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Article ; Online: Neuroprotective Effect of Resveratrol against Manganese-Induced Oxidative Stress and Matrix Metalloproteinase-9 in an "In Vivo" Model of Neurotoxicity.

Latronico, Tiziana / Rossano, Rocco / Miniero, Daniela Valeria / Casalino, Elisabetta / Liuzzi, Grazia Maria

International journal of molecular sciences

2024 Volume 25, Issue 4

Abstract: Chronic exposure to manganese (Mn) leads to its accumulation in the central nervous system (CNS) and neurotoxicity with not well-known mechanisms. We investigated the involvement of matrix metalloproteinase (MMP)-2 and -9 in Mn neurotoxicity in an in ... ...

Abstract	Chronic exposure to manganese (Mn) leads to its accumulation in the central nervous system (CNS) and neurotoxicity with not well-known mechanisms. We investigated the involvement of matrix metalloproteinase (MMP)-2 and -9 in Mn neurotoxicity in an in vivo model of rats treated through an intraperitoneal injection, for 4 weeks, with 50 mg/kg of MnCl
MeSH term(s)	Animals ; Rats ; Manganese/toxicity ; Matrix Metalloproteinase 9/drug effects ; Neuroprotective Agents/pharmacology ; Neurotoxicity Syndromes/drug therapy ; Neurotoxicity Syndromes/etiology ; Neurotoxicity Syndromes/prevention & control ; Oxidative Stress ; Resveratrol/pharmacology
Chemical Substances	Manganese (42Z2K6ZL8P) ; Matrix Metalloproteinase 9 (EC 3.4.24.35) ; Neuroprotective Agents ; Resveratrol (Q369O8926L)
Language	English
Publishing date	2024-02-10
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms25042142
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Article ; Online: Inhibition of MMP-2 and MMP-9 by Dietary Antioxidants in THP-1 Macrophages and Sera from Patients with Breast Cancer.

Latronico, Tiziana / Petraglia, Tania / Sileo, Carmela / Bilancia, Domenico / Rossano, Rocco / Liuzzi, Grazia Maria

Molecules (Basel, Switzerland)

2024 Volume 29, Issue 8

Abstract: Polyphenols, the main antioxidants of diet, have shown anti-inflammatory, antioxidant and anticarcinogenic activities. Here, we compared the effects of four polyphenolic compounds on ROS production and on the levels of matrix metalloproteinase (MMP)-2 ... ...

Abstract	Polyphenols, the main antioxidants of diet, have shown anti-inflammatory, antioxidant and anticarcinogenic activities. Here, we compared the effects of four polyphenolic compounds on ROS production and on the levels of matrix metalloproteinase (MMP)-2 and -9, which represent important pathogenetic factors of breast cancer. THP-1 differentiated macrophages were activated by LPS and simultaneously treated with different doses of a green tea extract (GTE), resveratrol (RSV), curcumin (CRC) and an olive fruit extract (oliplus). By using the 2,2-Diphenyl-1-picrylhydrazyl (DPPH) radical scavenging assay, we found that all of the tested compounds showed antioxidant activity in vitro. In addition, GTE, RSV and CRC were able to counteract ROS production induced by H
MeSH term(s)	Humans ; Matrix Metalloproteinase 9/metabolism ; Matrix Metalloproteinase 2/metabolism ; Antioxidants/pharmacology ; Female ; Breast Neoplasms/drug therapy ; Breast Neoplasms/metabolism ; Breast Neoplasms/pathology ; Macrophages/drug effects ; Macrophages/metabolism ; Reactive Oxygen Species/metabolism ; Resveratrol/pharmacology ; THP-1 Cells ; Matrix Metalloproteinase Inhibitors/pharmacology ; Plant Extracts/pharmacology ; Plant Extracts/chemistry ; Curcumin/pharmacology
Chemical Substances	Matrix Metalloproteinase 9 (EC 3.4.24.35) ; Matrix Metalloproteinase 2 (EC 3.4.24.24) ; Antioxidants ; Reactive Oxygen Species ; Resveratrol (Q369O8926L) ; Matrix Metalloproteinase Inhibitors ; Plant Extracts ; MMP9 protein, human (EC 3.4.24.35) ; MMP2 protein, human (EC 3.4.24.24) ; Curcumin (IT942ZTH98)
Language	English
Publishing date	2024-04-10
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1413402-0
ISSN	1420-3049 ; 1431-5165 ; 1420-3049
ISSN (online)	1420-3049
ISSN	1431-5165 ; 1420-3049
DOI	10.3390/molecules29081718
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Article ; Online: The human gut microbiota is neither an organ nor a commensal.

