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Article ; Online: Wide-range and area-selective threshold voltage tunability in ultrathin indium oxide transistors.

Tseng, Robert / Wang, Sung-Tsun / Ahmed, Tanveer / Pan, Yi-Yu / Chen, Shih-Chieh / Shih, Che-Chi / Tsai, Wu-Wei / Chen, Hai-Ching / Kei, Chi-Chung / Chou, Tsung-Te / Hung, Wen-Ching / Chen, Jyh-Chen / Kuo, Yi-Hou / Lin, Chun-Liang / Woon, Wei-Yen / Liao, Szuya Sandy / Lien, Der-Hsien

Nature communications

2023 Volume 14, Issue 1, Page(s) 5243

Abstract: The scaling of transistors with thinner channel thicknesses has led to a surge in research on two-dimensional (2D) and quasi-2D semiconductors. However, modulating the threshold voltage ( ... ...

Abstract	The scaling of transistors with thinner channel thicknesses has led to a surge in research on two-dimensional (2D) and quasi-2D semiconductors. However, modulating the threshold voltage (V
Language	English
Publishing date	2023-08-28
Publishing country	England
Document type	Journal Article
ZDB-ID	2553671-0
ISSN	2041-1723 ; 2041-1723
ISSN (online)	2041-1723
ISSN	2041-1723
DOI	10.1038/s41467-023-41041-y
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Article ; Online: Association of Urinary Lead and Cadmium Levels, and Serum Lipids with Subclinical Arteriosclerosis: Evidence from Taiwan.

Lin, Chien-Yu / Hsu, Sandy Huey-Jen / Chen, Ching-Way / Wang, Chikang / Sung, Fung-Chang / Su, Ta-Chen

Nutrients

2023 Volume 15, Issue 3

Abstract: Background: Exposure to lead and cadmium has been linked to changes in lipid metabolism and the development of arteriosclerosis, but the role of lipoprotein profiles in this relationship is not well understood, including the potential role of novel ... ...

Abstract	Background: Exposure to lead and cadmium has been linked to changes in lipid metabolism and the development of arteriosclerosis, but the role of lipoprotein profiles in this relationship is not well understood, including the potential role of novel lipid biomarkers. Methods: In this study, we enrolled 736 young Taiwanese subjects aged 12 to 30 years to assess the correlation between urine levels of lead and cadmium, lipoprotein profiles, and carotid intima-media thickness (CIMT). Results: Higher levels of lead and cadmium were significantly associated with higher levels of low-density lipoprotein cholesterol (LDL-C), small dense LDL-C (sdLDL-C), LDL-triglyceride (LDL-TG), and CIMT. Participants with higher levels of lead and cadmium had the highest mean values of CIMT, LDL-C, sdLDL-C, and LDL-TG. In a structural equation model, lead had a direct and indirect association with CIMT through LDL-C and sdLDL-C, whereas cadmium had a direct association with CIMT and an indirect association through LDL-C. Conclusion: Our results suggest higher levels of lead and cadmium are associated with abnormal lipid profiles and increased CIMT. These heavy metals could have additive effects on lipids and CIMT, and the relationship between them may be mediated by lipoprotein levels. Further research is needed to determine the causal relationship.
MeSH term(s)	Humans ; Arteriosclerosis/epidemiology ; Cadmium/urine ; Carotid Intima-Media Thickness ; Cholesterol, LDL ; Lead/urine ; Risk Factors ; Taiwan ; Lipids/blood
Chemical Substances	Cadmium (00BH33GNGH) ; Cholesterol, LDL ; Lead (2P299V784P) ; Lipids
Language	English
Publishing date	2023-01-21
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2518386-2
ISSN	2072-6643 ; 2072-6643
ISSN (online)	2072-6643
ISSN	2072-6643
DOI	10.3390/nu15030571
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Article ; Online: Exploring the diverse definitions of 'evidence': a scoping review.

