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  1. Book ; Online: Planktic foraminiferal and sea surface temperature record during the last 1 Myr across the Subtropical Front, Southwest Pacific, supplementary data to: Schaefer, Grace; Rodger, J Stuart; Hayward, Bruce W; Kennett, James P; Sabaa, Ashwaq T; Scott, George H (2005): Planktic foraminiferal and sea surface temperature record during the last 1 Myr across the Subtropical Front, Southwest Pacific. Marine Micropaleontology, 54(3-4), 191-212

    Schaefer, Grace / Hayward, Bruce W / Kennett, James P / Rodger, J Stuart / Sabaa, Ashwaq T / Scott, George H

    2005  

    Abstract: Planktic foraminiferal faunas and modern analogue technique estimates of sea surface temperature (SST) for the last 1 million years (Myr) are compared between core sites to the north (ODP 1125, 178 faunas) and south (DSDP 594, 374 faunas) of the present ... ...

    Abstract Planktic foraminiferal faunas and modern analogue technique estimates of sea surface temperature (SST) for the last 1 million years (Myr) are compared between core sites to the north (ODP 1125, 178 faunas) and south (DSDP 594, 374 faunas) of the present location of the Subtropical Front (STF), east of New Zealand. Faunas beneath cool subtropical water (STW) north of the STF are dominated by dextral Neogloboquadrina pachyderma, Globorotalia inflata, and Globigerina bulloides, whereas faunas to the south are strongly dominated by sinistral N. pachyderma (80-95% in glacials), with increased G. bulloides (20-50%) and dextral N. pachyderma (15-50%) in interglacials (beneath Subantarctic Water, or SAW). Canonical correspondence analysis indicates that at both sites, SST and related factors were the most important environmental influences on faunal composition. Greater climate-related faunal fluctuations occur in the south. Significant faunal changes occur through time at both sites, particularly towards the end of the mid-Pleistocene climate transition, MIS18-15 (e.g., decline of Globorotalia crassula in STW, disappearance of Globorotalia puncticulata in SAW), and during MIS8-5.
    Interglacial SST estimates in the north are similar to the present day throughout the last 1 Myr. To the south, interglacial SSTs are more variable with peaks 4-7 ?C cooler than present through much of the early and middle Pleistocene, but in MIS11, MIS5.5, and early MIS1, peaks are estimated to have been 2-4 ?C warmer than present. These high temperatures are attributed to southward spread of the STF across the submarine Chatham Rise, along which the STF appears to have been dynamically positioned throughout most of the last 1 Myr. For much of the last 1 Myr, glacial SST estimates in the north were only 1-2 ?C cooler than the present interglacial, except in MIS16, MIS8, MIS6, and MIS4-2 when estimates are 4-7 ?C cooler. These cooler temperatures are attributed to jetting of SAW through the Mernoo Saddle (across the Chatham Rise) and/or waning of the STW current. To the south, glacial SST estimates were consistently 10-11 ?C cooler than present, similar to temperatures and faunas currently found in the vicinity of the Polar Front. One interpretation is that these cold temperatures reflect thermocline changes and increased Circumpolar Surface Water spinning off the Subantarctic Front as an enhanced Bounty Gyre along the south side of the Chatham Rise. For most of the last 1 Myr, the temperature gradient across the STF has been considerably greater than the present 4 ?C. During glacial episodes, the STF in this region did not migrate northwards, but instead there was an intensification of the temperature gradient across it (interglacials 4-11 ?C; glacials 8-14 ?C).
    Language English
    Dates of publication 2005-9999
    Size Online-Ressource
    Publisher PANGAEA - Data Publisher for Earth & Environmental Science
    Publishing place Bremen/Bremerhaven
    Document type Book ; Online
    Note This dataset is supplement to doi:10.1016/j.marmicro.2004.12.001
    DOI 10.1594/PANGAEA.691478
    Database Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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  2. Book ; Online: Implications of Integrating Women into the Marine Corps Infantry

    Schaefer, Agnes Gereben / Wenger, Jennie W / Kavanagh, Jennifer / Wong, Jonathan P / Oak, Gillian S

    2015  

    Keywords Advice on careers & achieving success ; Personnel & human resources management ; Defence strategy, planning & research ; Management & Organizational Behavior ; History ; Business
    Language English
    Size 1 Online-Ressource
    Publisher RAND Corporation
    Document type Book ; Online
    Note English
    HBZ-ID HT030611834
    ISBN 9780833092038 ; 0833092030
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  3. Article: Functional Classification of Fusion Proteins in Sarcoma.

