and necessitates liver transplantation. Here, we examine to what extent Notch signaling is necessary throughout embryonic life to initiate the proliferation and specification of biliary cells and concentrate on the animal and human models that have been used to define how perturbations in this signaling pathway result in developmental liver disorders.
    Keywords bile duct ; cholangiocyte ; liver ; notch ; Medicine ; R ; Pathology ; RB1-214
    Language English
    Publishing date 2021-09-01T00:00:00Z
    Publisher The Company of Biologists
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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    Inter-library loan at ZB MED

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  10. Article ; Online: Van Gogh-like 2 is essential for the architectural patterning of the mammalian biliary tree.

    Raab, Michaela / Christodoulou, Ersi / Krishnankutty, Roopesh / Gradinaru, Andreea / Walker, Alexander Daniel / Olaizola, Paula / Younger, Nicholas Thomas / Lyons, Anabel Martinez / Jarman, Edward Joseph / Gournopanos, Konstantinos / von Kriegsheim, Alexander / Waddell, Scott Hamilton / Boulter, Luke

    Journal of hepatology

    2024  

    Abstract: Background & aims: In the developing liver, bipotent epithelial progenitor cells undergo lineage segregation to form hepatocytes, which constitute the bulk of the liver parenchyma, and biliary epithelial cells (cholangiocytes), which comprise the bile ... ...

    Abstract Background & aims: In the developing liver, bipotent epithelial progenitor cells undergo lineage segregation to form hepatocytes, which constitute the bulk of the liver parenchyma, and biliary epithelial cells (cholangiocytes), which comprise the bile duct (a complex tubular network that is critical for normal liver function). Notch and TGFβ signalling promote the formation of a sheet of biliary epithelial cells, the ductal plate, that organises into discontinuous tubular structures. How these structures elongate and connect to form a continuous duct remains undefined. We aimed to define the mechanisms by which the ductal plate transitions from a simple sheet of epithelial cells into a complex and connected bile duct.
    Methods: By combining single-cell RNA sequencing of embryonic mouse livers with genetic tools and organoid models we functionally dissected the role of planar cell polarity in duct patterning.
    Results: We show that the planar cell polarity protein VANGL2 is expressed late in intrahepatic bile duct development and patterns the formation of cell-cell contacts between biliary cells. The patterning of these cell contacts regulates the normal polarisation of the actin cytoskeleton within biliary cells and loss of Vangl2 function results in the abnormal distribution of cortical actin remodelling, leading to the failure of bile duct formation.
    Conclusions: Planar cell polarity is a critical step in the post-specification sculpture of the bile duct and is essential for establishing normal tissue architecture.
    Impact and implications: Like other branched tissues, such as the lung and kidney, the bile ducts use planar cell polarity signalling to coordinate cell movements; however, how these biochemical signals are linked to ductular patterning remains unclear. Here we show that the core planar cell polarity protein VANGL2 patterns how cell-cell contacts form in the mammalian bile duct and how ductular cells transmit confluent mechanical changes along the length of a duct. This work sheds light on how biological tubes are patterned across mammalian tissues (including within the liver) and will be important in how we promote ductular growth in patients where the duct is mis-patterned or poorly formed.
    Language English
    Publishing date 2024-03-07
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 605953-3
    ISSN 1600-0641 ; 0168-8278
    ISSN (online) 1600-0641
    ISSN 0168-8278
    DOI 10.1016/j.jhep.2024.02.030
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2027: Show issues Location:
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    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
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    ab Jg. 2022: Lesesaal (EG)

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