Riccio, Paolo / Rossano, Rocco

FEBS letters

2020 Volume 594, Issue 20, Page(s) 3262–3271

Abstract: The recent explosive increase in the number of works on gut microbiota has been accompanied by the spread of rather vague or improper definitions, chosen more for common use than for experimental evidence. Among them are those defining the human gut ... ...

Abstract	The recent explosive increase in the number of works on gut microbiota has been accompanied by the spread of rather vague or improper definitions, chosen more for common use than for experimental evidence. Among them are those defining the human gut microbiota as an organ of our body or as a commensal. But, is the human gut microbiota an organ or a commensal? Here, we address this issue to spearhead a reflection on the real roles of the human gut microbiota in our life. Actually, the misuse of the vocabulary used to describe the properties and functions of the gut microbiota may generate confusion and cause misunderstandings both in the scientific community and among the general public.
MeSH term(s)	Biotransformation ; Gastrointestinal Microbiome ; Gastrointestinal Tract/microbiology ; Humans ; Symbiosis
Language	English
Publishing date	2020-10-19
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	212746-5
ISSN	1873-3468 ; 0014-5793
ISSN (online)	1873-3468
ISSN	0014-5793
DOI	10.1002/1873-3468.13946
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Article ; Online: Antioxidant Activity of Polysaccharides from the Edible Mushroom

Petraglia, Tania / Latronico, Tiziana / Fanigliulo, Angela / Crescenzi, Aniello / Liuzzi, Grazia Maria / Rossano, Rocco

Molecules (Basel, Switzerland)

2023 Volume 28, Issue 5

Abstract: In this study the antioxidant and neuroprotective activity of an enriched polysaccharide fraction (EPF) obtained from the fruiting body of ... ...

Abstract	In this study the antioxidant and neuroprotective activity of an enriched polysaccharide fraction (EPF) obtained from the fruiting body of cultivated
MeSH term(s)	Antioxidants/chemistry ; Agaricales/metabolism ; Superoxides/metabolism ; Nitric Oxide/metabolism ; Hydrogen Peroxide/metabolism ; Pleurotus/chemistry ; Polysaccharides/chemistry ; Hydroxyl Radical/metabolism
Chemical Substances	Antioxidants ; Superoxides (11062-77-4) ; Nitric Oxide (31C4KY9ESH) ; Hydrogen Peroxide (BBX060AN9V) ; Polysaccharides ; Hydroxyl Radical (3352-57-6)
Language	English
Publishing date	2023-02-26
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1413402-0
ISSN	1420-3049 ; 1431-5165 ; 1420-3049
ISSN (online)	1420-3049
ISSN	1431-5165 ; 1420-3049
DOI	10.3390/molecules28052176
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Article ; Online: Antioxidant Compounds from Edible Mushrooms as Potential Candidates for Treating Age-Related Neurodegenerative Diseases.

Liuzzi, Grazia Maria / Petraglia, Tania / Latronico, Tiziana / Crescenzi, Aniello / Rossano, Rocco

Nutrients

2023 Volume 15, Issue 8

Abstract: The last century has seen an increase in our life expectancy. As a result, various age-related diseases, such as neurodegenerative diseases (NDs), have emerged, representing new challenges to society. Oxidative stress (OS), a condition of redox imbalance ...

Abstract	The last century has seen an increase in our life expectancy. As a result, various age-related diseases, such as neurodegenerative diseases (NDs), have emerged, representing new challenges to society. Oxidative stress (OS), a condition of redox imbalance resulting from excessive production of reactive oxygen species, represents a common feature that characterizes the brains of elderly people, thus contributing to NDs. Consequently, antioxidant supplementation or dietary intake of antioxidant-containing foods could represent an effective preventive and therapeutic intervention to maintain the integrity and survival of neurons and to counteract the neurodegenerative pathologies associated with aging. Food contains numerous bioactive molecules with beneficial actions for human health. To this purpose, a wide range of edible mushrooms have been reported to produce different antioxidant compounds such as phenolics, flavonoids, polysaccharides, vitamins, carotenoids, ergothioneine, and others, which might be used for dietary supplementation to enhance antioxidant defenses and, consequently, the prevention of age-related neurological diseases. In this review, we summarized the role of oxidative stress in age-related NDs, focusing on the current knowledge of the antioxidant compounds present in edible mushrooms, and highlighting their potential to preserve healthy aging by counteracting age-associated NDs.
MeSH term(s)	Humans ; Aged ; Antioxidants/therapeutic use ; Agaricales ; Neurodegenerative Diseases/drug therapy ; Neurodegenerative Diseases/prevention & control ; Oxidative Stress ; Vitamins/therapeutic use
Chemical Substances	Antioxidants ; Vitamins
Language	English
Publishing date	2023-04-15
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2518386-2
ISSN	2072-6643 ; 2072-6643
ISSN (online)	2072-6643
ISSN	2072-6643
DOI	10.3390/nu15081913
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Article ; Online: Undigested Food and Gut Microbiota May Cooperate in the Pathogenesis of Neuroinflammatory Diseases: A Matter of Barriers and a Proposal on the Origin of Organ Specificity.