    Wachtel, Marco / Surdez, Didier / Grünewald, Thomas G P / Schäfer, Beat W

    Cancers

    2024  Volume 16, Issue 7

    Abstract: Sarcomas comprise a heterogeneous group of malignant tumors of mesenchymal origin. More than 80 entities are associated with different mesenchymal lineages. Sarcomas with fibroblastic, muscle, bone, vascular, adipocytic, and other characteristics are ... ...

    Abstract Sarcomas comprise a heterogeneous group of malignant tumors of mesenchymal origin. More than 80 entities are associated with different mesenchymal lineages. Sarcomas with fibroblastic, muscle, bone, vascular, adipocytic, and other characteristics are distinguished. Nearly half of all entities contain specific chromosomal translocations that give rise to fusion proteins. These are mostly pathognomonic, and their detection by various molecular techniques supports histopathologic classification. Moreover, the fusion proteins act as oncogenic drivers, and their blockade represents a promising therapeutic approach. This review summarizes the current knowledge on fusion proteins in sarcoma. We categorize the different fusion proteins into functional classes, including kinases, epigenetic regulators, and transcription factors, and describe their mechanisms of action. Interestingly, while fusion proteins acting as transcription factors are found in all mesenchymal lineages, the others have a more restricted pattern. Most kinase-driven sarcomas belong to the fibroblastic/myofibroblastic lineage. Fusion proteins with an epigenetic function are mainly associated with sarcomas of unclear differentiation, suggesting that epigenetic dysregulation leads to a major change in cell identity. Comparison of mechanisms of action reveals recurrent functional modes, including antagonism of Polycomb activity by fusion proteins with epigenetic activity and recruitment of histone acetyltransferases by fusion transcription factors of the myogenic lineage. Finally, based on their biology, we describe potential approaches to block the activity of fusion proteins for therapeutic intervention. Overall, our work highlights differences as well as similarities in the biology of fusion proteins from different sarcomas and provides the basis for a functional classification.
    Language English
    Publishing date 2024-03-29
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers16071355
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Musical Mnemonics in Cognitively Unimpaired Individuals and Individuals with Alzheimer's Dementia: A Systematic Review.

    Derks-Dijkman, Marije W / Schaefer, Rebecca S / Kessels, Roy P C

    Neuropsychology review

    2023  

    Abstract: Based on the idea that music acts as a mnemonic aid, musical mnemonics (i.e., sung presentation of information, also referred to as 'music as a structural prompt'), are being used in educational and therapeutic settings. However, evidence in general and ... ...

    Abstract Based on the idea that music acts as a mnemonic aid, musical mnemonics (i.e., sung presentation of information, also referred to as 'music as a structural prompt'), are being used in educational and therapeutic settings. However, evidence in general and patient populations is still scarce. We investigated whether musical mnemonics affect working and episodic memory performance in cognitively unimpaired individuals and persons with Alzheimer's dementia (AD). Furthermore, we examined the possible contribution of musical expertise. We comprehensively searched the PubMed and PsycINFO databases for studies published between 1970 and 2022. Also, reference lists of all identified papers were manually extracted to identify additional articles. Of 1,126 records identified, 37 were eligible and included. Beneficial effects of musical mnemonics on some aspect of memory performance were reported in 28 of 37 studies, including nine on AD. Nine studies found no beneficial effect. Familiarity contributed positively to this beneficial effect in cognitively unimpaired adults, but require more extensive investigation in AD. Musical expertise generally did not lead to additional benefits for cognitively unimpaired participants, but may benefit people with AD. Musical mnemonics may help to learn and remember verbal information in cognitively unimpaired individuals and individuals with memory impairment. Here, we provide a theoretical model of the possible underlying mechanisms of musical mnemonics, building on previous frameworks. We also discuss the implications for designing music-based mnemonics.
    Language English
    Publishing date 2023-04-14
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1062572-0
    ISSN 1573-6660 ; 1040-7308
    ISSN (online) 1573-6660
    ISSN 1040-7308
    DOI 10.1007/s11065-023-09585-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Das Birt-Hogg-Dubé Syndrom als seltene Differentialdiagnose eines spontanen Pneumothorax.