Yu, Xuan / Wu, Shouyuan / Sun, Yajia / Wang, Ping / Wang, Ling / Su, Renfeng / Zhao, Junxian / Fadlallah, Racha / Boeira, Laura / Oliver, Sandy / Abraha, Yoseph G / Sewankambo, Nelson K / El-Jardali, Fadi / Norris, Susan L / Chen, Yaolong

BMJ evidence-based medicine

2024 Volume 29, Issue 1, Page(s) 37–43

Abstract: Objectives: To systematically collect and analyse diverse definitions of 'evidence' in both health and social sciences, and help users to correctly use the term 'evidence' and rethink what is the definition of 'evidence' in scientific research.: ... ...

Abstract	Objectives: To systematically collect and analyse diverse definitions of 'evidence' in both health and social sciences, and help users to correctly use the term 'evidence' and rethink what is the definition of 'evidence' in scientific research. Design: Scoping review. Methods: Definitions of evidence in the health sciences and social sciences were included. We have excluded the definition of evidence applied in the legal field, abstracts without full text, documents not published in either Chinese or English and so on. We established a multidisciplinary working group and systematically searched five electronic databases including Medline, Web of Science, EBSCO, the Chinese Social Sciences Citation Index and the Chinese Science Citation Database from their inception to 26 February 2022. We also searched websites and reviewed the reference lists of the identified studies. Six reviewers working in pairs, independently, selected studies according to the inclusion and exclusion criteria, and extracted information. Any differences were discussed in pairs, and if there was disagreement, it was resolved via discussion or with the help of a third reviewer. Reviewers extracted document characteristics, the original content for the definitions of 'evidence', assessed definitions as either intensional or extensional, and any citations for the given definition. Results: Forty-nine documents were finally included after screening, and 68 definitions were obtained. After excluding duplicates, a total of 54 different definitions of 'evidence' were identified. There were 42 intensional definitions and 12 extensional definitions. The top three definiens were 'information', 'fact' and 'research/study'. The definition of 'evidence' differed between health and social sciences. The term 'research' appeared most frequently in the definitions. Conclusions: The definition of 'evidence' has gradually attracted the attention of many scholars and decision-makers in health and social sciences. Nevertheless, there is no widely recognised and accepted definition in scientific research. Given the wide use of the term, we need to think about whether, or under what circumstances, a standardised, clear, meaningful and widely applicable definition of 'evidence' might be helpful.
Language	English
Publishing date	2024-01-19
Publishing country	England
Document type	Journal Article
ISSN	2515-4478
ISSN (online)	2515-4478
DOI	10.1136/bmjebm-2023-112355
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Article ; Online: Clinical impact of recreational drug use among people living with HIV in southern Taiwan.

Chen, Guan-Lin / Lin, Shang-Yi / Lo, Hsiang-Yi / Wu, Hsaing-Chun / Lin, Ya-Mei / Chen, Tun-Chieh / Sandy Chu, Chieh-Yu / Lee, Wen-Chi / Chen, Yen-Hsu / Lu, Po-Liang

Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi

2020 Volume 54, Issue 5, Page(s) 952–962

Abstract: Background: It is unclear about the impact of recreational drug use on the adherence, drug-drug interaction and the occurrence of sexual transmitted diseases (STDs) among people living with HIV.: Material and methods: A retrospective study was ... ...