Riccio, Paolo / Rossano, Rocco

Nutrients

2019 Volume 11, Issue 11

Abstract: As food is an active subject and may have anti-inflammatory or pro-inflammatory effects, dietary habits may modulate the low-grade neuroinflammation associated with chronic neurodegenerative diseases. Food is living matter different from us, but made of ... ...

Abstract	As food is an active subject and may have anti-inflammatory or pro-inflammatory effects, dietary habits may modulate the low-grade neuroinflammation associated with chronic neurodegenerative diseases. Food is living matter different from us, but made of our own nature. Therefore, it is at the same time foreign to us (
MeSH term(s)	Animals ; Autistic Disorder/immunology ; Autistic Disorder/microbiology ; Autistic Disorder/physiopathology ; Diet ; Dysbiosis/immunology ; Dysbiosis/microbiology ; Dysbiosis/physiopathology ; Gastrointestinal Microbiome ; Humans ; Inflammation/immunology ; Inflammation/microbiology ; Inflammation/physiopathology ; Mice ; Neurodegenerative Diseases/immunology ; Neurodegenerative Diseases/microbiology ; Neurodegenerative Diseases/physiopathology ; Organ Specificity/immunology
Language	English
Publishing date	2019-11-09
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2518386-2
ISSN	2072-6643 ; 2072-6643
ISSN (online)	2072-6643
ISSN	2072-6643
DOI	10.3390/nu11112714
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Article ; Online: Antioxidant Activity of Polysaccharides from the Edible Mushroom Pleurotus eryngii

Tania Petraglia / Tiziana Latronico / Angela Fanigliulo / Aniello Crescenzi / Grazia Maria Liuzzi / Rocco Rossano

Molecules, Vol 28, Iss 2176, p

2023 Volume 2176

Abstract: In this study the antioxidant and neuroprotective activity of an enriched polysaccharide fraction (EPF) obtained from the fruiting body of cultivated P. eryngii was evaluated. Proximate composition (moisture, proteins, fat, carbohydrates and ash) was ... ...

Abstract	In this study the antioxidant and neuroprotective activity of an enriched polysaccharide fraction (EPF) obtained from the fruiting body of cultivated P. eryngii was evaluated. Proximate composition (moisture, proteins, fat, carbohydrates and ash) was determined using the AOAC procedures. The EPF was extracted by using, in sequence, hot water and alkaline extractions followed by deproteinization and precipitation with cold ethanol. Total α- and β-glucans were quantified using the Megazyme International Kit. The results showed that this procedure allows a high yield of polysaccharides with a higher content of (1-3; 1-6)-β-D-glucans. The antioxidant activity of EPF was detected from the total reducing power, DPPH, superoxide, hydroxyl and nitric oxide radical scavenging activities. The EPF was found to scavenge DPPH, superoxide, hydroxyl and nitric oxide radicals with a IC50 values of 0.52 ± 0.02, 1.15 ± 0.09, 0.89 ± 0.04 and 2.83 ± 0.16 mg/mL, respectively. As assessed by the MTT assay, the EPF was biocompatible for DI-TNC1 cells in the range of 0.006–1 mg/mL and, at concentrations ranging from 0.05 to 0.2 mg/mL, significantly counteracted H 2 O 2 -induced reactive oxygen species production. This study demonstrated that polysaccharides extracted from P. eryngii might be used as functional food to potentiate the antioxidant defenses and to reduce oxidative stress.
Keywords	mushrooms ; β-glucan ; Pleurotus eryngii ; polysaccharides ; antioxidant activity ; neuroprotection ; Organic chemistry ; QD241-441
Language	English
Publishing date	2023-02-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Unveiling a Hidden Biomarker of Inflammation and Tumor Progression

Rocco Rossano / Marilena Larocca / Margherita Macellaro / Domenico Bilancia / Paolo Riccio

Current Issues in Molecular Biology, Vol 44, Iss 8, Pp 105-

The 65 kDa Isoform of MMP-9 New Horizons for Therapy

2022 Volume 116

Abstract: Cancer metastasis is a stage of the disease where therapy is mostly ineffective; hence, the need to find reliable markers of its onset. The metalloproteinase-9 (MMP-9, gelatinase B) in its 82 kDa active form, is a good candidate, but here we show that ... ...

