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  1. Article ; Online: Diffuse pulmonary ill-defined centrilobular opacities: Not only bronchiolitis.

    Piciucchi, S / Poletti, V

    European journal of internal medicine

    2022  Volume 100, Page(s) 125–126

    MeSH term(s) Bronchiolitis/diagnosis ; Bronchiolitis/drug therapy ; Humans ; Lung/diagnostic imaging
    Language English
    Publishing date 2022-03-26
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1038679-8
    ISSN 1879-0828 ; 0953-6205
    ISSN (online) 1879-0828
    ISSN 0953-6205
    DOI 10.1016/j.ejim.2022.03.023
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2608: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Correlations between radiological and histological findings in patients with pulmonary vein stenosis after radiofrequency ablation: A case series.

    Poletti, E / Galvani, M / Dubini, A / Poletti, V / Piciucchi, S

    Pulmonology

    2022  Volume 28, Issue 5, Page(s) 396–398

    MeSH term(s) Catheter Ablation/adverse effects ; Humans ; Pulmonary Veins/diagnostic imaging ; Pulmonary Veins/surgery ; Radiofrequency Ablation/adverse effects ; Stenosis, Pulmonary Vein/diagnostic imaging ; Stenosis, Pulmonary Vein/etiology ; Stenosis, Pulmonary Vein/pathology
    Language English
    Publishing date 2022-07-25
    Publishing country Spain
    Document type Letter
    ZDB-ID 3009651-0
    ISSN 2531-0437 ; 2531-0429
    ISSN (online) 2531-0437
    ISSN 2531-0429
    DOI 10.1016/j.pulmoe.2022.03.011
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Relaxation Exponents of OTOCs and Overlap with Local Hamiltonians.

    Balachandran, Vinitha / Poletti, Dario

    Entropy (Basel, Switzerland)

    2022  Volume 25, Issue 1

    Abstract: OTOC has been used to characterize the information scrambling in quantum systems. Recent studies have shown that local conserved quantities play a crucial role in governing the relaxation dynamics of OTOC in non-integrable systems. In particular, the ... ...

    Abstract OTOC has been used to characterize the information scrambling in quantum systems. Recent studies have shown that local conserved quantities play a crucial role in governing the relaxation dynamics of OTOC in non-integrable systems. In particular, the slow scrambling of OTOC is seen for observables that have an overlap with local conserved quantities. However, an observable may not overlap with the Hamiltonian but instead with the Hamiltonian elevated to an exponent larger than one. Here, we show that higher exponents correspond to faster relaxation, although still algebraic, and such exponents can increase indefinitely. Our analytical results are supported by numerical experiments.
    Language English
    Publishing date 2022-12-28
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2014734-X
    ISSN 1099-4300 ; 1099-4300
    ISSN (online) 1099-4300
    ISSN 1099-4300
    DOI 10.3390/e25010059
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Illness Perceptions, Cognitions, and Beliefs on COPD Patients' Adherence to Treatment - A Systematic Review.

    Poletti, Valentina / Pagnini, Francesco / Banfi, Paolo / Volpato, Eleonora

    Patient preference and adherence

    2023  Volume 17, Page(s) 1845–1866

    Abstract: Background: Chronic Obstructive Pulmonary Disease (COPD) is a chronic inflammatory lung disease characterized by persistent respiratory symptoms and airflow limitation. Besides its irreversibility, COPD is a treatable condition, and patients would ... ...

    Abstract Background: Chronic Obstructive Pulmonary Disease (COPD) is a chronic inflammatory lung disease characterized by persistent respiratory symptoms and airflow limitation. Besides its irreversibility, COPD is a treatable condition, and patients would strongly benefit from being adherent to their treatments. However, almost half of them are non-adherent, and, according to several recent studies, the way the patient perceives the disease might influence this variable.
    Aim: This systematic review provided a synthesis of studies about the relationships between illness perceptions (IP), cognitions, beliefs, and adherence in COPD.
    Methods: English language publications were searched in PubMed, Medline, Scopus, ResearchGate, PsycINFO, and Cochrane Library databases from November 2022 to February 2023, following PRISMA guidelines. The reference lists of eligible studies were also searched. Data extraction and critical appraisal were undertaken by two reviewers working independently.
    Results: A total of 14 studies were included. Adherence to treatment in COPD is confirmed to be low, using both self-report questionnaires and objective assessment systems. Most studies concluded that COPD is perceived as a moderate threat destined to last forever, even if many participants referred to little disease knowledge. This perception did not change between adherent and non-adherent groups. Those who considered more necessary to take their medicines and had a caregiver were more adherent and less concerned about their future. On the other side, forgetfulness, lack of trust in medications, and difficulties in understanding how to take them were perceived as the main causes of non-adherence. Other predictors of non-adherence, like depression, low self-efficacy, and severity of disease were confirmed.
    Conclusion: The systematic review highlights the variability of the relationship between IP, cognitions and beliefs, and COPD treatment adherence. A new level of awareness of the relationship between patients' subjective point of view and treatment adherence may inform future treatment options and promote a more personalized intervention.
    Language English
    Publishing date 2023-07-28
    Publishing country New Zealand
    Document type Journal Article ; Review
    ZDB-ID 2455848-5
    ISSN 1177-889X
    ISSN 1177-889X
    DOI 10.2147/PPA.S412136
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Living beyond loss: a qualitative investigation of caregivers' experiences after the death of their relatives with amyotrophic lateral sclerosis.