    Klein, Manuel / Schäfer, Patrick / Hamer, Okka W

    RoFo : Fortschritte auf dem Gebiete der Rontgenstrahlen und der Nuklearmedizin

    2023  Volume 195, Issue 6, Page(s) 532–533

    Title translation Birt-Hogg-Dubé syndrome - a rare differential diagnosis of spontaneous pneumothorax.
    MeSH term(s) Humans ; Birt-Hogg-Dube Syndrome/diagnostic imaging ; Birt-Hogg-Dube Syndrome/genetics ; Pneumothorax/diagnostic imaging ; Diagnosis, Differential ; Cysts ; Tomography, X-Ray Computed
    Language German
    Publishing date 2023-02-01
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 554830-5
    ISSN 1438-9010 ; 0340-1618 ; 0936-6652 ; 1433-5972 ; 1438-9029
    ISSN (online) 1438-9010
    ISSN 0340-1618 ; 0936-6652 ; 1433-5972 ; 1438-9029
    DOI 10.1055/a-2007-9722
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Genetically and clinically confirmed atypical cerebrotendinous xanthomatosis with normal cholestanol and marked elevations of bile acid precursors and bile alcohols.

    DeBarber, Andrea E / Schaefer, Ernst J / Do, Jenny / Ray, Joseph W / Larson, Austin / Redder, Samantha / Fowler, Maya / Duell, P Barton

    Journal of clinical lipidology

    2024  

    Abstract: Background: Cerebrotendinous xanthomatosis (CTX) is a rare autosomal recessive lipid disorder. Affected patients often remain undiagnosed until the age of 20-30 years, when they have already developed significant neurologic disease that may not be ... ...

    Abstract Background: Cerebrotendinous xanthomatosis (CTX) is a rare autosomal recessive lipid disorder. Affected patients often remain undiagnosed until the age of 20-30 years, when they have already developed significant neurologic disease that may not be reversible. An elevated plasma cholestanol concentration has been accepted as a diagnostic criterion for CTX for decades.
    Objective: Full biochemical characterization was performed for three genetically and clinically confirmed atypical CTX cases with normal plasma cholestanol levels.
    Methods: Clinical assessment, and genetic/biochemical testing for patients with CTX was performed by their physician providing routine standard of care.
    Results: We report three new atypical CTX cases with large extensor tendon xanthomas but normal plasma cholestanol levels. All three cases had marked elevations of bile acid precursors and bile alcohols in plasma and urine that decreased on treatment with chenodeoxycholic acid. We also review eight published cases of atypical CTX with normal/near normal circulating cholestanol levels.
    Conclusion: The atypical biochemical presentation of these cases provides a diagnostic challenge for CTX; a disorder for which cholestanol has been believed to be a sensitive biomarker. These cases demonstrate measurements of plasma cholestanol alone are insufficient to exclude a diagnosis of CTX. The data presented is consistent with the concept that bile acid precursors and bile alcohols are sensitive biomarkers for atypical CTX with normal cholestanol, and that such testing is indicated, along with CYP27A1 gene analyses, in patients presenting with significant tendon and/or tuberous xanthomas and/or neurologic disease in early adulthood despite normal or near normal cholesterol and cholestanol levels.
    Language English
    Publishing date 2024-03-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2365061-8
    ISSN 1876-4789 ; 1933-2874
    ISSN (online) 1876-4789
    ISSN 1933-2874
    DOI 10.1016/j.jacl.2024.03.004
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Using patient-reported outcome measures and patient-reported experience measures to elevate the quality of healthcare.

    Casaca, Pedro / Schäfer, Willemijn / Nunes, Ana Beatriz / Sousa, Paulo

    International journal for quality in health care : journal of the International Society for Quality in Health Care

    2023  Volume 35, Issue 4

    MeSH term(s) Humans ; Patient Reported Outcome Measures ; Delivery of Health Care ; Health Facilities
    Language English
    Publishing date 2023-12-19
    Publishing country England
    Document type Journal Article
    ZDB-ID 1194150-9
    ISSN 1464-3677 ; 1353-4505
    ISSN (online) 1464-3677
    ISSN 1353-4505
    DOI 10.1093/intqhc/mzad098
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Conference proceedings: Brain tumors in pregnancy. Management and outcome of four consecutive cases

    Jost, E. / Merz, W. M. / Schäfer, N. / Borger, V. / Strizek, B. / Kosian, P.