Abstract	Cancer metastasis is a stage of the disease where therapy is mostly ineffective; hence, the need to find reliable markers of its onset. The metalloproteinase-9 (MMP-9, gelatinase B) in its 82 kDa active form, is a good candidate, but here we show that the correspondent little known 65 kDa active MMP-9 isoform, often misrepresented with the other gelatinase MMP-2, is a more suitable marker. Sera from patients with lung and breast cancer were analyzed by bidimensional zymography to detect the activity of MMP-9 and MMP-2. Enzyme identity was confirmed by comparison with MMP-9 standards and by western blotting. The 65 kDa isoform of MMP-9 is a suitable biomarker to monitor tumor progression from tissue neoplasms to metastatic stage, as its activity begins to appear when disease severity increases and becomes very high in metastasis. Moreover, the 65 kDa MMP-9, which derives from the 82 kDa MMP-9, no longer responds to natural MMP-9 inhibitors. As its activity cannot be controlled, its appearance may warn that the pathological process is becoming irreversible. Identification and inhibition of the enzymes converting the inhibitor-sensitive 82 kDa MMP-9 into the corresponding “wild” 65 kDa MMP-9 may allow to develop therapies capable of blocking metastases.
Keywords	inflammation ; matrix metalloproteinases ; MMP-9 ; cancer ; metastasis ; prognostic markers ; Biology (General) ; QH301-705.5
Subject code	616
Language	English
Publishing date	2022-12-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Edible Mushrooms as Source of Fibrin(ogen)olytic Enzymes: Comparison between Four Cultivated Species.

Petraglia, Tania / Latronico, Tiziana / Liuzzi, Grazia Maria / Fanigliulo, Angela / Crescenzi, Aniello / Rossano, Rocco

Molecules (Basel, Switzerland)

2022 Volume 27, Issue 23

Abstract: Cardiovascular diseases represent the main cause of death. A common feature of cardiovascular disease is thrombosis resulting from intravascular accumulation of fibrin. In the last years, several fibrinolytic enzymes have been discovered in many ... ...

Abstract	Cardiovascular diseases represent the main cause of death. A common feature of cardiovascular disease is thrombosis resulting from intravascular accumulation of fibrin. In the last years, several fibrinolytic enzymes have been discovered in many medicinal or edible mushrooms as potential new antithrombotic agents. This study aimed to compare the fibrin(ogen)olytic activity of crude extracts from the fruiting bodies of four cultivated edible mushrooms:
Language	English
Publishing date	2022-11-23
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1413402-0
ISSN	1420-3049 ; 1431-5165 ; 1420-3049
ISSN (online)	1420-3049
ISSN	1431-5165 ; 1420-3049
DOI	10.3390/molecules27238145
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Article ; Online: Unveiling a Hidden Biomarker of Inflammation and Tumor Progression: The 65 kDa Isoform of MMP-9 New Horizons for Therapy.

Rossano, Rocco / Larocca, Marilena / Macellaro, Margherita / Bilancia, Domenico / Riccio, Paolo

Current issues in molecular biology

2021 Volume 44, Issue 1, Page(s) 105–116

Abstract	Cancer metastasis is a stage of the disease where therapy is mostly ineffective; hence, the need to find reliable markers of its onset. The metalloproteinase-9 (MMP-9, gelatinase B) in its 82 kDa active form, is a good candidate, but here we show that the correspondent little known 65 kDa active MMP-9 isoform, often misrepresented with the other gelatinase MMP-2, is a more suitable marker. Sera from patients with lung and breast cancer were analyzed by bidimensional zymography to detect the activity of MMP-9 and MMP-2. Enzyme identity was confirmed by comparison with MMP-9 standards and by western blotting. The 65 kDa isoform of MMP-9 is a suitable biomarker to monitor tumor progression from tissue neoplasms to metastatic stage, as its activity begins to appear when disease severity increases and becomes very high in metastasis. Moreover, the 65 kDa MMP-9, which derives from the 82 kDa MMP-9, no longer responds to natural MMP-9 inhibitors. As its activity cannot be controlled, its appearance may warn that the pathological process is becoming irreversible. Identification and inhibition of the enzymes converting the inhibitor-sensitive 82 kDa MMP-9 into the corresponding "wild" 65 kDa MMP-9 may allow to develop therapies capable of blocking metastases.
Language	English
Publishing date	2021-12-25
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2000024-8
ISSN	1467-3045 ; 1467-3037
ISSN (online)	1467-3045
ISSN	1467-3037
DOI	10.3390/cimb44010008
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Zs.A 5122: Show issues

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