    Volpato, Eleonora / Banfi, Paolo / Poletti, Valentina / Pagnini, Francesco

    Amyotrophic lateral sclerosis & frontotemporal degeneration

    2023  Volume 25, Issue 1-2, Page(s) 75–87

    Abstract: Background: Caregivers of Amyotrophic Lateral Sclerosis (ALS) patients experience varying psychological responses following the patient's death, including sadness, loneliness, guilt, and a loss of purpose.: Objectives: This research aims to ... ...

    Abstract Background: Caregivers of Amyotrophic Lateral Sclerosis (ALS) patients experience varying psychological responses following the patient's death, including sadness, loneliness, guilt, and a loss of purpose.
    Objectives: This research aims to investigate the caregiver journey experienced from the time of diagnosis to the loss of a care recipient, with a specific focus on understanding the factors that contribute to improved coping with bereavement.
    Methods: The present study used the Interpretative Phenomenological Approach (IPA) to qualitatively explore the accounts of 41 Italian bereaved caregivers of people affected by ALS (Mean Age = 59.78; Female: 60.98%; Male: 39.02%).
    Results: Results revealed 5 overarching themes representing 5 macro areas that emerged from the analysis of the interviews ("
    Conclusions: Results emphasize the need to improve the psychological support offered to caregivers of person living with ALS after the patient's death, tailoring it to the specificity of the condition, to meet their emotional needs, reduce isolation and help them cope with practical challenges and plans.
    MeSH term(s) Humans ; Male ; Female ; Middle Aged ; Amyotrophic Lateral Sclerosis/psychology ; Caregivers/psychology ; Social Support ; Coping Skills ; Qualitative Research
    Language English
    Publishing date 2023-09-06
    Publishing country England
    Document type Journal Article
    ZDB-ID 2705049-X
    ISSN 2167-9223 ; 2167-8421
    ISSN (online) 2167-9223
    ISSN 2167-8421
    DOI 10.1080/21678421.2023.2255628
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5874: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article: Prostaglandin E2 as transduction enhancer affects competitive engraftment of human hematopoietic stem and progenitor cells.

    Poletti, Valentina / Montepeloso, Annita / Pellin, Danilo / Biffi, Alessandra

    Molecular therapy. Methods & clinical development

    2023  Volume 31, Page(s) 101131

    Abstract: ... Ex ... ...

    Abstract Ex vivo
    Language English
    Publishing date 2023-10-11
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2872938-9
    ISSN 2329-0501 ; 2329-0501
    ISSN (online) 2329-0501
    ISSN 2329-0501
    DOI 10.1016/j.omtm.2023.101131
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 7107: Show issues Location:
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  7. Article ; Online: Pinocchio and Interstitial Lung Abnormalities: Is It Just Another Lie?

    Tomassetti, Sara / Ravaglia, Claudia / Poletti, Venerino

    American journal of respiratory and critical care medicine

    2023  Volume 208, Issue 12, Page(s) 1341–1342

    MeSH term(s) Humans ; Tomography, X-Ray Computed ; Respiratory System Abnormalities ; Lung/diagnostic imaging
    Language English
    Publishing date 2023-10-19
    Publishing country United States
    Document type Letter
    ZDB-ID 1180953-x
    ISSN 1535-4970 ; 0003-0805 ; 1073-449X
    ISSN (online) 1535-4970
    ISSN 0003-0805 ; 1073-449X
    DOI 10.1164/rccm.202309-1683LE
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Uh II Zs.80: Show issues Location:
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  8. Article ; Online: The chaperone-assisted selective autophagy complex dynamics and dysfunctions.