Abstract	Background: It is unclear about the impact of recreational drug use on the adherence, drug-drug interaction and the occurrence of sexual transmitted diseases (STDs) among people living with HIV. Material and methods: A retrospective study was conducted between Dec 2016, and July 2018 to assess the clinical impact of recreational drug consumption in people living with HIV with antiretroviral therapy. We collected data of the demographics, recreational drug use, laboratory results and STDs diagnoses. Potential drug-drug interactions were checked with reference databases. The association between recreational drug use and STDs, HIV viral load suppression and drug interactions were evaluated. Results: A total of 462 participants were enrolled, included 384 recreational drug users and 78 non-recreational drug users. Younger age (adjusted odds ratio [aOR], 0.94; 95% CI: 0.91-0.98; p = 0.001), longer HIV infection period (aOR, 1.11; 95% CI: 1.03-1.20; p = 0.009) and poor antiretroviral drug adherence (1-2 pills missing per month: aOR, 6.82; 95% CI: 3.50-13.27; p < 0.001; >2 pills missing per month: aOR, 3.50; 95% CI: 1.28-9.61; p = 0.015) were factors associated with recreational drug use. Methamphetamine and nitrites were two most common recreational drugs. Recreational drug use was significantly associated with STDs in one-year follow-up period (aOR, 2.43; 95% CI: 1.11-5.32; p = 0.027) but was not significantly associated with unsuppressed viral load, though a trend was observed (OR, 2.23; 95% CI: 0.92-5.37; p = 0.074). Potential interactions with recreational drugs included 33.1% antiretroviral drugs and 31.3% medications for comorbidities. Conclusion: Recreational drug was associated with STDs. A great proportion of the patients consuming recreational drugs had potential interactions with antiretroviral drugs and medications for comorbidities. The association of recreational drug use and unsuppressed viral load warrants further investigation.
MeSH term(s)	Adult ; Anti-Retroviral Agents/therapeutic use ; Antiretroviral Therapy, Highly Active ; Drug Interactions ; Female ; HIV Infections/drug therapy ; HIV Infections/epidemiology ; Humans ; Male ; Medication Adherence/statistics & numerical data ; Middle Aged ; Recreational Drug Use/statistics & numerical data ; Retrospective Studies ; Sexually Transmitted Diseases/epidemiology ; Taiwan/epidemiology ; Viral Load/drug effects
Chemical Substances	Anti-Retroviral Agents
Language	English
Publishing date	2020-08-12
Publishing country	England
Document type	Journal Article
ZDB-ID	1497590-7
ISSN	1995-9133 ; 1684-1182 ; 0253-2662
ISSN (online)	1995-9133
ISSN	1684-1182 ; 0253-2662
DOI	10.1016/j.jmii.2020.07.016
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Article ; Online: Comparing apples to manzanas and oranges to naranjas: A new measure of English-Spanish vocabulary for dual language learners.

Tamis-LeMonda, Catherine S / Kachergis, George / Masek, Lillian R / Gonzalez, Sandy L / Soska, Kasey C / Herzberg, Orit / Xu, Melody / Adolph, Karen E / Gilmore, Rick O / Bornstein, Marc H / Casasola, Marianella / Fausey, Caitlin M / Frank, Michael C / Goldin-Meadow, Susan / Gros-Louis, Julie / Hirsh-Pasek, Kathy / Iverson, Jana / Lew-Williams, Casey / MacWhinney, Brian /

Marchman, Virginia A / Naigles, Letitia / Namy, Laura / Perry, Lynn K / Rowe, Meredith / Sheya, Adam / Soderstrom, Melanie / Song, Lulu / Walle, Eric / Warlaumont, Anne S / Yoshida, Hanako / Yu, Chen / Yurovsky, Dan

Infancy : the official journal of the International Society on Infant Studies

2024 Volume 29, Issue 3, Page(s) 302–326

Abstract: The valid assessment of vocabulary development in dual-language-learning infants is critical to developmental science. We developed the Dual Language Learners English-Spanish (DLL-ES) Inventories to measure vocabularies of U.S. English-Spanish DLLs. The ... ...