    Zeitschrift für Geburtshilfe und Neonatologie

    2023  Volume 227, Issue S 01

    Event/congress Abstracts zum 31. Kongress der Deutschen Gesellschaft für perinatale Medizin, Berlin, 2023-11-30
    Language German
    Publishing date 2023-11-01
    Publisher Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article ; Conference proceedings
    ZDB-ID 1226748-x
    ISSN 1439-1651 ; 0948-2393 ; 0300-967X ; 1615-5300
    ISSN (online) 1439-1651
    ISSN 0948-2393 ; 0300-967X ; 1615-5300
    DOI 10.1055/s-0043-1776553
    Database Thieme publisher's database

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  9. Article ; Online: Challenges in Differentiating Pediatric Autoimmune CNS Diseases with Similar Clinical and Imaging Phenotypes.

    Kelley, B P / Caruso, P A / Schaefer, P W

    AJNR. American journal of neuroradiology

    2019  Volume 40, Issue 10, Page(s) E60–E61

    MeSH term(s) Autoimmune Diseases ; Brain ; Central Nervous System Diseases ; Child ; Encephalomyelitis, Acute Disseminated ; Humans ; Magnetic Resonance Imaging ; Neuromyelitis Optica ; Phenotype
    Language English
    Publishing date 2019-09-12
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 603808-6
    ISSN 1936-959X ; 0195-6108
    ISSN (online) 1936-959X
    ISSN 0195-6108
    DOI 10.3174/ajnr.A6196
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Association of ultrasound-confirmed axillary artery vasculitis and clinical outcomes in giant cell arteritis.

    Bosch, P / Dejaco, C / Schmidt, W A / Schlüter, K D / Pregartner, G / Schäfer, Valentin S

    Seminars in arthritis and rheumatism

    2022  Volume 56, Page(s) 152051

    Abstract: ... significant) median time until GC discontinuation (42 months (95% CI: 33-84) vs 30 months (95% CI: 21-42), p=0 ... 060) and median cumulative GC dose (6801mg (range 1748-34169) vs 5633mg (range: 2553-19967), p=0.051 ... p=0522) and relapse rates (2 (range: 0-16) vs 1 (range: 0-13), p=0.67) were similar in both groups ...

    Abstract Objectives: The aim of this observational study was to compare clinical outcomes including glucocorticoid treatment and relapses between giant cell arteritis (GCA) patients with (axGCA) and without axillary artery involvement (non-axGCA).
    Methods: Axillary artery ultrasound was performed in 101 GCA patients at multiple time points. Patients with signs of vasculitis of the axillary arteries at baseline were compared to patients without signs of axillary artery involvement. Cumulative GC doses and relapse rates were calculated as well as survival curves to compare the time until GC discontinuation and occurrence of the first clinical relapse. A linear mixed model was used to assess the effect of a clinical relapse on the intima media thickness (IMT) in axGCA patients.
    Results: Sixty-seven patients were classified as axGCA, 34 as non-axGCA patients. Compared with non-axGCA, axGCA patients yielded a higher (albeit not significant) median time until GC discontinuation (42 months (95% CI: 33-84) vs 30 months (95% CI: 21-42), p=0.060) and median cumulative GC dose (6801mg (range 1748-34169) vs 5633mg (range: 2553-19967), p=0.051). Time until the first relapse (axGCA: 12 months (95% CI: 8-42) vs non-axGCA: 13.5 months (95% CI: 6-27), p=0522) and relapse rates (2 (range: 0-16) vs 1 (range: 0-13), p=0.67) were similar in both groups. Relapses resulted in an increase of the IMT by 0.18mm (95% CI: 0.07-0.30, p=0.003).
    Conclusion: Patients with axGCA have a trend towards longer treatment duration and higher GC requirements as compared to non-axGCA patients. A relapse leads to an increase of the IMT by 0.18mm.
    MeSH term(s) Axillary Artery/diagnostic imaging ; Carotid Intima-Media Thickness ; Giant Cell Arteritis/diagnostic imaging ; Giant Cell Arteritis/drug therapy ; Glucocorticoids/therapeutic use ; Humans ; Recurrence
    Chemical Substances Glucocorticoids
    Language English
    Publishing date 2022-06-15
    Publishing country United States
    Document type Journal Article ; Observational Study
    ZDB-ID 120247-9
    ISSN 1532-866X ; 0049-0172
    ISSN (online) 1532-866X
    ISSN 0049-0172
    DOI 10.1016/j.semarthrit.2022.152051
    Database MEDical Literature Analysis and Retrieval System OnLINE

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