    Tedesco, Barbara / Vendredy, Leen / Timmerman, Vincent / Poletti, Angelo

    Autophagy

    2023  Volume 19, Issue 6, Page(s) 1619–1641

    Abstract: Each protein must be synthesized with the correct amino acid sequence, folded into its native structure, and transported to a relevant subcellular location and protein complex. If any of these steps fail, the cell has the capacity to break down aberrant ... ...

    Abstract Each protein must be synthesized with the correct amino acid sequence, folded into its native structure, and transported to a relevant subcellular location and protein complex. If any of these steps fail, the cell has the capacity to break down aberrant proteins to maintain protein homeostasis (also called proteostasis). All cells possess a set of well-characterized protein quality control systems to minimize protein misfolding and the damage it might cause. Autophagy, a conserved pathway for the degradation of long-lived proteins, aggregates, and damaged organelles, was initially characterized as a bulk degradation pathway. However, it is now clear that autophagy also contributes to intracellular homeostasis by selectively degrading cargo material. One of the pathways involved in the selective removal of damaged and misfolded proteins is chaperone-assisted selective autophagy (CASA). The CASA complex is composed of three main proteins (HSPA, HSPB8 and BAG3), essential to maintain protein homeostasis in muscle and neuronal cells. A failure in the CASA complex, caused by mutations in the respective coding genes, can lead to (cardio)myopathies and neurodegenerative diseases. Here, we summarize our current understanding of the CASA complex and its dynamics. We also briefly discuss how CASA complex proteins are involved in disease and may represent an interesting therapeutic target.
    MeSH term(s) Autophagy/genetics ; Kelch-Like ECH-Associated Protein 1/metabolism ; NF-E2-Related Factor 2/metabolism ; Heat-Shock Proteins/metabolism ; Molecular Chaperones/metabolism ; Intracellular Signaling Peptides and Proteins/metabolism ; Ubiquitins/metabolism
    Chemical Substances Kelch-Like ECH-Associated Protein 1 ; NF-E2-Related Factor 2 ; Heat-Shock Proteins ; Molecular Chaperones ; Intracellular Signaling Peptides and Proteins ; Ubiquitins
    Language English
    Publishing date 2023-01-03
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2454135-7
    ISSN 1554-8635 ; 1554-8627
    ISSN (online) 1554-8635
    ISSN 1554-8627
    DOI 10.1080/15548627.2022.2160564
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6741: Show issues Location:
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  9. Article ; Online: Reversed halo sign in radiation induced organizing pneumonia: natural course of the underlying pathophysiology.

    Tzilas, V / Poletti, V / Bouros, D

    Pulmonology

    2021  Volume 27, Issue 5, Page(s) 460–464

    MeSH term(s) Cryptogenic Organizing Pneumonia/diagnostic imaging ; Cryptogenic Organizing Pneumonia/etiology ; Humans ; Pneumonia/diagnostic imaging ; Pneumonia/etiology ; Tomography, X-Ray Computed
    Language English
    Publishing date 2021-04-11
    Publishing country Spain
    Document type Letter
    ZDB-ID 3009651-0
    ISSN 2531-0437 ; 2531-0429
    ISSN (online) 2531-0437
    ISSN 2531-0429
    DOI 10.1016/j.pulmoe.2020.12.015
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Designing Lentiviral Vectors for Gene Therapy of Genetic Diseases

    Poletti, Valentina / Mavilio, Fulvio

    Viruses. 2021 Aug. 02, v. 13, no. 8

    2021  

    Abstract: Lentiviral vectors are the most frequently used tool to stably transfer and express genes in the context of gene therapy for monogenic diseases. The vast majority of clinical applications involves an ex vivo modality whereby lentiviral vectors are used ... ...

    Abstract Lentiviral vectors are the most frequently used tool to stably transfer and express genes in the context of gene therapy for monogenic diseases. The vast majority of clinical applications involves an ex vivo modality whereby lentiviral vectors are used to transduce autologous somatic cells, obtained from patients and re-delivered to patients after transduction. Examples are hematopoietic stem cells used in gene therapy for hematological or neurometabolic diseases or T cells for immunotherapy of cancer. We review the design and use of lentiviral vectors in gene therapy of monogenic diseases, with a focus on controlling gene expression by transcriptional or post-transcriptional mechanisms in the context of vectors that have already entered a clinical development phase.
    Keywords gene expression ; gene therapy ; immunotherapy ; transcription (genetics)
    Language English
    Dates of publication 2021-0802
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article
    ZDB-ID 2516098-9
    ISSN 1999-4915
    ISSN 1999-4915
    DOI 10.3390/v13081526
    Database NAL-Catalogue (AGRICOLA)

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