Abstract	The valid assessment of vocabulary development in dual-language-learning infants is critical to developmental science. We developed the Dual Language Learners English-Spanish (DLL-ES) Inventories to measure vocabularies of U.S. English-Spanish DLLs. The inventories provide translation equivalents for all Spanish and English items on Communicative Development Inventory (CDI) short forms; extended inventories based on CDI long forms; and Spanish language-variety options. Item-Response Theory analyses applied to Wordbank and Web-CDI data (n = 2603, 12-18 months; n = 6722, 16-36 months; half female; 1% Asian, 3% Black, 2% Hispanic, 30% White, 64% unknown) showed near-perfect associations between DLL-ES and CDI long-form scores. Interviews with 10 Hispanic mothers of 18- to 24-month-olds (2 White, 1 Black, 7 multi-racial; 6 female) provide a proof of concept for the value of the DLL-ES for assessing the vocabularies of DLLs.
MeSH term(s)	Child ; Infant ; Humans ; Female ; Vocabulary ; Malus ; Citrus sinensis ; Multilingualism ; Child Language ; Language Tests ; Language
Language	English
Publishing date	2024-01-13
Publishing country	United States
Document type	Journal Article
ZDB-ID	2020049-3
ISSN	1532-7078 ; 1525-0008
ISSN (online)	1532-7078
ISSN	1525-0008
DOI	10.1111/infa.12571
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Article ; Online: What Not to Keep

Janice Yu Chen Kung / Sandy Campbell

Journal of the Canadian Health Libraries Association, Vol 37, Iss

Not All Data Has Future Research Value

2016 Volume 2

Abstract: The rise of academic library involvement in research data management has presented numerous challenges for academic libraries. While libraries and archives have always had collection development policies that defined what they would or would not collect, ...

Abstract	The rise of academic library involvement in research data management has presented numerous challenges for academic libraries. While libraries and archives have always had collection development policies that defined what they would or would not collect, policies for selecting research data for preservation are in their infancy. This study surveyed and interviewed academic researchers. From this research an initial list of eight types of data were identified as research data that should not be preserved and made public by academic libraries and archives. These include research data that are sensitive or confidential, proprietary, easily replicable, do not have good metadata, are test, pilot or intermediate data, are bad or junk data, data that cannot be used by others for a variety of reasons, and older data that are not used and have no obvious cultural or historical value. Conclusions drawn from the study will help librarians and archivists make informed decisions about which types of research data are worth keeping.
Keywords	health data ; research data management ; data curation ; data preservation ; Bibliography. Library science. Information resources ; Z
Subject code	306
Language	English
Publishing date	2016-08-01T00:00:00Z
Publisher	University of Alberta
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Diffusion-weighted imaging parameters to track success of pyogenic brain abscess therapy.

Chen, Sandy Chen-Yu / Chung, Hsiao-Wen

AJNR. American journal of neuroradiology

2004 Volume 25, Issue 8, Page(s) 1303–1304

MeSH term(s)	Brain Abscess/diagnosis ; Brain Abscess/therapy ; Diffusion Magnetic Resonance Imaging ; Humans ; Treatment Outcome
Language	English
Publishing date	2004-08-10
Publishing country	United States
Document type	Comment ; Editorial
ZDB-ID	603808-6
ISSN	1936-959X ; 0195-6108
ISSN (online)	1936-959X
ISSN	0195-6108
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Article ; Online: Treatment Strategies and Survival Trends for Anorectal Melanoma: Is it Time for a Change?

Taylor, James P / Stem, Miloslawa / Yu, David / Chen, Sophia Y / Fang, Sandy H / Gearhart, Susan L / Safar, Bashar / Efron, Jonathan E

World journal of surgery

2019 Volume 43, Issue 7, Page(s) 1809–1819

Abstract: Background: Immunotherapy advances for the treatment of cutaneous melanoma question its efficacy in treating anorectal mucosal melanoma (ARMM). We aimed to identify the prevalence, current management, and overall survival (OS) for ARMM.: Methods: ... ...

