Article ; Online: Spermidine supplementation in rare translation-associated disorders.
Cell stress
2021 Volume 5, Issue 3, Page(s) 29–32
Abstract: The polyamine spermidine is essential for protein translation in eukaryotes, both as a substrate for the hypusination of the translation initiation factor eIF5A as well as general translational fidelity. Dwindling spermidine levels during aging have been ...
Abstract | The polyamine spermidine is essential for protein translation in eukaryotes, both as a substrate for the hypusination of the translation initiation factor eIF5A as well as general translational fidelity. Dwindling spermidine levels during aging have been implicated in reduced immune cell function through insufficient eIF5A hypusination, which can be restored by external supplementation. Recent findings characterize a group of novel Mendelian disorders linked to |
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Language | English |
Publishing date | 2021-03-08 |
Publishing country | Austria |
Document type | Journal Article ; Comment |
ISSN | 2523-0204 |
ISSN (online) | 2523-0204 |
DOI | 10.15698/cst2021.03.243 |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
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