Abstract	Background: Immunotherapy advances for the treatment of cutaneous melanoma question its efficacy in treating anorectal mucosal melanoma (ARMM). We aimed to identify the prevalence, current management, and overall survival (OS) for ARMM. Methods: Review of patients with ARMM from 2004 to 2015 National Cancer Database. Factors associated with immunotherapy were identified using multivariable logistic regression. The primary outcome was 2- and 5-year OS. Subgroup analysis by treatment type was performed. Results: A total of 1331 patients were identified with a significant increase in prevalence (2004: 6.99%, 2015: 10.53%). ARMM patients were older, white, on Medicare, and from the South. The most common treatment was surgery (48.77%), followed by surgery + radiation (11.75%), surgery + immunotherapy (8.68%), and surgery + chemotherapy (8.68%). 16.93% of patients received immunotherapy, with utilization increasing (7.24%: 2004, 21.27%: 2015, p < 0.001). Patients who received immunotherapy had a significantly better 2-year OS (42.47% vs. 49.21%, p < 0.001), and other therapies did not reveal a significant difference. Adjusted analysis showed no difference in 2- and 5-year OS based on therapy type. Conclusion: The prevalence of ARMM has increased. The use of immunotherapy has increased substantially. Some survival benefit with the administration of immunotherapy may exist that has yet to be revealed. A more aggressive treatment paradigm is warranted.
MeSH term(s)	Aged ; Aged, 80 and over ; Antineoplastic Agents, Immunological/therapeutic use ; Anus Neoplasms/therapy ; Combined Modality Therapy ; Databases, Factual ; Female ; Humans ; Immunotherapy ; Male ; Melanoma/therapy ; Middle Aged ; Rectal Neoplasms/therapy ; Survival Rate/trends
Chemical Substances	Antineoplastic Agents, Immunological
Language	English
Publishing date	2019-05-06
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	224043-9
ISSN	1432-2323 ; 0364-2313
ISSN (online)	1432-2323
ISSN	0364-2313
DOI	10.1007/s00268-019-04960-w
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Article ; Online: Super resolution convolutional neural network for feature extraction in spectroscopic data.

Peng, Han / Gao, Xiang / He, Yu / Li, Yiwei / Ji, Yuchen / Liu, Chuhang / Ekahana, Sandy A / Pei, Ding / Liu, Zhongkai / Shen, Zhixun / Chen, Yulin

The Review of scientific instruments

2020 Volume 91, Issue 3, Page(s) 33905

Abstract: Two dimensional (2D) peak finding is a common practice in data analysis for physics experiments, which is typically achieved by computing the local derivatives. However, this method is inherently unstable when the local landscape is complicated or the ... ...

Abstract	Two dimensional (2D) peak finding is a common practice in data analysis for physics experiments, which is typically achieved by computing the local derivatives. However, this method is inherently unstable when the local landscape is complicated or the signal-to-noise ratio of the data is low. In this work, we propose a new method in which the peak tracking task is formalized as an inverse problem, which thus can be solved with a convolutional neural network (CNN). In addition, we show that the underlying physics principle of the experiments can be used to generate the training data. By generalizing the trained neural network on real experimental data, we show that the CNN method can achieve comparable or better results than traditional derivative based methods. This approach can be further generalized in different physics experiments when the physical process is known.
Language	English
Publishing date	2020-04-04
Publishing country	United States
Document type	Journal Article
ZDB-ID	209865-9
ISSN	1089-7623 ; 0034-6748
ISSN (online)	1089-7623
ISSN	0034-6748
DOI	10.1063/1.5132586
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Article ; Online: Demographic and clinical characteristics associated with variations in antibody response to BNT162b2 COVID-19 vaccination among healthcare workers at an academic medical centre

Brian Claggett / Sonia Sharma / Min Wu / Peter Chen / Gil Y Melmed / Nancy Sun / Susan Cheng / Joseph E Ebinger / Matthew Driver / Dermot P B McGovern / Kimia Sobhani / Mohit Jain / Sandy Joung / Yunxian Liu / Brittany Weber / Patrick G Botting / Yu Hung Kao / Briana Khuu / Timothy Wynter /

Trevor-Trung Nguyen / Mona Alotaibi / John C Prostko / Edwin C Frias / James L Stewart / Helen S Goodridge / Stanley C Jordan / Justyna Fert-Bober / Jennifer E Van Eyk / Margo B Minissian / Moshe Arditi / Jonathan G Braun

BMJ Open, Vol 12, Iss

a longitudinal cohort analysis

2022 Volume 5

Keywords	Medicine ; R
Language	English
Publishing date	2022-05-01T00:00:00Z
Publisher	BMJ Publishing Group
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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